1) The document provides guidance on preparing for the NIPER JEE exam, noting that questions will be based on basic knowledge from organic chemistry, pharmacology, microbiology, and other subjects. 2) Specific topics highlighted for study include named organic reactions, IUPAC nomenclature, enzyme mechanisms, natural product extraction techniques, pharmacokinetics, and drug delivery systems. 3) References for further study are provided for each subject area, with textbooks like Rang & Dale, Remington's Pharmaceutical Sciences, and Silverstein recommended.

1. NIPER JEE 2019
What to study? 1niper jee syllabus

2. • There is no official syllabus prescribed
by NIPER for JEE. Study of 80% of part
which we have covered during GPAT
preparation will be helpful. Mostly
questions are asked directly, which
necessitate absolute basic knowledge
and some aptitude type questions
which have need of a logical way to
answer. Some specific parts, study of
which will be beneficial are given here.
2niper jee syllabus

3. Organic chemistry
• Basics of organic chemistry are important and
questions are asked from mainly these topics-
1) Named reactions [Like Aldol, Benzillic acid, Claisen,
Cannizaro, Curtius, Dieckmann, Darzen, Hoffmann,
Knoevenagel, perkin, Schimidt and especially
reactions of carbonyl compounds], Imine-enamine
Tautomerism, keto-enol tautomerism, pericyclic
reactions as Diels-Alder reaction, cope
arrangement, claisen arrangement. Racemic
mixture, resolution methods.
3niper jee syllabus

4. 2) IUPAC nomenclature, R and S nomenclature, E
and Z isomerism, atropiisomerism,
Conformations [*Stereochemistry is very
important]
3) Hybridization, aromaticity, Huckel’s rule reaction
mechanisms- Electrophilic, Nucleophilic, SN1,
SN2, SNi, Elimination E1 E2 etc. Ester hydrolysis,
Aac1 A
4niper jee syllabus

5. 4) Ester hydrolysis, Aac1 Aac2……all eight
mechanisms (Jerry march) Markovnikoves rule,
Bredts rule, Stereoselectivity, stereospecificity,
regioselectivity, chemoselectivity, chirality,
stereochemistry, conformations,
rearrangements, acids and bases.[*One
question is asked every year]
5niper jee syllabus

6. 5) Amino acids proteins, various methods for
amino acid detection, Ninhydrin test, peptide
sequencing, structures of amino acids, essential
and nonessential amino acids,
6) Carbohydrates classification, osazone test,
mutarotation, etc,
7) Various Heterocycles, Heterocycle synthesis,
reactions.
6niper jee syllabus

7. 8) Various reactions as oxidation, reduction,
hydrolysis etc. and reagents for them.
9) Cover one word answers from Morrison and
Boyd [ Like Super acid, Inductive effect,
Mesomeric effect]
10) Reaction kinetics and radio labelling
techniques.
7niper jee syllabus

8. Computer Aided Drug Designing
[CADD]
• Basics of CADD. Free Wilson model,
Hammet equation, Taft equation, Hansch
analysis (V Imp), regression and
correlation, COMFA, COMSIA, Topliss
decision tree, Molecular docking study,
Especially the kind of software used and
list of descriptors
8niper jee syllabus

9. Natural Products:-
• In natural products more stress should be given on
phytochemistry part rather than biological aspects.
Methods of extraction, isolation and characterization of
natural products. Various separation techniques used for
isolation of natural products.
1) Biosynthetic pathways. Primary metabolites, their
examples.Secondary metabolites, various classes of
secondary metabolites (e.g. Alkaloids, glycosides, tannins,
lignans, saponins, lipids, flavonoids, coumarins,
anthocyanidines etc.). Here most imp. Part is chemistry of
these classes.
9niper jee syllabus

10. 2) Important therapeutic classes: antidiabetics,
hepatoprotectives, immmunomodulators,
neutraceuticals, natural products for
gynecological disorders, anti-cancer, anti-viral
(mainly anti-HIV), adaptogens etc. Dietary
antioxidants, Marine natural products, Plant
growth regulators.
3) Biological sources of important classes of
natural products. (Selected ones only)
4) Standardization of natural products.
5) Difference between natural products and
pharmacognosy 10niper jee syllabus

11. • References:
1. For various therapeutic classes: Trease and
Evans
2. For spectroscopy: Silverstein, Pavia, Kemp.
3. For stereochemistry: I.L. Finar vol-II
11niper jee syllabus

12. Pharmacology and toxicology:-
• Approximately 25% questions are asked
from pharmacology, which mainly
includes molecular pharmacology,
classification, MOA, specific side effects
(like Steven Johnson syndrome, Jarisch-
Herxheimer reaction, Lepra reaction,
Gray baby syndrome etc.) drug
interaction and contraindications.
12niper jee syllabus

13. I- Basics
1) Pharmacokinetics, pharmacodynamics, pharmacological effect,
desired, undesired, toxic, adverse effects, tachyphylaxis, drug
dependence.
2) Bioavailability, bioequivalence, various factors of ADME. (From
Bramhankar)
3) Drug metabolism: various pathways and other details.
4) Drug interactions, agonist, antagonist, partial agonist, protein
binding, drug distribution, distribution volume, excretion
pathways etc. 13niper jee syllabus

14. 5) Pharmacological screening: general principles,
various screening models, screening
methodologies (in vitro and in vivo tests).
Bioassay methods, various requirements. Brief
knowledge of the statistical tests.
6) Mechanism of drug action, drug-receptor
interaction. Various adrenergic, cholinergic and
other receptors
14niper jee syllabus

15. • II. Detailed study of CNS pharmacology
• III. Others
1) Neuroscience: neurodegenerative disorders
(AD,PD, HD, ALS, stroke) and other CNS
related diseases
2) CVS , toxicology, blood , GPCR and glutamate
receptors
3) Cancer, diabetes, endocrinology and other
metabolic disorders
15niper jee syllabus

16. 4) Gel electrophoresis and SDS page,
immunohistochemistry (dye's)
5) Chemotherapy (mainly malaria, TB)
6) Autophagy, apopotosis, excitotoxicity,
oxidative stress, inflammation etc.
16niper jee syllabus

17. References:
1. Rang and Dale (all chemotherapy classes of drugs.
If you read the whole book, then nothing else is
needed)
2. New drugs included in KDT
3. F. S. K. Barar
4. Wilson and Griswold (for Mechanism)
5. Kasture (for Bioassay and Screening)
6. Goodman & gillman
17niper jee syllabus

18. Microbiology:-
•Staining techniques,
vaccines (Especially storage),
basics of HIV, Influenza and
cancer (Role of virus)
18niper jee syllabus

19. Pharmaceutics and formulation
(Pharmaceuticl Technology):-
1) Drug delivery systems (DDS): NDDS models, osmotic
pumps, various release patterns eg. Controlled release,
delayed release. Sustained release etc order of release.
Oral controlled DDS, factors affecting controlled release.
Carriers in DDS: polymers and their classification, types,
carbohydrates, surfactants, proteins, lipids, prodrugs etc.
2) Transdermal drug delivery systems (TDDS): principles,
absorption enhancers, evaluation of TDDS.
3) Parenterals: requirements, advantages, disadvantages,
release pattern, route of drug delivery. Drug targeting:
microspheres, nano particles, liposomes, monoclonal
antibodies, etc.
19niper jee syllabus

20. 4) Preformulation detailed.Complexation,
solubilization, polymerization, viscosity
measurements. Dosage form development-
stages, implications of dosage form.
5) Additives of formulation, types, examples,
advantages, disadvantages, drug excipient
interaction, incompatibility, various types of
incompatibilities.
6) Dosage forms: solid (tablets, capsules, pills etc),
liquid (emulsion, suspension etc), sterile
(injectables), aerosols. Principles, advantages,
disadvantages and problems. Coating - in detail.
20niper jee syllabus

21. 7) Packaging: materials, labeling etc. Types of
containers (e.g. Tamper-proof containers) In
process controls, Product specification,
documentation.
8) Compartmental modeling. (From Bramhankar)
9) Bioavailability, bioequivalence studies. Methods
of improvement of oral bioavailability.
Evaluation of formulation, principles and
methods of release control in oral formulations.
21niper jee syllabus

22. References:
1. Lachmann (ALL new and old techniques in
Pharmaceutical Industry)
2. Alfred Martin (ALL physical chemistry BASICS)
3. Remington’s Pharmaceutical Sciences
(Parentrals)
4. Banker series.
5. Other: Bramhankar(Dissolution
chapter),Liberman Series
22niper jee syllabus

23. Jurisprudence:-
•All schedules, Various
years, Committee, Some
basic knowledge of IPR
23niper jee syllabus

24. Analysis
1. UV & visible spectroscopy:
• Basic principle, characteristic regions of
spectrum, energy levels (Nomenclatures) &
selection rules, woodward – fieser , fieser-kuhn
& nelson rule. Influence of substituent, ring
size & strain on spectral characteristics, solvent
effect, non-conjugated interaction ,spectral
correlation with structure , UV- values and
their advancements. (ref. Pavia )
24niper jee syllabus

25. 2. Infrared spectroscopy:-
• Characteristic regions of spectrum,
influence of substituents, ring size,
hydrogen bond, vibrational coupling &
field effect on frequency. Spectral
interpretation, IR - Frequencies of various
groups specially carbonyls and their
advancements. (ref. Pavia and Kemp )
25niper jee syllabus

26. 3. Nuclear magnetic resonance
spectrum:-
Magnetic nuclei, chemical shift & shielding,
relaxation, processes, chemical & magnetic non
equivalence, local diamagnetic shielding,
magnetic anisotropy, spin – spin splitting, pascal
triangle, coupling constant, C-13 NMR and other
advancements. (ref. Pavia and Kemp)
26niper jee syllabus

27. 4. Mass Spectroscopy
• Basic concepts about various peaks M+1,
molecular ion, base peak etc.,
Fragmentation Pattern, and fragments
formed and their advancements.{Mc-
lafferty rearrangement and Tropllium ion
Vimp*} (ref. Pavia, Kemp or Silverstein)
27niper jee syllabus

28. 5. AAS,
• Flama photometry,
• Fluorimetry,
• Nepheloturbidimetry,
• XRD,
• ESR and Raman spectroscopy
28niper jee syllabus

29. 6.Chromatography:-
• General principles (Theoretical plates, HETP, Rf
values, separation factor, Resolution),
classification, normal & reversed phase, bonded
phase, sepration mechanisms.
• Details of every chromatographic method.
Types:
a. Column chromatography.
b. Flash chromatography.
c. Vacuum liquid chromatography.
d. HPLC
29niper jee syllabus

30. e. TLC, HPTLC, OPLC (over pressure layer
chromatography)
f. HPCPC
g. SFC
h. Ion exchange, affinity, size exclusion &
ion pair chromatography, perfusion,
fast protein liquid chromatography
i. GC, GC-MS, LC- MS.
30niper jee syllabus

31. 7. Titrimetry and related
techniques:
• Neutralization, Redox titration,
Complexometric, Precipitation, Gravimetry,
Potentiometry, conductometry,
Polarography, Amperometry, Coulometry,
Karl- Fischer, Oxygen flask, Kjeldahl, etc
(particularly basic principal)
31niper jee syllabus

32. 6. Thermal techniques: DSC, DTA, TGA,
TMA .
7. ORD-CD.
8. Electrophoresis: Capillary, Gel.
9. Other: Crystallography 32niper jee syllabus

33. • Stability testing of pharmaceuticals, various
stability tests, kinetic studies, shelf life
determination, thermal stability, formulation
stability.
• Various analytical techniques
• Tests: physical and chemical tests, limit tests,
microbiological tests, biological tests, disintegration
and dissolution tests. Particle sizing: law of
diffraction.
• QA and QC: GLP, TQM, ISO system.
33niper jee syllabus

34. References:
1. Willard
2. Silverstein (Mass Spectroscopy)
3. William Kemp (NMR)
4. Pavia (for spectroscopy)
5. Others like Alfred Martin, Garry Christen
(Chemical Methods)
34niper jee syllabus

35. Biotechnology:, Pharmaceutical
technology biotechnology:-
• Genetic Engg: Gene expression, mutation,
replication, transcription, translation,
recombination, bacteriophages. Cloning:
methods, isolation of nucleic acids, enzymes in
cloning (restriction endonucleases, DNA ligase,
DNA gyrase, polymerases etc...), functions of
these enzymes, Pallindromes.
35niper jee syllabus

36. • Fermentation: fermenters, fermentation
process, its regulation, conditions,
bioprocessors, various enzymes in fermentation
technology.
• Fermentation of Antibiotics, vitamins, amino
acids, hydroxy acids such as lactic acid etc.
• Chemical engg. aspects realated to fermentation
36niper jee syllabus

37. • Gene therapy: methods and applications.
• Monoclonal antibodies, insulin,
interferons, enkephalins, angiotensin
analogues and other peptides.
• References:
• 1. Vyas and Dixit
• 2. IP Appendices
37niper jee syllabus

38. Practice of Pharmacy:-
• Remington’s Pharmaceutical Sciences. This
branch is quite new here, so till dates students
of branch used to do case study of prescriptions
in Fortis hospital, PGI Chandigarh and govt.
college chd... This is much like pharmacology
and drug-drug interactions and different
interactions are emphasized. Diabetes, heart
diseases are main area of study……….
38niper jee syllabus

39. Pharmacoinformatics:-
• Terminologies related with new
emerging informatics e.g. proteomics,
genomics, QSAR (2D, 3D, regression,
correlation). Specially which software is
used for what purpose? (QSAR chapter
from Bothra)
39niper jee syllabus

40. References:
• Foye, Williams and Lemke,
Medicinal chemistry, 5th/6th
edition, chapter 1 6.
(Computational drug design
and molecular modeling).
40niper jee syllabus

41. Others:
• Statistics, general mathematics
and aptitude questions. Use
MBA entrance test books like
CET or CAT in MBA. Additionally
some general awareness
questions.
41niper jee syllabus

42. NIPER’s thrust areas are:-
• Microbial and viral diseases: Yeast, and fungi.
• Parasitic and tropical diseases: Malaria,
Leishmaniasis, amoebiasis, etc.
• Metabolic Disorders: Diabetes
• Strokes
• Peptide and carbohydrate chemistry.
• Genomics and proteomics: yeast and fungi
• Hormonal disorders: TRH related diseases.
*Tuberculosis
42niper jee syllabus

43. Biostatistics:- (Only surface)
1. Introduction
• data collection, organization, central
tendency dispersion , sampling techniques ,
sample size, coefficient of variation , mean
error, relative error, precision , accuracy .
2. Probability
• definition , normal, binominal polynominal
distribution ,fiducial limits , pofit & loss
analysis. 43niper jee syllabus

44. 3. Regression
• linear , multiple regression ,correlation
concept . parametric / non parametric test
:chi-square , sign , wilcoxon sign rank,
goodness of fit. mann-whitney test .
4. Expeimental design
• factorial design , latin square
design,crossover & parallel design
• *Basics of ANOVA
44niper jee syllabus

45. General study
1. English- Synonyms, Antonyms,
phrases etc. (very easy)
2. I.Q. test- problem
fig.,numerical (Series) etc. (Just
apply logic)
45niper jee syllabus

46. 3. General Knowledge- Dolly clone in which
yr, about sports (current information),
current affairs (Simple and especially in
field of medicine, Business event of
pharmacy)
• About statue of unity
• Name of various CSIR lab /their location.
46niper jee syllabus

47. • Noble prize winner?
• About Famous scientist like Father of
modern pharmacology, father of
modern anesthesia, Chemotherapy
word is given by, Alexander fleming,
Louis Pasteur etc and other scientist
like Stephan Hawking
47niper jee syllabus

48. Some very important topics and
questions
• Ramachandran plot, hanz plot, structure of
proteins,docking
• definition of software COMfa – molecular
mechanics , molecular dynamics
• QSAR, hammett equation, Hansch analysis, Free
Wilson model, Docking study, Pre ADMET tool
48niper jee syllabus

49. • Name organic chemistry reactions
• NIPER MBA programme: private fund, bank
account, public account, credit and debt,
mutual fund, number. of members in public,
private and government company. cooperative
and joint sector,(right now its 85 % to ur nipper
score and 15 % to your G.D. and P.I. ,there
prepare for the group discussion and personnel
interview.
49niper jee syllabus

50. It always seems impossible until
it’s done
50niper jee syllabus