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17-11-18
1
Prof. dr. Andreas Voss
MD, PhD, FSHEA, FESCMID, FISAC
President-Elect ISAC
Nijmegen, The Netherlands
I hope that Houston
knows that “we” is
not Infection
Control but the
surgeons
SSI
Surgeon
IPC
OR
Ward
Wound
care
Anesth.
Buyers etc …
Your are entering the
operating theatre
There are many pre-and perioperative
factors that determine whether or not
a patient will develop a SSI
No influence possible
¤ Age
¤ Underlying disease
¤ Malignancy
¤ Wound classification
¤ Prosthetic material
Influence not probable
• Laminar air-flow
• Sterilization
• Pre-op hospitalization
Influence by others
• BMI >30
• Nicotine use
• Malnutrition
• Infection at remote site
Can & should be influenced
• Surveillance
• S. aureus colonization
• Normothermia/hyperoxia
• Glucose levels
• Hair-removal
• Antimicrobial prophylaxis
• Skin disinfection/decolonization
¤ Basic practices
² that should be adopted by all acute care hospitals
¤ Special approaches
²that can be considered for use in locations and/or populations within
hospitals when “preventive maximum” is reached
² incision drapes, coated sutures, …
17-11-18
2
¤ Prioritize your efforts by initially focusing on
the implementation of basic practices
Classen. NEJM 1992;328:281.
Infections(%)
Hours From Incision
17-11-18
3
¤Inappropriate:
²Shaving
¤Appropriate:
²No hair removal at all
²Clipping
²Depilatory use
Warning: Free-ranging
Hospital Administrator
Why buy
expensive clipper
heads. Blunt
razors are fine
• Hypothermia reduces tissue oxygen tension by
vasoconstriction.
• Hypothermia reduces leukocyte superoxide production.
• Hypothermia increases bleeding and transfusion
requirements.
• Hypothermia increases duration of hospital stay even in
uninfected patients.
Kurz et al. NEJM 1996; 334:1209-15
Patients with
colorectal
operations sample
SSI rate (%)
6 %
19 %
Normothermia
Hypothermia
p=0.009
200 Patients
17-11-18
4
SSI-rate
Local Systemic Control
5 (4%) 8 (6%) 19 (14%)
Melling. Lancet. 2001; 358:876.
NEJM
I don’t know
why but I
want pink !
I used red
stuff for 20
years!
Why switch?
I want no
color! If I
can’t see the
patients dies!
I need
nothing, I
have no
infections!
This IC people really bore
me. Just leave my OR!
Meet my surgical team
Darouiche et al NEJM 2010;362:18-26
Great study: It matters which skin disinfectant you use!
Only problem: wrong comparator !
Charehbili Surg Infect 2014;15:DOI: 10.1089/sur.2012.185
non-randomized, non-blinded
V
17-11-18
5
Charehbili et al. Surg Infect 2014;15:DOI: 10.1089/sur.2012.185
Nasal S. aureus decolonization
Bode et al. NEJM 2010, January 7th
van Rijen M et al. JAC 2008
year
No significant risk
reduction was
observed for patients
operated on during
the second and third
surveillance years
% SSI
Geubels et al Intern J Qual Health Care 2006;18:127-133
17-11-18
6
Brandt et al, Ann Surg 2008; 248:695-700.
¤ Antibiotic prophylaxis
¤ Clipper for hair removal
¤ Alcohol-based skin disinfectant
¤ Perioperative glycemic control
¤ Perioperative normothermia
¤ Oxygination
¤ STAU decolonization
¤ Alcohol-based skin disinfection
¤ Surveillance & feedback

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Preventing SSI

  • 1. 17-11-18 1 Prof. dr. Andreas Voss MD, PhD, FSHEA, FESCMID, FISAC President-Elect ISAC Nijmegen, The Netherlands I hope that Houston knows that “we” is not Infection Control but the surgeons SSI Surgeon IPC OR Ward Wound care Anesth. Buyers etc … Your are entering the operating theatre There are many pre-and perioperative factors that determine whether or not a patient will develop a SSI No influence possible ¤ Age ¤ Underlying disease ¤ Malignancy ¤ Wound classification ¤ Prosthetic material Influence not probable • Laminar air-flow • Sterilization • Pre-op hospitalization Influence by others • BMI >30 • Nicotine use • Malnutrition • Infection at remote site Can & should be influenced • Surveillance • S. aureus colonization • Normothermia/hyperoxia • Glucose levels • Hair-removal • Antimicrobial prophylaxis • Skin disinfection/decolonization ¤ Basic practices ² that should be adopted by all acute care hospitals ¤ Special approaches ²that can be considered for use in locations and/or populations within hospitals when “preventive maximum” is reached ² incision drapes, coated sutures, …
  • 2. 17-11-18 2 ¤ Prioritize your efforts by initially focusing on the implementation of basic practices Classen. NEJM 1992;328:281. Infections(%) Hours From Incision
  • 3. 17-11-18 3 ¤Inappropriate: ²Shaving ¤Appropriate: ²No hair removal at all ²Clipping ²Depilatory use Warning: Free-ranging Hospital Administrator Why buy expensive clipper heads. Blunt razors are fine • Hypothermia reduces tissue oxygen tension by vasoconstriction. • Hypothermia reduces leukocyte superoxide production. • Hypothermia increases bleeding and transfusion requirements. • Hypothermia increases duration of hospital stay even in uninfected patients. Kurz et al. NEJM 1996; 334:1209-15 Patients with colorectal operations sample SSI rate (%) 6 % 19 % Normothermia Hypothermia p=0.009 200 Patients
  • 4. 17-11-18 4 SSI-rate Local Systemic Control 5 (4%) 8 (6%) 19 (14%) Melling. Lancet. 2001; 358:876. NEJM I don’t know why but I want pink ! I used red stuff for 20 years! Why switch? I want no color! If I can’t see the patients dies! I need nothing, I have no infections! This IC people really bore me. Just leave my OR! Meet my surgical team Darouiche et al NEJM 2010;362:18-26 Great study: It matters which skin disinfectant you use! Only problem: wrong comparator ! Charehbili Surg Infect 2014;15:DOI: 10.1089/sur.2012.185 non-randomized, non-blinded V
  • 5. 17-11-18 5 Charehbili et al. Surg Infect 2014;15:DOI: 10.1089/sur.2012.185 Nasal S. aureus decolonization Bode et al. NEJM 2010, January 7th van Rijen M et al. JAC 2008 year No significant risk reduction was observed for patients operated on during the second and third surveillance years % SSI Geubels et al Intern J Qual Health Care 2006;18:127-133
  • 6. 17-11-18 6 Brandt et al, Ann Surg 2008; 248:695-700. ¤ Antibiotic prophylaxis ¤ Clipper for hair removal ¤ Alcohol-based skin disinfectant ¤ Perioperative glycemic control ¤ Perioperative normothermia ¤ Oxygination ¤ STAU decolonization ¤ Alcohol-based skin disinfection ¤ Surveillance & feedback