This document describes various types of equipment used in pharmaceutical manufacturing, including sampling booths, dispensing booths, sifting equipment, mills, granulation equipment, blending equipment, tablet compression machines, coating equipment, and packaging equipment. It provides details on the components, functioning, and purposes of different pieces of equipment for processes like sampling, milling, granulation, blending, compression, coating, and packaging.

1. M+W Group-India
Pharmaceutical Equipment's
Part-1

2. © M+W Group
Safety Moment

3. © M+W Group
SAMPLING BOOTH
Used to carry out sampling of Raw Materials under controlled environment
Can be Laminar Air Flow Type or Reverse Laminar Air Flow type
Air Flow Rate of 90 fpm ± 20% is maintained inside the booth
Class 100 and Lux level of 750 is maintained inside the booth
Inlet level Air Filtration : 10 micron + 3 micron + HEPA Filter (0.3 micron)
Exhaust level Air Filtration : HEPA (0.3 micron)

4. © M+W Group
SAMPLING BOOTH

5. © M+W Group
Used to carry out Dispensing of Raw Materials under controlled environment
Can be Laminar Air Flow Type or Reverse Laminar Air Flow type
Air Flow Rate of 90 fpm ± 20% is maintained inside the booth
Class 100 and Lux level of 750 is maintained inside the booth
Inlet Air Filtration : 10 micron + 3 micron + HEPA Filter (0.3 micron)
Exhaust Air Filtration : HEPA Filter (0.3 micron)
DISPENSING BOOTH
LAF RLAF
Air flow parallel
Flow once through
Air flow turbulent
Re circulated flow
Protect the product only
Not recommended for raw material
dispensing.
Protect the product and area
Recommended for product/raw material
dispensing.

6. © M+W Group
DISPENSING BOOTH

7. © M+W Group
Used to carry out Sifting (sieving) of ingredients
Particle size is controlled by passing the material through vibrating screen
Material fed manually to feed hopper
Provision variable for easy dismantling of screen for cleaning purpose
SIFTING

8. © M+W Group
Used for Particle size reduction
Types of Mills available
Multi Mill
Communiting Mill
Colloid Mill
All Mills consist of three basic parts
Feed chute
Grinding Mechanism (usually consisting of rotor and stator)
Discharge chute
MILLING

9. © M+W Group
MULTILL MILL
Used for mixing & chopping of ingredients
Has hammer blades
Screen present for particle size selection
Material fed in charging hopper, travels to
chamber where it gets chopped, then
if finally passes through the screen

10. © M+W Group
COMMUNITING MILL
Used for particle size reduction
System consists of feed chute, Rotor assembly with fixed beater & screen
Facility available for varying and setting Rotor speed

11. © M+W Group
COLLOID MILL
Used for homogenizing, emulsifying, dispersing of liquids including high viscous liquids
Product is processed by high shear pressure & friction between Rotor & Stator

12. © M+W Group
SELECTION OF A MILL
Product specifications (size range, particle size distribution shape, moisture content,
physical & chemical properties of the material
Capacity of the mill & production rate requirements.
Dust control (loss of costing drugs, health hazardous contamination of plant
Economic factors

13. © M+W Group
It is process that attempts to improve the flow of powdered material by forming sphere
like or regularly shaped aggregates called granules.
Need of Granulation
- For flowability
- For Compressibility
The process involves mixing of Active pharmaceuticals ingredients and excipients
followed by addition of Binder
Types of Granulation
- Wet Granulation
- Dry Granulation
Granulation involves Mixing + Milling + Drying
GRANULATION

14. © M+W Group
WET GRANULATION
The Process involves binding the powder together with an adhesive (binder)
Equipment used for Wet Granulation
- RMG (Rapid Mixer Granulator) – used for Mixing & Milling
- Fluid Bed Dryer – used for Drying
Alternatively instead of above two equipments both the operations can be performed
together in a FBP (Fluid Bed Processor)
RMG (RAPID MIXER GRANULATOR)
Used for Mixing of ingredients & for Wet Granulation by addition of binder
Equipment consists of
- Mixing Bowl, Impeller (for Mixing), Chopper (lump breaker)
Provision available for monitoring & setting chopper, impeller speed and Granulation
time.

15. © M+W Group
RMG (RAPID MIXER GRANULATOR)

16. © M+W Group
Used for uniform drying of ingredients by Air fluidization
Hot Air surrounds the material completely which gives higher heat transfer rate & faster
drying
System consist of
- Inlet Air Handling Unit consisting of coarse, fine followed by HEPA filter, Chilled
water & Steam Coils.
- Outlet Air Exhaust blower to create an induced draft of hot air
- Main machine tower consisting of Product container & trolley filter bag assembly for
removing the powder
- Explosion frame & flap for releasing excessive pressure
Necessary Instruments & Controls
FLUID BED DRYER

17. © M+W Group
FLUID BED DRYER

18. © M+W Group
Granulation process carried out without any addition of binder
Done with the help of Roll Compactor
Roll Compactor
- Utilizes Rollers for carrying out compaction
- Compaction means improving the bulk density and giving equal quality
to granules
Feed
Hopper
Rolls
DRY GRANULATION

19. © M+W Group
ROLL COMPACTOR

20. © M+W Group
Used for mixing of Dry powder &
homogenous lubrication of
Granules
Equipment's of Blending
- Octagonal Blender
- Due to octagonal shape it is
designed to process large volume
of material
- Occupies less space
- Well balanced in high
capacities and has removable
baffles
BLENDING
OCTAGONAL BLENDER

21. © M+W Group
DOUBLE CONE BLENDER
Double Cone Blender
- Conical shape at both ends enables
uniform mixing & easy discharge
- Baffles can be provided for better
mixing
Important parameters during Blending
operation
- Blending time
- Rotational speed of Bin

22. © M+W Group
CONTA BLENDER
Conta Blender
- It has completely
replaced conventional
blenders
- Can accept varying
sizes of containers or bins
- Mixing efficiency better
than other types of blender
as it Rotates in diagonal &
in a eccentric plane.

23. © M+W Group
Tablets are made by compressing a formulation containing a drug with excipients on
stamping machines called presses
Compression machines is made of following
- Dies for defining shape & size of tablets
- Punches for compressing the ingredients within the dies
- A feeding mechanism for moving ingredients into the dies
Tablet machine is categorized by
- No. of compression station (like 20,32,37,55 etc.)
- Rotational speed of press (like 480,1640 etc.)
- Type of tooling set (like ‘B’, ‘BB’, ‘DD’)
COMPRESSION

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COMPRESSION
Process steps involved in compression
- Die fill
- Weight Adjustment
- Compression
- Ejection

25. © M+W Group
COMPRESSION CYCLE OF ROTARY PRESS

26. © M+W Group
TABLET TOOLING; PUNCHES & DIES

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Coating performs number of jobs for example
- Prevent tablet cracking or breaking in transit
- Allowing the controlled release of Active ingredients over a longer time
- Mask the taste
- Make the tablet easier to swallow
Coating can be with water based or non-aqueous solvents
Coating equipment
- Auto coater
COATING

28. © M+W Group
AUTOCOATER
System consists of
• Solution tank with stirrer on platform scale
• Peristaltic feed pump
• Perforated coating pan with baffles
• Compressed Air atomized spray system
including spray gun
• Conditioned Supply & Exhaust Air System

29. © M+W Group
Types of Packing
- Blister Packing
- Strip Packing
PACKING

30. © M+W Group
Used for packing for Capsules & Tablets
Formed by Heat softening sheet of plastic into the mould followed by cooling and filling into the
moulds.
Blister or Base material can be PVC / PVDC film (may be transparent)
Lidding material can be aluminum foil (Alu-Alu)
Process steps involved
- Feeding of tablets
- Sheet forming
- Tablet filling
Batch code printing
- Punching to cut Blister as per layout
Miss fill detectors present to detect empty Blisters
Line perforation tool provided
For checking the printing on lidding material edge to edge print registration control system
BLISTER PACKING

31. © M+W Group
BLISTER PACKING

32. © M+W Group
Used for packing of tablets & capsule
Consist of set of rollers with heaters
Laminated foils drawn from two rollers packs & seals the product in continuous strip
Strip is then cut to desired size by cutter assembly
STRIP PACKING

33. © M+W Group
TABLET MANUFACTURING

34. © M+W Group
STAGES OF PHARMA MANUFACURING

35. © M+W Group
DRUG PRODUCT MANUFACTURE

36. © M+W Group
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