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FACTORS NACESSARY FOR ERYTHROPOIESIS :
• Stimulating factors
• Maturation factor
• Factors necessary for hemoglobin formation
• Stimulating factors :
1) Hypoxia :
• Reduced availability of oxygen which stimulates the erythropoietin secretion that involves to induce the
hypoxia inducible factor which activates the transcription of genes to produce substances from proteins.
2) Erythropoietin :
• Stimulated by hypoxia , glycoprotein with 165 amino acids , secreted by peritubular capillaries from kidney
& liver & brain.
• Actions :
• Production of proerythroblasts from CFU- E of bone marrow
• Development of proerythroblasts into matured RBC by different stages
early normoblast into intermediate and late normoblasts and reticulocytes
• Release of mature RBC into blood.
3) Thyroxine :
• It accelerates the erythropoiesis.
4) Hematopoietic Growth Factors :
• These are interleukins , glycoproteins and belongs to cytokines family.
• It induces the production of PHSCs.
• Interleukins involve in erythropoiesis.
1) Interleukin 3 secreted by t –cells .
2) Interleukin 6 secreted by t cells , macrophages , endothelial .
3) Interleukin 11 secreted by osteoblast .
5) Vitamins :
• Vitamin B3 : deficiency causes anemia & pellagra ( characterized by skin lesions, diarrhea, weakness,
nervousness and dementia).
• Vitamin B6 : deficiency causes anemia and peripheral neuropathy (condition causing damage or disease of
nerves)
• Vitamin C : deficiency leads to anemia and scurvy (impaired collagen synthesis resulting in rough skin, bleeding
gums, loosening of teeth).
• Vitamin D : deficiency results in anemia and rickets.
• Vitamin E : deficiency leads to anemia and malnutrition
Thank you

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Physiology

  • 1. FACTORS NACESSARY FOR ERYTHROPOIESIS : • Stimulating factors • Maturation factor • Factors necessary for hemoglobin formation • Stimulating factors : 1) Hypoxia : • Reduced availability of oxygen which stimulates the erythropoietin secretion that involves to induce the hypoxia inducible factor which activates the transcription of genes to produce substances from proteins. 2) Erythropoietin : • Stimulated by hypoxia , glycoprotein with 165 amino acids , secreted by peritubular capillaries from kidney & liver & brain.
  • 2. • Actions : • Production of proerythroblasts from CFU- E of bone marrow • Development of proerythroblasts into matured RBC by different stages early normoblast into intermediate and late normoblasts and reticulocytes • Release of mature RBC into blood. 3) Thyroxine : • It accelerates the erythropoiesis. 4) Hematopoietic Growth Factors : • These are interleukins , glycoproteins and belongs to cytokines family. • It induces the production of PHSCs. • Interleukins involve in erythropoiesis. 1) Interleukin 3 secreted by t –cells . 2) Interleukin 6 secreted by t cells , macrophages , endothelial . 3) Interleukin 11 secreted by osteoblast .
  • 3. 5) Vitamins : • Vitamin B3 : deficiency causes anemia & pellagra ( characterized by skin lesions, diarrhea, weakness, nervousness and dementia). • Vitamin B6 : deficiency causes anemia and peripheral neuropathy (condition causing damage or disease of nerves) • Vitamin C : deficiency leads to anemia and scurvy (impaired collagen synthesis resulting in rough skin, bleeding gums, loosening of teeth). • Vitamin D : deficiency results in anemia and rickets. • Vitamin E : deficiency leads to anemia and malnutrition