Prescription drug abuse has increased significantly in India due to overprescription of drugs like benzodiazepines without proper warnings, unlawful over-the-counter selling of prescription drugs, and legislation that lumps all drugs together. Commonly abused prescription drugs include opioids, CNS depressants, stimulants, and steroids. Doctors are uniquely positioned to screen for prescription drug abuse during routine exams and help patients receive treatment, which may involve behavioral therapies and medication to manage withdrawal symptoms and prevent relapse. Prevention requires vigilance about false prescriptions, educating pharmacists, and considering alternative means of dispensing potentially abusable drugs.
Radio pharmacuticals are the compounds and substances that emits radiation and which are used in the pharmacy are called as radiopharmaceuticals.
The process of emitting radiation by the radioactive isotopes is called as RADIOACTIVITY.
Egs:uranium-238 isotope
cobalit-60
gallium etc.
Pharmacovigilanc: The science & activities relating to the Detection, Assessment, Understanding and Prevention of adverse effects or any other drug related problems
The Thalidomide Tragedy (Lessons for Drug Safety and Regulation)
CLASSIFICATION OF ADRS (RAWLIN AND THOMPSON CLASSIFICATION)
Why PV is Necessary?
Objective of PV
Outcomes of Drugs
Causal Relationship
Adverse drug reaction and causality assessment scales
Classification of AE
Serious Adverse Event (SAE)
Sources of Adverse Events (AE) reports
Sources of AE Reports(Solicited Reports)
What to Report?
Who to Report?
When to Report?
Individual case data flow
Radio pharmacuticals are the compounds and substances that emits radiation and which are used in the pharmacy are called as radiopharmaceuticals.
The process of emitting radiation by the radioactive isotopes is called as RADIOACTIVITY.
Egs:uranium-238 isotope
cobalit-60
gallium etc.
Pharmacovigilanc: The science & activities relating to the Detection, Assessment, Understanding and Prevention of adverse effects or any other drug related problems
The Thalidomide Tragedy (Lessons for Drug Safety and Regulation)
CLASSIFICATION OF ADRS (RAWLIN AND THOMPSON CLASSIFICATION)
Why PV is Necessary?
Objective of PV
Outcomes of Drugs
Causal Relationship
Adverse drug reaction and causality assessment scales
Classification of AE
Serious Adverse Event (SAE)
Sources of Adverse Events (AE) reports
Sources of AE Reports(Solicited Reports)
What to Report?
Who to Report?
When to Report?
Individual case data flow
Table of Content:
Introduction
Why are Prescription Drugs Abused
Prescription Drug Addiction
Factors Encouraging Prescription Drug Addiction
How to Avoid Slipping Into a Prescription Drug Addiction
How to Beat a Prescription Drug Addiction
Prescription Drug Misuse: Among Young Adultsamankhosa
A project that explains the prevalence of prescription drug misuse, specifically among the young adult population. Includes information on warning and behavioural signs of prescription drug abuse, commonly abused prescription drugs, cultural awareness, and related policies and prevention strategies.
Polypharmacy and Rational Prescribing in Elderly Patients.pptxAhmed Mshari
Polypharmacy is typically defined as the prescription of five or more medications.
It also refers to the prescription of medications that do not have a specific current indication, that duplicate other medications, or that are known to be ineffective for the condition being treated.
In other words, polypharmacy is the use of multiple medications that are unnecessary and have the potential to do more harm than good.
HELPING PEOPLE CHANGE DRUG SEEKING BEHAVIOURMadhu Oswal
DRUG ADDICTION IS A CHRONIC, RELAPSING DISEASE OF THE BRAIN AND NEEDS BEHAVIORAL INTERVENTION ALONG WITH PHARMACOTHERAPY. HERE IS WHAT A DOCTOR CAN DO IN BUSY OPD TO HELP PATIENTS QUIT DRUGS
WHY DOCTORS NEED TO LEARN ABOUT ADDICTION?Madhu Oswal
Understanding the gravity of drug Addiction in India, Who, why, what , from where-all drug related questions answered. Why a family physician need to learn about addiction medicine
PPT is for primary care physicians and oral health specialist. Gives information about gravity of Tobacco addiction problem, oral cancer and its prevention.
Universal precations for health care workersMadhu Oswal
Lecture for medical students, , doctors or ant health care workers. It gives details how a medico can protect one self while caring for patients. Without discrimination.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
1. Prescription Drug Abuse
Dr Madhu Oswal
What is prescription drug abuse? It is the use of a prescription medication in a way not
intended by the prescribing doctor -the nonmedical use or abuse of prescription drugs.
Has the problem of prescription drug abuse increased, and if so, why? In 1999, the Ministry
of Social Justice and Empowerment, Government of India (MSJE, GOI) and the United Nations
International Drug Control Programme, Regional Office for South Asia (UNIDCP, ROSA)
decided to undertake a large-scale national survey to obtain information on extent, pattern and
magnitude of substance abuse in the country. Results show that nationally about 10 per cent of
drug abuse involves prescription drugs. We have a huge population that knowingly or
unknowingly is hooked on to prescription drugs. What’s the reason? First reason is the way in
which drugs like benzodiazepines are prescribed as anxiolytics or sedatives right and left without
giving patient enough warning about its dependence potential. Secondly, in India we have
rampant unlawful selling of these drugs without prescription. Thirdly it’s the very act which was
enacted to prevent this menace, is fuelling this problem. We in India have always had a tradition
of substances like ganja and charas which did not do any great harm. The Narcotic Drugs and
Psychotropic Substances Act (NDPS), 1985 put all of them at a par with hardcore drugs making
all drugs illegal and equally punishable. This led to a surge in heroin and increase in intravenous
drug use. During the late 1980s and early 1990s, the pharmaceutical buprenorphine became
popular and its availability in ampoule form made it injectable - this drug and mode of
administration became popular throughout most major cites of India and adjoining states. They're
cheaper too, at only Rs 20 per cocktail ampoule, compared to Rs 80-150 for the same amount of
heroin. The other main advantage of prescription drugs for addicts is their easy and lawful
availability. These are also difficult to detect. Even better, when caught-one just needs to feign a
cough or headache convincingly and explain the need for possessing that drug
Which are the commonly abused prescription drugs?
2. Opioids, which are most often prescribed to treat pain;
CNS depressants, which are used to treat anxiety and sleep disorders;
Stimulants, which are prescribed to treat the attention-deficit hyperactivity disorder
(ADHD) and obesity.
Steroids (Anabolic-Androgenic steroids) used to treat conditions resulting from steroid
hormone deficiency, such as delayed puberty, or to increase lean muscle mass esp. cancer
and AIDS.
Most of these drugs are schedule H drugs- that is these are to be sold only on prescription of a
registered medical practitioner. But there is rampant over the counter(OTC) sell of these drugs.
Opioids like morphine, codeine, and related drugs are commonly prescribed because of their
effective analgesic, anti-tussive and anti- diarrheal properties. Commercially available
preparations include propoxyphene (Darvocet), pentazocine (Fortwin) injections, fentanyl
(Duragesic), dextropropoxyphene (Proxyvon), dextromethorphan (Dexcof) buprenorphine
(Tidegesic), codeine (III/IV) and diphenoxylate (Lomotil). Cough syrups such as Corex and
Phensedyl have opiates, and antihistamines as well as alcohol. Opioid drugs cause euphoria by
affecting the brain regions that mediate what we perceive as pleasure and that’s the reason of it
being abused.
CNS depressants like benzodiazepines and barbiturates are the class of drugs most frequently
abused. Commonly used molecules are diazepam (Valium), chlordiazepoxide HCl (Librium),
alprazolam (Restyl), lorazopam (Larpoze), and nitrazepam (Nitrosun). Barbituarates are
available as phenobarbital( Gardinal). Benzodiazepines should not be taken for more than 2-3
weeks and then the drug should be tapered off gradually. But patients often easily acquire the
medicines without prescription or re-fill their prescriptions from a chemist. Also, they suffer
withdrawal symptoms when they try to reduce or stop the drugs and the withdrawal symptoms
are very similar to the illness for which they started the drug. So they again take the drug and in
progressively higher doses falling in a vicious cycle
Stimulants like dextroamphetamine (Dexedrine) and methylphenidate (Ritalin) are drugs causing
an increase in alertness, attention, and energy. Stimulants are prescribed for the treatment of only
3. a few health conditions like narcolepsy, attention-deficit hyperactivity disorder, and recalcitrant
or severe depression. Stimulants may be used as appetite suppressants for short-term treatment of
obesity.
Steroids (Anabolic-Androgenic) like nandrolone ( Durabolin), testosterone (Testoviron depot)
are demanded by patients or prescribed by doctors to enhance performance and/or improve
physical appearance. Patients on these drugs feel good about themselves but mood swings can
also occur, including manic-like symptoms that could lead to violence. Users may also suffer
from paranoid jealousy, irritability, delusions, and impaired judgment.
Who is at risk? Although prescription drug abuse can affect anyone, older adults, adolescents,
women and we medical professional, are at highest risk. Older adults are prescribed these drugs
for their ailments like osteoarthritis, insomnia, depression, etc. In women- without dealing with
the underlying cause of the problem, we doctors prescribe anti-anxiety drugs like diazepam
(Calmpose), alprazolam (Alprax), for their anxiety and depression. And in adolescent- use of
drugs can be an experimentation, occasional recreational drugs or may provide a way of coping
with the stress of modern world and its expectations. Others are abusers, popping a pill along
with alcohol or marijuana for an added "kick". Some see prescription drugs as back-up, to be
used when their main source like of addiction drugs heroin, Ecstasy are not available or
feasible. Unlike the pills, injected drug use is common among this age group and so they are at
risk of infections like HIV, hepatitis B and C, and other problems like cellulitis,
thrombophlebitis, endocarditis, septicaemia, etc. Also, health care professionals - including
physicians, nurses, pharmacists, dentists, anesthesiologists, and veterinarians are at increased
risk of prescription drug abuse because of easy availability with self-prescription. Overall, men
and women have roughly similar rates of abuse of prescription drugs, though young women are
more likely than young men to use benzodiazepines.
4. What is our role as doctors? We are in a unique position to identify prescription drug abuse,
help the patient recognize it and then manage the problem. Screening for any type of substance
abuse can be incorporated into routine history taking. Eg. ASSIST questionnaire developed by
WHO or Drug Abuse Screening Test (DAST). Discussing and motivating our neighboring
chemists about this issue with can play a key role in preventing prescription drug abuse, as these
are the places where the drugs are procured from. They should be vigilant about false or altered
prescriptions and should not unlawfully refill prescriptions. Other alternative could be dispensing
from our clinics the drugs that can be potentially abused, instead of prescribing them.
How to treat? The two main categories of drug addiction treatment are behavioral and
pharmacological. Brief interventional therapy takes not more than few minutes and has found to
be effective. The A-FRAMES model is the core structure of a brief intervention: Assessment,
providing objective Feedback, emphasizing that Responsibility for change belongs to the patient,
How to diagnose this disorder? We need to have a high level of clinical suspicion to diagnose
prescription drug abuse disorder in our busy practice. We should take notice if a patient demands
to increase the dose these prescribed drugs or comes frequently to us for refills before the
quantity prescribed should have been used. This may indicate the development of tolerance. We
should also be aware of “doctor shoppers” patients, those moving from doctor to doctor to get
multiple prescriptions for the drug they abuse. We can also diagnosis if we are aware of
withdrawal symptoms of these abused prescription drugs. Symptoms of opiate withdrawal
include restlessness, muscle and bone pain, insomnia, diarrhea, vomiting, cold flashes with goose
bumps ("cold turkey"), and involuntary leg movements. Taking a large single dose of an opoid
could cause severe respiratory depression and can also lead to death. Benzodiazepines in
withdrawal state cause sleeplessness, restlessness, tremors of the hand, slurring, irritability,
vomiting, sadness, altered appetite, and abnormal behavior, even delirium in extreme cases.
Although the use of stimulants may not lead to physical dependence and risk of withdrawal, they
can be addictive in that individuals begin to use them compulsively. Taking high doses of some
stimulants repeatedly over a short time can lead to feelings of hostility or paranoia. Withdrawal
symptoms of anabolic steroids include mood swings, fatigue, restlessness, loss of appetite,
insomnia, reduced sex drive, and depression, all of which may contribute to continued abuse.
5. giving clear Advice about the benefits of change, providing a Menu of options for treatment to
facilitate change, using Empathic listening, and emphasizing and encouraging Self-efficacy with
the patient.
Medications are used to relieve the symptoms of withdrawal, to treat an overdose, or to help
overcome drug cravings. For withdrawal symptoms of opioid, buprenorphine (Tidigesic) 1.2-4.0
mg or 6-12capsules of dextropropoxyphene (Proxyvon) are given initially and tapered off after
the third day. Usually, detoxification medicines are required for 2-3 weeks. Methadone
(60mg/day), or buprenorphine 4 mg and 8 mg /day) are used as maintainance therapy.
Naltrexone( Naltima) (antagonist) given three times a week(100mg on 1
t
and 3
rd
day and 150mg
on 5
h
day or 50mg/day), act as anti-craving agent for abstinence. In cases of mild to moderate
benzodiazepine dependence, an outpatient detoxification by tapering of the drug, with weekly
reduction in doses can be carried out. In patients with severe dependence, particularly with
dependence on short acting benzodiazepines, indoor detoxification is preferred. In indoor setting,
the drugs can be tapered off at a rate of 10% a day. In patients dependent on short or
intermediately acting benzodiazepine (oxazepam, alprazolam, etc), risk of withdrawal seizures
should be kept in mind and to prevent the seizures, detoxification is started with equivalent doses
of long acting benzodiazepines (diazepam, chlordiazepoxide ), which then should be tapered off as
usual. Usually, detoxification in indoor set-ting is over within 2 weeks. In cases where only
insomnia persists, non-benzodiazepine hypnotics like zopiclone alone should be tried. Treatment
of addiction to prescription stimulants, such as Ritalin, is often based on behavioral as there are
no proven medications for the treatment of stimulant addiction. However, antidepressants may
help manage the symptoms of depression that can accompany the early days of abstinence from
stimulants. For steroids, if withdrawal symptoms are severe or prolonged, symptomatic
medications or hospitalization may be needed.
To summarize, we as general practitioners are in a unique position to prevent, diagnose and
manage the problem of prescription drug abuse- what we need is a little awareness and
motivation!!
REF: APA Practice Guidelines: Practice Guideline for the Treatment of Patients With Substance Use
Disorders, Second Edition