The document discusses drugs that act on the respiratory system. It describes the main functions of the respiratory system as delivering oxygen to cells, eliminating carbon dioxide from the body, and regulating blood pH. It then discusses various components of lung function including ventilation, distribution, diffusion, and perfusion. It provides details on common respiratory drugs like bronchodilators, corticosteroids, leukotriene receptor antagonists, expectorants, mucolytics, antitussives, and methylxanthines. It also covers adverse effects and guidelines for treating conditions like asthma and acute bronchitis.
antitussive drugs, uses, lists, sideffect and many morefcapital
June 15 2016 Antitussives are drugs that suppress coughing, possibly by reducing the activity of the cough center in the brain. Antitussive agents are used to relieve dry cough.
respiratory drugs is a very important topic for pg entrance.....topics dicussed in this ppt are :
1) drugs for bronchial asthma
2) antitussives
3) mucolytics
4) expectorants
5) drugs for PAH
antitussive drugs, uses, lists, sideffect and many morefcapital
June 15 2016 Antitussives are drugs that suppress coughing, possibly by reducing the activity of the cough center in the brain. Antitussive agents are used to relieve dry cough.
respiratory drugs is a very important topic for pg entrance.....topics dicussed in this ppt are :
1) drugs for bronchial asthma
2) antitussives
3) mucolytics
4) expectorants
5) drugs for PAH
Dr. Jibachha Sah,M.V.Sc( Veterinary pharmacology, TU,Nepal),posted lecturer notes on AUTONOMIC AND SYSTEMIC PHARMACOLOGY for B.V.Sc & A.H. 6 th semester veterinary students of College of veterinary science,Nepal Polytechnique Institute, Bharatpur, Bhojard, Chitwan, Nepal.I hope this lecture notes may be beneficial for other Nepalese veterinary students. Please send your comment and suggestion .Email:jibachhashah@gmail.com,moble,00977-9845024121
The expectorant helps thin and loosen mucus in the lungs, making it easier to cough up the mucus.Antitussives, also known as cough suppressants, help prevent coughing by working on a part of the brain that controls the action.
Coughing is an innate reflex and part of the immune system’s response to get rid of foreign objects. Antitussives help suppress the urge to cough.
Asthma is a chronic inflammatory disorder of the airways that is characterized by increased responsiveness of the tracheobranchial tree to a variety of stimuli resulting in widespread spasmodic narrowing of the air passages which may be relieved spontaneously or by therapy.
Cough is a protective reflex, its purpose being expulsion of respiratory secretions or foreign particles from air passages.
It occurs due to stimulation of mechano or chemoreceptors in throat,
respiratory passages or stretch receptors in the lungs.
Act peripherally in the respiratory tract to reduce tussal impulses.
They aim to control rather than eliminate cough.
Many H-1 anti histamines have been conventionally added to antitussive /expectorant formulations.
Antihistamines afford relief in cough due to their sedative and Anticholinergic actions but lack selectivity for cough centre.
Analeptics stimulate respiration and can have resuscitative value in
Coma or fainting.
They stimulate respiration in sub convulsive doses,
but margin of safety is narrow.
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
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June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
1. BHOLE NATH, Lecturer Dept. of Pharmacy LINCOLN UNIVERSITY COLLEGE MALAYSIA DRUGS ACTING ON THE RESPIRATORY SYSTEM
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4. VENTILATION Movement of air to and from the lungs DISTRIBUTION Air entering lungs are distributed to all parts including the alveoli DIFFUSION Oxygen from the inspired air diffuses through the walls of the alveoli to the blood capillaries surrounding the alveoli-similarly carbon dioxide diffuses in opposite direction PERFUSION Blood with high concentrations of carbon dioxide and low in oxygen is pumped to the pulmonary arteries by the right ventricle and after diffusion, the arterial blood is returned to the left atrium by the pulmonary veins COMPONENTS OF LUNG FUNCTION
5. PASSAGE OF OXYGEN AND CARBON DIOXIDE SOURCE OF OXYGEN – INSPIRED AIR SOURCE OF CARBON DIOXIDE-ALVEOLI- Following diffusion from the blood due to metabolism in the body. PATHWAY FOR THE GASES: PHARYNX LARYNX-TRACHEA BRONCHI BRONCHIOLES ALVEOLI VENTILATION
6. atmosphere o oxygen c Carbon dioxide Right heart-arteries Left heart-arteries Systemic circulation oxygen Carbon dioxide
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8. Mucosal surface lining respiratory tract Impulses relayed via vagus Cough centre in brain Efferent's diaphragm glottis muscles of chest and abdomen COUGH – FORCED EXPIRATION AGAINST A CLOSED GLOTTIS WHICH SUDDENLY OPENS TO EXPEL AIR AND UNWANTED MATERIAL FROM THE RESPIRATORY TRACT MAY BE VOLUNTARY OR INVOLUNTARY
9. Mucokinetics are a class of drugs which aid in the clearance of mucous from the airways, lungs , bronchi , and trachea . Such drugs can be further categorized by their mechanism of action. expectorants mucolytic agents In general, clearance ability is hampered by bonding to surfaces (stickiness) and by the viscosity (thickness) of mucous secretions in the lungs . In turn, the viscosity is dependent upon the concentration of mucoprotein in the secretions.
10. Expectorants and mucolytic agents are different types of medication, yet both intend to promote drainage of mucus from the lungs. An expectorant (from the Latin expectorare , to expel from the chest) works by signaling the body to increase the amount or hydration of secretions, resulting in more yet clearer secretions and as a byproduct lubricating the irritated respiratory tract. One expectorant guaifenesin is commonly available in many cough syrups. Sometimes the term "expectorant" is incorrectly extended to any cough medicine, since it is a universal component. A mucolytic agent is an agent which dissolves thick mucus and is usually used to help relieve respiratory difficulties. It does so by dissolving various chemical bonds within secretions, which in turn can lower the viscosity by altering the mucin-containing components.e.g ,Bromohexine, Acetyl Cysteine
11. A cough medicine (or linctus , when in syrup form) is a medicinal drug used in an attempt to treat coughing and related conditions. For dry coughs, treatment with cough suppressants ( antitussives ) may be attempted to suppress the body's urge to cough. However, in productive coughs (coughs that produce phlegm ), treatment is instead attempted with expectorants (typically guaifenesin , in most commercial medications) in an attempt to loosen mucus from the respiratory tract . These are the drugs that act in the CNS to the threshold of cough center or act peripherally in the respiratory tract to reduce tussal impulses. NOTE: It is only for dry unproductive coughs
12. ANTITUSSIVE/ COUGH SUPPRESSANTS Unproductive distressing cough- central cough depressants e.g. pholcodine, dextromethorphan Productive cough-do not use cough suppressants Use expectorants and mucolytics Expectorants-act by increasing the volume of secretions in respiratory tract so that they may be more easily removed by ciliary action and coughing e.g.ammonium salts, guaphenesin, ipecacuanha Mucolytics- considered to affect sputum viscosity e.g.acetylcysteine, bromhexine, carbocisteijne, methyl cysteine
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17. DORNOSA ALFA ACTS AS A MUCOLYTIC BY HYDROLYSING DNA THAT HAS ACCUMULATED IN THE SPUTUM FROM DECAYING NEUTROPHILS USED AS A NEBULIZING SOLUTION IN PATIENTS WITH CYSTIC FIBROSIS
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19. Adrenergic agonists All adrenergic agonists have variable alpha and beta receptor affinity. Due to the distribution of alpha and beta receptors- non-selective beta receptor agonists such as isoprenaline or mixed alpha and beta receptor agonists such as adrenaline are more likely to produce cardiovascular side effects than similarly administered selective beta agonists. THEREFORE DRUGS WITH PREFERENTIAL AFFINITY FOR BETA 2 RECEPTORS PROVIDE MORE EFFECTIVE BRONCHODILATION WITH FEWER SIDE EFFECTS. A possible exception may be with the treatment of acute allergic bronchospasm. The M-2 receptor-mediated inhibition of cholinergic bronchospasm may be helpful. For this reason, the use of an adrenergic agent with both alpha 2 and beta 2 agonist activity may be beneficial in the peracute management of allergic bronchospasm. Due to risks associated with administering systemic non-selective adrenergic agonists to a hypoxic and already tachycardic patient, it is preferable for them to be administered by inhalation. Selective beta 2 agonists- lead to rapid and effective pulmonary beta 2 receptor activation with low systemic drug concentrations by inhalation of small doses of the drug in aerosol form.
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21. Widely available at present- codeine phosphate and hydrocodone. Codeine has a high oral-parenteral potency with oral administration providing around 60% of its parenteral efficacy. Once absorbed, codeine is metabolized by the liver . Inactive metabolites excreted predominantly in the urine. In man approximately 10% of administered codeine is demethylated to form morphine -and both free and conjugated forms of morphine can be found in the urine of patients receiving therapeutic doses of codeine. In man, codeine's plasma half-life is around 2 to 4 hours. Codeine phosphate is contained in numerous "over the counter" analgesic preparations as well as in 30 and 60mg tablets which have restricted scheduling. Hydrocodone is generally marketed in combination with homatropine as both an elixir and tablet formulations. The addition of homatropine is designed to enhance any reduction in respiratory secretions, which may come about as a result of the administration of hydrocodone. BENZONATATE Cough suppressant believed to act both centrally and peripherally. Related to amethocaine ( a local anaesthetic) and therefore has a local anaesthetic action on the mucosa. . OPIOID ANTITUSSIVES
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23. DEMULCENTS INDIRECTLY ACTING COUGH SUPPRESSANTS ? MODE OF ACTION POSSIBLY BY PROVIDING A PROTECTIVE COATING OVER THE SENSORY RECEPTORS IN THE PHARYNX EXAMPLES- GLYCEROL, HONEY, LIQUORICE AND SUCROSE SYRUPS
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26. ACUTE BRONCHITIS TREATMENT USUALLY NOT REQUIRED IN PREVIOUSLY HEALTHY PATIENTS BELOW AGE 60 EXACCERBATION OF COPD-START WITH DOXYCYCLINE 200MG OD -SECOND LINE-AMOXICILIIN (OR CO-AMOXICLAV) BRONCHIECTASIS-CO-AMOXICLAV 1.2 G TDS IV OR IF AVAILABLE PIPERICILLIN + TAZOBACTAM 4.5 G TDS CYSTIC FIBROSIS- CIPROFLOXACIN 500MG BD ORALLY OR 400MG BD IV IF PSEUDOMONAS IS SUSPECTED Adapted from Pocket Prescriber
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28. SALBUTAMOL BETA 2 AGONIST- SHORT ACTING ACTIONS: 1. DILATES BRONCHIAL SMOOTH MUSCLE 2. RELAXES UTERINE SMOOTH MUSCLE 3.INHIBITS MAST-CELL MEDIATOR RELEASE BEWARE USE -IN CARDIO-VASCULAR DISEASE Esp. arrhythmias-susceptibility to increased QTc - DIABETES MELLITUS- MAY INCREASE RISK OF DIABETIC KETO-ACIDOSIS - MAY INCREAE THYROXINE LEVELS SIDE EFFECTS- FINE TREMOR, HEADACHE, NERVOUSNESS INCREASE IN HEART RATE, PALPITATIONS, ARRHYTHMIAS DECREASE IN SERUM POTASSIUM MUSCLE CRAMPS Prolonged treatment -? Increased risk of glaucoma