Pharmacological action of Parada murchit aushadhi i. e. 1. Kharaliya Rasayana 2. Parpati Rasayana, 3. Pottali Rasayana, 4. Kupipakwa Rasayana.

1. VD. PRITI H. PUSAM
PG SCHOLAR
(RASASHASTRA DEPT.)
G.A.C. OSMANABAD

2. INTRODUCTION:
Rasaushadhi = Rasa= Parada Aushadhi= formulation
अल्पमात्रा उपयोगित्वात अरूचे: अप्रसंित्वात
क्षिप्र आरोग्यदाययत्वात अगिको रस:
PARADA:
 “रसेषु उत्तम:”
 “सववरोिववनाशक:”
 Heart of Rasashastra
 Master metal
 Yogavahi
 Rasayana
 Any rasakalpa containing mercury has increased strength of
medicine.

3.  CLASSIFICATION OF RASAKALPAS:
(PARADA MURCHIT KALPA)
As per method of preparation:
Kharaliya
Rasayana
Parpati
Rasayana
Pottali
Rasayana
Kupipakwa
Rasayana

4. 1. KHARALIYA RASAYANA:
 Prepared in crucible hence known as khalviya rasayana.
 Ex. – Kajjali
KAJJALI:-
1. Is an example of sagandha niragni kalpana of kharaliya
kalpa.
2. Purified Parada & gandhaka are constantly triturated
under pressure at atmospheric temperature.
3. Constant & consistent pressurized triturating of kajjali
enhances pharmaco dynamic properties.
4. The process of constant trituration will pack the gandhaka
molecule in between layer of parada molecule.
therefore sustained release of active
molecules take place.

5.  CONCEPT:-
 Most widely and frequently used in therapeutics.
 Prolong shelf life.
 Enhance the therapeutic efficacy.
 Decrease the duration of treatment.
 Can be administered directly as per required doses.
 Can be transformed into the form of pills, tablets,
capsules etc…

6. 2. PARPATI RASAYANA
द्रुतकज्जलिका मोचापत्रके गचपटीकृ ता च l
स पोट: पपवटी सैव बिाद्यखििरोिनुत II
र. र. स. ११/७२

7. CONCEPT:
 Sagandha sagni parada murchit kalpana.
 Ex. - Rasaparpati
 Brittle flakes of sulphuric mercurial combination, gray to
blackish in color.
 Kajjali is the base material.
 Agni sanskara is an important aspect of parpati kalpana
Method of preparation:
 kajjali is placed an iron pan and heated on mild fire till it
get semi liquid to liquid consistency , then it is placed on
banana leaves and pressed with a flat heavy object after
covering with another banana leaf.

8.  Parpati-
Is potabandha of Parada which control the
movement and fragility of Parada.
 Heat-
Heat energy enhance the therapeutic efficacy &
emphasizes lightness.
 Gomaya –
Comes from alimentary tract of the cow and have
enzymatic activity.
 Ghee-
It has synergistic effect.
 Patra (kadali or eranda)-
Increases potency of drug. Highly rich in chlorophyll
which able to neutralize negative effects of free radicals in
the body.
IMPORTANCE OF PARPATI RASAYANA

9. 3. POTTALI RASAYANA
ववस्ताररतस्या द्रव्यस्य अल्ल्पभावानं पोट्टमं l
पोट्टमंिायत ग्रीह्नाती इयत
पोट्टलि:

10. DIFFERENT METHODS OF POTTALI PREPARATION:-
MODE OF ADMINISTRATION OF POTTALI RASAYANA:
 POTTALI- Should be rubbed over a scratch stone with Ghrita or
Madhu and make paste.
 IN RASAMRUTA- Rub the pottali with adraka or nagavalli
swarasa in sannipata condition.
1.Gandhaka drava
paka
2. Putapaka
3.Bhavana vidhi

11. IMPORTANCE OF POTTALI RASAYANA
 The word pottali means to minimize the shape of
drug into a more compact and potent form.
 Used as emergency & life saving remedy.
 Method of administration via tongue help in quick
absorption.
 Unique preparation method.
 Less dose with high potency.
 Convenience in transportation.
 Long shelf life.

12. 4. KUPIPAKWA RASAYANA
“कु प्याम अग्नीनां पक्वं यद रसायनमं तत
कु वपपक्वारसायनं l “

13.  DISCRIPTION:
 This is unique & different method of preparation
of preparing bhasma.
 In a specially built furnace, earthen vessel filled
with sand , a coated glass of bottle with mixture is
kept.
 Heat is given from below the ascending
temperature for 24 to 72 hours.
 The desired medicine obtained from neck and
bottom of the bottle.

14. IMPORTANCE OF KUPIPAKWA RASAYANA:
 Best rasayana
 It requires minimum dose.
 Easy for administration.
 More potent and quicker action.
 Potency of these drug remain for longer period.
 Cure even asadhya rogas.

15. CONCLUSION:
 Parada is yogvahi - thus quick in action.
 Chemical bond becomes stronger in following order- KAJJALI-
PARPARI-POTTALI-KUPIPAKWA RASAYANA.
 In kajjali preparation- The triturating causes friction, pressure,
motion
it help to form smallest particle of drug, so bioavailability
increases.
 In parpati rasayana- Due to Agni sanskara emphasizes lightness.
 In pottali rasayana- technique give compactness to the scattered
material.
 In kupipakwa rasayana- Trituration, heat application (mrudu-
madhya-trivragni) helps in particle size reduction.
 Making drug to reach at difficult sites in body.
 Due to shodhan, maran, mardan, agni sanskar, puta the particle
size reduces as to provide better bioavailability & faster
absorption .
 Can reach fast up to utter dhatu i.e. asthi, majja, sukra etc.

16. DISCUSSION:
 Life saving remedy.
 Easy to handle.
 Useful in acute condition.
 Can use as antibiotics of Ayurveda.
 Easy administration of medicine.
 Easy to transport and carry .

17. REFFERENCES
1. Ayurvediya aushadhikarn, Bhag 1 &2, by vd. P.V. Dhamankar & vd. G.V.
Puranik, 2nd edition, Dhutpapeshwar publication.
2. Ayurvediya Rasashastra by dr. Sidhinandan mishra, ISBN:97881-7637-114-8,
Chaukhamba Orientalia publication.
3. Shri vagbhatacharya virachit Rasaratnasamuchya by dr Sidhinandan mishra,
, Chaukhamba Orientalia publication.
4. Chaturvidha rasayana by dr Raghuveer
5. Chemistry of Kupipakwa rasayanas a review by P.K Sarkar et al, april 2008,
vol:No xxvii(4) april, may, june – 2008
6. Pottali kalpana: a concise & potent pharmaceutical dosage form of indian
system of medicine by S.Palbag et al.journal of biological & scintific
opinion, vol 1(1)2013
7. A comprehensive review on parpati kalpa, by D. Shrilakshmi /Int.J.Res.
Ayurveda Pharma.6(2), mar-apr 2015
8. www.wjpr.net
9. Pharmaceutical study of hemagarbha pottali by S. Vedbhushan et al.
Int.J.Res. Ayurveda Pharma. , ISSN:2322-0910

18. THANK YOU