The document discusses the processes of ovulation, fertilization, and implantation. It explains that ovulation is triggered by hormones like LH and FSH, leading to the release of an egg. If fertilization by sperm occurs, the fertilized egg undergoes cell division and develops into a blastocyst over a week. The blastocyst then implants in the uterus by attaching to the endometrial lining with the help of hormonal changes brought on by the corpus luteum.
Steps of fertilization, where transport of gametes(oocyte and spermatozoon) , illustrated with images.
Differences in characteristics of egg and sperm of fertilization are tabulated.
Capacitation and acrosomal reaction are shown with diagrams to understand.
Barriers protecting female gamete shown with images.
Flowchart has been drawn to show the phases of fertilization and response of egg after entry of the sperm with explanation.
The result of fertilization is highlighted .
Ends
Steps of fertilization, where transport of gametes(oocyte and spermatozoon) , illustrated with images.
Differences in characteristics of egg and sperm of fertilization are tabulated.
Capacitation and acrosomal reaction are shown with diagrams to understand.
Barriers protecting female gamete shown with images.
Flowchart has been drawn to show the phases of fertilization and response of egg after entry of the sperm with explanation.
The result of fertilization is highlighted .
Ends
Embryology-all basic definition,Stage wise development of fetus,development o...sonal patel
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Embryology-all basic definition,Stage wise development of fetus,development o...sonal patel
Embryology-all basic definition,Stage wise development of fetus,development of Zygote stage ,development of Embrionic Stage ,development of Fetus Stage all are according week development,Amnione,chorion,Fetal layer, Umbilical Cord developmentmade By sonal Patel
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Implantation and formation of placenta is an essential developmental process during human embryogenesis as it marks the connection between maternal and fetal blood, a condition specific to mammals more precisely eutherians. It works as a passage of required nutrients to the growing embryo and collection of its waste. It also discusses various types of placenta that are seen in mammals.
This presentation covers fact about fertilization events across plants and animal kingdom. This is pdf file, please email (at mahlaranjeet@gmail.com) for ppts
USMLE GENERAL EMBRYOLOGY 008 First week of development A embryo .pdfAHMED ASHOUR
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These events lay the foundation for subsequent processes in the following weeks. The successful implantation of the blastocyst into the uterus marks the transition from the first week to the second week of embryonic development.
3 GEN EMBRYOLOGY third Week 3 germ layer .pptxAkhilaV16
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This presentation was prepared by Isaac Monyrun Meen Ngeny, medical student in university of Juba. South Sudan.
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The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
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Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
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2. DESIRED LEARNING OUTCOMES
This lecture will enable you to:
1. explain the process of ovulation & list the hormones influencing it
2. explain the luteinization & the formation of corpus luteum (of
menstruation & of pregnancy), their functions & fate
3. explain the precondition of the sperm for fertilization
4. describe phases of fertilization
5. explain the reaction of oocyte to the fertilization & results of fertilization
6. describe the different stages from zygote to blastocyst
7. define implantation & its normal sites in the uterus
8. explain the decidua reaction of the uterus during implantation
9. explain the abnormal implantation & its results
3. CONTENTS
1. Ovulation
a. Ovarian cycle
b. Time of ovulation
c. Hormonal changes during ovulation
d. Luteinization
2. Corpus luteum of
a. menstruation
b. pregnancy
3. Fertilization
a. Conditioning of the sperm for fertilization
b. Preconditions of fertilization
c. Phases of fertilization
d. Reaction and result of fertilization
4. Cleavage, morula and blastula
5. Implantation
a. Normal implantation
b. Abnormal implantation
4. Ovarian Cycle
• Monthly cycle for female at puberty
• Control by hypothalamus
• Release GnRH anterior pit gland
gonadotrophins (FSH & LH)
• FSH & LH act on ovaries
• FSH:
• stimulates the development of ovarian follicles
and production of estrogen by follicular cells
• LH:
• Trigger ovulation
• Stimulates follicular cells and corpus luteum to
produce progesterone
5. Ovarian Cycle
Beginning of Ovarian Cycle
• FSH stimulates 15-20 primary stage follicles to grow
• Only one reaches full maturity and only one oocyte is
discharged
• Others degenerate and become atretic
• FSH stimulates maturation of follicular (granulosa) cells
• Proliferation of follicular cells is mediated by GDF-9
• Granulosa and thecal cells produce estrogens
• Effects of estrogen:
1. Thinning of cervical mucus
2. Uterine endometrium to enter follicular/proliferative
phase
3. Stimulate pituitary gland to secrete LH
6. Ovarian Cycle
Mid-cycle
• LH surge causes:
1. Oocyte complete meiosis I and
initiate meiosis II
2. Stimulates production of
progesterone by follicular cells
3. Follicular rupture and ovulation
7. Ovulation
• Secondary follicle expanse rapidly under the influence of FSH and LH and
become preovulatory follicle
• Meiosis II is initiated and arrested at the metaphase II, 3 hours before
ovulation
• Follicle is displaced to the surface of ovary where it forms a bulge and
stigma
• LH collagenase activity increases causes digestion of collagen fibers
surrounding the follicle
• LH increase in prostaglandin causes muscular contraction on the
ovarian wall release of oocyte with surrounding cumulus oophorus
8.
9.
10. Corpus luteum
• The granulosa cells and theca interna remaining in the wall of ruptured follicle
are vascularized by surrounding vessels
• Under the influence of LH, the remaining cells develop into yellowish pigment
and change into lutean cells (corpus luteum) which secretes progesterone
• Progesterone and estrogen causes endometrial layer to enter secretory phase
(preparation for implantation)
11. Corpus albicans
• If fertilization does not occur, on day 9 of ovulation, corpus luteum shrinks,
degenerate and form a mass of fibrotic scar tissue (corpus albicans)
reduce progesterone level menstrual bleed
• If fertilization occur, degeneration of corpus luteum is prevented by hCG
(human chorionic gonadotropin) (secreted by syncytiotrophoblast of
developing embryo)
• CL continue to grow at the end of 3rd month of pregnancy CL size is
half of ovary secretes progesterone until 4 month of pregnancy
• After that CL regress slowly as secretion of progesterone by trophoblastic
component of placenta becomes adequate for maintenance of pregnancy
12. Oocyte transport
• Fimbriae sweep over the surface of the
ovary and catch the oocyte that are
released from the ovary
• In the tube, the oocyte move towards
the uterine cavity by the contraction of
the tube and propelled by cilia
• Fertilized egg reach uterine lumen 3-4
days
14. Fertilization
• Begins with contact between sperms and secondary oocyte and ends at
metaphase I of zygote
• Occur in the ampulla of uterine tube
• 200-500 million sperms ejaculated into the vagina, only 200 sperms reach
secondary oocyte
• Occur 12-24 hours after ovulation
• Sperm remains viable for 48 hours, secondary oocyte viable for 24 hours after
released from the ovary
• Sperm swim from vagina to cervix by propelled whiplike movement of their tail
• Movement from cervix to the tube - help by contraction of uterus and tube
• Sperm need to wait for 7 hours to fertilize the oocyte, must undergo:
1. Capacitation
2. Acrosome reaction
15.
16. Capacitation:
• Functional changes that causes the tail of sperms to beat vigirously
• For fusion of plasma membrane of the sperm and plasma
membrane of oocyte
• Removal of glycoprotein coat and seminal plasma proteins from
plasma membrane that overlies acrosomal region of spermatozoa
(head)
• Capacitated sperm pass through corona radiata and undergo
acrosome reaction
Fertilization
17.
18. Fertilization
Is a sequence of coordinated events:
1. Passage of sperm through corona radiata (CR)
• Only capacitated sperm able to pass CR
2. Penetration of zona pellucida (ZP)
• ZP is a glycoprotein layer contain ligand ZP3 (zona protein)
• ZP3 bind with protein on acrosome causes release of acrosomal
enzymes (acrosin) penetration of ZP head of sperm comes in
contact with plasma membrane of oocyte plasma membrane of
oocyte release lysosomal enzymes alteration on ZP become
impermeable to other sperms (prevent polyspermy)
19. Fertilization
Acrosome reaction
• Needed to penetrate zona pellucida
• Acrosome is a helmet like structure that covers the head of sperm
which contains several enzymes
• Release of acrosomal enzymes (acrosin) after glycoprotein in ZP bind
to a specific membrane proteins on the acrosome
20.
21. 3. Fusion of cell membranes of oocyte and sperm
• Plasma membrane of oocyte and sperm fuse and break down at the area
of fusion
• Head and tail of sperm enter the cytoplasm of oocyte but plasma
membrane of sperm is left behind on oocyte surface
4. Completion of second meiotic division of oocyte and formation of
female pronucleus
• Oocyte finishes second meiotic division after entry of sperm forming
a mature oocyte and a second polar body
• Female pronucleus (22 + X) is formed following decondensation of
maternal chromosomes
Fertilization
22. Fertilization
5. Formation of male pronucleus
• Nucleus of sperm enlarges within the cytoplasm of the oocyte and form male pronucleus
• Tail of the sperm degenerates
• Male and female pronucleus are morphologically indistinguishable
• Each pronucleus must replicate its DNA
6. As the pronuclei fuse into a single diploid aggregation of chromosomes, it become
zygote
• Chromosomes in the zygote become arranged on a cleavage spindle in preparation for a
normal mitotic division
• Zygote has 23 maternal and 23 paternal (double) chromosomes- new combination of
chromosomes that are different
• Fertilization by X- bearing sperm produces a 46 XX zygote (female)
• Fertilization by Y- bearing sperm produces a 46 XY zygote (male)
25. Cleavage
• Repeated mitotic divisions of the zygote
• Cell numbers increase without increase in cell size (overall
size)
• Blastomeres = progressively smaller cells produced by
clevage
• Occurs as the zygote passes along the uterine tube to the
uterus
• 1st division of zygote begins 24 H after fertilization
• 16 cell morula (day 4 fertilization):
• Inner cells constitute inner cell mass, surrounding cells compose
of outer cell mass
• Inner cell mass gives rise to embryoblast, outer cell mass forms
trophoblast
26. Cleavage
• Compaction = after 3rd cleavage, blastomeres maximize contact with
each other, forming a compact ball of cells
• Greater cell to cell interaction
• Importance step before develop inner cell mass or embryoblast of the blastocyst
27.
28. Trophoblast
Embryoblast
Blastocystic
cavity
Blastocyst
• Blastocystic cavity (fluid-filled space) appears inside the morula – day 4 of
fertilization
• Fluid from uterine cavity passes zona pellucida to form the cavity
• Fluid increases separate blastomeres into 2 parts:
• Trophoblast
• thin, outer layer
• Give rise to embryonic part of the placenta
• Embryoblast
• Inner cell mass
• Give rise to embryo
• Zona pellucida degenerates and disappears
• Allow the blastocyst to increase it size rapidly
• In the uterus, the embryo is nourished by secretions from uterine glands
29. Blastocyst
• Trophoblast cells begin to penetrate between the epithelial cells of the
uterine mucosa on day 6 of fertilization
• As it attaches to the endometrium, it will proliferates and differentiates
into 2 layers:
• Inner layer of cytotrophoblast
• Outer layer of syncytiotrophoblast
30.
31. Implantation
• Definition: attachment of the blastocyst to the epithelial lining of the uterus
• Wall of uterus has 3 layers:
a. Endometrium
b. Myometrium
c. Perimetrium
• During menstrual cycle, endometrium becomes follicular/proliferative phase,
secretory/progestational phase and menstrual phase
• Proliferative phase:
• Under the influence of estrogen secreted by follicles
• Occur after the menstrual phase
• Secretory phase:
• Start after ovulation
• Influence by progesterone secreted by corpus luteum
32.
33. Implantation
• If fertilization occur, endometrium will assist with implantation
• Implantation occur during secretory phase of endometrium
• Blastocyst implants stimulates decidual reaction:
• The adjacent cells of the endometrial stroma respond to its presence and to
the progesterone secreted by the corpus luteum by differentiating into
metabolically active, secretory cells called decidual cells.
• The endometrial glands enlarged, uterine wall becomes highly
vascularized and edematous.
• Blastocyst implants at the anterior/posterior body of uterus
• Embedded between uterine gland
34.
35. • If no fertilization, endometrium shed off menstrual phase
• Blood comes out from superficial arteries
• Small pieces of stroma and glands break away
36. Ectopic pregnancy
• Implantation can occur outside uterus
• Epithelium at these abnormal sites
responds to the implanting blastocyst
with increased vascularity and other
supportive changes, so that the
blastocyst is able to develop
• These is medical emergencies:
• Threatening to the mother because blood
vessels that form at the abnormal site are
prone to rupture as a result of growth of
the embryo and placenta.
• Symptoms: abdominal pain and/or
vaginal bleeding
• Treatment: surgery
1. Abdominal pregnancy
2. Tubal pregnancy
3. Tubal pregnancy
4. Tubal pregnancy
5. Internal os