This disease is a long-term and gradually worsening condition that causes bones to become thinner, weaker, and more likely to break. Over time, the structure of the bones breaks down and their overall strength decreases, making them more fragile and prone to fractures. The FRAX® tool has been developed to evaluate fracture risk of patients. It is based on individual patient models that integrate the risks associated with clinical risk factors as well as bone mineral density (BMD) at the femoral neck.