This document outlines four vital signs for effective online continuing medical education: 1) Comprehensive analysis and design, 2) Engaging storylines and scenarios, 3) Purposeful interactivities, and 4) Intentional use of media. It describes how the American Association of Critical-Care Nurses (AACN) partnered with Enspire Learning to develop an online palliative care course using these principles, including conducting design workshops and creating an immersive virtual hospital environment. The course was well-received by learners for its realistic narrative approach and practical decision-making interactivities.