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Normal histology
Hassall corpuscles:
• Distinguishing
feature of thymic
medulla
• Spherical or oval in
shape
• Their nuclei are flat and cytoplasm is markedly
eosinophilic
• They may become keratinized or calcified
H&E staining of section of a Spleen
White pulp and red pulp:
• White pulp contains lymphoid aggregations, mostly
lymphocytes, and macrophages
• The lymphocytes are both T and B-cells.
• Red pulp is vascular, and has parencyhma and lots
of vascular sinuses and hence the name red pulp.
• The damaged cells are phagocytosed by the
numerous macrophages in the red pulp
This is an H&E
stained section of a
lymph node at low
magnification. We
can recognise the
outer capsule,
trabeculae, cortex
and medulla,
afferent lymphatic
vessels, lymphoid
follicles, medullary
cords, the Hilium
and efferent
lymphatic vessels
• Respiratory epi: Pseudostratified
columnar ciliated
• The mucosa of the digestive, respiratory and
urinary tracts often contains small aggregations of
lymphocytes (mostly T lymphos) called lymphoid
follicles. These are called 'Mucosa associated
lymphoid tissue' (MALT).
Normal histology of lymphatic system

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Normal histology of lymphatic system

  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12. Hassall corpuscles: • Distinguishing feature of thymic medulla • Spherical or oval in shape • Their nuclei are flat and cytoplasm is markedly eosinophilic • They may become keratinized or calcified
  • 13.
  • 14. H&E staining of section of a Spleen
  • 15. White pulp and red pulp: • White pulp contains lymphoid aggregations, mostly lymphocytes, and macrophages • The lymphocytes are both T and B-cells. • Red pulp is vascular, and has parencyhma and lots of vascular sinuses and hence the name red pulp. • The damaged cells are phagocytosed by the numerous macrophages in the red pulp
  • 16.
  • 17.
  • 18.
  • 19. This is an H&E stained section of a lymph node at low magnification. We can recognise the outer capsule, trabeculae, cortex and medulla, afferent lymphatic vessels, lymphoid follicles, medullary cords, the Hilium and efferent lymphatic vessels
  • 20.
  • 21.
  • 22.
  • 23. • Respiratory epi: Pseudostratified columnar ciliated
  • 24. • The mucosa of the digestive, respiratory and urinary tracts often contains small aggregations of lymphocytes (mostly T lymphos) called lymphoid follicles. These are called 'Mucosa associated lymphoid tissue' (MALT).