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Ovulation and
the ovarian
cycle
GnRH
(Gonadotropin
releasing hormone)
hypothalamus
Gonadotropin
FSH LH
Stimulate and
control cyclic
changes in the ovary
Pituitary gland
ovary
• At the beginning of each ovarian cycle, 15-20
preantral follicles are stimulated to grow
under the influence of FSH
• One follicle reaches full maturity
• Only one oocyte is discharged
• Others degenerate and become atretic
• Corpus atreticum
• FSH also stimulates maturation of follicular
(granulosa) cells surrounding the oocyte
• Granulosa and theca cells produce estrogens
that
1. Cause the uterine endometrium to enter the
follicular or proliferative phase
2. Cause thinning of the cervical mucus to allow
passage sperm
3. Stimulate the pituitary gland to secrete LH
• At mid-cycle, there is a LH surge that
1. Causes oocyte to complete meiosis I and
initiate meiosis II
2. Luteinization
3. Causes follicular rupture and ovulation
• Secondary follicle grows rapidly to diameter of
25mm
• Completion of meiosis I with initiation of
meiosis II but oocyte is arrested in metaphase
approximately 3 hours before ovulation
• Surface of ovary begins to bulge stigma
(avascular) muscular contractions in the
ovarian wall extrude the oocyte
• This break free and floats out of the ovary
• Corona
Corpus luteum
• After ovulation, granulosa cells remaining +
cells from theca interna are vascularized
• Under the influence of LH lutean cells
(yellowish) corpus luteum which
secretes the hormone progesterone
• Progesterone + estrogenic hormones causes
uterine mucosa to enter the progestational or
secretory state (preparation for implantation)
Oocyte
• Tube contract rhythmically
• Sweeping movements of the fimbriae
• In humans, the fertilized oocyte reaches the
uterine lumen in approximately 3 to 4 days
Corpus albicans
• Degeneration of lutean cells and form a mass
of fibrotic scar tissue, the corpus albicans
• Progesterone production decreases
precipitating menstrual bleeding
Corpus luteum graviditatis
• Continues to secrete progesterone until the
end of the 4th month
• Removal of corpus luteum of pregnancy
before 4th month usually leads to abortion
ovulation.pptx

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ovulation.pptx

  • 2.
  • 3.
  • 4. GnRH (Gonadotropin releasing hormone) hypothalamus Gonadotropin FSH LH Stimulate and control cyclic changes in the ovary Pituitary gland ovary
  • 5.
  • 6.
  • 7. • At the beginning of each ovarian cycle, 15-20 preantral follicles are stimulated to grow under the influence of FSH • One follicle reaches full maturity • Only one oocyte is discharged • Others degenerate and become atretic • Corpus atreticum
  • 8. • FSH also stimulates maturation of follicular (granulosa) cells surrounding the oocyte
  • 9.
  • 10. • Granulosa and theca cells produce estrogens that 1. Cause the uterine endometrium to enter the follicular or proliferative phase 2. Cause thinning of the cervical mucus to allow passage sperm 3. Stimulate the pituitary gland to secrete LH
  • 11.
  • 12. • At mid-cycle, there is a LH surge that 1. Causes oocyte to complete meiosis I and initiate meiosis II 2. Luteinization 3. Causes follicular rupture and ovulation
  • 13. • Secondary follicle grows rapidly to diameter of 25mm • Completion of meiosis I with initiation of meiosis II but oocyte is arrested in metaphase approximately 3 hours before ovulation
  • 14. • Surface of ovary begins to bulge stigma (avascular) muscular contractions in the ovarian wall extrude the oocyte • This break free and floats out of the ovary • Corona
  • 15.
  • 16.
  • 17. Corpus luteum • After ovulation, granulosa cells remaining + cells from theca interna are vascularized • Under the influence of LH lutean cells (yellowish) corpus luteum which secretes the hormone progesterone
  • 18. • Progesterone + estrogenic hormones causes uterine mucosa to enter the progestational or secretory state (preparation for implantation)
  • 19. Oocyte • Tube contract rhythmically • Sweeping movements of the fimbriae • In humans, the fertilized oocyte reaches the uterine lumen in approximately 3 to 4 days
  • 20. Corpus albicans • Degeneration of lutean cells and form a mass of fibrotic scar tissue, the corpus albicans • Progesterone production decreases precipitating menstrual bleeding
  • 21. Corpus luteum graviditatis • Continues to secrete progesterone until the end of the 4th month • Removal of corpus luteum of pregnancy before 4th month usually leads to abortion