Hosted by with Sophie Tully BSc MSc, 10th October
This presentation addresses the role of cholesterol in CVD and the latest evidence into nutritional strategies to manage and treat high cholesterol and support healthy CVD function. Sophie covers the aetiology of CVD and why cholesterol has long been considered an important marker of CVD health and the emergence of newly identified CVD risk factors which may offer a more effective diagnostic tool. Finally she discusses new opinions on nutritional approaches to keep cholesterol levels healthy and prevent CVD events.
With a growing number of conditions being grouped under the ‘umbrella’ of autoimmune disease, supporting clients who are, increasingly, presenting with various, and often multiple, autoimmune conditions, can appear complex at first glance.
In this webinar, Dr Danielle Crida outlines a clinical protocol that can support most autoimmune conditions, and takes a deep dive into the role of the immune system and key inflammatory processes at play.
Products refresher training webinar, with Sophie Tully BSc MSc, Wednesday 29th January
In this training webinar, Education Manager Sophie Tully takes you through each of the therapeutic Igennus products and the key points for recommending them to clients to help refresh your memory, offering fresh research, understanding and clinical tools.
Breast cancer is the leading cause of death from cancer among women, accounting for 23% of the total cancer cases and 14% of cancer deaths in 2008. As dietary fat is thought to be one of the main risk factors, this webinar will focus on the opposing effects of the omega-6 fatty acid arachidonic acid (AA) and the omega-3 fatty acid eicosapentaenoic acid (EPA) on factors related to breast cancer risk, development and prognosis, including their influence on cyclooxygenase activity and prostaglandin production, the impact of inflammation within the tissue microenvironment, impact on aromatase and oestrogen production and impact on genetic aspects of breast cancer such as modulation of BRAC1 and BRAC2 genes.
Guest Lecture at University of Delhi - The Entangled Relationship between Dia...Vinod Nikhra
The talk at Ramjas College, University of Delhi on 18th Feb 2015. It highlights the latest issues in biological and molecular research which link overweight/obesity with diabetes, metabolic syndrome and aging.
With a growing number of conditions being grouped under the ‘umbrella’ of autoimmune disease, supporting clients who are, increasingly, presenting with various, and often multiple, autoimmune conditions, can appear complex at first glance.
In this webinar, Dr Danielle Crida outlines a clinical protocol that can support most autoimmune conditions, and takes a deep dive into the role of the immune system and key inflammatory processes at play.
Products refresher training webinar, with Sophie Tully BSc MSc, Wednesday 29th January
In this training webinar, Education Manager Sophie Tully takes you through each of the therapeutic Igennus products and the key points for recommending them to clients to help refresh your memory, offering fresh research, understanding and clinical tools.
Breast cancer is the leading cause of death from cancer among women, accounting for 23% of the total cancer cases and 14% of cancer deaths in 2008. As dietary fat is thought to be one of the main risk factors, this webinar will focus on the opposing effects of the omega-6 fatty acid arachidonic acid (AA) and the omega-3 fatty acid eicosapentaenoic acid (EPA) on factors related to breast cancer risk, development and prognosis, including their influence on cyclooxygenase activity and prostaglandin production, the impact of inflammation within the tissue microenvironment, impact on aromatase and oestrogen production and impact on genetic aspects of breast cancer such as modulation of BRAC1 and BRAC2 genes.
Guest Lecture at University of Delhi - The Entangled Relationship between Dia...Vinod Nikhra
The talk at Ramjas College, University of Delhi on 18th Feb 2015. It highlights the latest issues in biological and molecular research which link overweight/obesity with diabetes, metabolic syndrome and aging.
Anti-Obesity Pharmacotherapy: Where are we now? Where are we going?InsideScientific
Obesity is a treatable chronic disease. With nearly 2 billion individuals worldwide classified as being overweight and 650 million as having obesity, it is critical to optimize implementation of existing treatment interventions and develop novel therapies to mitigate the obesity pandemic. Anti-obesity medications are one of the essential tools in our medical toolbox to help patients achieve their health and weight goals.
In this webinar, Dr. Jastreboff discusses current use of anti-obesity pharmacotherapy, mechanisms involved, and agents in various stages of development with considerations for next steps. The presentation aims to inspire development of innovative therapeutics while optimizing use of existing agents to address the urgent need to effectively and sustainably treat millions of individuals with obesity around the world.
Key Topics Include:
- Understand the role of anti-obesity pharmacotherapy in the treatment of obesity
- Describe current anti-obesity pharmacotherapy
- Discuss anti-obesity medications under development
By Juliana C N Chan, MBChB, MD, FRCP Professor of Medicine & Therapeutics, Director, Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China
This presentation was delivered at Puri on 10th january 2015
on the occasion of annual Rotary District Conference along with IMA Puri. It highlights on metabolic syndrome and its surgical solution.
Kyla covers the complications of hormone levels in the body, explaining some of the most common causes of imbalanced hormones and how this relates to symptoms; PMS, fertility and skin conditions in particular are detailed, considering both male and female hormones. Methods used to identify hormone imbalances, including symptoms and diagnostic testing, are also covered. During this webinar, Kyla will offers practical diet and supplement advice to modulate hormones to healthy levels in the most natural way possible, so your clients can avoid dependence on hormone medication.
explained about the reasons for obesity, its pathology, how to prevent obesity and how to overcome it. also discussed about the genes, receptors, enzymes and hormones involved in obesity.
Are you Struggling to Control of your Diabetes and Weight?
People who are overweight or obese are more prone to developing Type 2 diabetes. Those who have Type 1 and Type 2 diabetes with weight problems struggle to control their blood sugar levels. Research shows that people with diabetes find it more difficult to lose weight than those without diabetes.
Weight loss significantly improves blood sugar control and also reduces the risk of getting complications from diabetes. However, whilst attempting to lose weight, people with diabetes find it hard to restrict their intake of food since eating less may trigger hypoglycaemia (low blood sugar). All these facts explain the need for specialist input in management of weight in people with diabetes.
This Slideshow gives you insight to Diabesity
For more information please visit
http://www.simplyweight.co.uk
Articles
http://www.simplyweight.co.uk/articles/
Videos
http://www.simplyweight.co.uk/video/
Blogs
http://simplyweight.co.uk/blogs/
Forum
http://www.simplyweight.co.uk/forum/forum.php
Contact Us
http://www.simplyweight.co.uk/how-to-contact-us/
prevention of heart attacks is the theme on this world heart day.heart disease is increasing in india like an epidemic & affecting younger people with more mortality
CAD is spreading like an epidemic in south east Asia,esp india where its affecting younger ppl with grave prognosis. due to limited resourses, primary prevention becomes the most important tool to arrest this epidemic
Anti-Obesity Pharmacotherapy: Where are we now? Where are we going?InsideScientific
Obesity is a treatable chronic disease. With nearly 2 billion individuals worldwide classified as being overweight and 650 million as having obesity, it is critical to optimize implementation of existing treatment interventions and develop novel therapies to mitigate the obesity pandemic. Anti-obesity medications are one of the essential tools in our medical toolbox to help patients achieve their health and weight goals.
In this webinar, Dr. Jastreboff discusses current use of anti-obesity pharmacotherapy, mechanisms involved, and agents in various stages of development with considerations for next steps. The presentation aims to inspire development of innovative therapeutics while optimizing use of existing agents to address the urgent need to effectively and sustainably treat millions of individuals with obesity around the world.
Key Topics Include:
- Understand the role of anti-obesity pharmacotherapy in the treatment of obesity
- Describe current anti-obesity pharmacotherapy
- Discuss anti-obesity medications under development
By Juliana C N Chan, MBChB, MD, FRCP Professor of Medicine & Therapeutics, Director, Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China
This presentation was delivered at Puri on 10th january 2015
on the occasion of annual Rotary District Conference along with IMA Puri. It highlights on metabolic syndrome and its surgical solution.
Kyla covers the complications of hormone levels in the body, explaining some of the most common causes of imbalanced hormones and how this relates to symptoms; PMS, fertility and skin conditions in particular are detailed, considering both male and female hormones. Methods used to identify hormone imbalances, including symptoms and diagnostic testing, are also covered. During this webinar, Kyla will offers practical diet and supplement advice to modulate hormones to healthy levels in the most natural way possible, so your clients can avoid dependence on hormone medication.
explained about the reasons for obesity, its pathology, how to prevent obesity and how to overcome it. also discussed about the genes, receptors, enzymes and hormones involved in obesity.
Are you Struggling to Control of your Diabetes and Weight?
People who are overweight or obese are more prone to developing Type 2 diabetes. Those who have Type 1 and Type 2 diabetes with weight problems struggle to control their blood sugar levels. Research shows that people with diabetes find it more difficult to lose weight than those without diabetes.
Weight loss significantly improves blood sugar control and also reduces the risk of getting complications from diabetes. However, whilst attempting to lose weight, people with diabetes find it hard to restrict their intake of food since eating less may trigger hypoglycaemia (low blood sugar). All these facts explain the need for specialist input in management of weight in people with diabetes.
This Slideshow gives you insight to Diabesity
For more information please visit
http://www.simplyweight.co.uk
Articles
http://www.simplyweight.co.uk/articles/
Videos
http://www.simplyweight.co.uk/video/
Blogs
http://simplyweight.co.uk/blogs/
Forum
http://www.simplyweight.co.uk/forum/forum.php
Contact Us
http://www.simplyweight.co.uk/how-to-contact-us/
prevention of heart attacks is the theme on this world heart day.heart disease is increasing in india like an epidemic & affecting younger people with more mortality
CAD is spreading like an epidemic in south east Asia,esp india where its affecting younger ppl with grave prognosis. due to limited resourses, primary prevention becomes the most important tool to arrest this epidemic
How to prevent heart disease and diabetesEsserHealth
Heart disease is the leading cause of death in men and women in America today. Learn how the food you eat can radically alter your risk of both heart disease and type two diabetes. You can achieve better health starting today.
Heart of the Matter - Ali Ahmad, MD, FACC - Livingston Library - 1.6.2020Summit Health
Heart disease is the leading killer of adults nationwide and it carries a significant morbidity for the population at risk. Learn about traditional and non-traditional risk factors associated with coronary artery disease, and how to modify your risk and prevent heart disease. Also, learn about how heart disease affects different ethnic backgrounds, particularly the high-risk groups, such as South Asians.
DAMA- DIETARY APPROACH TO MANAGE ATHEROSCLEROSIS.pptJYOTI PACHISIA
Atherosclerosis is the basic pathological process of many diseases, such as coronary atherosclerosis and stroke. Nutrients can affect the occurrence and development of atherosclerosis. At present, in nutrition science, the research on atherosclerosis focuses on which nutrients play an important role in its prevention strategy, and what are the possible mechanisms of its action. Diet is an inseparable part of our lives. It is generally believed that good eating habits have a certain inhibitory effect on the development of atherosclerosis. In recent years, some nutrients [such as polyunsaturated fatty acids (PUFAs), vitamins, and polyphenols], it can stabilize atherosclerotic plaque or reduce the level of biomarkers related to inflammation
Learn about the Mediterranean diet, including its role in preventing cardiovascular disease. Find out how the Mediterranean diet can help protect and improve your health and increase your odds for a long life.
How Can a Heart Attack Be Prevented?
Making lifestyle changes is the most effective way to prevent having a heart attack.
Lowering your risk factors for coronary heart disease can help you prevent a heart attack. Even if you already have coronary heart disease.
For more information visit:
www.srisriholistichospitals.com
Lowering your risk factors for coronary heart disease can help you prevent a heart attack. Even if you already have coronary heart disease
Making lifestyle changes is the most effective way to prevent having a heart attack.
http://www.srisriholistichospitals.com/
All too often we hear nutrition myths. They confuse many people and result in personal choices that compromise health and increase the risk of disease. In this powerpoint, Dr Esser reviews some foundational and a few specific myths and presents compelling science to set the record straight. Enjoy and remember to keep on asking questions and learning how you can achieve your best health in 2018.
Many clients take bone health for granted until they’re presented with a diagnosis of osteoporosis, often following a fracture. Whether your client is nutrient deficient, concerned about bone health, or diagnosed with a metabolic bone disease, adding the right nutrients to a protocol is paramount.
In her latest webinar, Dr Danielle Crida discusses:
- The importance of bone health
- Consequences of low bone mineral density
- The most important nutrients for bone health and their synergistic roles
- Exercise and lifestyle choices for bone strength
- Supplement and dosing recommendations, introducing our new Ca/Mg/D3/K2/Boron product
Did you know that food storage and preparation can hugely affect its nutritional value? For example, the antioxidant capacity of blueberries actually increases with freezing, and letting crushed garlic rest for 10 minutes before cooking allows for the development of compounds with amazing health benefits.
Learn the tricks of the trade for getting the most out of your food in this short webinar with nutritionist Dr Danielle Crida.
Confused about what to eat for better health? Dr Danielle Crida, trained medical doctor and nutritionist, will guide you through the basic ingredients of a nutritious and delicious diet. This short webinar will discuss how to build the foundations of your meals with macronutrients, and provide tips on how to ensure you are meeting your requirements for vitamins and minerals. We know getting started is the hard part, so we’ll provide a free editable shopping list and tips for a kitchen clearout to set you up for success.
Magnesium plays a role in over 300 biochemical reactions, therefore affecting almost every system of the body when levels are insufficient. In her latest webinar, Dr Danielle Crida focuses on the important role magnesium plays in all stages of a woman’s life, supporting:
- Menstrual cramps
- A healthy pregnancy and postpartum
- Menopausal symptoms, such as hot flushes and mood changes
- Women-predominant conditions, e.g. osteoporosis and thyroid conditions
Veganism is on the rise due to growing concerns about the environment and perceived health benefits. However, certain nutrients such as EPA & DHA are difficult to obtain from plant-based diets. Until recently, the only supplemental source of long-chain omega-3s was fish oil. Igennus has recently launched a vegan omega-3 product which combines algae-sourced EPA & DHA with the additional benefit of astaxanthin, a powerful antioxidant.
In this hour-long webinar, Dr Danielle Crida discusses:
- The importance of omega-3s and the omega 6:3 ratio
- Vegan options for omega-3 supplementation
- Our new Vegan Omega-3 & Astaxanthin product
- How to assess omega-3 requirements and measure response to supplementation
- Ensuring optimal nutrition on a plant-based diet: common nutrient deficiencies and how to address them
While Lyme disease is considered to be relatively uncommon in the UK, it is likely that many cases are simply undiagnosed, many of which turn up in our clinics frustrated by conventional approaches to managing their symptoms. Being able to identify clients with suspected Lyme disease is vital, as many cases that present with early or initial symptoms of fever, headache or other neurological symptoms as a consequence of a tick-borne bacterial infection, simply do not relate these symptoms to having been bitten. As such, this highlights the importance of the need to take comprehensive and detailed client history notes, certainly when a client is reporting symptoms that have not responded to conventional interventions.
With appropriate antibiotic treatment, most patients with early-stage Lyme disease recover rapidly and completely. Signs and symptoms of Lyme disease, however, vary by disease stage, and because many individuals who present with symptoms fail to recall a history of a tick bite or to report the classic bulls-eye rash, they often miss out on what is a relatively narrow window of opportunity to prevent the condition from progressing.
As Lyme disease is a multi-system illness, if left untreated, it can progress to affect the skin, joints, immune system, nervous system, or other vital organs, with many of the symptoms becoming indistinguishable from other multi-system conditions such as fibromyalgia or chronic fatigue syndrome.
In this hour-long webinar, Dr Nina Bailey discusses strategies for practitioners to help identify and manage symptoms of Lyme disease.
Around 250,000 people in the UK are currently thought to be affected by CFS/ME. The high level of disability that is often associated with this debilitating condition can be both physically and mentally challenging for patients and appears to stem from a combination of symptoms such as fatigue, pain, sleep disturbance, cognitive impairment, depression and, in many cases, symptoms mirroring those of irritable bowel syndrome.
With no current cure and no validated, universally accepted, ‘one-size-fits-all’ approach to the treatment, many clients are seeking natural alternatives to conventional approaches.
Taking a personalised and functional medicine approach, Dr Nina Bailey reviews the latest science on ME/CFS and the underlying mechanisms that can be targeted with nutritional interventions and explains how to ensure your therapeutic approach is right for your clients.
Covered in the webinar:
1. CFS/ME background /causes/symptoms
2. Update on the mechanisms associated with CFS/ME:
- Immune disturbances
- Oxidative stress and inflammation
- The kynurenine pathway and neurotransmitter dysregulation
- Mitochondrial dysfunction and related mechanisms
* Methylation
* Detoxification
* Glycolysis
* Citric acid cycle/Krebs
* Oxidative phosphorylation
3. An overview of current treatment options
4. Nutritional intervention – an evidence-based approach
5. Nutritional supplementation
As healthcare practitioners, we are well aware of the endless benefits of vitamin C in supporting immune health, antioxidant support, energy production, collagen formation, nervous system function and iron absorption. Faced with a huge array of vitamin C products, however, how can we be confident we’re recommending the best supplement to our clients?
During R&D for our latest addition to the Igennus Healthcare Nutrition synergistic range of supplements, we were impressed by both the high absorption of Ester-C and the unprecedented uptake and retention in immune cells. Ester-C boasts an impressive 10x higher bioavailability in leukocytes, whilst its pH neutral composition means it’s also gentle on the stomach.
In this webinar, Dr Danielle Crida discusses:
- A recap of vitamin C basics
- The research that led to the production of Ester-C
- The case for Ester-C: success in clinical use above standard vitamin C supplements
- Practical applications and dosing
As natural healthcare practitioners, we all understand the pivotal and complex role that magnesium plays. Required for over 300 biochemical reactions and metabolic functions including cellular signalling, function & energy production, it is no surprise magnesium is one of the most used supplements in a clinician’s toolbox.
Magnesium supplementation is, however, not as straightforward as we are led to believe. With considerations such as carrier, dose and bioavailability to consider, are we really doing clients (and magnesium) justice with a standard ‘go-to’ product?
In this educational webinar, Dr Nina Bailey not only discusses magnesium in clinical practice but, importantly, also uncovers the perils and pitfalls of the magnesium supplement ‘scene’, in the quest to provide clinical excellence, and the important supplemental factors that must be considered to optimise magnesium status and provide clinical efficacy.
Dr Bailey discusses:
1. A brief overview of the clinical implications of magnesium deficiency
2. Magnesium in practice:
-Supporting digestive complaints and overcoming
malabsorption
-The importance of magnesium for structural support
-Supporting energy levels and insulin sensitivity
3. How to ensure clinically effective dosing and supplementation
The imbalance between free radical production and endogenous antioxidant defence may result in cellular oxidative stress, causing oxidative damage to various cellular components, such as DNA, proteins and membrane lipids. The human system employs the use of endogenous enzymatic and non-enzymatic antioxidant defence systems against the onslaught of free radicals and oxidative stress.
Unsurprisingly, oxidative damage has been implicated in and is believed to be a key factor causing various pathological conditions, such as cardiovascular disease, neurodegenerative disease, diabetes and cancer. Free radicals can be quenched through a number of mechanisms. Antioxidants directly scavenge free radicals (e.g., via hydrogen atom transfer or electron transfer), prevent free radical formation by chelating metal ions and by interrupting the radical chain reactions of lipid peroxidation, thus retarding its progression. Enzymatic antioxidants include superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. Non-enzymatic antioxidants include vitamins A, C, and E, glutathione, alpha-lipoic acid, carotenoids, and coenzyme Q10. Other antioxidants include polyphenols, minerals (copper, zinc, manganese, and selenium), and cofactors (B-vitamins). Together, antioxidants work synergistically with each other using different mechanisms against different free radicals and stages of oxidative stress.
The benefits associated with antioxidants are numerous and diverse but it can be a minefield when choosing the appropriate antioxidant support for clients. In this hour-long webinar, Dr Nina Bailey discusses the direct and indirect benefits and actions of key antioxidants including (but not limited to) astaxanthin, alpha lipoic acid, polyphenols and co-enzyme Q10, with a focus on:
-Antioxidant sources and benefits
-Mechanisms and actions
-When to combine antioxidants for synergistic effects
-Overcoming bioavailability issues
-Targeted intervention, which antioxidant(s) and why
Astaxanthin, the naturally occurring carotenoid responsible for the pink-red pigmentation of wild salmon and crustaceans such as shrimp and lobsters, is a potent and effective antioxidant that boasts an ability to combat oxidative stress 6000x greater than that of vitamin C, 800x coenzyme Q10, 550x vitamin E and 75x alpha lipoic acid. Naturally, we are very excited to introduce AstaPure astaxanthin to our Pure Essentials range, launching in March!
Most commonly associated with preventing age-related diseases, astaxanthin’s unique chemical structure that spans the cell membrane gives rise to an exciting and diverse array of health benefits. New research is coming out daily suggesting astaxanthin is a highly effective tool in combating age-related diseases and cardiovascular disease, as well as boosting the immune system, liver and brain function.
Join Dr Nina Bailey for this ‘Introductory’ ingredient training webinar and discover:
Astaxanthin’s most exciting mechanisms of action
How its unique structure makes it so potent
An overview of some of the most compelling research into astaxanthin’s health benefits
When to use astaxanthin in clinical practice & dosing guidelines
Fibromyalgia syndrome is a common chronic pain condition that affects at least 2% of the adult population. Chronic widespread pain is the defining feature of FM, but patients may also exhibit a range of other symptoms, including sleep disturbance, fatigue, irritable bowel syndrome, headaches and mood disorders. While the aetiology of the condition is not completely understood, it is believed that a number of factors (rather than one in isolation) are most likely to lead to its development. Thus, the onset of fibromyalgia syndrome can be influenced by hormonal and/or chemical imbalances, chronic stress and/or a traumatic event, genetic predisposition and even pre-existing illness.
In this hour-long webinar, Dr Nina Bailey covers:
• An overview of the aetiology of fibromyalgia
• The signs and symptoms of fibromyalgia
• Factors that can contribute to or exacerbate fibromyalgia syndrome
• Managing symptoms via dietary manipulation and lifestyle change
• Supporting nutrients/supplements for those with fibromyalgia syndrome
Histamine intolerance (which can easily be mistaken for an IgE reaction) results from the imbalance of accumulated histamine and the capacity for histamine degradation. Symptoms of histamine intolerance are diverse in nature because histamine exerts its numerous biological reactions via 4 receptors, located on target cells in various tissues, with the severity of symptoms dependent on circulating histamine levels. The signs and symptoms of histamine intolerance can often be misinterpreted or simply go undetected in many individuals.
In this hour-long webinar, Dr Nina Bailey covers:
· The biological roles of histamine and how/why histamine intolerance arises
· The signs and symptoms of histamine intolerance
· High histamine foods/histamine liberators
· Factors that can contribute to or exacerbate histamine intolerance
· How to optimise your diet to reduce histamine reactions
· Supporting nutrients/supplements for those with histamine intolerance
Polycystic ovary syndrome (PCOS) is a common hormonal disorder, thought to affect between 4%–8% of women of reproductive age. Due to a lack of awareness, and the dramatic variation in the signs and symptoms between individuals, a large number of women may have PCOS without being at all aware of it. Unless help is sought for common symptoms (including oily skin and recurring acne; irregular, infrequent or absent periods; excess facial and body hair growth; head hair loss or thinning; weight gain) a formal diagnosis may never be made and issues can persist unmanaged until menopause. PCOS is most commonly diagnosed in women hoping to become pregnant, but who experience fertility issues as a result of irregular ovulation or miscarriage. In this webinar, Dr Nina Bailey PhD outlines the key mechanisms in the pathophysiology of PCOS, the signs and symptoms that should trigger further investigation, and the key nutritional strategies that can be adopted to help women manage the condition.
During this webinar, Sophie covers the double-edged sword of inflammation and oxidative stress as driving factors in chronic modern illness and why addressing these factors with nutritional intervention does not always produce the desired effects; it may even, in some cases, be harmful. Taking a personalised and functional medicine approach, Sophie reviews the underlying mechanisms that can be targeted with nutritional interventions and explains how to ensure your therapeutic approach is right for your clients.
Igennus are excited to announce the launch of our new product, Longvida® Curcumin. During this webinar, Dr Bailey reviews the research behind the therapeutic use of curcumin and why Longvida is the world’s most advanced formulation of the nutrient.
Curcumin is a polyphenol compound obtained from the rhizome of Curcuma longa, also known as turmeric. This Indian spice has a long history of use in Ayurvedic medicine as a treatment for inflammatory conditions. Curcumin is well documented for its antioxidant, anti-inflammatory and anti-cancer activities. Although it has been shown to be safe at high doses (12g/d), it is poorly absorbed, undergoes rapid intestinal and hepatic metabolism and is rapidly eliminated from the body. As such, standard curcumin demonstrates poor bioavailability, even at high doses, limiting its therapeutic potential.
After much research and discussion (it’s a big and complicated topic!) between the Igennus nutrition scientists, the decision as to which type of curcumin we would use for our Synergistic Nutrients range was actually a very straightforward one. Longvida Curcumin utilises a novel delivery system (SLCP), which protects curcumin from the harsh environment of the stomach and promotes its rapid absorption into the bloodstream and target tissues, even at low doses – resulting in an incredible 285x superior bioavaibility compared with standard curcumin, 65x higher peak plasma levels and 7x longer-lasting action. Longvida is the only formulation proven to deliver high levels of free form, unconjugated curcumin, into the bloodstream. Free form curcumin is the form required for therapeutic benefits, and the only form proven to cross the blood brain barrier.
This webinar covers:
- What curcumin is, what it does and how?
- Why free form curcumin is essential for therapeutic effects
- The research and current evidence for Longvida Curcumin’s unique health benefits
- How Longvida overcomes significant bioavailability issues associated with curcumin use
- To who, why and when you should recommend curcumin
…and more.
Nutrition science seems to change on an almost daily basis and much of what was previously considered mainstream or consensus science is being challenged and changed as the new wave of more personalised intervention trials start to clarify many of the reasons behind why nutrition study results can be so conflicting.
No research area, it seems, is more subject to conflicting and confusing results than that of omega-3s which is why, here at Igennus, we do our best to stay on top of ALL the omega-3 research so we can not only help you unpick the fact from fiction (and answer all your questions about every single product on the market!), but also ensure our formulations and education reflect the most cutting edge and clinically proven ingredient research.
Dr Bailey’s ever-growing brain contains a veritable treasure chest of omega-3 knowledge and as we know you are big fans of the work she does, this webinar is dedicated to Dr Bailey’s brain and sharing with you all the latest updates, innovations and applied therapeutic research that she has been reading about over the last year. We aim to help you separate fish oil fact from fiction by answering as many of your omega-3 and fatty acid therapeutic-related questions as possible. Covering everything from which and how much omega-3 to take for certain conditions, how and when taking omega-3 can affect the benefit and amount absorbed, why very high doses can be dangerous, the truth behind what companies and headlines are telling you about omega-3s, to any other areas you want us to cover! We will do our best to cover the most common and important questions and concerns we hear about from you via phone or email and when out and about training in stores and at events every day. As always, we will also clarify some of the reasons behind the frustratingly confusing conflicts in the research and media and what exciting things are coming out of the omega-3 world.
Catherine Jeans has been working with children’s nutrition for the past six years, specialising in family health, including babies, toddlers and teens. Working with children presents various challenges as a nutritional practitioner – not only getting the child to jump on board with the changes, but as important, making sure the parents are able to motivate their child and make the time to help them prepare the right food.
In this webinar, Catherine will go through:
– Logistical challenges – managing parents and their expectations, at what point to include children in consultations and how to talk to children about weight loss, digestive health and sugar.
-The realities of changing a child’s diet – what can you realistically achieve and how to motivate children to change.
– Case studies from babies to teens – Catherine will go through various case studies from her practice, including allergies, food intolerances, Coeliac disease, weight management and sugar addicts.
Nutrition is a key factor in the onset and progression of cognitive decline, yet despite a growing pool of research, little evidence exists to support the efficacy of single nutrients in this complex area. The most promising evidence comes from specific dietary patterns and nutrients in the prevention and slowed progression of neurodegenerative disease. During this webinar, Dr Bailey will focus on the synergistic role of key nutrients involved in the mechanisms that drive cognitive decline and support healthy brain aging. Topics include:
- Risk factors for cognitive decline
- Biological mechanisms underpinning cognitive decline
Dietary patterns that offer protection and support against cognitive decline
- The role of specific nutrients in protecting brain health and function
- Nutritional recommendations for healthy brain ageing
This webinar will give you an interesting insight into the practicalities of working with women and couples as they go through their fertility journey, from pre-conception, through to pregnancy and post-natal recovery. Catherine presents this online lecture through the use of key case studies, highlighting:
• The importance of supporting the adrenals for female fertility, and how this may impact on progesterone levels
• Key functional tests which may help you understand what may be preventing conception and successful pregnancy outcomes
• How to work with women going through assisted conception
• How to become a “fertility detective” and support couples with unexplained fertility issues
• Using a 3 month window between trying to conceive again – key supplements for optimal results
• Managing common problems found in pregnancy - iron deficiency anaemia to hyperemesis gravidarum
• How nutritional therapists can support women before birth and the early post-natal recovery – what really needs to go in the hospital bag!
• Preventing post-natal burn out - many women, especially after their second pregnancy, experience post-natal burn out after roughly 6 to 9 months after birth. Why is this and how we can we support women through this?
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Are There Any Natural Remedies To Treat Syphilis.pdf
Nutritional approaches to managing cholesterol and cvd webinar igennus
1. Nutritional approaches to managing
cholesterol and CVD.
Key messages from the research.
Sophie Tully BSc MSc DIPPT
2. What is CVD?
Cardiovascular disease (CVD) is a general term that describes a disease of the
heart or blood vessels.
• Blood flow to the heart, brain or body can be reduced as a result of a:
– blood clot (thrombosis)
– build-up of fatty deposits inside an artery, leading to the artery hardening
and narrowing (atherosclerosis)
Types of CVD:
• Coronary heart disease
• Stroke
• Peripheral arterial disease
• Aortic disease
www.NHS.uk/conditions
3.
4.
5. Risk factors
•
•
•
•
•
•
•
•
Smoking
Being physically inactive
Being overweight or obese
Diabetes
Family history of heart disease
Ethnic background
Sex - men are more likely to develop CVD at an earlier age than women
Age - the older you are, the more likely you are to develop CVD
• High blood pressure
• High blood cholesterol
• Stress, alcohol, the type of job you do may also influence your risk of
developing CVD
www.bhf.org.uk
7. • Today 6-7million UK inhabitants are on daily statins!
• In the US between 2005-2009 nearly 20% of the population
were taking antihypertensive medication
• Approximately 2 million US inhabitants take blood thinners
daily
• Common side effects of these drugs include: water
retention, depression+/anxiety, headache, dry mouth,
insomnia, chest pain, impotence, hair loss, skin rash,
nausea / diarrhoea, kidney & liver damage……….
9. The truth about fat
Fat-free =
• flavour, texture and satisfaction free
• sugar and artificial ingredients added to make product
edible!
Fat is:
• an essential membrane component of every single cell in the
body (including saturated fat!)
• a highly efficient source of fuel that humans are designed to
thrive on
• an energy store, insulator to protect our vital organs, acts as a
messenger, aids protein function, contributes to normal growth,
immune function, reproduction and other aspects of basic
metabolism
10. The truth about Cholesterol
Low cholesterol intake =
• Inadequate supply of the building blocks for hormones
• Inability to produce bile acids
• Inability to synthesise Vitamin D
Now widely recognised that dietary intake of cholesterol has very
little impact on the body’s cholesterol levels
The body requires a continuous supply of cholesterol and
possesses the ability to synthesise cholesterol itself
11. Per
Nutrition information medium
size egg
Per 100g
What about eggs?
66kcal
131kcal
Protein
6.4g
12.6g
Carbohydrate
of which sugars
trace
trace
Cutting out eggs cuts out a cheap,
healthy and widely available source
of lots of nutrients that contribute to
reaching vital RDAs
Fat
of which saturates
monounsaturates
polyunsaturates
4.6g
1.3g
1.7g
0.7g
9.0g
2.5g
3.4g
1.4g
Sodium
78mg
154mg
Energy
Delicious, nutritious
and filling!
http://healthyegg.co.uk/nutritionalcomposition
12. The ‘evidence’ for fat and cholesterol
• Early studies (1980) by Ancel and Keys found:
– total fat does not affect CHD death
– but % energy from saturated fat does correlate with CHD
• Replacing saturated fat with any nutrient = reduced LDL = good for CVD
• However, 2 studies in 2010 say otherwise:
– meta-analysis, just under 350,000 subjects found NO link between saturated fat intake
and coronary events
– Japanese cohort following 58,453 women over 14 years found those eating ‘ideal’ 2.511g saturated fat daily had 45% increased stroke risk and 22% increased CVD vs those
eating more (18g) daily
• Today ~50% of our calories come from carbohydrate but CVD risk is still on
the rise!
13. The ‘evidence’ for fat and cholesterol
• 1% increased energy intake from sat fat vs CHO = increased LDL by 0.03 mmol/L
• 5% increased energy CHO vs sat fat = 7% increased CHD
• Increased sat fat intake = increased LDL particle size
• Increased CHO intake = increased triglycerides and reduced HDL and reduced LDL
particle size = increased atherosclerosis risk
– small LDL particles = increased vessel wall damage and penetration
– reduced binding capacity of LDL particles to receptors = remain in circulation
for longer
– more susceptible to oxidative damage
14. The ‘evidence’ for fat and cholesterol
• GI of CHO source very important:
– high GI = 33% increased heart attack risk, med GI = no effect, low GI =
small reduced risk
– low GI diet is typically high in vegetables, fruit, legumes and
unprocessed grains = high in vitamins, minerals, phytonutrients and
fibre – all essential for CV health
The Health delusion: a big fat mistake, Glen Matten and Aidan Goggins
15. What really works?
Polyunsaturated fatty acids (PUFAs)
• A 5% switch from sat fat to PUFA = 10% reduced CHD
• Replacing CHO with PUFA = most favourable CHD outcomes
• Thus increasing PUFA = CHD benefits
• But two types of PUFA
– omega-6s are abundant in plant oils, animal protein, nuts and
grains
– omega-3s found in small amounts in foods, mainly fish
16. PUFAs continued…
•
Omega-6 intake already around upper recommended limits
but omega-3 intake generally low
• Studies looking at increasing omega-6 only vs omega-3&6
intake found:
– increasing omega-6 intake only = small increase CHD risk
•
Thus benefits of PUFA intake mainly down to omega-3s
– specifically EPA & DHA found in fish
Why?
17. PUFAs continued…
EPA and DHA have been shown to be/offer:
– anti-inflammatory
– vasodilator activity
– triglyceride lowering
– reduced platelet aggregation
– plaque stabilisation
– antiarrhythmic
– hypotensive effects
(Halcox, 2010)
Importance of omega-3s in CV function:
• The omega-3 index is an indicator of cardiovascular disease risk
• RBC omega-3 levels and the AA to EPA ratio may be a more potent risk
factor for sudden cardiac death than high blood cholesterol levels or creactive protein (Dawczynski et al., 2010)
18. Inflammation and CVD
• PUFAs – strongly linked to control of the inflammatory response
• Optimal EPA (and DHA) levels = healthy inflammatory control
• AA intake important for inflammatory control
• AA to EPA ratio = very useful biomarker of inflammation and chronic
disease risk
• Stress and high GI foods – linked to CVD and both increase inflammation
• Inflammation leads to increased susceptibility to damage of blood vessel
walls and reduced cellular communication
(Boer, Van Wetten and Pruiboom, 2012)
19. AA to EPA ratio is a direct measure of inflammation
By modifying diet we can influence the ratio of pro-inflammatory (from AA)
to anti-inflammatory eicosanoids (from EPA)
20. Conditions associated with a high AA to EPA ratio
•
•
•
•
•
•
•
•
•
Depression
Bipolar disorder
Schizophrenia
Myalgic encephalomyelitis
Fibromyalgia
Chronic pain syndromes
Diabetes
Cardiovascular disease
Cancer
•
•
•
•
•
•
Inflammatory disorders
Inflammatory bowel disease:
(Crohn’s disease, ulcerative colitis)
Neurodevelopmental disorders:
(autism, dyslexia, dyspraxia, ADHD)
Alzheimer’s disease
Huntington’s disease
Skin conditions:
(eczema, psoriasis, dermatitis)
21. EPA, DHA and CVD – the research
• Red blood cell omega-3 levels strongly inversely associated with sudden
cardiac death
• Daily fish oil associated with reduced risk of all cause mortality and
secondary coronary events in post-myocardial infarction cohorts
• Fish oil supplementation resulted in reduced risk of death or
hospitalisation due to CV events
• Recommended minimum 1g daily intake of fish oil from supplements
predominantly EPA or oily fish intake
– fish consumption associated with high toxin levels and large volumes needed
(Weitz et al., 2010)
22.
23. EPA and DHA benefits shared or different?
• 2011 two very comprehensive reviews were published
• EPA alone = reduced TGs and risk of coronary events and conditions
• DHA alone = reduced TGs, increased LDL particle size and reduced BP and
HR
• Either alone or in combination, contribute differentially to reduced
inflammation, oxidative stress and platelet aggregation, enhanced cardiac
and arterial function seen with omega-3 intake
• Both reviews concluded evidence on the whole for the enhanced effects of
one fat over the other on any CV marker was poor due to low number of
studies, under-powered and poor design
24. EPA and DHA benefits shared or different?
Overall conclusions:
In order to determine which type of omega-3 and dose would be optimal
requires many more studies, as response varies dependant on the
individual and their specific CVD profile.
It was noted however that EPA levels were more impacted by increasing
intakes than DHA, suggesting DHA in the cell may be more stable and
thus potentially the need to supplement is not so great.
25. A new wave of pure omega-3 studies
Following these reviews numerous pure oil studies were carried out:
1) JELIS study found
–
1.8g/day of ethyl-EPA in just under 20,000 hypercholesterolemic
subjects randomised to EPA + statins or statins alone = 19%
reduced incidence of major CVD
–
that increasing EPA and reducing AA:EPA ratio were both useful
in preventing coronary artery disease
26. A new wave of pure omega-3 studies
2)
Tani et al., 2013
– Hypertriglyceridaemia patients randomised to 2 x 900mg ethyl-EPA for
6 months had significantly increased LDL particle size, reduced serum
TGs and non-HDL cholesterol vs no significant changes in controls
– LDL particle size at 6 months positively correlated with serum EPA and
negatively correlated with AA:EPA ratio
– 6 month AA:EPA ratio was found to be better than any other marker at
predicting LDL particle size
27. What next?
• Importance of EPA as stand alone and co-therapy for CVD now well
established
• In 2012 the FDA approved a high purity ethyl-EPA product for use in
treating hypertriglyceridaemia
• Phase III placebo controlled clinical trials using ‘Vascepa™’ further
support the benefits of ethyl-EPA in managing and treating CVD
28. Vascepa™ trials:
• ANCHOR & MARINE looked at role of EPA on inflammatory markers
associated with CVD and atherosclerosis in hypertriglyceridaemic
patients taking statins for cholesterol control.
• Both studies randomised subjects to 12 weeks of taking 4 or 2g EPA or
placebo daily
• Results showed 4g EPA reduced TGs, non-HDL cholesterol and other
markers of atherosclerosis without increasing total LDL
• The ANCHOR study used predominantly (>70%) diabetic subjects and
showed 4g EPA daily significantly improved lipid profiles and lipid related
markers without negatively impacting glycaemic control
29. There’s more to come!
• REDUCE-IT study currently ongoing
• Aim is to determine efficacy of IPE in preventing CV events in high risk
patients on statins
• Overall Vascepa™ has been hailed as safe, effective and a new
alternative with potential benefits over existing treatments
30. Igennus CVD support protocol
Pharmepa Step 1: Restore
2 capsules = 1g pure ethyl EPA
Vitamin E for antioxidant protection
Designed to
• Increase cellular EPA levels quickly
• Restore a healthy AA:EPA ratio
• Reduce the production of pro-inflammatory products
• Increase the production of anti-inflammatory products
• Support cardiovascular health and cholesterol levels
31. VESIsorb Ubiquinol-QH
CoQ10 and cholesterol-lowering drugs
• Igennus is the only independent manufacturer
of reductase is an enzyme that plays critical role Based in
• HMG-CoAspecialist Fatty Acid ina the UK. in the
regulation of cholesterol synthesis, as well as CoQ10 synthesis hub for the
Cambridge the medical innovation
UK:
• HMG-CoA reductase inhibitors, generally known as statins (such as
atorvastatin, cerivastatin, lovastatin, pravastatin, simvastatin), are
- Seven elevated
commonly used to treat Seas blood Merck Pharma blocking
cholesterol levels by Germany
cholesterol biosynthesis; in doing so, they also block CoQ10 Canada
- Minami
Atrium Pharma
biosynthesis
- Biocare
Elder Pharma India
• Taking ubiquinol supplements can correct the deficiency causedSweden
- Eskimo 3
Bringwell Pharma by
such medications without affecting the medication's positive effects
- Equizen
Vifor Pharma Swiss
on cholesterol levels and can improve statin-induced myopathy
33. VESIsorb Ubiquinol-QH
Faster acting, stronger plasma concentration and longer lasting effects
• Igennus is the only independent manufacturer
Unprecedented bioavailability Acid in the UK. Based in
of specialist Fatty
Fully reduced ‘bioactive’ form
Cambridge the medical innovation hub for the
Solubilised for maximum absorption
NovelUK:
VESIsorb® delivery system mimics the natural transport system
of the intestine, providing significantly higher plasma concentrations†
- delivery Seas
Merck Pharma
than any other Seven system offering a comparable dose Germany
One capsule Minami a therapeutic dose (100 mg)
- daily delivers
Atrium Pharma Canada
- Biocare
Elder Pharma India
Enhances energy production
Potent antioxidant
Supports antioxidant turnover
- Eskimo
Bringwell Pharma Sweden
Enhances cellular communication3Cell cycle support
Reduces statin-associated myopathy
Cardioprotective
Neuroprotective
Anti-inflammatory
- Equizen
Vifor Pharma Swiss
34. Homocysteine Control
Sustained Release
Homocysteine is an amino acid derivative of methionine, anmanufacturer
• Igennus is the only independent
essential amino acid obtained from protein-rich foods
of specialist Fatty Acid in the UK. Based in
The amount of homocysteine in medical a predictive marker
Cambridge the the blood is innovation hub for the
of cardiovascular health status
UK:
High levels are Seven Seas
- a reliable risk factor for cardiovascular diseaseGermany
Merck Pharma
- lowers levels
Atrium Pharma Canada
Homocysteine Minami of nitric oxide, a gas that is critical to
maintaining healthy and flexible arterialElder Pharma India
walls
- Biocare
- Eskimo 3
Bringwell affecting
Elevated homocysteine directly damages cholesterol, Pharma Sweden
arterial walls, causing them to thicken which can lead to
- Equizen
Vifor Pharma Swiss
atherosclerosis
35. Homocysteine Control
Sustained Release
• Igennus is the only independent manufacturer
of specialist Fatty Acid in the UK. Based in
for the
UK:
Formulated at proven dosages for efficacy
Homocysteine ControlTM Sustained Release tablets contain a
synergistic blend of bioavailable vitamins B6, B12 and folic acid at
precise dosages for maintaining healthy homocysteine levels.
Cambridge the medical innovation hub
Highly bioavailable actives
- Seven
Merck Pharma Germany
Easy-to-swallow tabletsSeas
Suitable for vegetarians & vegans
- Minami
Atrium Pharma Canada
Sustained release tablets to maintain optimal blood
Elder Pharma India
concentrations Biocare
Split dosing overcomes bioavailability issues associated with Sweden
- Eskimo 3
Bringwell Pharma
B12 supplementation
- Equizen
Vifor Pharma Swiss
36. www.igennus.com
01223 421434
• Igennus is the only independent manufacturer
info@igennus.com
of specialist Fatty Acid in the UK. Based in
Cambridge the medical innovation hub for the
UK:
- Seven Seas Sophie Tully
Merck Pharma Germany
Nutrition education manager
- Minami
Atrium Pharma Canada
sophiet@igennus.com
- Biocare
Elder Pharma India
education@igennus.com
- Eskimo 3 07908683174 Pharma Sweden
Bringwell
- Equizen
Vifor Pharma Swiss