The document discusses NUMA (Non-Uniform Memory Access) architecture and optimization. With NUMA, memory is divided across multiple nodes and latency depends on memory location. Local memory has the lowest latency while remote memory has higher latency. The document provides examples of local and remote memory access and discusses how process-parallel and shared-memory threading applications are affected by NUMA. It also covers NUMA-aware operating system differences, techniques for process affinity, and NUMA optimization strategies like minimizing remote memory access.