Physio Renal 5.

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The document discusses control of sodium excretion and extracellular fluid volume through various mechanisms: 1. Sodium excretion is controlled by ADH, thirst, salt appetite, and cardiovascular reflexes. 2. Extracellular sodium and osmolarity are controlled by an osmoreceptor feedback system involving ADH and thirst, as well as salt appetite at low sodium levels. 3. Aldosterone regulates sodium absorption in the distal tubules and sodium excretion is well-controlled even without aldosterone feedback through mechanisms like ADH and thirst.

Control of Na+ excretion. Dr.Mohamad Shaikhani.

Control of Na+ excretion. Through: 1.ADH. 2.Thirst. 3.Salt appetite 4.Cardiovascular reflexes (BP & blood volume).

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In an average 70-kilogram man, the combined blood ﬂow through both kidneys is about 1100 ml/min, or about 22 per cent of the cardiac output. Two kidneys makes about 0.4 % of total body weight but receive very high blood flow as compared with other body organ. The purpose of additional blood flow is to supply sufficient plasma for high rates of GF which is essential for regulating body fluid volumes & solute concentrations. Characteristics of the renal blood flow: 1, High blood flow. 1100 ml/min, or 22 percent of the cardiac output. 94% to the cortex. 2, Two capillary beds High hydrostatic pressure in glomerular capillary (about 60 mmHg) and low hydrostatic pressure in peritubular capillaries (about 13 mmHg) Blood flow to renal medulla is supplied by vasa recta. Blood flow in vasa recta of medulla is very low as compared to blood flow in cortex. Blood flow in renal medulla is 1-2 % of total renal blood flow. Vasa recta are important to form concentrated urine.

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Physio Renal 5.

1. Control of Na+ excretion. Dr.Mohamad Shaikhani.

2. Control of Na+ excretion. Through: 1.ADH. 2.Thirst. 3.Salt appetite 4.Cardiovascular reflexes (BP & blood volume).

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Physio Renal 5.

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