A solution is a homogeneous mixture composed of a solute dissolved in a solvent. The solute is the minority component that is dissolved, while the solvent makes up the majority of the solution. Solutions can be classified based on the physical states involved, such as liquid solutions which are the most common. The concentration of a solution describes how much solute is present and can be expressed in terms such as molarity. Properties like vapor pressure, boiling point, and freezing point are influenced by the presence of solute particles in colligative properties.
Presentation include chapter solubility of drugs from second yr B-Pharm
Solubility, solubility expression, solute solvent interactions, solubility parameters, solvation and dissolution, factors affecting solubility, solubility of gases in liquids, liquids in liquids, fractional distillation, azeotropes, dissolution and drug release and diffusion.
Pharmaceutical Solutions. Definition: Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
3. What Is a Solution?
• is a type of homogeneous mixture
that is made up of two or more
substances.
• A homogeneous mixture is a type
of mixture with a uniform
composition.
4. Let's make use of our salt water example to talk about
the two main parts of a solution. These are:
Solute: this is the substance that makes up the minority
of the solution, or this is the part that is dissolved.
Example, the salt water, the solute is the salt.
Solvent: this is the substance that makes up the majority
of the solution. This is the part where the solute is
dissolved. Example, the salt water, the solvent is water.
5. TYPES OF SOLUTIONSOn the basis of physical states of solute and solvents
Gaseous Solutions: gases can spontaneously mix in any
proportion.
Solid Solutions: they are generally called alloys, where
two or more metals are present. Mercury alloys are
called amalgams, and they can be liquid or solid.
Liquid Solutions: liquid solutions are the most common
and they can be obtained by dissolution of a gaseous,
liquid or solid solute.
6. TYPES OF SOLUTIONSOn the basis of dissolution of solute in solvent
A saturated solution contains the maximum amount of a
solute that will dissolve in a given solvent at a specific
temperature.
An unsaturated solution contains less solute than the
solvent has the capacity to dissolve at a specific
temperature.
A supersaturated solution contains more solute than is
present in a saturated solution at a specific temperature.
7.
8. Energies of Solution Formation
• "Like dissolves like"
Step 1: Seperating the solution into individual components
of the solute (expanding the solute).
Step 2: Overcoming intermolecular forces in the solvent to
make room for the solute (expanding the solute)
Step 3: Allowing the solute and solvent to interact to form
the solution
• Enthalpy of hydration is step 1 and step 2 combined into 1
step
11. Concentration Units
The concentration of a solution is the
amount of solute present in a given
quantity of solvent or solution.
12. a.) Percent by Mass
% by mass =
mass of solute
mass of solute + mass of solvent
x
100%
=
mass of solute
solute mass of solution
x 100%
Percent by Volume
% by volume =
volume of solute
volume of solution
x 100%
13. b.) Mole Fraction (X)
𝑋𝐴=
moles of A
sum of moles of all components
c.) Molarity (M)
M =
moles of solute
liters of solution
14. d.) Molality (m)
m =
moles of solute
mass of solvent (kg)
e.) Parts per million
ppm =
mass of solute
mass of solution
x 106
15. ppm
1 ppm is one part by weight, or volume, of solute
in 1 million parts by weight, or volume, of solution.
In weight/volume (w/v) terms,1 ppm = 1g
m-3 = 1 mg L-1 = 1 μg mL-1
In weight/weight (w/w) terms,1 ppm = 1 mg kg-
1 = 1 μg g-1
18. How many moles of water form when
25.0 mls of 0.100 M HNO3 (nitric acid)
solution is completely neutralized by
NaOH (a base)?
EXAMPLE
19.
20.
21.
22.
23. SOLUBILITY
is the maximum amount of a substance
that will dissolve in a given amount of
solvent at a specific temperature.
24. Factors Affecting Solubility
There are two direct factors that affect solubility:
temperature and pressure.
• Temperature affects the solubility of both solids
and gases.
• Surface area does not affect how much of a solute
will be dissolved, but it is a factor in how quickly or
slowly the substance will dissolve.
• But pressure only affects the solubility of gases.
25. The Effect of Temperature on Solubility
Temperature has a direct effect on solubility.
For the majority of ionic solids, increasing the
temperature increases how quickly the solution can
be made.
As the temperature increases, the particles of the
solid move faster, which increases the chances that
they will interact with more of the solvent particles.
This results in increasing the rate at which a solution
occurs.
26. The Effect of Pressure on Solubility
The second factor, pressure, affects the solubility of a gas
in a liquid but never of a solid dissolving in a liquid.
When pressure is applied to a gas that is above the surface
of a solvent, the gas will move into the solvent and occupy
some of the spaces between the particles of the solvent.
This gas pressure factor is expressed in Henry’s law.
Henry’s law states that, at a given temperature, the
solubility of a gas in a liquid is proportional to the partial
pressure of the gas above the liquid.
27. The Effect of Surface Area on the Rate of
Dissolving
If we were to increase the surface area of a solid, then it
would have been broken into smaller pieces. We would do
this to increase how quickly the solute would dissolve in
solution
If you were to dissolve sugar in water, a sugar cube will
dissolve slower than an equal amount of tiny pieces of sugar
crystals. The combined surface area of all of the sugar
crystals have a much greater surface area than the one sugar
cube and will have more contact with the water molecules.
This allows the sugar crystals to dissolve much more quickly.
28.
29. Colligative Properties of Nonelectrolytes
and Electrolyte Solutions
depend on the concentration of solute particles
but not on their chemical identity.
The concentration of solute particles depends on
the amount of dissolved solute as well as on its
ability to dissociate to ions in solution
Colligative Properties
30. • Weak electrolytes – dissociate partially (weak
acids and bases)
• Strong electrolytes – dissociate completely
(soluble salts, strong acids and bases)
• Nonelectrolytes – do not dissociate (many
organic compounds)
• Nonvolatile Nonelectrolyte Solutions – No
dissociation; no vapor pressure (glucose, sugar,
…)
31. Vapor pressure lowering (ΔP)
• the vapor pressure of the solvent over the
solution (Psolv) is always lower than the vapor
pressure over the pure solvent (P°solv) at a
given temperature
Raoultʼs law
32. Raoult’s Law
• the vapor pressure of the solvent over the
solution is directly proportional to the mole
fraction of the solvent
• Followed strictly at all concentrations only by
ideal solutions
33. Boiling point elevation (ΔTb) and
freezing point depression (ΔTf)
• The solution boils at a higher temperature
compared to the pure solvent (the solution
has lower vapor P so it needs higher T to boil)
• The solution freezes at a lower temperature
compared to the pure solvent
34. Osmotic pressure (Π)
• Osmosis – the flow of solvent trough a semi
permeable membrane from a less
concentrated into a more concentrated
solution
• Semipermeable membrane – the solute
particles can’t pass through
35. The solvent tends to
flow into the solution
where the disorder is
greater
36. • Π is the hydrostatic pressure necessary to stop
the net flow of solvent caused by osmosis
Π = MRT
Π = (nsolute/Vsoln)RT
M – molarity of solution R – gas constant;
T – temperature in K
37. • The equation is the equivalent of the ideal
gas law (P = nRT/V) applied to solutions.
• Π is the pressure the solute would exert if it
it were an ideal gas occupying alone the
volume of the solution.
38. • Osmosis is essential for controlling the
shape and size of biological cells and
purifying blood through dialysis
• Reverse osmosis – reversing the flow by
applying external pressure (used to purify
sea water)