Osteoporosis is defined as a disease characterized by low bone mass and deterioration of bone tissue, leading to fragile bones and increased risk of fractures. It is most common in older adults, especially post-menopausal women, and can be caused by factors like estrogen deficiency, low calcium intake, smoking, excess alcohol, and certain medications. Common symptoms include back pain from compressed fractures and loss of height over time. Prevention focuses on building peak bone mass through nutrition and exercise in childhood and maintaining bone health with calcium, vitamin D, weight-bearing exercise, and lifestyle factors as an adult. Treatment may include these supplements, bisphosphonate medications, and calcitonin to decrease bone loss and risk of fractures.
Osteoporosis is a chronic, progressive skeletal disease characterized by low bone mass, microarchitecture deterioration of bone tissue, bone fragility, and a consequent increase in fracture risk.
Osteoporosis is a chronic, progressive skeletal disease characterized by low bone mass, microarchitecture deterioration of bone tissue, bone fragility, and a consequent increase in fracture risk.
Osteomalacia is the softening of the bones caused by defective bone mineralization secondary to inadequate levels of available phosphate and calcium.
The true prevalence of osteomalacia across the globe remains unknown.
OSTEOPOROSIS:A Barebone guide to diagnosis and managementGovindRankawat1
“Progressive systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk”
True Definition: bone with lower density and higher fracture risk
WHO: utilizes Bone Mineral Density as definition (T score <-2.5)
Osteoporosis is silent because there are no symptoms initially.
The most common are fractures of the spine, hip, and wrist.
Osteoporosis is not an inevitable part of aging, but is a disease that can be prevented and treated, provided it is detected early.
The main goal of treating osteoporosis is to prevent such fractures in the first place.
Bare bone term used for “necked bone with necked eye”
“There is clearly a problem of underdiagnosis and undertreatment of osteoporosis and we want to raise awareness about the risk factors for osteoporosis so that those who need treatment get treatment”.
Learning Objectives
Utilize recent recommendations for osteoporosis prevention and treatment and how to apply them in practice.
Explain controversies surrounding pharmacologic osteoporosis therapy including side effects and the risk/benefit ratio of therapy.
Determine when and how to utilize the current pharmacologic therapies including anabolic versus anti-resorptive approaches and how to transition or discontinue treatment
Osteoporosis only causes symptoms when it is far advanced.
Symptoms include loss of height, deformed spine (“dowager’s hump”), unexplained back pain, and fractures.
It is best to detect problems at an early stage, when treatment is most effective.
The best test for detecting osteoporosis is bone densitometry, done with a technique called “Dual-energy X-ray Absorptiometry” or DXA.
Osteomalacia is the softening of the bones caused by defective bone mineralization secondary to inadequate levels of available phosphate and calcium.
The true prevalence of osteomalacia across the globe remains unknown.
OSTEOPOROSIS:A Barebone guide to diagnosis and managementGovindRankawat1
“Progressive systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk”
True Definition: bone with lower density and higher fracture risk
WHO: utilizes Bone Mineral Density as definition (T score <-2.5)
Osteoporosis is silent because there are no symptoms initially.
The most common are fractures of the spine, hip, and wrist.
Osteoporosis is not an inevitable part of aging, but is a disease that can be prevented and treated, provided it is detected early.
The main goal of treating osteoporosis is to prevent such fractures in the first place.
Bare bone term used for “necked bone with necked eye”
“There is clearly a problem of underdiagnosis and undertreatment of osteoporosis and we want to raise awareness about the risk factors for osteoporosis so that those who need treatment get treatment”.
Learning Objectives
Utilize recent recommendations for osteoporosis prevention and treatment and how to apply them in practice.
Explain controversies surrounding pharmacologic osteoporosis therapy including side effects and the risk/benefit ratio of therapy.
Determine when and how to utilize the current pharmacologic therapies including anabolic versus anti-resorptive approaches and how to transition or discontinue treatment
Osteoporosis only causes symptoms when it is far advanced.
Symptoms include loss of height, deformed spine (“dowager’s hump”), unexplained back pain, and fractures.
It is best to detect problems at an early stage, when treatment is most effective.
The best test for detecting osteoporosis is bone densitometry, done with a technique called “Dual-energy X-ray Absorptiometry” or DXA.
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Forearm bones and the work of right sided mid shaft femur and tibia and distal end of radius of right sided intertrochanteric femur and tibia and distal femur
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
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2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Executive Directors Chat Leveraging AI for Diversity, Equity, and InclusionTechSoup
Let’s explore the intersection of technology and equity in the final session of our DEI series. Discover how AI tools, like ChatGPT, can be used to support and enhance your nonprofit's DEI initiatives. Participants will gain insights into practical AI applications and get tips for leveraging technology to advance their DEI goals.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
2. Defining Osteoporosis
⚫“Progressive systemic skeletal disease
characterized by low bone mass and
microarchitectural deterioration of bone
tissue, leading toenhanced bone fragility
and aconsequent increase in fracture risk”
⚫True Definition: bonewith lowerdensity
and higher fracturerisk
⚫WHO: utilizes Bone Mineral Density as
definition (T score <-2.5); surrogate marker
3. Who Gets Osteoporosis?
⚫Age
⚫Estrogen deficiency
⚫Testosteronedeficiency
⚫Family history/genetics
⚫Femalesex
⚫Low calcium/vitamin D intake
⚫Poorexercise
⚫Smoking
⚫Alcohol
4. Who gets osteoporosis?
⚫Low body weight/anorexia
⚫Hyperthyroidism
⚫Hyperparathyroidism
⚫Prednisone use
⚫Liverand renal disease (think aboutvitd
synthesis)
⚫Low sunexposure
⚫Medications (antiepileptics, heparin)
⚫Malignancies (metastaticdisease; multiple
myeloma can presentasosteopenia!)
⚫Hemiplegia s/p CVA/ immobility
5. Back pain, which can be severe if fractured or collapsed
vertebra
Loss of height over time, with an accompanying stooped
posture
Fractureof thevertebrae, wrists, hipsorother bones
8. T-Score
WHO, Guidelines for Preclinical Evaluation and Clinical Trials in Osteoporosis, 1998.
World Health Organization (WHO)
Osteoporosis Guidelines
1.4
1.3
1.2
1.1
1.0
0.9
0.8
0.7
0.6
0.5
0.4
0.3
20 30 40 50 60 70 80
Age
BMD
Mean
–2 SD
Considerpreventive interventio
Considertherapeutic interventio
Mean LumbarSpineBMD:
Decades 3 to 9 of a Woman’s Life
Bone Mineral Density Values
9. Osteoporosis
⚫PATHOGENESIS
⚫1. Peak bone mass : about 20 yearsold
- genetic, hormone, nutrition, lifestyle
⚫2. Rateof bone loss : afterage 30-45, bone resorption
(osteoclast)> formation (osteoblast) and become
exaggerated after menopause
(50 yearsold)
⚫3. Boneremodeling : keep balanceat 20-30 yearsold,
afterthat become negative balance
9
11. Osteoporosis
⚫ Type 1
Postmenopausal
Type 2
Senile
Type 3
secondary
⚫Age 55 -70 years
⚫Sex(F/M)
⚫Fxsite
6:1
vertebrae
70-90 years
2 :1
vertebrae
distal forearm hip
all
1:1
vertebrae
hip
distal forearm
⚫The threshold for Fx is reduced forosteoporotic
bone
11
13. Lab Investigations
CBC
ESR
Serum calcium (8.6 – 10.4 mg/dl)
Serum phosphorus (3.00 – 4.5 mg/dl) Children 4-6 mg/dl
Serum alkaline phosphatase (44 – 147 Iu/lit.) Children 1.5 -
2.5 times more
Liver function tests
Renal function tests
T3,T4, TSH
Para thyroid hormones
Vitamin D 25 (25 – 80 ng/ml)
Protein electrophoresis (M band)
Anti endomysial antibody (Coeliacdisease)
14. Osteoporosis Treatment: Calcium and
Vitamin D
⚫Fewerthan half adults take recommended
amounts
⚫Higher risk: malabsorption, renal disease, liver
disease
⚫Calcium and vit D supplementation shown to
decrease risk of hip fracture in olderadults
⚫1000 mg/day standard; 1500 mg/day in
postmenopausal women/osteoporosis
⚫Vitamin D (25 and 1,25): 400 IU day at least;
⚫Frail older patients with limited sun exposure may need
up to 800 IU/day
15. Osteoporosis Treatment: Calcitonin
⚫Likely notas effectiveas
bisphosphonates
⚫200 IU nasally/day (alternating
nares)
⚫Decrease pain with acutevertebral
compression fracture
16. Osteoporosis Treatment: Bisphosphonates
⚫Decrease bone resorption
⚫Multiple studies demonstratedecrease in hipand
vertebral fractures
⚫Alendronate, risodronate
⚫IV: pamidronate, zolendronate (usually used for
hypercalcemiaof malignancy, malignancy related
fractures, and multiple myeloma related
osteopenia)
⚫Ibandronate (boniva): once/month
⚫Thoseat highest risk of fracture (pre-existing
vertebral fractures) had greatest benefitwith
treatment
19. A study of disease management in
a rural healthcare population
demonstrated that a preventive
program was able to reduce hip
fractures and save money.
98% of a woman’s skeletal mass is acquired byage 20
Optimal strategies for building strong bonesoccurs during childhood and
adolescence
1. A balanced dietrich in calciumand
vitamin D
2. Weight-bearingand resistance-
training exercises
3. A healthy lifestylewith nosmoking
orexcessivealcohol intake
4. Talking toone’s healthcare
professional about bone health
5. Bone density testing and
medicationwhen appropriate
Five Steps Toward Prevention