SlideShare a Scribd company logo
1 of 31
[object Object],[object Object],[object Object]
Learning Objectives   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
The depolarization-induced biphasic current of squid giant axons
Inward sodium and outward currents
Sodium and Potassium whole-cell currents
Topology of a voltage-gated K +  channel
Ion channel topologies
Voltage-gated channels show an increased P o  at more depolarized potentials
Non-inactivating K +  channel currents
Inactivating Na +  channel currents
P o  of voltage-gated Na +  channels and the resting K +  conductance
Effect of K +  or Na +  channel activation on membrane potential
Mechanism of fast inactivation  of voltage-gated channels
The Action Potential (AP) of a Squid Giant Axon
The neuromuscular junction
Signaling in the neuromuscular junction
Atomic Resolution Structures Voltage-dependent gating
Long SB, Campbell EB, Mackinnon R. Crystal structure of a mammalian voltage-dependent Shaker family K +  channel. Science. 2005;309:897-903
 
 
 
 
Channelopathies
 
 
 
 
 
 

More Related Content

What's hot

Sodium Ion Channel
Sodium Ion ChannelSodium Ion Channel
Sodium Ion Channelnisha rani
 
voltage gated ion channel
voltage gated ion channel voltage gated ion channel
voltage gated ion channel BANTAYEHU ADDIS
 
Light gated ion channels
Light gated ion channelsLight gated ion channels
Light gated ion channelsIIT Kanpur
 
Potassium (K+) channels
Potassium (K+) channelsPotassium (K+) channels
Potassium (K+) channelsJaineel Dharod
 
cardiac ion channels and channelopathies
cardiac ion channels and channelopathiescardiac ion channels and channelopathies
cardiac ion channels and channelopathiesShivani Rao
 
Presentation on Electrical Properties of Cell Membrane
Presentation on Electrical Properties of Cell MembranePresentation on Electrical Properties of Cell Membrane
Presentation on Electrical Properties of Cell MembraneRubinaRoy1
 
Potassium channel modulators
Potassium channel modulatorsPotassium channel modulators
Potassium channel modulatorsDrSahilKumar
 
Ion channel RECEPTOR
 Ion channel RECEPTOR Ion channel RECEPTOR
Ion channel RECEPTORmarymelna1
 
Barbiturates and Chloride channel
Barbiturates and Chloride channelBarbiturates and Chloride channel
Barbiturates and Chloride channel Mahesh Kumar
 
Calcium channels –physiology and Therapeutics uses..
Calcium channels –physiology and Therapeutics uses..Calcium channels –physiology and Therapeutics uses..
Calcium channels –physiology and Therapeutics uses..Dr. Kapil Dev Doddamani
 
Cell Bio101
Cell Bio101 Cell Bio101
Cell Bio101 swasticcc
 

What's hot (19)

Sodium Ion Channel
Sodium Ion ChannelSodium Ion Channel
Sodium Ion Channel
 
voltage gated ion channel
voltage gated ion channel voltage gated ion channel
voltage gated ion channel
 
Sodium channel modulators
Sodium channel modulatorsSodium channel modulators
Sodium channel modulators
 
channelopathies
channelopathieschannelopathies
channelopathies
 
Light gated ion channels
Light gated ion channelsLight gated ion channels
Light gated ion channels
 
Lecture 1 Dl.ppt
Lecture 1 Dl.pptLecture 1 Dl.ppt
Lecture 1 Dl.ppt
 
Ion channels
Ion channelsIon channels
Ion channels
 
Potassium (K+) channels
Potassium (K+) channelsPotassium (K+) channels
Potassium (K+) channels
 
cardiac ion channels and channelopathies
cardiac ion channels and channelopathiescardiac ion channels and channelopathies
cardiac ion channels and channelopathies
 
K+ channel modulators
K+ channel modulatorsK+ channel modulators
K+ channel modulators
 
Lecture 2 Dl.ppt
Lecture 2 Dl.pptLecture 2 Dl.ppt
Lecture 2 Dl.ppt
 
Presentation on Electrical Properties of Cell Membrane
Presentation on Electrical Properties of Cell MembranePresentation on Electrical Properties of Cell Membrane
Presentation on Electrical Properties of Cell Membrane
 
Potassium channel modulators
Potassium channel modulatorsPotassium channel modulators
Potassium channel modulators
 
Ion channel RECEPTOR
 Ion channel RECEPTOR Ion channel RECEPTOR
Ion channel RECEPTOR
 
Barbiturates and Chloride channel
Barbiturates and Chloride channelBarbiturates and Chloride channel
Barbiturates and Chloride channel
 
Calcium channels –physiology and Therapeutics uses..
Calcium channels –physiology and Therapeutics uses..Calcium channels –physiology and Therapeutics uses..
Calcium channels –physiology and Therapeutics uses..
 
The Nervous System2
The Nervous System2The Nervous System2
The Nervous System2
 
Lecture 3 Dl.doc
Lecture 3 Dl.docLecture 3 Dl.doc
Lecture 3 Dl.doc
 
Cell Bio101
Cell Bio101 Cell Bio101
Cell Bio101
 

Viewers also liked

General Structure of Ion Channels
General Structure of Ion ChannelsGeneral Structure of Ion Channels
General Structure of Ion ChannelsSatadru Dey
 
Ionic Equilibria and Membrane Potential
Ionic Equilibria and Membrane PotentialIonic Equilibria and Membrane Potential
Ionic Equilibria and Membrane PotentialCsilla Egri
 
Introduction to Human Resource Management - HRM Dessler 12e Chapter 01
Introduction to Human Resource Management - HRM Dessler 12e Chapter 01Introduction to Human Resource Management - HRM Dessler 12e Chapter 01
Introduction to Human Resource Management - HRM Dessler 12e Chapter 01Kashif Sohail
 

Viewers also liked (9)

General Structure of Ion Channels
General Structure of Ion ChannelsGeneral Structure of Ion Channels
General Structure of Ion Channels
 
PPIT Lecture 17
PPIT Lecture 17PPIT Lecture 17
PPIT Lecture 17
 
Ionic Equilibria and Membrane Potential
Ionic Equilibria and Membrane PotentialIonic Equilibria and Membrane Potential
Ionic Equilibria and Membrane Potential
 
PPIT Lecture 4
PPIT Lecture 4PPIT Lecture 4
PPIT Lecture 4
 
PPIT Lecture 1
PPIT Lecture 1PPIT Lecture 1
PPIT Lecture 1
 
PPIT Lecture 2
PPIT Lecture 2PPIT Lecture 2
PPIT Lecture 2
 
PPIT Lecture 19
PPIT Lecture 19PPIT Lecture 19
PPIT Lecture 19
 
Introduction to Human Resource Management - HRM Dessler 12e Chapter 01
Introduction to Human Resource Management - HRM Dessler 12e Chapter 01Introduction to Human Resource Management - HRM Dessler 12e Chapter 01
Introduction to Human Resource Management - HRM Dessler 12e Chapter 01
 
Ion channels
Ion channelsIon channels
Ion channels
 

Similar to Lecture 3 Dl.ppt

Plant physiolgy
Plant physiolgyPlant physiolgy
Plant physiolgyaziikhan2
 
Bioelectric potential
Bioelectric potentialBioelectric potential
Bioelectric potentialanju jha
 
P.resting membrane potential by Artist Rimsha
P.resting membrane potential by Artist Rimsha P.resting membrane potential by Artist Rimsha
P.resting membrane potential by Artist Rimsha Artist Rimsha
 
NERVE AND MUSCLE VETERINARY PHYSIOLOGY .pdf
NERVE AND MUSCLE VETERINARY PHYSIOLOGY .pdfNERVE AND MUSCLE VETERINARY PHYSIOLOGY .pdf
NERVE AND MUSCLE VETERINARY PHYSIOLOGY .pdfTatendaMageja
 
Resting membrane potential by DR. IRUM
Resting membrane potential by DR. IRUMResting membrane potential by DR. IRUM
Resting membrane potential by DR. IRUMSMS_2015
 
Nerve physiology
Nerve physiologyNerve physiology
Nerve physiologydrnaveent
 
Mac Gregor Paracellular La 03192007
Mac Gregor Paracellular La 03192007Mac Gregor Paracellular La 03192007
Mac Gregor Paracellular La 03192007Gordon MacGregor
 
Ion Channel Fluctuations in Transmemembrane Proteins within Cell Membranes
Ion Channel Fluctuations in Transmemembrane Proteins within Cell MembranesIon Channel Fluctuations in Transmemembrane Proteins within Cell Membranes
Ion Channel Fluctuations in Transmemembrane Proteins within Cell MembranesIowa State University
 
Ionic basis of action potential and its propagation
Ionic basis of action potential and its propagationIonic basis of action potential and its propagation
Ionic basis of action potential and its propagationDr Harshith J
 
patchclamptechnique-121024031232-phpapp02.pdf
patchclamptechnique-121024031232-phpapp02.pdfpatchclamptechnique-121024031232-phpapp02.pdf
patchclamptechnique-121024031232-phpapp02.pdfnguyentruongsinh3
 
Patch clamp lecture
Patch clamp lecturePatch clamp lecture
Patch clamp lecturesmoof
 
1. lectura potencial de membrana
1. lectura   potencial de membrana1. lectura   potencial de membrana
1. lectura potencial de membranaPaulo Osmar
 
PNP what is in a name july 25 1 2019
PNP what is in a name july 25 1 2019PNP what is in a name july 25 1 2019
PNP what is in a name july 25 1 2019Bob Eisenberg
 
Action potential (niraj)
Action potential (niraj)Action potential (niraj)
Action potential (niraj)Niraj Kumar
 

Similar to Lecture 3 Dl.ppt (20)

Plant physiolgy
Plant physiolgyPlant physiolgy
Plant physiolgy
 
Bioelectric potential
Bioelectric potentialBioelectric potential
Bioelectric potential
 
P.resting membrane potential by Artist Rimsha
P.resting membrane potential by Artist Rimsha P.resting membrane potential by Artist Rimsha
P.resting membrane potential by Artist Rimsha
 
NERVE AND MUSCLE VETERINARY PHYSIOLOGY .pdf
NERVE AND MUSCLE VETERINARY PHYSIOLOGY .pdfNERVE AND MUSCLE VETERINARY PHYSIOLOGY .pdf
NERVE AND MUSCLE VETERINARY PHYSIOLOGY .pdf
 
Resting membrane potential by DR. IRUM
Resting membrane potential by DR. IRUMResting membrane potential by DR. IRUM
Resting membrane potential by DR. IRUM
 
Nerve physiology
Nerve physiologyNerve physiology
Nerve physiology
 
Research Poster
Research PosterResearch Poster
Research Poster
 
Ojchd.000529
Ojchd.000529Ojchd.000529
Ojchd.000529
 
Mac Gregor Paracellular La 03192007
Mac Gregor Paracellular La 03192007Mac Gregor Paracellular La 03192007
Mac Gregor Paracellular La 03192007
 
MEMBRANE POTENTIALS
MEMBRANE POTENTIALS MEMBRANE POTENTIALS
MEMBRANE POTENTIALS
 
Ion Channel Fluctuations in Transmemembrane Proteins within Cell Membranes
Ion Channel Fluctuations in Transmemembrane Proteins within Cell MembranesIon Channel Fluctuations in Transmemembrane Proteins within Cell Membranes
Ion Channel Fluctuations in Transmemembrane Proteins within Cell Membranes
 
Ionic basis of action potential and its propagation
Ionic basis of action potential and its propagationIonic basis of action potential and its propagation
Ionic basis of action potential and its propagation
 
Physiology com3-week2
Physiology com3-week2Physiology com3-week2
Physiology com3-week2
 
patchclamptechnique-121024031232-phpapp02.pdf
patchclamptechnique-121024031232-phpapp02.pdfpatchclamptechnique-121024031232-phpapp02.pdf
patchclamptechnique-121024031232-phpapp02.pdf
 
Patch clamp lecture
Patch clamp lecturePatch clamp lecture
Patch clamp lecture
 
1. lectura potencial de membrana
1. lectura   potencial de membrana1. lectura   potencial de membrana
1. lectura potencial de membrana
 
Publication_8
Publication_8Publication_8
Publication_8
 
PNP what is in a name july 25 1 2019
PNP what is in a name july 25 1 2019PNP what is in a name july 25 1 2019
PNP what is in a name july 25 1 2019
 
CAD Simulation of ion channels
CAD Simulation of ion channelsCAD Simulation of ion channels
CAD Simulation of ion channels
 
Action potential (niraj)
Action potential (niraj)Action potential (niraj)
Action potential (niraj)
 

Lecture 3 Dl.ppt