This document discusses bioelectrochemistry and membrane potentials. It introduces how electrochemistry studies ions and electrodes in biological systems. Cells are surrounded by membranes made of phospholipids that contain uneven distributions of ions like potassium, sodium, and chloride. This ion gradient across the cell membrane generates a resting membrane potential. Ions can cross the membrane through permeability or active transport via sodium-potassium pumps. The difference in ion concentrations, not the ions themselves, cause the membrane potential. Protein adsorption on metal electrodes is also examined as a model for interfacial electron transfer in biological systems.