This document discusses principles for effective instruction of 21st century learners. It recommends that teachers establish engaging learning environments, assess students' prior knowledge, consider individual differences, state clear objectives, develop metacognitive skills, provide social interaction and real-world contexts, and offer frequent feedback. Teachers should also be competent using technology and media according to national standards, and leverage various text sources while addressing potential disadvantages like reading level. The goal is to prepare students for success through motivated, relevant learning experiences.