This document discusses particle size distribution (PSD), including defining PSD, the significance of PSD, sampling and measurement techniques like sieve analysis and sedimentation methods, and graphical representation of PSD using histograms. Particle size and shape are first defined to understand PSD. Sieve analysis separates particles by size but is limited to larger particles, while sedimentation methods produce fractional analysis for finer particles below 100 μm.
Physics of tablet compression, mechanism of tablet
formation, bonding in tablets, the effect of compressional force on tablet properties, effect
of lubricants on tablet compression, binding, instrumented tablet machines and tooling,
problems associated with large scale manufacturing of tablets.
Physics of tablet compression, mechanism of tablet
formation, bonding in tablets, the effect of compressional force on tablet properties, effect
of lubricants on tablet compression, binding, instrumented tablet machines and tooling,
problems associated with large scale manufacturing of tablets.
Dissolution, factors affecting drug dissolution, methods to evaluate dissolution, advantages and disadvantages, recent approaches--these are the topics covered in this presentation.
Objectives, applications, Mechanism, official standards of powders, Sieve, Standard for Sieve, Principles, construction, working, uses, merits and demerits of Air separator.
Micromeritics ,1. Micromeritics: Importance of particle size determination, different means of expressing particle size, methods of particle size determination: Optical and electron microscope studies, Coulter counter methods, laser beam technique, sieve analysis, sedimentation methods; particle shape and surface area. Measurement of particle surface area.
Powder Technology
Particle analysis in pharmaceuticals
Determination of particle size and surface area
Large scale equipment for powders
Types of powders
This is a comprehensive presentation on particle size distribution. A fundamental property in bulk solids handling.
Link to file: https://drive.google.com/open?id=11dn9O0onwCLaX44R6ApNLhi9PHYGdLr6
Dissolution, factors affecting drug dissolution, methods to evaluate dissolution, advantages and disadvantages, recent approaches--these are the topics covered in this presentation.
Objectives, applications, Mechanism, official standards of powders, Sieve, Standard for Sieve, Principles, construction, working, uses, merits and demerits of Air separator.
Micromeritics ,1. Micromeritics: Importance of particle size determination, different means of expressing particle size, methods of particle size determination: Optical and electron microscope studies, Coulter counter methods, laser beam technique, sieve analysis, sedimentation methods; particle shape and surface area. Measurement of particle surface area.
Powder Technology
Particle analysis in pharmaceuticals
Determination of particle size and surface area
Large scale equipment for powders
Types of powders
This is a comprehensive presentation on particle size distribution. A fundamental property in bulk solids handling.
Link to file: https://drive.google.com/open?id=11dn9O0onwCLaX44R6ApNLhi9PHYGdLr6
The word Micromeritics refers to a discipline of science and technology that deals with studies related to the fundamental as well derived properties of particles. The knowledge and control of the size of particles is of importance in pharmacy and materials science.
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Chemical reaction engineering is that engineering activity which is concerned with the exploitation of chemical reactions on commercial scale.
The areas of different fields of science like:
Oil Refining
Pharmaceuticals
Biotechnology
Chemical Industries
Sustainable Development
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The areas of different fields of science like:
Oil Refining
Pharmaceuticals
Biotechnology
Chemical Industries
Sustainable Development
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2. Particle Size Distribution
Objective
Understanding of Particle Size and Particle Shape
Particle Size Distribution (PSD)
Significance of Particle Size Distribution (PSD)
Particle Size Distribution: Sampling
Particle Size Distribution: Measurement Techniques
Particle Size Distribution: Graphical Representation
3. Particle Size Distribution
Understanding of Particle Size and
Particle Shape
Particle Size
Particle size or grain size refers to the diameter of a grain of
granular material
5. Particle Size Distribution
The size of a spherical homogeneous particle is uniquely
defined by its diameter.
For regular, compact particles such as cubes or regular
tetrahedra, a single dimension can be used to define size.
With some regular particles it may be necessary to specify
more than one dimension: For a cone the base diameter
and height are required whilst for a cuboid three
dimensions are needed.
6. Particle Size Distribution
For irregular particles, it is desirable to quote the size of a
particle in terms of a single quantity, and the expression most
often used is the "equivalent diameter".
This refers to the diameter of a sphere that would behave in the
same manner as the particle when submitted to some specified
operation.
The assigned equivalent diameter usually depends on the
method of measurement, hence the particle-sizing
technique should, wherever possible, duplicate the
process one wishes to control.
Several equivalent diameters are commonly encountered.
For example, the Stokes' diameter is measured by
sedimentation and elutriation techniques; the projected
area diameter is measured microscopically and the sieve-
aperture diameter is measured by means of sieving.
8. Particle Size Distribution
Influences of Particle Size
Particle size influences dissolution
Small particles dissolve more rapidly than large ones, which is
important not only in determining the behavior of the drug in vivo
but also in various manufacturing processes.
Particle size influences flow properties of powders
The flow properties of powders are strongly dependent on particle
size and, in particular, particle shape. Since most powders are
moved from one place to another by flowing, control of flow behavior
is highly important. Generally, coarse, roughly spherical particles
flow much more easily than small or elongated particles.
Particle size influences stability of dispersions
The stability of dispersions, such as suspensions and emulsions,
depends on the size of the dispersed material. The forces between
colloidal particles depend on their dimensions, and the settling.
11. Particle Size Distribution
The length is the distance between two tangential planes
which are perpendicular to those defining the thickness and
breadth.
In practice it may be difficult to measure the particle thickness,
particularly from microscopy, and so often we are limited to using
simply the elongation ratio, as shown in Figure.
12. Particle Size Distribution
Particle Size Distribution
The particle size distribution (PSD) may be defined as
“Particle size distribution (PSD) of a powder, or granular material,
or particles dispersed in fluid, is a list of values or a mathematical
function that defines the relative amounts of particles present,
sorted according to size.”
Particle size distribution is also known as grain size distribution.
14. Particle Size Distribution
Significance of Particle Size Distribution (PSD)
The PSD of a material can be important in understanding its
physical and chemical properties.
It affects the strength and load-bearing properties of rocks and
soils.
It affects the reactivity of solids participating in chemical
reactions, and needs to be tightly controlled in many industrial
products such as the manufacture of printer toner and cosmetics.
15. Particle Size Distribution
Particle Size Distribution: Measurement Techniques
There is a wide range of instrumental and other methods of
particle size analysis available. Some of the more common
methods are:
1. Sieve Analysis
2. Sedimentation Methods
16. Particle Size Distribution
1. Sieve Analysis
Sieve analysis is one of the oldest methods of size analysis.
Sieve analysis is accomplished by passing a known weight of
sample material successively through finer sieves and weighing
the amount collected on each sieve to determine the percentage
weight in each size fraction.
Sieving is carried out with wet or dry materials and the sieves
are usually agitated to expose all the particles to the openings.
17. Particle Size Distribution
Process of Sieving
The process of sieving may be divided into two stages.
First, the elimination of particles considerably smaller than the
screen apertures, which should occur fairly rapidly and, second,
the separation of the so-called "near-size" particles, which is a
gradual process rarely reaching final completion.
The effectiveness of a sieving test depends on the amount of
material put on the sieve (the "charge") and the type of movement
imparted to the sieve.
18. Particle Size Distribution
The woven sieve is the oldest design, and it is normally made
by weaving fine metal wire into a square pattern, then soldering
the edges securely into a flattish cylindrical Container.
Woven-wire sieves were originally designated by a mesh
number, which referred to the number of wires per inch, which is
the same as the number of square apertures per square inch.
19. Particle Size Distribution
Presentation of Results
There are several ways in which the results of a sieve test can
be tabulated. The three most convenient methods are shown in
table.
20. Particle Size Distribution
Table shows:
(1) The sieve size ranges used in the test.
(2) The weight of material in each size range, e.g. 1.32 g of
material passed through the 250 μm sieve, but was
retained on the 180 μm sieve: the material therefore is in
the size range -250 to +180 μm.
(3) The weight of material in each size range expressed as a
percentage of the total weight.
(4) The nominal aperture sizes of the sieves used in the test.
(5) The cumulative percentage of material passing through
the sieves, e.g. 87.5% of the material is less than 125 μm
in size.
(6) The cumulative percentage of material retained on the
sieves.
21. Particle Size Distribution
Technique Advantages
1) This technique is well-adapted for bulk materials.
2) It is required to produce a separated size fraction for
further study.
3) The material flows easily as discrete particles.
4) The material is fairly coarse, e.g. above 100 μm, and
contains few fines.
5) The powder is composed of materials with a range of
different densities, different refractive indices or is water-
soluble.
22. Particle Size Distribution
Technique Disadvantages
1) Much fine material below 100 μm is present, unless
specialized microsieving equipment is available.
2) The particles are fragile.
3) The particles are in the form of elongated needles.
4) The material adheres to the sieve or forms clumps.
5) The powder easily acquires an electrostatic charge.
23. Particle Size Distribution
2. Sedimentation Methods
Sedimentation methods are based on the measurement of the
rate of settling of the powder particles uniformly dispersed in a
fluid and the principle is well illustrated by the common laboratory
method of "beaker decantation".
24. Particle Size Distribution
The material under test is uniformly dispersed in low
concentration in water contained in a beaker. A wetting agent may
need to be added to ensure complete dispersion of the particles.
A syphon tube is immersed into the water to a depth of ‘h’ below
the water level, corresponding to about 90% of the liquid depth ‘L’.
The terminal velocity ‘v’ is calculated from Stokes' law for the
various sizes of particle in the material, say 35, 25, 15, and
10 μm.
25. Particle Size Distribution
The time required for a 10 μm particle to settle from the water
level to the bottom of the syphon tube, distance ‘h’, is calculated
(t = h/v).
The pulp is gently stirred to disperse the particles through the
whole volume of water and then it is allowed to stand for the
calculated time.
The water above the end of the tube is syphoned off and all
particles in this water are assumed to be smaller than 10 μm
diameter.
26. Particle Size Distribution
Technique Advantages
The method is simple and cheap.
This methods has the advantage over many other sub-sieve
techniques in that it produces a true fractional size analysis.
Technique Disadvantages
This method is, however, extremely tedious, as long settling
times are required for very fine particles, and separate tests must
be performed for each particle size.
27. Particle Size Distribution
Particle Size Distribution: Graphical Representation
A histogram is one of the simplest ways to display a particle
size distribution.
It is a particle frequency distribution that shows the percentage
of particles found in each size range.
Frequency can be plotted on the Y-axis by number count,
surface area, or mass and particle diameter in μm can be plotted
on X-axis.
28. Particle Size Distribution
The median particle size (mass median particle diameter) is
the particle diameter that divides the frequency distribution in half.
The arithmetic mean diameter, usually simply termed the
mean diameter, is the arithmetic average particle diameter of the
distribution.
The mode represents the value that occurs most frequently in a
distribution. In particle size distributions, the mode is the particle
diameter that occurs most frequently.