Based on advanced technology and years of experience, Creative Biolabs offers a variety of customized antibody drug conjugates, linker-Toxin products, ADCs cytotoxin, ADCs linkers, Anti-drug Abs and Anti-Ab ADCs for your ADC projects and promote your progress in ADC development
This document contains information about glycoside hydrolase family 81 (GH81) enzymes from Clostridium thermocellum, including amino acid sequences, multiple sequence alignments, and primer sequences for site-directed mutagenesis. Specifically, it provides the amino acid sequences of GH81 enzymes from C. thermocellum strains ATCC27405 and DSM1313, along with relevant accession numbers. It also includes a multiple sequence alignment of the wild type and double mutant forms of GH81. Finally, the document lists primers designed to introduce mutations into GH81, such as amino acid substitutions D415A, E492A, E496A, and a double mutation M2/M3.
Creative Biolabs provides a wide range of antibody-drug conjugates (ADCs) for research purposes. Their anti-antibody ADCs can help screen antibody leads as ADC candidates in a cost-efficient manner. They offer various ADCs linked to different payloads such as MMAF, MMAE, and DM1, conjugated through cleavable or non-cleavable linkers to antibodies against human, mouse, rabbit, and rat IgG. All products are in stock with quantity discounts for bulk orders and fast worldwide shipping.
Conventional monoclonal antibodies cannot reach adequate therapeutic effects in some cases. Enhancing the effector functions is one of the major strategies for the development of engineered monoclonal antibodies to make up for the deficiencies. Here, we will discuss the development of effector function-enhanced antibodies, and the solutions provided by Creative Biolabs.
Lund-Johansen presentation at the 1st International Antibody Validation Forum 2014
Slides for the YouTube link
https://www.youtube.com/watch?v=-unaiyl0DSY
This data sheet provides packaging information for several Harris Semiconductor integrated circuits, including the CD4011B, CD4012B, and CD4023B. It lists the available package types for each device, including details like number of pins, package quantity, lead finish, and moisture sensitivity levels. The packages include plastic dual-in-line packages, ceramic dual-in-line packages, small outline packages, and thin shrink small outline packages.
Presentation of Fridtof Lund-Johansen in 1st International Antibody Validatio...St John's Laboratory Ltd
Fridtjof Lund-Johansen is an MDPhD who has worked for 30 years with antibodies and flow cytometry. He took his degree at the University of Bergen in Norway. He then did post-docs in California, first at Becton Dickinson in San Jose and then at DNAX instiute of Immunology in Palo Alto. He is now a PI at the Institute of Immunology at Oslo University Hospital where he leads an effort to develop antibody-based proteomics. His technology is called MAP for microsphere affinity proteomics. He will talk about how MAP can be used to test thousands of antibodies in parallel.
For more details about 1st international antibody validation forum please check on http://www.stjohnslabs.com/ac_cms/blog
Crude oil produced from wells often contains water that needs to be separated. Demulsifiers are added to emulsions of oil and water to weaken the interface and promote separation. Solvay offers a wide range of demulsifier chemistries from various chemical classes that are tailored for different applications and oil types. The document provides product details, specifications, and performance characteristics for Solvay's line of demulsifiers.
This document contains information about glycoside hydrolase family 81 (GH81) enzymes from Clostridium thermocellum, including amino acid sequences, multiple sequence alignments, and primer sequences for site-directed mutagenesis. Specifically, it provides the amino acid sequences of GH81 enzymes from C. thermocellum strains ATCC27405 and DSM1313, along with relevant accession numbers. It also includes a multiple sequence alignment of the wild type and double mutant forms of GH81. Finally, the document lists primers designed to introduce mutations into GH81, such as amino acid substitutions D415A, E492A, E496A, and a double mutation M2/M3.
Creative Biolabs provides a wide range of antibody-drug conjugates (ADCs) for research purposes. Their anti-antibody ADCs can help screen antibody leads as ADC candidates in a cost-efficient manner. They offer various ADCs linked to different payloads such as MMAF, MMAE, and DM1, conjugated through cleavable or non-cleavable linkers to antibodies against human, mouse, rabbit, and rat IgG. All products are in stock with quantity discounts for bulk orders and fast worldwide shipping.
Conventional monoclonal antibodies cannot reach adequate therapeutic effects in some cases. Enhancing the effector functions is one of the major strategies for the development of engineered monoclonal antibodies to make up for the deficiencies. Here, we will discuss the development of effector function-enhanced antibodies, and the solutions provided by Creative Biolabs.
Lund-Johansen presentation at the 1st International Antibody Validation Forum 2014
Slides for the YouTube link
https://www.youtube.com/watch?v=-unaiyl0DSY
This data sheet provides packaging information for several Harris Semiconductor integrated circuits, including the CD4011B, CD4012B, and CD4023B. It lists the available package types for each device, including details like number of pins, package quantity, lead finish, and moisture sensitivity levels. The packages include plastic dual-in-line packages, ceramic dual-in-line packages, small outline packages, and thin shrink small outline packages.
Presentation of Fridtof Lund-Johansen in 1st International Antibody Validatio...St John's Laboratory Ltd
Fridtjof Lund-Johansen is an MDPhD who has worked for 30 years with antibodies and flow cytometry. He took his degree at the University of Bergen in Norway. He then did post-docs in California, first at Becton Dickinson in San Jose and then at DNAX instiute of Immunology in Palo Alto. He is now a PI at the Institute of Immunology at Oslo University Hospital where he leads an effort to develop antibody-based proteomics. His technology is called MAP for microsphere affinity proteomics. He will talk about how MAP can be used to test thousands of antibodies in parallel.
For more details about 1st international antibody validation forum please check on http://www.stjohnslabs.com/ac_cms/blog
Crude oil produced from wells often contains water that needs to be separated. Demulsifiers are added to emulsions of oil and water to weaken the interface and promote separation. Solvay offers a wide range of demulsifier chemistries from various chemical classes that are tailored for different applications and oil types. The document provides product details, specifications, and performance characteristics for Solvay's line of demulsifiers.
The document is a data sheet from Harris Semiconductor that describes the CD4060B integrated circuit. It consists of an oscillator and 14 ripple-carry binary counter stages. It has a reset input that resets the counter and disables the oscillator. All stages are master-slave flip-flops that advance the counter state on each negative transition of the input signal. The chip is available in various package types including ceramic and plastic dual-in-line packages as well as small outline packages.
Spicepark is a parts inventory database managed by Bee Technologies. The September 2020 inventory includes 5,310 parts consisting mainly of semiconductors (75%), passive components (12%), batteries (10%), and small amounts of mechanical parts and motors. The database provides details on the types and manufacturers of each part number.
This document provides a selection guide for discrete semiconductors including diodes, bipolar transistors, MOSFETs, TVS diodes, bridge rectifiers, and ESD protection devices. It lists component families and package types for each device type along with key electrical ratings like forward voltage, current, and breakdown voltage. The guide is published by Bruckewell Technology Corporation and is intended to help engineers select discrete components for their circuit designs.
This document summarizes utilization analysis reports for two immunossay analyzers located in the central lab. For the micro lab analyzer, the total potential tests according to purchased reagents exceeded actual tests performed by over 2,000 tests, representing an estimated annual loss of over Rs. 1.79 lakhs. Similarly, for the biochemistry lab analyzer, over 6,000 more tests could have been performed according to purchased reagents, with an estimated annual loss of over Rs. 6.99 lakhs. Recommendations to improve reagent utilization were requested.
This document provides product specifications for a 123eWireless AL5DF-PSA connector. It includes details on electrical and mechanical specifications, environmental testing specifications, frequency band performance specifications for VSWR and return loss, and applicable regulatory compliance certifications. It also lists the discontinued status and manufacturer of the product.
This document provides product details and specifications for an Andrew AL6DF-PSA 7-16 DIN Female Positive Stop connector. It includes information on ordering, payment, shipping, warranty and technical specifications such as frequency range, impedance, insertion loss, temperature ratings, and certification compliance. Launch 3 Telecom is advertised as the supplier and provider of additional services for the connector such as repair, maintenance contracts, and installation.
The document discusses solutions for LED backlighting in portable devices. It outlines the basics of LED backlighting and challenges in the design. It then provides recommendations for core chips that can be used in an LED backlight reference design, including charge pump and inductive boost driver options from various manufacturers. Key considerations for LED backlight design such as output voltage, current, efficiency and dimming control are also covered.
Refsyn Biosciences Pvt Ltd offers custom synthesis services to support for the supplying of Research chemicals, Fine chemicals, Pharmaceutical reference standards, API related substances, drug impurities and drug metabolites to Pharmaceutical, Biotech, Biopharma, Drug discovery organizations, Clinical research organizations, Research institutions and many chemical trading companies.
We are supplying drug impurities and metabolites on the milligram scale at competitive price.
We are the leading synthesizer and suppliers of working standards and certified reference standards in India. Our products are supplied only for R&D or industrial use, not consumption for human or animals.
We are sending our instock product list for your reference. Kindly send your enquiry, addition to others. We are always a good service provider to our customers and we support for the best quality products with more competitive price.
This document provides product information and instructions for purchasing an Andrew AL5DF-PSA connector from Launch 3 Telecom. Key details include:
- The AL5DF-PSA is a 7/16 DIN female positive stop connector for 7/8 in AL5-50 and AVA5-50 cable.
- Launch 3 Telecom is a supplier and distributor of telecommunications hardware and genuine Andrew replacement parts.
- Payment options and same day shipping are offered for purchases. Warranty and return policies are also described.
This document provides product information and specifications for a Commscope-Andrew ADCB-DFDM-DB dual band DC block. It lists details like the operating frequency band, insertion loss, return loss, environmental testing standards met, and how to purchase the product from Launch 3 Telecom. Launch 3 Telecom is described as a supplier of telecom hardware and genuine replacement parts that offers services like repair, maintenance contracts, de-installation, and more.
This document contains a price list for electrical distribution equipment applicable in Pakistan. It lists Schneider brand miniature circuit breakers (MCBs) in single pole, double pole, triple pole and four pole configurations with ratings from 1A to 125A. It also lists other Schneider equipment like earth leakage circuit breakers, surge arrestors, time switches and impulse relays along with their unit prices in Pakistani Rupees. The document provides contact information for the distributor Azcorp Engineering Services based in Karachi, Pakistan.
Semiconductor Equipment Inventory.Please email us for more info/ the availability of these equipment. These are subject to prior sale.Appreciate your time! sales@semistarcorp.com
This document provides product specifications for an Andrew AL5DM-PSA 7/8" DIN-Male Connector. It includes details on the connector such as its impedance, operating frequency band, insertion loss, environmental specifications, and regulatory compliance certifications. Contact and payment information is also provided for purchasing the product from Launch 3 Telecom.
This document lists EPROM devices that are supported by True USB GQ Universal Programmer models GQ-3X and GQ-4X. It provides the device name, required adapter (if any), and supported programmer model for over 100 EPROM device types. The supported devices include 27xx, 27Cxx, AT27xx, M5L/M/MX27xx, and other common EPROM chips that can be programmed with the listed universal programmers.
Biopharmaceutical Attribute Monitoring with the Waters ACQUITY QDa Mass DetectorWaters Corporation
Bringing greater sensitivity, selectivity, and productivity to routine analysis of biotherapeutics, whether you're in characterization or in downstream production of biologics.
This document provides an inventory update of parts in SpicePark as of January 2020. It lists the various components grouped by type, with semiconductors making up 75% of the total inventory of 5,133 parts. Within semiconductors, the largest subcategories are Schottky rectifiers at 953 pieces and ceramic capacitors at 126 pieces. The document also provides detailed part number and manufacturer information for 953 Schottky rectifiers in the inventory.
This document provides an inventory of parts at SpicePark as of May 2023. It lists 6,415 total parts, grouped into categories of Semiconductor, Passive Parts, Battery, Mechanical Parts, DC Motor, and Lamp. The Semiconductor category is further broken down and provides the most detail, including a breakdown of the 1,562 Schottky Rectifier (SBD) diodes by manufacturer, part number, thermal rating, and other information.
This document summarizes the specifications and features of Fairchild Semiconductor's DB3-DB3TG 150mW bi-directional trigger diodes. Key specifications include a break-over voltage of 32V, a break-over current of 15uA, and a power dissipation rating of 150mW. The diodes feature a DO-35 package and meet RoHS compliance standards. They are rated for high temperature soldering up to 260C for 10 seconds.
Bee Technologies' SpicePark document provides an inventory of components as of October 2020. It lists 5,340 total pieces, with semiconductors making up 75% of the inventory. The document includes a breakdown of the types and manufacturers of 121 light-emitting diodes (LEDs) in the inventory.
The document provides an inventory update from March 2020 of components in SpicePark, a collection of electronic parts maintained by Bee Technologies. It shows that the total number of parts is 5,203, with semiconductor components making up 75% of the collection. Diodes and Schottky rectifiers are the most numerous semiconductor, totaling 1,023 pieces from various manufacturers.
The document is a data sheet from Harris Semiconductor that describes the CD4060B integrated circuit. It consists of an oscillator and 14 ripple-carry binary counter stages. It has a reset input that resets the counter and disables the oscillator. All stages are master-slave flip-flops that advance the counter state on each negative transition of the input signal. The chip is available in various package types including ceramic and plastic dual-in-line packages as well as small outline packages.
Spicepark is a parts inventory database managed by Bee Technologies. The September 2020 inventory includes 5,310 parts consisting mainly of semiconductors (75%), passive components (12%), batteries (10%), and small amounts of mechanical parts and motors. The database provides details on the types and manufacturers of each part number.
This document provides a selection guide for discrete semiconductors including diodes, bipolar transistors, MOSFETs, TVS diodes, bridge rectifiers, and ESD protection devices. It lists component families and package types for each device type along with key electrical ratings like forward voltage, current, and breakdown voltage. The guide is published by Bruckewell Technology Corporation and is intended to help engineers select discrete components for their circuit designs.
This document summarizes utilization analysis reports for two immunossay analyzers located in the central lab. For the micro lab analyzer, the total potential tests according to purchased reagents exceeded actual tests performed by over 2,000 tests, representing an estimated annual loss of over Rs. 1.79 lakhs. Similarly, for the biochemistry lab analyzer, over 6,000 more tests could have been performed according to purchased reagents, with an estimated annual loss of over Rs. 6.99 lakhs. Recommendations to improve reagent utilization were requested.
This document provides product specifications for a 123eWireless AL5DF-PSA connector. It includes details on electrical and mechanical specifications, environmental testing specifications, frequency band performance specifications for VSWR and return loss, and applicable regulatory compliance certifications. It also lists the discontinued status and manufacturer of the product.
This document provides product details and specifications for an Andrew AL6DF-PSA 7-16 DIN Female Positive Stop connector. It includes information on ordering, payment, shipping, warranty and technical specifications such as frequency range, impedance, insertion loss, temperature ratings, and certification compliance. Launch 3 Telecom is advertised as the supplier and provider of additional services for the connector such as repair, maintenance contracts, and installation.
The document discusses solutions for LED backlighting in portable devices. It outlines the basics of LED backlighting and challenges in the design. It then provides recommendations for core chips that can be used in an LED backlight reference design, including charge pump and inductive boost driver options from various manufacturers. Key considerations for LED backlight design such as output voltage, current, efficiency and dimming control are also covered.
Refsyn Biosciences Pvt Ltd offers custom synthesis services to support for the supplying of Research chemicals, Fine chemicals, Pharmaceutical reference standards, API related substances, drug impurities and drug metabolites to Pharmaceutical, Biotech, Biopharma, Drug discovery organizations, Clinical research organizations, Research institutions and many chemical trading companies.
We are supplying drug impurities and metabolites on the milligram scale at competitive price.
We are the leading synthesizer and suppliers of working standards and certified reference standards in India. Our products are supplied only for R&D or industrial use, not consumption for human or animals.
We are sending our instock product list for your reference. Kindly send your enquiry, addition to others. We are always a good service provider to our customers and we support for the best quality products with more competitive price.
This document provides product information and instructions for purchasing an Andrew AL5DF-PSA connector from Launch 3 Telecom. Key details include:
- The AL5DF-PSA is a 7/16 DIN female positive stop connector for 7/8 in AL5-50 and AVA5-50 cable.
- Launch 3 Telecom is a supplier and distributor of telecommunications hardware and genuine Andrew replacement parts.
- Payment options and same day shipping are offered for purchases. Warranty and return policies are also described.
This document provides product information and specifications for a Commscope-Andrew ADCB-DFDM-DB dual band DC block. It lists details like the operating frequency band, insertion loss, return loss, environmental testing standards met, and how to purchase the product from Launch 3 Telecom. Launch 3 Telecom is described as a supplier of telecom hardware and genuine replacement parts that offers services like repair, maintenance contracts, de-installation, and more.
This document contains a price list for electrical distribution equipment applicable in Pakistan. It lists Schneider brand miniature circuit breakers (MCBs) in single pole, double pole, triple pole and four pole configurations with ratings from 1A to 125A. It also lists other Schneider equipment like earth leakage circuit breakers, surge arrestors, time switches and impulse relays along with their unit prices in Pakistani Rupees. The document provides contact information for the distributor Azcorp Engineering Services based in Karachi, Pakistan.
Semiconductor Equipment Inventory.Please email us for more info/ the availability of these equipment. These are subject to prior sale.Appreciate your time! sales@semistarcorp.com
This document provides product specifications for an Andrew AL5DM-PSA 7/8" DIN-Male Connector. It includes details on the connector such as its impedance, operating frequency band, insertion loss, environmental specifications, and regulatory compliance certifications. Contact and payment information is also provided for purchasing the product from Launch 3 Telecom.
This document lists EPROM devices that are supported by True USB GQ Universal Programmer models GQ-3X and GQ-4X. It provides the device name, required adapter (if any), and supported programmer model for over 100 EPROM device types. The supported devices include 27xx, 27Cxx, AT27xx, M5L/M/MX27xx, and other common EPROM chips that can be programmed with the listed universal programmers.
Biopharmaceutical Attribute Monitoring with the Waters ACQUITY QDa Mass DetectorWaters Corporation
Bringing greater sensitivity, selectivity, and productivity to routine analysis of biotherapeutics, whether you're in characterization or in downstream production of biologics.
This document provides an inventory update of parts in SpicePark as of January 2020. It lists the various components grouped by type, with semiconductors making up 75% of the total inventory of 5,133 parts. Within semiconductors, the largest subcategories are Schottky rectifiers at 953 pieces and ceramic capacitors at 126 pieces. The document also provides detailed part number and manufacturer information for 953 Schottky rectifiers in the inventory.
This document provides an inventory of parts at SpicePark as of May 2023. It lists 6,415 total parts, grouped into categories of Semiconductor, Passive Parts, Battery, Mechanical Parts, DC Motor, and Lamp. The Semiconductor category is further broken down and provides the most detail, including a breakdown of the 1,562 Schottky Rectifier (SBD) diodes by manufacturer, part number, thermal rating, and other information.
This document summarizes the specifications and features of Fairchild Semiconductor's DB3-DB3TG 150mW bi-directional trigger diodes. Key specifications include a break-over voltage of 32V, a break-over current of 15uA, and a power dissipation rating of 150mW. The diodes feature a DO-35 package and meet RoHS compliance standards. They are rated for high temperature soldering up to 260C for 10 seconds.
Bee Technologies' SpicePark document provides an inventory of components as of October 2020. It lists 5,340 total pieces, with semiconductors making up 75% of the inventory. The document includes a breakdown of the types and manufacturers of 121 light-emitting diodes (LEDs) in the inventory.
The document provides an inventory update from March 2020 of components in SpicePark, a collection of electronic parts maintained by Bee Technologies. It shows that the total number of parts is 5,203, with semiconductor components making up 75% of the collection. Diodes and Schottky rectifiers are the most numerous semiconductor, totaling 1,023 pieces from various manufacturers.
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar Kanvaria
Executive Directors Chat Leveraging AI for Diversity, Equity, and InclusionTechSoup
Let’s explore the intersection of technology and equity in the final session of our DEI series. Discover how AI tools, like ChatGPT, can be used to support and enhance your nonprofit's DEI initiatives. Participants will gain insights into practical AI applications and get tips for leveraging technology to advance their DEI goals.
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
How to Make a Field Mandatory in Odoo 17Celine George
In Odoo, making a field required can be done through both Python code and XML views. When you set the required attribute to True in Python code, it makes the field required across all views where it's used. Conversely, when you set the required attribute in XML views, it makes the field required only in the context of that particular view.
2. Established in 2004, Creative Biolabs is a
world-renowned service provider for
antibody-drug conjugate (ADC) service and
products. After years of pursuit for perfection,
Creative BioLabs has established leadership
in targeted immunotherapy and ADC
development.
Based on advanced technology and years
of experience, Creative Biolabs offers a
variety of customized ADC, linker-Toxin
products, ADCs cytotoxin, ADCs linkers,
Anti-drug Abs and Anti-Ab ADCs for your
ADC projects and promote your progress in
ADC development.
Creative Biolabs
ADC Products
ANTIBODY-DRUG
CONJUGATE
Comprehensive one-stop-shop
for all aspects in ADC research
and development
A n t i b o d y - d r u g C o n j u g a t e
4. CUSTOMIZED ADCS
Creative Biolabs offers a variety of customarily prepared ADC
products to serve the course of ADC development and evaluation.
Taken advantage of our large inventory of therapeutic antibodies,
our scientists help create the custom ADC products by conjugating
therapeutic antibodies against cancer surface antigens with
different drug-linker complexes.
APPLICATION
ADCs have created a new paradigm for novel anticancer drug
development. With both the specificity of the large-molecule
monoclonal antibody and the potency of the small molecule
cytotoxic drug, ADCs have tremendous potential to be part of the
future of cancer precision medicine as well as cancer
combination therapies.
A n t i b o d y - d r u g C o n j u g a t e
7. LINKER-TOXIN
Creative Biolabs offers a large collection of pre-assembled drug-
linker complexes for ready-to-go antibody conjugation to speed up
new ADC development processes. From well-established
compounds such as MC-vc-PAB-MMAE, to more innovative
complex sets including peptide linker-based duocarmycin derivative,
pH labile linker-based calicheamicin set…
APPLICATION
With toxin targeting defined intracellular targets and linker with
various releasing mechanisms, the drug-linker complexes will
help promote the progress of customized ADC projects.
A n t i b o d y - d r u g C o n j u g a t e
9. ADCS CYTOTOXIN
Creative Biolabs offers highly potent toxins and toxin derivatives
targeting a variety of cellular pathways, including microtubule
assemble and dynamics (microtubule toxins), DNA biochemistry
and structure (DNA toxins), and gene transcription (transcription
toxins) … for ADC development.
FEATRUES
ADC toxins target crucial intracellular pathways to induce cell
death and they can be over 1000-fold more potent than chemo
therapeutic agents. The toxins from Creative Biolabs are of high
purity (>95%) and defined structure as often characterized by LC-
MS and 1HNMR.
A n t i b o d y - d r u g C o n j u g a t e
11. ADCS LINKER
Creative Biolabs offers a variety of chemically versatile linker
molecules to facilitate ADC development projects. All chemical
linkers are of >95% purity and they are the basic building blocks for
a successful ADC. Linkers facilities the conjugation of ADC toxins
to antibodies and in the meantime, they also dictate the release
mechanism of an ADC.
FEATRUES
We carry a series of cleavable linkers (pH-sensitive linkers,
disulfide linker, peptide linkers, β-glucuronide linkers), non-
cleavable linkers, and intermediate linker modules. We also offer
the services in the DrugLnk synthesis platform to prepare
customized linkers with unique structures.
A n t i b o d y - d r u g C o n j u g a t e
14. ANTI-DRUG AB
Due to the high potency of ADC toxins, antibodies against
ADC cytotoxic are difficult to develop. After devoting a
tremendous amount of effort, Creative Biolabs has raised a series
of antibodies, collectively anti-drug Abs, against ADC toxin
antigens include MMAE, MMAF, DM1, DM4, Calicheamicin,
Duocarmycin.
APPLICATION
These anti-drug Abs will be valuable assets to facilitate the PK
and safety evaluation of newly developed ADCs bearing these
drugs.
A n t i b o d y - d r u g C o n j u g a t e
17. ANTI-AB ADCS
The basic concept of ADC requires the internalization of an
antibody upon target recognition and the intracellular release of the
cytotoxin. Creative Biolabs has developed a series of anti-Ab ADC
products that are used for screening of ADC-suitable internalizing
antibodies under “load-bearing” conditions.
FEATRUES
Our Anti-Ab ADC products are essentially proteins (either Protein
A or Protein G) or secondary antibodies that interact with the
certain region of a monoclonal antibody and they are pre-loaded
with toxins. Once applied, the desired antibody will be identified
when enhanced target cell death is observed due to the
internalized toxin.
A n t i b o d y - d r u g C o n j u g a t e
18. ADC Toxins
Cat. No Product Name Antibody Linker Payload
ADC-AA-001 anti-HIgG(Fc)-N-MMAF ADC anti-human IgG Fc specific polyclonal IgG antibody Noncleavable linkers MMAF
ADC-AA-002 anti-HIgG(Fc)-C-MMAF ADC anti-human IgG Fc specific polyclonal IgG antibody Cleavable linkers MMAF
ADC-AA-003 anti-HIgG(Fc)-C-MMAE ADC anti-human IgG Fc specific polyclonal IgG antibody Cleavable linkers MMAE
ADC-AA-008 anti-HIgG(Fc)-N-DM1 ADC anti-human IgG Fc specific polyclonal IgG antibody Noncleavable linkers DM1
ADC-AA-009 anti-HIgG(Fc)Fab-N-MMAF ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Noncleavable linkers MMAF
ADC-AA-010 anti-HIgG(Fc)Fab-C-MMAF ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Cleavable linkers MMAF
ADC-AA-011 anti-HIgG(Fc)Fab-C-MMAE ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Cleavable linkers MMAE
ADC-AA-015 anti-HIgG(Fc)Fab-N-DM1 ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Noncleavable linkers DM1
ADC-AA-017 anti-HIgG(Fab)-C-MMAE ADC anti-human IgG Fab specific polyclonal IgG antibody Cleavable linkers MMAE
ADC-AA-018 anti-HIgG(Fab)-N-DM1 ADC anti-human IgG Fab specific polyclonal IgG antibody Noncleavable linkers DM1
ADC-AA-019 anti-MIgG(Fc)-N-MMAF ADC anti-mouse IgG Fc specific polyclonal IgG antibody Noncleavable linkers MMAF
ADC-AA-020 anti-MIgG(Fc)-C-MMAF ADC anti-mouse IgG Fc specific polyclonal IgG antibody Cleavable linkers MMAF
ADC-AA-021 anti-MIgG(Fc)-C-MMAE ADC anti-mouse IgG Fc specific polyclonal IgG antibody Cleavable linkers MMAE
ADC-AA-026 anti-MIgG(Fc)-N-DM1 ADC anti-mouse IgG Fc specific polyclonal IgG antibody Noncleavable linkers DM1
Anti-Ab ADCs
19. ADC Toxins
Cat. No Product Name Antibody Linker Payload
ADC-AA-027 anti-MIgG (Fc)Fab-N-MMAF ADC Fab fragment of anti-mouse IgG Fc specific polyclonal antibody Noncleavable linkers MMAF
ADC-AA-028 anti-MIgG (Fc)Fab-C-MMAF ADC Fab fragment of anti-mouse IgG Fc specific polyclonal antibody Cleavable linkers MMAF
ADC-AA-029 anti-MIgG (Fc)Fab-C-MMAE ADC Fab fragment of anti-mouse IgG Fc specific polyclonal antibody Cleavable linkers MMAE
ADC-AA-031 anti-MIgG (Fc)Fab-N-DM1 ADC Fab fragment of anti-mouse IgG Fc specific polyclonal antibody Noncleavable linkers DM1
ADC-AA-056 Anti-MIgG (clone 187.1)-VC-MMAE ADC Anti-mouse IgG Antibody, clone # q187.1 VC MMAE
ADC-AA-057 Anti-MIgG (clone HB43)-VC-MMAE ADC Anti-mouse IgG Antibody, clone # HB43 VC MMAE
ADC-AA-048 Protein G-VC-MMAE ADC Protein G VC MMAE
ADC-AA-049 Protein G-MMAF ADC Protein G None MMAE
ADC-AA-050 Protein G-MCC-DM1 ADC Protein G MCC DM1
ADC-AA-051 Protein G-Duocarmycin ADC Protein G None Duocarmycins
ADC-AA-052 Protein A-VC-MMAE ADC Protein A VC MMAE
ADC-AA-053 Protein A-MMAF ADC Protein A None MMAF
ADC-AA-054 Protein A-MCC-DM1 ADC Protein A MCC DM1
ADC-AA-055 Protein A-Duocarmycin ADC Protein A None Duocarmycins
Anti-Ab ADCs
20. 45-1 Ramsey Road, Shirley, NY 11967, USA
1-631-871-5806
1-631-207-8356
info@creative-biolabs.com
www.creative-biolabs.com/ADC
CONTACT US
COMPREHENSIVE ONE-STOP-SHOP FOR
ALL ASPECTS IN ADC RESEARCH AND
DEVELOPMENT