GraalVM is an optimized open-source virtual machine for running applications in multiple programming languages, enabling polyglot development with support for languages like Java, JavaScript, Python, Ruby, and more. It features a Just-In-Time (JIT) compiler for better performance and offers native image generation for producing statically linked executables. The document discusses GraalVM's components, installation, interoperability with Java and other languages, and its applications within the Jakarta EE ecosystem.