This document discusses various preoperative, perioperative, and postoperative factors that can influence the risk of surgical site infections (SSIs). It identifies factors that are not influenceable, not probably influenceable, can be influenced by others, and can and should be influenced by healthcare providers. It emphasizes the importance of implementing basic practices first, such as appropriate hair removal methods, proper skin antisepsis, maintenance of normothermia, and use of antibiotic prophylaxis. Studies are referenced showing the impact of these factors, such as higher SSI rates with hypothermia during surgery. The document advocates a multifaceted approach focusing on modifiable factors to optimize SSI prevention.