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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Neurons:
Cellular and Network Properties
• Neurons:
Cellular and Network Properties
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
• Positive feedback loop
• Absolute refractory period
• Relative refractory period
Regulating the AP
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Regulating the AP
Figure 8-11: Ion movements during the action potential
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Regulating the AP
Figure 8-12: Refractory periods
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
• Firing rate
• "Wave" of APs
• Proportional neurotransmitter (NT) release
• Stronger GP initiates more APs & more NT
Frequency of Action Potentials
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Frequency of Action Potentials
Figure 8-13: Coding for stimulus intensity
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
• Kinetic energy
• Depolarizes ahead
• Drives AP to terminal
Conduction of Action Potentials
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Conduction of Action Potentials
Figure 8-14a: Conduction of action potentials
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Conduction of Action Potentials
Figure 8-14b: Conduction of action potentials
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Conduction of Action Potentials
Figure 8-14c: Conduction of action potentials
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
• Larger diameter faster conduction
• Myelinated axon faster conduction
• Salutatory conduction
• Disease damage to myelin
• Chemicals that block channels
• Alteration of ECF ion concentrations
Speed of Conduction
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Speed of Conduction
Figure 8-16b: Axon diameter and speed of conduction
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Speed of Conduction
Figure 8-17: Saltatory conduction
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Cell to Cell Conduction: the Synapse
• Electrical synapses: gap junctions
• Very fast conduction
• Example: cardiac muscle
• Chemical synapses
• Pre synaptic terminal
• Synthesis of Neurotransmitters
• Ca2+
releases Neurotransmitters
• Synaptic cleft
• Postsynaptic cell: Neurotransmitter receptors
PLAY Animation: Nervous System II: Anatomy Reviewvisit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Cell to Cell Conduction: the Synapse
Figure 8-19: A chemical synapse
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Synapse Mechanism
Figure 8-20: Events at the synapse
PLAY Animation: Nervous System II: Synaptic Transmissionvisit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Acetylcholine synthesis
Figure 8-21: Synthesis and recycling of acetylcholine at the synapse
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
• Neurotransmitters
• Neuromodulators
• Neurohormones
Neurocrines
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Neurocrines
Table 8-4-1: Major Neurocrines
visit us www.dentaltutor.in
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Neurocrines
Table 8-4-2: Major Neurocrines
visit us www.dentaltutor.in

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Neurons

  • 1. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Neurons: Cellular and Network Properties • Neurons: Cellular and Network Properties visit us www.dentaltutor.in
  • 2. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings • Positive feedback loop • Absolute refractory period • Relative refractory period Regulating the AP visit us www.dentaltutor.in
  • 3. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Regulating the AP Figure 8-11: Ion movements during the action potential visit us www.dentaltutor.in
  • 4. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Regulating the AP Figure 8-12: Refractory periods visit us www.dentaltutor.in
  • 5. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings • Firing rate • "Wave" of APs • Proportional neurotransmitter (NT) release • Stronger GP initiates more APs & more NT Frequency of Action Potentials visit us www.dentaltutor.in
  • 6. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Frequency of Action Potentials Figure 8-13: Coding for stimulus intensity visit us www.dentaltutor.in
  • 7. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings • Kinetic energy • Depolarizes ahead • Drives AP to terminal Conduction of Action Potentials visit us www.dentaltutor.in
  • 8. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Conduction of Action Potentials Figure 8-14a: Conduction of action potentials visit us www.dentaltutor.in
  • 9. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Conduction of Action Potentials Figure 8-14b: Conduction of action potentials visit us www.dentaltutor.in
  • 10. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Conduction of Action Potentials Figure 8-14c: Conduction of action potentials visit us www.dentaltutor.in
  • 11. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings • Larger diameter faster conduction • Myelinated axon faster conduction • Salutatory conduction • Disease damage to myelin • Chemicals that block channels • Alteration of ECF ion concentrations Speed of Conduction visit us www.dentaltutor.in
  • 12. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Speed of Conduction Figure 8-16b: Axon diameter and speed of conduction visit us www.dentaltutor.in
  • 13. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Speed of Conduction Figure 8-17: Saltatory conduction visit us www.dentaltutor.in
  • 14. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Cell to Cell Conduction: the Synapse • Electrical synapses: gap junctions • Very fast conduction • Example: cardiac muscle • Chemical synapses • Pre synaptic terminal • Synthesis of Neurotransmitters • Ca2+ releases Neurotransmitters • Synaptic cleft • Postsynaptic cell: Neurotransmitter receptors PLAY Animation: Nervous System II: Anatomy Reviewvisit us www.dentaltutor.in
  • 15. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Cell to Cell Conduction: the Synapse Figure 8-19: A chemical synapse visit us www.dentaltutor.in
  • 16. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Synapse Mechanism Figure 8-20: Events at the synapse PLAY Animation: Nervous System II: Synaptic Transmissionvisit us www.dentaltutor.in
  • 17. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Acetylcholine synthesis Figure 8-21: Synthesis and recycling of acetylcholine at the synapse visit us www.dentaltutor.in
  • 18. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings • Neurotransmitters • Neuromodulators • Neurohormones Neurocrines visit us www.dentaltutor.in
  • 19. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Neurocrines Table 8-4-1: Major Neurocrines visit us www.dentaltutor.in
  • 20. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Neurocrines Table 8-4-2: Major Neurocrines visit us www.dentaltutor.in