Ojchd.000529

The document presents a hypothesis regarding the function of cardiac L-type calcium channels, suggesting they open in a stochastic manner influenced by calcium-ion interactions with the sarcolemma. It discusses the electrical properties of cardiac cells and the role of calcium in excitation-contraction coupling, emphasizing the high electric field force that protects cellular integrity. The hypothesis highlights the dynamic nature of the plasma membrane and the mechanisms of calcium ingress and channel inactivation related to voltage and calcium levels.