Nad+ precursors in aging role of the (nr) nicotinamide riboside chloride fact in anti aging

Xuchang shangke Chemical Co., Ltd
Phcoker www.phcoker.com
Email: info@phcoker.com
1
NAD+ Precursors in Aging: Role of The (NR) Nicotinamide Riboside
Chloride Fact in Anti-aging
Nicotinamide riboside (NR) and nicotinamide riboside (Chloride)
Nicotinamide riboside (NR) chloride is a chlorinated form of nicotinamide riboside
(NR).
1.What is Nicotinamide Riboside (NR)?
NR is a form of vitamin B3 or niacin. The compound was discovered in the 1940s as a
growth factor for H. influenza. At the onset of the 21st century, scores of studies
would prove that NR is a precursor of NAD+. In the human body, this nutrient lowers
cholesterol levels, eases the risk of cardiovascular diseases, boosts brain functions,
and alleviates arthritis.
Nicotinamide riboside (NR) is a pyridine-nucleoside, serving as a precursor to NAD+
(Nicotinamide adenine dinucleotide). NAD+ fuels most biological functions including
DNA repair, generation of cellular energy, setting the body’s circadian rhythm, and
more. Unfortunately, these molecules naturally decline with senescence.
2.What is Nicotinamide Riboside (NR) Chloride?
Nicotinamide Riboside (NR) chloride (NIAGEN) is a derivative of NR and chlorine. The
compound augments the levels of NAD+ and activates SIRT1 and SIRT3. It reverses
aging by enhancing oxidative metabolism and countering diet-related metabolic

2
comorbidities.
In the US, nicotinamide riboside chloride is generally recognized as safe. Therefore, it
is an approved dietary ingredient for use in protein shakes, vitamin waters, gums, and
related supplements.
3.Conclusion
Humanity has been countering aging by targeting the skin. At one point, you must
have come across some anti-aging creams for clearing deep facial wrinkles, sagging
skin, and blotchiness. However, these treatments are erratic and short-term. The
guaranteed way of aging gracefully is through establishing the biological changes
behind senescence and dealing with the root cause.
Researchers have since established the link between low NAD+ levels and age-related
diseases. This radical discovery has been the icing on the cake in the medical scope by
augmenting the probability of reversing the aging process. For this reason,
nicotinamide riboside chloride powder has frequented the corridors of clinical
research labs due to its efficacy in overturning the biological clock.
The Chemical Specification of Nicotinamide Riboside (Chloride) Powder
Product Name Nicotinamide riboside chloride (NR-CL) (23111-00-4)
Chemical Name NRC;3-Carbamoyl-1-beta-D-ribofuranosylpyridinium
chloride; Nicotinamide ribose chloride; 3-Carbamoyl-1-(β
-D-ribofuranosyl)pyridinium chloride; Nicotinamide B-D

3
Riboside Chloride(WX900111); NR-CL;
CAS Number 23111-00-4
InChIKey YABIFCKURFRPPO-IVOJBTPCSA-N
SMILE C1=CC(=C[N+](=C1)C2C(C(C(O2)CO)O)O)C(=O)N.[Cl-]
Molecular Formula C11H15ClN2O5
Molecular Weight 290.7002
Monoisotopic Mass 290.066949 g/mol
Melting Point N/A
Color white
Storage temp -20°C Freezer
Application dietary supplements, pharmaceutical field
Knowing the Benefits of Nicotinamide riboside (NR), what are the Benefits of
Nicotinamide Riboside Chloride?
The benefits of nicotinamide riboside chloride vs nicotinamide riboside are similar
since they both work to activate NAD and sirtuin 1 proteins.
Healthy Metabolism for Managing Obesity
Scores of research have proven the efficacy of nicotinamide riboside chloride in
reducing weight. Users can lose up to 10% of their body fat without appetite
suppression or physical training.
Taking the drug helps lower LDL cholesterol while raising the levels of good

4
cholesterol. This happens when it holds back the action of the enzymes responsible
for the synthesis of triglycerides. Consequently, the production of low-density
lipoproteins slows down.
Nicotinamide riboside chloride benefits overweight patients with diabetes. The
supplement boosts metabolism by improving glucose intolerance
Neuroprotection
When NAD levels fall below optimum, your neurological system and cognitive health
may be at stake. Take, for example, patients with Alzheimer’s disease exhibit a low
concentration of NAD+ and mitochondria dysfunction.
Among the clinical nicotinamide riboside chloride uses, the management of
neurodegeneration in aging tops the list. The drug acts against intracerebral damage,
ischemic stroke, neurological inflammation, and neuronal death.
Anti-aging Supplement
One of the key Nicotinamide riboside chloride uses includes promoting healthy aging.
The compound leads to an increase in NAD production, which plays a significant role
in the cell. For instance, it raises the cellular energy levels within the muscles, liver,
and kidneys. Besides, Nicotinamide riboside chloride prevents senescence by
increasing the circulation of blood in these vital organs.
DNA Repair
Nicotinamide riboside chloride benefits genetic makeup by repairing the old and
damaged DNA. If the concentration of NAD falls, the injured deoxyribonucleic acid

5
may trigger the reactive oxygen species, leading to oxidative stress, and susceptibility
to cancer.
How Can Nicotinamide Riboside Chloride Reverse Aging?
During aging, the body experiences some physiological changes as the cellular
functions fall back. For instance, the body depletes NAD+ and SIRT1 proteins than it
can synthesize. Low levels of these coenzymes accelerate senescence while sparking
off age-related comorbidities including diabetes, cardiovascular diseases, and obesity.
Administering nicotinamide riboside chloride benefits the immune system by
boosting the blood vessels, such as lymphocytes and leucocytes. The compound
upregulates the synthesis of NAD+, hence, stepping up the levels of SIRT1 proteins.
Consequently, SIRT1 slows down vascular aging by increasing blood flow to the
skeletal muscles, cardiovascular system, and the neurological tissues.
Besides, nicotinamide riboside chloride supplement reverses aging by producing
more NAD+ to aid in DNA repair within the cellular structure. This effect prevents
oxidative stress
The available research also confirms that nicotinamide riboside chloride counters
bone density depletion, a decrease in tear production, and fundus hypopigmentation.
All these conditions are pervasive among the elderly.
NAD⁺ Precursors: Nicotinamide Riboside Chloride vs Nicotinamide Mononucleotide
There are over five NAD+ precursors but for now, we can shift our focus to
nicotinamide riboside chloride vs nicotinamide mononucleotide (NMN).

6
These two compounds augment the NAD+ levels in the body to improve cellular
functions and slow down senescence.
What tells these two apart is that NMN is not a vitamin B3 form. The chemical does
not penetrate through the cell until it converts to nicotinamide riboside. The reason is
that its molecular size is larger relatively bigger than that of nicotinamide riboside
chloride powder. Due to this property, the bioavailability of NMN and its prospects of
activating NAD+ levels has been a bone of contention in the research realm.
According to Dr. Sinclair, a geneticist at Harvard University, the efficiency of NMN is
unmatched. He confesses to using this supplement, which makes him feel young and
rejuvenated. Sinclair equals the effectiveness of NMN to running in a treadmill. The
scientist noted that it improves blood circulation, promotes muscle endurance, and
efficient metabolism.
Conversely, Nicotinamide riboside chloride is directly taken up by the cell. The
molecule is a vitamin B3 alternative. It will augment NAD+ levels by over 60% in the
human body. Unlike most NAD precursors, which are on the FDA’s watch list,
nicotinamide riboside (NR) chloride is in the whitelist of GRAS (Generally Recognized
as Safe) food products.
Why not take NAD powder directly? Nicotinamide Riboside Chloride vs
Nicotinamide Adenine Dinucleotide (NAD)
Since our focus is about elevating NAD in the body, you are probably questioning why
the fuss over nicotinamide riboside chloride. Shouldn’t you administer NAD directly

7
into your system rather than going through the hassle of using intermediates such as
NIAGEN, NR, or NMN? Well, allow me to brief you about nicotinamide riboside
chloride vs nicotinamide adenine dinucleotide.
The principal reason why you should never take NAD directly is that the biomarker is
relatively impermeable to the cell.
The plus of using nicotinamide riboside chloride vs nicotinamide adenine
dinucleotide is that the former is quite permeable to the plasmic membrane. Its
absorption rate is significantly higher through the digestive system, into the
bloodstream, and finally to the brain.
Nicotinamide riboside (NR) Chloride Dosage: How to Use?
In 2016, the nicotinamide riboside chloride supplement won the GRAS status. A year
before, the FDA had approved of it as a source of niacin and a dietary ingredient at a
daily dose of 180mg.
Currently, the maximum licit nicotinamide riboside chloride dosage levels to 300mg
per day. However, in some human trials, the subjects would ingest up to 2000mg of
the drug. You should note that exceeding a dose of 500mg will likely lead to
insufferable nicotinamide riboside side effects.
The niacin dose only applies to healthy adults, inclusive of expectant women and
lactating moms.
Nicotinamide Riboside Chloride Side Effects: Is it Safe to Use Nicotinamide Riboside
Chloride Supplement?

8
Nicotinamide riboside chloride powder is safe and it holds the highly coveted status
of GRAS substances. This fact doesn’t mean that the compound has no adverse
symptoms. After all, water is life but it also drags some negative upshots when you
abuse it. To counter the side effects, ensure that your Nicotinamide riboside chloride
dosage is as low as possible.
Some of the adverse reactions include;
♦Stomach upset
♦Nausea
♦Vomiting
♦Diarrhea
♦Skin reactions such as rash and increased bruising
Besides the above nicotinamide riboside chloride side effects, you are also likely to
experience weight loss. However, this outcome is a blessing in disguise especially if
you are overweight, obesity, or you’re trying to keep your weight in check.
Where to Buy (NR) Nicotinamide Riboside Chloride in Bulk?
You can make a nicotinamide riboside chloride buy at an online store. Whether you
want the pharmaceutical-grade powder in bulk or some food-grade supplement,
ensure to look out for a genuine supplier. The plus of virtual shopping is that you can
compare pricing and check out real-time customer feedback. However, you are also
likely to fall for counterfeits.
We are a trusted brand and all our products adhere to the quality control measures.

9
We deal with different chemicals and dietary supplements. Contact us for your order
and a friendly quotation.
References
[1]Conze, D., Brenner, C., & Kruger, C.L. (2019). Safety and Metabolism of Long-Term
Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized,
Double-Blind, Placebo-Controlled Clinical Trial of Healthy Overweight Adults.
Scientific Reports.
[2]Bogan, K.L. & Brenner, C. (2008). Nicotinic Acid, Nicotinamide, and Nicotinamide
Riboside: A Molecular Evaluation of NAD+ precursor Vitamins in Human Nutrition.
Annual Review of Nutrition.
[3]Mehmel, M., Jovanovic, N., & Spitz, U. (2020). Nicotinamide Riboside – The Current
State of Research and Therapeutic Uses.
[4]Turck, D., Castenimiller, J., et al. (2019). Safety of Nicotinamide Riboside Chloride
as a Novel Food Pursuant to Regulation (EU) 2015/2283 and Bioavailability of
Nicotinamide from this Source, in the Context of Directive 2002/46/EC. EFSA Journal.
[5]Elhassan, Y.S. et al. (2019). Nicotinamide Riboside Augments the Aged Human
Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and
Anti-Inflammatory Signatures. Cell Reports.
[6]Aman, Y., Qiu, Y., Tao, J., & Fang, E.F. (2018). Therapeutic Potential of Boosting
NAD+ in Aging and Age-Related Diseases. Translational Medicine of Aging.

Nad+ precursors in aging role of the (nr) nicotinamide riboside chloride fact in anti aging

Recommended

Recommended

More Related Content

Similar to Nad+ precursors in aging role of the (nr) nicotinamide riboside chloride fact in anti aging

Similar to Nad+ precursors in aging role of the (nr) nicotinamide riboside chloride fact in anti aging (13)

More from phcoker.com

More from phcoker.com (16)

Recently uploaded

Recently uploaded (20)

Nad+ precursors in aging role of the (nr) nicotinamide riboside chloride fact in anti aging