BOC Sciences has strong capabilities in designing, developing, synthesizing, and producing nucleosides and nucleotides. They have an experienced team that can provide these products in scales ranging from milligrams to hundreds of kilograms. Some of their top-selling products are PseudoUridine and N1-MethylpseudoUridine, of which they produce over 500kg and 1000kg annually, respectively. They also have a wide range of modified nucleosides and nucleotides available.

1. Nucleosides &
Nucleotides
https://nucleotech.bocsci.com/
International: 1-631-504-6093
US & Canada (Toll free): 1-844-BOC(262)-0123
Fax: 1-631-614-7828 Email: info@bocsci.com
45-16 Ramsey Road, Shirley, NY 11967, USA

2. 1
BOC Sciences has strong capabilities in design, development, synthesis and production of nucleosides and nucleotides.
Our skilled and experienced team is capable of providing the products in scales ranging from milligram, kilogram to
hundreds kilogram quantities.
PseudoUridine
CAS 1445-07-4
Purity: ≥ 99%
Annual output over 500 kg
Nucleosides and Nucleotides
Our superstars – PseudoUridine & N1-MethylpseudoUridine
N1-MethylpseudoUridine
CAS 13860-38-3
Purity: ≥ 99%
Annual output over 1000 kg
&
O
HO
HO OH
NH
H
N
O
O
O
HO
HO OH
N
H
N
O
O
Competitive Advantages
Guaranteed quality
Competitive price
Timely delivery
Sufficient stock for catalog products
Flexible packing options from vials to drums

3. 2
PseudoUridine derivatives under development
PseudoUridine modification plays an important role in multiple biological processes. PseudoUridine modification could
fine tune RNA functions for specific RNA species. For example, PseudoUridine in mRNA can affect mRNA splicing,
stability and translation. In recent years, the role of pseudoUridine derivatives in the biological process has also been
extensively studied. An example is that N1-methylpseudoUridine substituted mRNA can enhance protein expression and
reduce immunogenicity with a more superior effect than PseudoUridine-incorporated mRNA.
Base modified pseudoUridine
Name
3-(3-Amino-3-Carboxypropyl)-1-MethylpseudoUridine
1,3-DimethylpseudoUridine
1,3-Dimethyl-2’-DeoxypseudoUridine
3-MethylpseudoUridine
1-MethylpseudoUridine
N1-BenzylpseudoUridine
N1-EthylpseudoUridine
2-ThiopseudoUridine
N1-(1,1-Difluoroethyl)pseudoUridine
N1-(1,1,1-Trifluoroethyl)pseudoUridine
N1-MethylsulfonylpseudoUridine
N1-(2-Methyl)propylpseudoUridine
N1-MethoxymethylpseudoUridine
N1,N3-Bis(cyanomethyl)pseudoUridine
N1-CyanomethylpseudoUridine
N1-Ethoxymethyl pseudoUridine
CAS No.
52777-29-4
64272-68-0
65358-16-9
81691-06-7
13860-38-3
1613530-22-5
1613529-72-8
59464-18-5
N/A
1613529-80-8
N/A
N/A
N/A
N/A
N/A
2131744-33-5

4. 3
2'-modified pseudoUridine
Name
2'-O-MethylpseudoUridine
CAS No.
2140-68-3
Protected pseudoUridine
Name
2',3'-Bis-O-(t-butyldimethylsilyl)-N1-methylpseudoUridine
5'-O-DMT-N1-methylpseudoUridine
CAS No.
N/A
875302-39-9
Phosphate pseudoUridine
Name
PseudoUridine 5'-monophosphate
2'-O-MethylpseudoUridine-5'-Triphosphate Lithium salt
N1-Methyl-2'-O-MethylpseudoUridine-5'-Triphosphate Lithium salt
N1-MethoxymethylpseudoUridine-5'-Triphosphate Lithium salt
N1-PropylpseudoUridine-5'-Triphosphate Lithium salt
CAS No.
1157-60-4
N/A
N/A
N/A
N/A
Phosphoramidite pseudoUridine
Name
2'-O-tert-Butyldimethylsilyl-5'-O-DMT-pseudoUridine 3'-CE phosphoramidite
2′-Deoxy-5′-O-DMT-pseudoUridine 3′-CE phosphoramidite
2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N1-MethylpseudoUridine 3'-CE phosphoramidite
CAS No.
163496-23-9
289712-98-7
875302-45-7

5. 4
Nucleosides
These modified nucleosides play an extremely important role in the expression of biological functions of nucleic acids.
Therefore, the existence of rare nucleosides has attracted the massive attention in academia and industrials. The
correlated research in the field of vaccine and cancer is getting more funded and recognized.
3′-O-Methylguanosine
10300-27-3
2′-Deoxyadenosine
958-09-8
2′-Deoxycytidine
951-77-9
2′-Deoxyuridine
951-78-0
2′-Deoxyguanosine
961-07-9
2′-O-Methyluridine
2140-76-3
2,2′-Cyclouridine
3736-77-4
5-Ethynyl-2′-Deoxyuridine
61135-33-9
3′-O-(2-Methoxyethyl)guanosine
256224-03-0
3′-O-Methyl-5-methyluridine
2305415-87-4
3′-O-Methyluridine
6038-59-1
3′-O-Methylcytidine
20594-00-7
NH2
OH
HO
O
O
O
NH
N
N
N
NH2
N
N
N
N
HO
HO
O
NH2
HO
O
O
N
N
HO
HO
O
O
O
N
H
N
HO
NH2
HO
HO
O
O
NH
N
N
N
HO O
O
O
O
N
H
N
HO
N
O
O
N
O OH
OH
H
H
H
N
N
O O
O
HO
HO
O
NH2
HO
HO
O
O
NH
N
N
N
O
O
NH
N
OH
O
O
HO
OH
O
O
O
O
N
H
N
HO
NH2
OH
O
O
O
N
N
HO

6. 5
2′-Deoxy-2′-Fluorouridine
784-71-4
2′-Deoxy-2′-Fluoroguanosine
78842-13-4
5-Iodo-2′-Deoxyuridine
54-42-2
2′-Deoxy-2′-Fluorocytidine
10212-20-1
2′-Fluoro-2′-Deoxyadenosine
64183-27-3
3′-O-Methyladenosine
10300-22-8
N6-Methyladenosine
1867-73-8
1-Methyladenosine
15763-06-1
2′-O-Methyladenosine
2140-79-6
N6-(3-Methyl-2-Butenyl)Adenosine
7724-76-7
2-Methylthio-N6-(4-Hydroxy-3-
Methylbut-2-Enyl)Adenosine
52049-48-6
N6-Threonylcarbamoyladenosine
24719-82-2
2′-O-Methylcytidine
2140-72-9
N4-Acetylcytidine
3768-18-1
5-Formylcytidine
148608-53-1
F
HO
O
O
O
N
H
N
HO
NH2
F
HO
HO
O
O
NH
N
N
N
H
N
N
O O
I
O
HO
HO
NH2
F
HO
O
O
N
N
HO
NH2
N
N
N
N
F
HO
HO
O
NH2
N
N
N
N
HO
O OH
O
HO
HN
N
N
N
N
OH
HO
O
HO
NH
N
N
N
N
OH
HO
O
NH2
N
N
N
N
HO
O
HO
O
O
HO OH
N
N N
N
HN
HO
OH
HN
S
N
N
N
N
OH
HO
O
HO
O OH
OH
HN
HN O
N
N N
N
O
HO OH
HO
N
N
O
O
O
HO
NH2
HO
O
NH
N
N
O
O
HO OH
HO
N
N O
O
O
HO OH
NH2
HO

7. 6
N4-Methylcytidine
10578-79-7
5-Hydroxymethylcytidine
19235-17-7
1-Methylguanosine
2140-65-0
N2-Methylguanosine
2140-77-4
7-Methylguanosine
20244-86-4
2′-O-Methylguanosine
2140-71-8
N,N-Dimethylguanosine
2140-67-2
5-Methyluridine
1463-10-1
2′-O-Methyluridine
2140-76-3
2′-O-Methyl-5-Methyluridine
55486-09-4
2-Thiouridine
20235-78-3
5-Methyl-2-Thiouridine
32738-09-3
5-Hydroxyuridine
957-77-7
5-Methoxycarbonylmethyluridine
29428-50-0
5-Methoxycarbonylmethyl-
2′-O-Methyluridine
60197-31-1
N
N
O
NH
O
HO OH
HO
N
N
O
OH
O
HO OH
NH2
HO N
N N
N
O
O
HO
HO OH
NH2
OH
HO
HO
O N
H
O
NH
N
N
N
NH2
OH
HO
HO
O
O
NH
N
N
+
N
NH2
HO
HO
O
O
O
NH
N
N
N
OH
HO
HO
O N
O
NH
N
N
N
H
N
N
O O
O
HO OH
HO
HO O
O
O
O
N
H
N
HO
H
N
N
O O
O
O
HO
HO
H
N
N
O
S
O
HO OH
HO
H
N
N
O
S
O
HO OH
HO
H
N
N
O O
OH
O
HO OH
HO O
O
H
N
N
O
O
O
HO OH
HO O
O
H
N
N
O
O
O
O
HO
HO

8. 7
Nucleotides
BOC Sciences supplies nucleotides in scales ranging from kilogram to hundreds kilogram quantities. We provide a full
list of dNMPs/NMPs, dNDPs/dNDPs and dNTPs/NTPs and could customize the specification to meet any requirements
by customers. We also can supply the modified nucleotides according to the customers need.
Monophosphate Products (NMPs/dNMPs)
Unmodified Nucleotides
P
O
OH
HO
O
O
R
HO
B
B=A, T, G, C, U
R=OH, H
Unmodified Monophosphate
B=A, T, G, C, U
R=OH, H
Unmodified Diphosphate
B=A, T, G, C, U
R=OH, H
Unmodified Triphosphate
O
R
HO
B
P
O
OH
O O
P
O
OH
HO
O
R
HO
B
P
O
OH
O O
P
O
OH
HO
P
O
O
OH
dAMP-2H
dAMP-2Na
dCMP-2H
dCMP-2Na
dUMP-2Na
dTMP-2Na
dGMP-2Na
AMP
AMP-2Na
CMP
CMP-2Na
GMP-2Na
UMP
UMP-2Na
Name
2'-Deoxyadenosine-5'-monophosphate
2'-Deoxyadenosine-5'-monophosphate disodium salt
2’-Deoxycytidine-5’-monophosphate
2'-Deoxycytidine-5'-monophosphate disodium salt
2′-Deoxyuridine-5′-monophosphate disodium salt
2'-Deoxythymidine-5'-monophosphate disodium salt
2'-Deoxyguanosine 5'-monophosphate disodium salt
Adenosine 5'-monophosphate
Adenosine 5'-monophosphate disodium salt
Cytidine-5'-monophosphate
Cytidine 5'-monophosphate disodium salt
Guanosine 5'-monophosphate disodium salt
Uridine-5'-monophosphate
Uridine 5'-monophosphate disodium salt
CAS No.
653-63-4
2922-74-9
1032-65-1
13085-50-2
42155-08-8
33430-62-5
33430-61-4
61-19-8
4578-31-8
63-37-6
6757-06-8
5550-12-9
58-97-9
3387-36-8

9. 8
Diphosphate Products (NDPs/dNDPs)
ADP
ADP-Na
ADP-2Na
ADP-3Na
ADP-K
ADP-2K
ADP-3Li
CDP-2Na
CDP-3Na
GDP-2Na
UDP-2Na
dADP-2Na
dGDP-3Na
dCDP-3Na
dUDP-2Na
Name
Adenosine 5'-diphosphate
Adenosine 5'-diphosphate monosodium salt
Adenosine 5'-diphosphate disodium salt
Adenosine-5'-diphosphate trisodium salt
Adenosine 5'-diphosphate monopotassium salt
Adenosine 5'-diphosphate dipotassium salt
Adenosine-5'-diphosphate trilithium salt
Cytidine-5'-diphosphate disodium salt
Cytidine 5'-Diphosphate Trisodium Salt
Guanosine-5'-diphosphate disodium salt
Uridine-5'-diphosphate disodium salt
2'-Deoxyadenosine-5'-diphosphate disodium salt
2'-Deoxyguanosine-5'-Diphosphate Trisodium Salt
2'-Deoxycytidine-5'-diphosphate trisodium salt
2'-Deoxyuridine-5'-diphosphate disodium salt
CAS No.
58-64-0
20398-34-9
16178-48-6
2092-65-1
72696-48-1
114702-55-5
31008-64-7
54394-90-0
34393-59-4
7415-69-2
27821-45-0
72003-83-9
102783-74-4
151151-32-5
102814-06-2
m7GDP [TEA Salt] 7-MethylGuanosine-5'-Diphosphate [TEA Salt] 117723-13-4 (free acid)

10. 9
Triphosphate Products (NTPs/dNTPs)
ATP
ATP-2Na
CTP-2Na
GTP-2Na
UTP-3Na
dATP-2Na
dATP-3Na
dTTP-3Na
dGTP-3Na
dCTP-2Na
dUTP
Pseudo-UTP, Sodium salt
N1-Methylpseudo-UTP,
Sodium salt
5-Methyl-UTP
5-Methoxy-UTP
5-methyl-CTP
7-Deaza-dATP
7-Deaza-dGTP
Name
Adenosine-5'-triphosphate
Adenosine 5'-Triphosphate, disodium salt
Cytidine 5'-triphosphate disodium salt
Guanosine-5,-triphosphoric aicd disodium salt
Uridine-5'-triphosphoric acid trisodium salt
2'-Deoxyadenosine-5'-triphosphate disodium salt
2'-Deoxyadenosine-5'-triphosphate Trisodium salt
2'-Deoxythymidine-5'-triphosphate, trisodium Salt
2'-Deoxyguanosine-5'-triphosphate trisodium salt
2'-Deoxycytidine 5'-triphosphate disodium salt
2'-Deoxyuridine 5'-Triphosphate
Pseudouridine-5'-triphosphate, sodium salt
5-methyluridine 5'-triphosphate
5-Methoxyuridine 5'-triphosphate
5-Methylcytidine 5'-triphosphate
7-Deaza-2'-Deoxyadenosine Triphosphate
7-Deaza-2'-Deoxyguanosine Triphosphate
CAS No.
56-65-5
987-65-5
36051-68-0
56001-37-7
19817-92-6
74299-50-6
54680-12-5
27821-54-1
93919-41-6
102783-51-7
1173-82-6
1175-34-4 (for free acid)
1428903-59-6
(for free acid)
23198-01-8
847649-65-4
327174-86-7
N/A
101515-08-6
N1-Methylpseudouridine-5'-triphosphate, sodium salt
We can supply both solid and solution form triphosphate products
The solution form products are all free of DNase and RNase contamination and all have been passed the functionality
test in transcription reaction

11. 10
Scale up capability
BOC Sciences with 3 Million sq.ft of
facility area, has established powerful
synthesis and fermentation platforms
to produce high-quality chemicals.
kg to MT scale Cleanroom Class 100 to Class 100,000,
HPAPI production with OEL < 1 μg/m³
GMP capability：
BOC Sciences provides CDMO services for GMP grade products. Our facilities
are US and EU GMP compliant and have passed US FDA inspection. Our
manufacturing sites are equipped with hundreds of fermentors, reactors and
multiple purification workshops.

12. International: 1-631-504-6093
US & Canada (Toll free): 1-844-BOC(262)-0123
Fax: 1-631-614-7828
Email: info@bocsci.com
45-16 Ramsey Road, Shirley, NY 11967, USA
Contact Us
https://www.bocsci.com/