Vaginal route of administration by Sandeep Mewada

1. VAGINAL ROUTE OF
ADMINISTRATION
Sandeep Mewada

2. Novel concept in vaginal drug delivery
• NVDDS are designed with desirable
• distribution, bio adhesive, retention and
• release characteristic.

4. ADVANTAGES
• Ease of administration
• Reduce side effects
• Avoids first pass metabolism
• Effective for orally inactive drugs
• High vascularization
• Low enzymatic activity.

5. DISADVANTAGES
• Local irritation of some drugs
• Personal hygiene
• Gender specificity
• Influence of sexual intercourse
• Cultural sensitivity
• Some of drugs are sensitive to vaginal pH. 37

6. RECENT ADVANCES IN VAGINAL DRUG
DELIEVRY
• Achieved by the use of bio adhesive and other
novel delivery system

7. Bio adhesives delivery systems
• Bio adhesive vaginal formulations that are
capable of delivering the active agent for an
extended period at a predictable rate

8. Other novel delivery systems
• Phase change polymers
• Formulations based on a thermoplastic graft co
polymer

9. Evaluation Of Vaginal Formulations
In vivo studies
In Vitro studies
Recent developments
Effervescent vaginal tablets of nystatin
Bio adhesive effervescent
ketoconazole tablets

10. APPLICATIONS OF INTRA VAGINAL
DRUG DELIEVERY SYSTEM
• Vaginal immunization
• Treatment of HIV infection
• Treatment of local fungal infection
• Delivery of hormones
• Multi-cycle administration of vaginal
contraceptive rings

11. Vaginal ring
• Vaginal rings are 'doughnut-shaped' polymeric drug
delivery devices designed to provide controlled release of
drugs to the vagina over extended periods of time.
• Several vaginal ring products are currently available,
including:
Femring :
• a low-dose estradiol-acetate releasing ring, manufactured
from silicone elastomer, for the relief of hot flashes and
vaginal atrophy associated with menopause.
NuvaRing:
• a low-dose contraceptive vaginal ring, releasing
progesterone and estrogen.