Nzomics Biocatalysis provides custom enzyme discovery, development, and production services to companies in industries such as chemicals, pharmaceuticals, biofuels, food and drink, and FMCG. They work with clients to understand their needs and identify novel enzyme activities from sequence databases, optimize enzymes for clients' processes, and scale enzymes up for commercial production. Nzomics has worked successfully with major companies like Almac Group, GSK, Avecia, and Astra Zeneca to develop customized biocatalytic solutions.

1. Enzyme Discovery, Supply and Testing
About Nzomics Biocatalysis
Highlights:
•Clients include –
“Nzomics works with major
Almac Group, GSK, worldwide companies who want to
Avecia, Astra Zeneca
embrace biocatalysis to provide
•Proven technology clean technology which can make a
process
positive economic and
•Global partners in US,
Europe, Asia environmental impact”.

2. Enzyme Discovery, Supply and Testing
Our Markets and Products
Nzomics focuses on global markets driven by
increasing demand for cost-effective clean
technology. Nzomics is addressing these markets:
•Chemicals
•Pharmaceuticals
•Biofuels
•Food and Drink
•FMCG

3. Enzyme Discovery, Supply and Testing
What we do
Provide custom-made enzymes, including:
• Any desired enzyme activity
- we can provide commercial quantities of almost any enzyme with a
recognized catalytic activity that interests you.
• A diverse library representing a specific enzyme class
- we can supply enzymes in collections of 10 or more which are sequence
distinct.
• Optimized, evolved enzymes
- we can use the latest techniques in molecular evolution to convert a known
enzyme activity to your particular process.

4. Enzyme Discovery, Supply and Testing
How we do it
•Search publically
available databases
Known for a reaction type
Enzyme •Use expertise to
choose diverse range
Activity of primary sequences
1. Correct primary
2. Obtain DNA from 3. Over-express in E.
sequence for
host organism or coli with or without
optimum
DNA synthesis affinity tag
•Use bioinformatics expression in E.coli
to search database
Known using similarity to
sequence data
Primary •Use expertise to
Sequence choose a range of
similar sequences
From the universe of known enzymes, a family of potential candidates is selected according to
specific reaction criteria and conditions. These potential enzyme candidates are then carefully
selected and synthesized and then screened to select the best candidates for process
development and scale up.

5. Enzyme Discovery, Supply and Testing
Why we are different
Nzomics provides expertise in enzyme research and development. Our approach is
to work with clients to identify and develop the best enzymes available to match
their business requirements.
We also work closely with our with our clients in defined stages:
1. We work with clients to understand technical and business requirements . We
then recommend a customised enzyme development programme based on the
information provided.
2. We develop a family of unique enzymes which are then screened and further
modified to provide the best enzyme ‘hits’.
3. We can then provide scale up to kilo/tonne quantities and/or provide
continued support to develop the industrial process.

6. Enzyme Discovery, Supply and Testing
What our customers say
“We are delighted to be working with Nzomics. They have identified and cloned genes,
encoding a range of enzymes for biocatalytic synthesis to be used in the field of chiral
pharmaceutical intermediates – successfully adding to Almac’s growing proprietary
enzyme collection.”
Dr Tom Moody, New Technology Team Leader, Almac Sciences
“Megazyme have used protein identification services from Nzomics on numerous
occasions and each time received impressive customer support and rapid turnaround
enabling new analytical products to be developed within exacting deadlines. Nzomics
have also successfully delivered specific enzyme activities requested by Megazyme on
a royalty basis arrangement.”
Dr Simon Charnock, Senior Scientist, Megazyme International

7. Enzyme Discovery, Supply and Testing
Contact
If you would like any further information regarding any of our services, please contact
us:
Email: nzomics@northumbria.ac.uk
Postal contact address:
Nzomics Biocatalysis
Ellison Building
Newcastle upon Tyne
NE1 8ST
UK
Telephone: +44 191 227 3550