This document discusses the physiology of coordination in the nervous system. It describes the different types of neurons found in animals and the functional divisions of the nervous system. The resting membrane potential is explained, which is normally around -90 mV due to mechanisms like the sodium-potassium pump and Donnan equilibrium. Ion concentrations differ inside and outside cells, with higher potassium and lower sodium and chloride inside. Ion permeability is selective, with potassium able to pass more easily than hydrated sodium ions. Diseases can impact ion concentrations and membrane potentials.
regulation of cardiac activity is given in brief along with the cardiac diseases. For diseases, just pictures are added you need to go through the explanation separately so that pictures will make you to explain it easily.
these slides contain a brief introduction of neurons and its classification as well as details of generation of action potential, resting potential and eletrotonic potential.
regulation of cardiac activity is given in brief along with the cardiac diseases. For diseases, just pictures are added you need to go through the explanation separately so that pictures will make you to explain it easily.
these slides contain a brief introduction of neurons and its classification as well as details of generation of action potential, resting potential and eletrotonic potential.
Hormones are chemical messengers that are secreted directly into the blood, which carries them to organs and tissues of the body to exert their functions. There are many types of hormones that act on different aspects of bodily functions and processes.
this ppt shares what synapses are and how information of one neuron is transmitted to other through the synapses. it also includes the properties and plasticity of synaptic transmission
Objective of the Study:- Introduction, Structure of Sodium-Potassium Pump, History, Forms of the pump, Mechanism of working, Inhibition and Functions of the pump.
Hormones are chemical messengers that are secreted directly into the blood, which carries them to organs and tissues of the body to exert their functions. There are many types of hormones that act on different aspects of bodily functions and processes.
this ppt shares what synapses are and how information of one neuron is transmitted to other through the synapses. it also includes the properties and plasticity of synaptic transmission
Objective of the Study:- Introduction, Structure of Sodium-Potassium Pump, History, Forms of the pump, Mechanism of working, Inhibition and Functions of the pump.
Ion channels, types and their importace in managment of diseasesFarazaJaved
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cellular level understanding of potassium channels, molecular levels, K+ channels, drugs on potassium channels, transmission of potassium across membrane, cell transport system, types of potassium channels, voltage gated, ligand gated, tandem pore
A hypothesis is presented which suggests that the cardiac L-type calcium channel opens in a stochastic fashion as the calcium channel protein complex moves around in the lipid of the outer leaflet of the sarcolemma. Opening occurs when there is release of calcium ions that are bound in the polarised state to anionic phospholipid of the inner leaflet, the release being a consequence of proton penetration into the sarcolemma upon depolarisation.
Chloride Channel / Ion Channels / Integral Membrane Proteins .pdfSELF-EXPLANATORY
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For more details visit on YouTube; @SELF-EXPLANATORY; https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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Physiology means study of functions. It is a subject that include everything about how organisms work and how they coordinate within their own bodies and also how they respond to the ever-changing environment.
Welcome to the wonderful world of physiology.
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Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
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Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
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5. Physiology of Coordination, Dr
Saba Butt
5
Effectors Division
CNS Division
Sensory Division
Functional
Divisions of
Nervous
System
6. Physiology of Coordination, Dr
Saba Butt
6
RESTING MEMBRANE POTENTIAL
RMP is “normal
membrane
potential of an
un-stimulated
cell”.
In most cells, it
is – 90 mV (range
is – 70 to – 90
mV).
7. Physiology of Coordination, Dr
Saba Butt
7
MECHANISMS RESPONSIBLE FOR RMP
Essentially there are three (3) mechanisms
contribute in RMP, these are:
• The Electrogenic ion Pump (Na+-K+ pump)
• Donnan Equilibrium
• Diffusion potentials
9. Physiology of Coordination, Dr
Saba Butt
9
DONNAN EQUILIBRIUM
• Biological membranes vary greatly in their
permeability to different solutes thus they
are complex semipermeable membranes.
• The semipermeability of biological
membrane has far reaching
consequences.
10. Physiology of Coordination, Dr
Saba Butt
10
DONNAN EQULIBRIUM
This property of the cell membrane and
movement of ions across membrane create
equilibrium on their both sides with
distribution of permeable and impermeable
ions, which is called as Donnan equilibrium.
11. Physiology of Coordination, Dr Saba
Butt
11
There are three important aspects to the electrical contribution of
ions to membrane potentials:
oIon mobility
oionic concentration difference
oIonic permeability
Diffusion Potentials
12. 1. Ion Mobility: Different ions have varied mobility
due to different sizes and charge density because of
varying hydration layer.
2. Ionic concentration difference: Inside of the cell
has lower Na+& Cl- concentration and higher K+
concentration. There are similar conc. differences of
other ions across membrane.
Physiology of Coordination, Dr
Saba Butt
12
13. Physiology of Coordination, Dr
Saba Butt
13
3. Ion permeability:
– There is selective permeabilities of the membranes to
the different ions.
– The ion channels impart this characteristic. Na+, K+,
Ca2+ & Cl- channels are specific for their respective
ions.
– These channels work variedly for the ions
permeabilities at different times.
– Channels action is understood by their channel
blocking agents e.g. Tetrodotoxin from puffer fish
blocks Na+ channels. Saxitoxin blocks Na+ channel in
dinoflagellate, passed to shell fish.
14. Physiology of Coordination, Dr
Saba Butt
14
CONCENTRATION OF IMPORTANT IONS
INSIDE AND OUTSIDE THE CELL
The most important ions are
potassium (K+), chloride
(Cl-), sodium (Na+), and
calcium (Ca++).
These are listed in order of
increasing size of the
hydrated ion.
Most pores are large
enough to pass K+, but few
will carry Na+, and almost
none can transport Ca++.
15. Physiology of Coordination, Dr
Saba Butt
15
HYDRATED IONS
Water molecules are slightly
polarized molecule and are
attracted to other polarized
molecules or to ions.
For an ion to move through the
lipid bilayer, it would have to shed
its associated waters, a process
very expensive energetically.
The waters of hydration vs. the
hydrophobic lipid layers prevents
movement of electrolytes across
the cell membrane. Pores and
gates are necessary.
16. Physiology of Coordination, Dr
Saba Butt
16
RELATIVE ION SIZE
But in living system, all hydrated ions are in the same solution. The
larger the unhydrated ion in size, the more dispersed is its own charge
and the less strongly it will attract water. This leads to the incongruous
situation of the larger the ion, the less hydrated it is, and the
smaller the relative size of the hydrated whole. Thus, K+ > Na+, but
hydrated K+ < hydrated Na+.
The cloud of water molecules
that associates with an ion is
somewhat indeterminant in
size, depending on energy
dynamics of the solution.
17. Physiology of Coordination, Dr
Saba Butt
17
The above figure shows
the situation generally
found in cell membranes.
The result is that most ion
channels allow K+ to pass
inside the cell due to its
small “Hydrated ion size”
but do not allow Na+ due to
its large “hydrated ion
size”.
There is a relative abundance of pores large enough to
pass K+* but too small for Na+. There is a small population
of chloride pores, and a small number of Na+ and Ca++
pores. The effect of this, of course, is a differential
permiability for these 3 ions across the membrane. Quite
simply, there are very many more entryways for K+
than for sodium ion, and very many more Na+
passages than calcium ion tunnels. The intracellular ion
populations reflect these differences.
18. Physiology of Coordination, Dr
Saba Butt
18
• The plasma membranes of RBCs with Hereditary
spherocytosis is 3X more permeable than normal. The
level of Na+, K+ ATPase also remains elevated there.
Consequently anemia is caused in these patients.
• Cardiac glycosides such as digitalis increase heart’s
strength of contraction as these inhibit Na+, K+ pump,
thus increase intracellular Na+ and Ca2+ to cause
forceful contraction.
• Changes in intracellular K+ cause serious cardiac
arrhythmias. Hypokalemia by long term use of diuretics
hyperpolarizes a cells and Hyperkalemia in acute renal
failure causes partial depolarization.
In the case of a disease --