The document discusses diagnosing and managing HIV/AIDS in primary care settings in India. It notes that 40% of HIV positive people in India are unaware of their status. As frontline healthcare providers, general practitioners are well-positioned to test and diagnose HIV through awareness of clinical manifestations, taking a sexual history, and having a high index of clinical suspicion for high-risk groups. It outlines various opportunistic infections and conditions that may indicate HIV at different stages based on CD4 count, as well as recommendations around HIV testing.
This presentation will cover the basics of HIV and AIDS. By the end of this presentation, we hope that everyone will understand what HIV and AIDS mean, how the virus is transmitted, and Saskatchewan HIV statistics.
pergaulan bebas semakin menjamur dikalangan remaja. disebabkan itu banyak sekali penyakit menular seksual yang berbahaya bagi tubuh. salah satunya adalah penyakit HIV AIDS yang sampai saat ini belum ada obatnya.
HIV and Cardiovascular Disease.How Worried Should We Be ? 2015hivlifeinfo
In this downloadable slideset, David A. Wohl, MD, reviews the association between HIV and cardiovascular disease, including potential contributing factors and best practices in prevention.
Format: Microsoft PowerPoint (.ppt)
File size: 5.01 MB
Date posted: 6/26/2015
This presentation will cover the basics of HIV and AIDS. By the end of this presentation, we hope that everyone will understand what HIV and AIDS mean, how the virus is transmitted, and Saskatchewan HIV statistics.
pergaulan bebas semakin menjamur dikalangan remaja. disebabkan itu banyak sekali penyakit menular seksual yang berbahaya bagi tubuh. salah satunya adalah penyakit HIV AIDS yang sampai saat ini belum ada obatnya.
HIV and Cardiovascular Disease.How Worried Should We Be ? 2015hivlifeinfo
In this downloadable slideset, David A. Wohl, MD, reviews the association between HIV and cardiovascular disease, including potential contributing factors and best practices in prevention.
Format: Microsoft PowerPoint (.ppt)
File size: 5.01 MB
Date posted: 6/26/2015
Integrating Recent Data When Selecting First-line Antiretroviral Therapy.2015...hivlifeinfo
Joseph J. Eron Jr., MD
W. David Hardy, MD
Paul E. Sax, MD
How do leading experts select first-line antiretroviral therapy for their HIV-infected patients?
Review these downloadable slides for key clinical trial data and the latest DHHS recommendations for first-line antiretroviral therapy.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Сердечно-сосудистые заболевания у ВИЧ-инфицированных пациентов : предсказать ...hivlifeinfo
Cardiovascular Disease in HIV-Infected Patients.Predict It and Prevent It. 2015
In this downloadable slideset, Priscilla Y. Hsue, MD, and David A. Wohl, MD, discuss data on using traditional and newer markers and modalities to predict and prevent cardiovascular disease in HIV-infected patients.
Format: Microsoft PowerPoint (.ppt)
File size: 3.21 MB
Date posted: 7/16/2015
HIV AIDS Lecture Presented by me in my Community Dentistry Class, BIBI ASIFA DENTAL COLLEGE, SHAHEED MOHTARMA BENAZIR BHUTTO MEDICAL UNIVERSITY LARKANA, SINDH, PAKISTAN.
Aids - Acquired immune deficiency syndrome is a disease which is caused by the virus HIV i.e human immuno deficiency virus.
It can be transmitted by sharing infected needles , sexual contact etc. now a days its awareness and knowledge among the youth is very known due to media , newspapers and may health organisations .
AIDS is caused by the human immunodeficiency virus (HIV).
The primary mechanism is to infect a particular subset of T lymphocyte called CD4 cells.
Over the time HIV decreases the number of CD4 cells.
As a person’s CD4 count drops, they become at increasing risk of developing opportunistic infections.
HIV, by itself, does not harm the patient.
HIV harms by destroying cell-mediated immunity
The infections that develop are what harm patients.
HELPING PEOPLE CHANGE DRUG SEEKING BEHAVIOURMadhu Oswal
DRUG ADDICTION IS A CHRONIC, RELAPSING DISEASE OF THE BRAIN AND NEEDS BEHAVIORAL INTERVENTION ALONG WITH PHARMACOTHERAPY. HERE IS WHAT A DOCTOR CAN DO IN BUSY OPD TO HELP PATIENTS QUIT DRUGS
WHY DOCTORS NEED TO LEARN ABOUT ADDICTION?Madhu Oswal
Understanding the gravity of drug Addiction in India, Who, why, what , from where-all drug related questions answered. Why a family physician need to learn about addiction medicine
PPT is for primary care physicians and oral health specialist. Gives information about gravity of Tobacco addiction problem, oral cancer and its prevention.
Universal precations for health care workersMadhu Oswal
Lecture for medical students, , doctors or ant health care workers. It gives details how a medico can protect one self while caring for patients. Without discrimination.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. Who is suppose to take this lecture ?
• “ Truly speaking, all HIV patients come with
diagnosis to me, so I don’t have to think about
“Could it be HIV?”- Dr Sanjay Pujari
11/29/13
Samvad HIV AIDS Helpline
2
3. COULD IT BE HIV?
Dr Madhu Oswal
Samvad HIV AIDS Helpline
4. “India has 23 lakh estimated HIV infected
people. But 10 lakh ( 40%) people with HIV
don't know their status” – Dr B B Rewari from
National AIDS Control Organization
11/29/13
Samvad HIV AIDS Helpline
4
5. Who will diagnose HIV infection in
these 10 lakh people?
We as general practitioners are front line
warriors- the first contact point. So we are
best placed to suspect and diagnose HIV
infection.
11/29/13
Samvad HIV AIDS Helpline
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6. And it’s not so difficult
• Knowledge about clinical manifestation of HIV
• High index of clinical suspicion
• Comfort in taking sexual history and speaking
about HIV
• “The fire in the belly”
11/29/13
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7. Whom should we offer HIV test?
•
•
•
•
•
•
•
•
•
STDs and their partners
Tuberculosis
Herpes zoster
HBV and HCV
Young patient with stroke
ANC
MSM,FSW, IVDUs
Single migrant, long distance truckers
H/o high risk sexual behavior.
11/29/13
Samvad HIV AIDS Helpline
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8. Whom should we offer HIV test?
• Partners and children of known HIV positive
person
• Any one who “comes” for an HIV TEST!!!!!!
(Find the hidden clues- feeling weak,
loosing weight, anxiety, cannot sleep,
etc)
• Age, gender, occupation, status , religion-HIV
does not discriminate. So why we should?
11/29/13
Samvad HIV AIDS Helpline
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9. When will we suspect HIV infection
in our practice?
11/29/13
Samvad HIV AIDS Helpline
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10. Acute Primary HIV Syndrome“A Flu like illness”
– Fever
– Pharyngitis
– Rash “ erythematous maculopapular truncal eruption”
– Fatigue
– Generalized lymphadenopathy
– Headaches, malaise, anorexia
– Myalgias/ arthralgias
– Sudden onset, lasting from 3-14 days
– H/o unprotected exposure in past 2 to 3 weeks
11/29/13
Samvad HIV AIDS Helpline
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11. Rash of Acute Primary HIV Syndrome
11/29/13
Samvad HIV AIDS Helpline
11
12. Why we miss
Acute Primary HIV Syndrome?
•
•
•
•
Wide range in clinical manifestations
Non-specific signs & symptoms
Lack of clinical suspicion
Asking difficult questions: You need to elicit
exposure history!
• Fail to understand diagnostic criteria
11/29/13
12
Samvad HIV AIDS Helpline
14. Diagnostic Tests for Acute Primary HIV
infection
• Acute or Primary HIV Infection
– Negative ELISA + positive HIV viral RNA
• Early HIV Infection
– Positive ELISA + indeterminate Western Blot
11/29/13
14
Samvad HIV AIDS Helpline
44. Stage I
• Acute HIV Primary HIV Syndrome
• ASYMTOMATIC
11/29/13
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44
45. Stage II: EARLY SYMPTOMATIC STAGE
CD4 > 500
•
•
•
•
•
PGL-no treatment
TB
HZ
Headaches
Vaginal candidiasis-recurrent
11/29/13
Samvad HIV AIDS Helpline
45
46. Stage III: SYMPTOMATIC HIV DISEASE
CD4- (500-200)
• Many skin or oral lesions e.g. Herpes zoster, mild oral or
vaginal candidiasis, seborrhoeic dermatitis, oral hairy
leukoplakia,itchy folliculitis, apthous ulcer, etc.
• Recurrent diarrhea.
• Recurrent fever
• Bacterial infections like impetigo, pneumonitis, sinusitis, etc.
• Tuberculosis
• Herpes zoster
In this the diseases are those which we see in those with normal
immunity, but are more frequent.
11/29/13
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47. Stage IV LATE SYMPTOMATIC DISESASE
CD4 < 200
•
•
•
•
•
•
•
•
Severe Wt loss
Wasting syndrome
Chronic diarrhea
Fever> 1 month
Cough > 1 month
Skin infections
CNS infections
Recurrent pneumonias
11/29/13
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48. Stage IV LATE SYMPTOMATIC
DISESASE CD4 < 200
Malignancies
• Ca. Cervix
• Ca rectum
Non-Hodgkin’s and Hodgkin’s Lymphoma,
• Primary CNS Lymphoma
• Kaposi's sarcoma
11/29/13
Samvad HIV AIDS Helpline
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49. Stage IV LATE SYMPTOMATIC
DISESASE CD4 < 200
•
•
•
•
Gastro-intestinal diseases
Oesophageal candidiasis
Diarrhea due to Isospora, cryptosporidium and
microsporidium
Abdominal tuberculosis
MAC
11/29/13
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50. Stage IV LATE SYMPTOMATIC
DISESASE CD4 < 200
Neurological diseases
•
•
•
•
•
•
•
Tubercular meningitis
Toxoplasmosis
Progressive Multifocal Leucoencephalopathy (PML)
HIV associated dementia
Cryptococcal meningitis
Primary CNS Lymphoma
Peripheral neuropathy
11/29/13
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51. Stage IV LATE SYMPTOMATIC
DISEASES CD4 < 200
•
•
•
•
•
•
•
•
•
•
Pulmonary Complications
Pulmonary tuberculosis
Recurrent pneumonias
Pneumocystis Carinii Pneumonia
Lymphoma
Histoplasmosis
Aspergillosis
Cryotoccocosis
M. Kansassi
MAC
CMV
11/29/13
Samvad HIV AIDS Helpline
51
Acute HIV: immediate period after infection b/f detectable Ab active HIV viral replication & transient immunosuppression, CD4 cells drop.
Within days to weeks, transient viremia in 5-6 log range can climb to 1 million copies/mL. Large # of susceptible CD4 cells infected. PEAK ~ Symptoms.
Within days: Viral dissemination into various anatomic compartments/reservoirs: T-cells, LN, periph blood mono/macro lineage, CSF, semen, vaginal fluid.
By 2-6 weeks: sx’s resolve. COINCIDENT with this is partial clearance of viremia.
HIV-specific cytotoxic T cells emerge. Both humoral & cellular immune responses develop to deal with HIV
But not fully cleared. An equilibrium (balance) between replication/destruction of HIV felt to occur.
Standard ELISA: These later-generation assays are quite sensitive and turn + by 1 month of infecton in most individuals.
Case Definitions that have been made in the literature for recent infection.
Herpes zoster is the virus that causes chickenpox and shingles in children and adults, respectively, and is spread by aerosolized viral particles. (Baylor, p. 88)
A person is contagious for 24 to 48 hours before a vesicular (raised, fluid-filled lesions) rash is observed, and until all of the lesions are crusted over. (Baylor, p. 88)
In children initial infection results in the development of chicken pox, although most persons that become infected develop no symptoms and signs of infection.
In immune suppressed persons, zoster is often multidermatomal in distribution and is persistent and extensive. It is associated with severe pain and debility. (Zim, Viral Infections)
Herpes simplex virus infection (HSV) can be severe in patients with HIV/AIDS.
Eruptions of HSV are red, painful, burning, itchy sores on the mouth and genitals.
Dissemination may lead to infection of the lungs, the oesophagus, and the brain.
Molluscum contagiosum is a superficial skin infection caused by the molluscum contagiosum virus (MCV).
The virus invades the skin causing the appearance of firm, flesh-coloured papules containing a white sebaceous material that can occur anywhere on the body and often remain unchanged for many months, after which they disappear.
Cryptococcosis most often appears as meningitis, and occasionally as pulmonary or disseminated disease.
Cryptococcal meningitis is the most frequent systemic fungal infection in HIV-infected persons.
The most common symptom patients present with is headache.
The second most common is diplopia or double vision, and the third, indolent fever.
Characterized by thinning of the buccal fat pad. May result or exacerbate stigma associated with HIV.
Appears to be most common with long-term stavudine use.
Usually not reversible, but changing medications may prevent progression.