Addiction is a complex illness caused by changes in the brain due to repeated drug use. Drugs of abuse trigger the brain's reward system by increasing the neurotransmitter dopamine, especially in the nucleus accumbens. Over time, this causes long-lasting changes in other brain systems and behaviors. Current pharmacological treatments aim to manage withdrawal, achieve and maintain abstinence, and reduce harms. Methadone maintenance is effective by occupying opioid receptors and blocking the effects of other opioids. New treatments target other neurotransmitter systems and pathways involved in addiction and relapse.
TREATMENT RESISTANT DEPRESSION IS A AREA THAT IS NOT EXPLORED MUCH, BUT IT REALLY NEEDS LOT OF ATTENTION AS IT IS ONE OF THE MOST COMMON OBSTACLE IN ACHIEVING COMPLETE REMISSION IN DEPRESSION
Reviews the uses for benzodiazepines and barbiturates, the signs of intoxication and withdrawal, impact on sports performance. Continuing Education for mental health and substance abuse counselors and therapists.
Addiction is an old enemy of mankind. Here in this presentation, it is discussed how substances having abuse potential causes temporary and permanent changes to neuronal circuits in our brain.
This presentation is to test the animation of the powerpoint created by Presenter Media templates, to be used for educational purposes, not available for file download by others.
TREATMENT RESISTANT DEPRESSION IS A AREA THAT IS NOT EXPLORED MUCH, BUT IT REALLY NEEDS LOT OF ATTENTION AS IT IS ONE OF THE MOST COMMON OBSTACLE IN ACHIEVING COMPLETE REMISSION IN DEPRESSION
Reviews the uses for benzodiazepines and barbiturates, the signs of intoxication and withdrawal, impact on sports performance. Continuing Education for mental health and substance abuse counselors and therapists.
Addiction is an old enemy of mankind. Here in this presentation, it is discussed how substances having abuse potential causes temporary and permanent changes to neuronal circuits in our brain.
This presentation is to test the animation of the powerpoint created by Presenter Media templates, to be used for educational purposes, not available for file download by others.
Presentation by Dr. Jacob Kagan on addiction psychiatry, covers the neurobiology of addiction, diagnosis and management od dually-diagnosed patients, relapse prevention, psycopharmacology interventions and more. http://www.jacobkaganmd.com
Addiction as a brain disease Brain Imaging in AddictionsRiverMend Health
Gene-Jack Wang, M.D.-
Member, RiverMend Health Scientific Advisory Board for Addiction & Psychiatry
Professor of Radiology, Stony Brook University
Sr. Scientist, Bioscience Department, Brookhaven National Laboratory.
Dr. Gene Wang addresses the RiverMend Heath Scientific Advisory Board on addiction as a brain disease as well as comparing and analyzingy brain scans of addicts to those of non addicts.
To watch lecture: http://vimeo.com/97724513
For more information visit: http://www.rivermendhealth.com/scientific-advisory-board-addiction.html
Amphetamine is a stimulant that is primarily used to treat narcolepsy and attention-deficit hyperactivity disorder. It is also used recreationally as a club drug and as a performance enhancer.
Here is a concise and conceptual view of Drug Addiction,explaining how physiologically and psychologically a person become addict,also what are the chemical changes in which part of brain responsible for addiction.
Hallucinogens are a type of drug that changes a person's perception of reality. Also known as 'psychedelic drugs', hallucinogens make a person see, feel and hear things that aren't real, or distort their interpretation of what's going on around them
Effective treatment for drug addiction in Mindheal Homeopathy clinic ,Chembur...Shewta shetty
"Drug Addiction- drug addiction is characterized by the use of narcotic drugs or alcohol excessively so that when its usage is stopped withdrawal symptoms are manifested in the body. Drug addiction is a complex but treatable condition. It can be treated by proper rehabilitation of the patient along with mindheal therapy."/>
Homeopathic Doctor - Dr. Anita Salunke homeopathic clinic for Drug Addiction ...Shewta shetty
Homeopathic Doctor Anita Salunke practices in Chembur, Mumbai, India in her homeopathic clinic Mindheal. Find more information about homeopathic treatment at Mindheal. Welcome to safe, sure and effective homeopathic treatment Drug Addiction
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
3. ADDICTION IS A COMPLEX ILLNESSADDICTION IS A COMPLEX ILLNESS
4. NIAAA National Epidemiologic Survey on Alcohol and Related Conditions, 2003
Age
Age at tobacco, at alcohol and at cannabis dependence as per DSM IV
0.0%
0.2%
0.4%
0.6%
0.8%
1.0%
1.2%
1.4%
1.6%
1.8%
5 10 15 2125 30 35 40 45 50 55 60 65
%ineachagegroupwhodevelop
firsttimedependence
THC
ALCOHOL
TOBACCO
Addiction is a Developmental Disease
13. 0
50
100
150
200
0 60 120 180
Time (min)
%ofBasalDA
Output
NAc shell
Empty
Box Feeding
Source: Di Chiara et al.
FOOD
100
150
200
DAConcentration(%Baseline)
Mounts
Intromissions
Ejaculations
15
0
5
10
CopulationFrequency
Sample
Number
1 2 3 4 5 6 7 8 9 1011 1213 1415 1617
Female 1 Female 2
Source: Fiorino and Phillips
SEX
The Natural Rewards
14. 0
50
100
150
200
250
F
latency 8'45"± 30"
amount eaten 2± 0.2g
Fonzies naive
0
50
100
150
200
250
F
latency to eat 15"± 0
amount eaten 4± 0.2g
1 day post Fonzies
0 60 120 180 240
0
50
100
150
200
250
F
amount eaten 4.2± 0.2g
latency to eat 22"± 0
5 days post Fonzies
time (min)
%ofbasalDA Time-course of habituation
of NAc shell DA
responsiveness to one trial
Fonzies feeding
Bassareo and Di Chiara,J.Neurosci.1999
15. 0
100
200
300
400
500
600
700
800
900
1000
1100
0 1 2 3 4 5 hr
Time After Amphetamine
%ofBasalRelease
DADOPACHVA
Accumbens
AMPHETAMINE
0
100
200
300
400
0 1 2 3 4 5 hr
Time After Cocaine
%ofBasalRelease
DA
DOPAC
HVA
Accumbens COCAINE
0
100
150
200
250
0 1 2 3 hr
Time After Nicotine
%ofBasalRelease
Accumbens
Caudate
NICOTINE
100
150
200
250
0 1 2 3 4hr
Time After Ethanol
%ofBasalRelease
0.25
0.5
1
2.5
Accumbens
0
Dose (g/kg ip)
ETHANOLETHANOL
Source: Di Chiara and Imperato
The Drugs of Abuse and DA Output
16. Tanda, Pontieri & Di Chiara, Science, 1997
Selective increase of DA in the Nac
shell after i.v.THC and heroin
30. Neurocircuitry of Addiction
Derived from: Koob G, Everitt, B and Robbins T, Reward, motivation, and addiction. In: Squire LR, Berg D, Bloom
FE, du Lac S, Ghosh A, Spitzer NC (Eds.), Fundamental Neuroscience, 3rd edition, Academic Press,
Amsterdam, 2008, pp. 987-1016.
31. Reward Transmitters Implicated in the
Motivational Effects of Drugs of Abuse
Dopamine … “dysphoria”
Opioid peptides ... pain
Serotonin … “dysphoria”
GABA … anxiety, panic attacks
Dopamine
Opioid peptides
Serotonin
GABA
Positive Hedonic
Effects
Negative Hedonic Effects
of Withdrawal
32. Extracellular DA and 5-HT in the Nucleus
Accumbens During Cocaine Self-
Administration and Withdrawal
33. Stress and Anti-stress Neurotransmitters
Implicated in the Motivational
Effects of Drugs of Abuse
Corticotropin-releasing factor
Norepinephrine
Vasopressin
Orexin (hypocretin)
Dynoprhin
Neuropeptide Y
Nociceptin (orphanin FQ)
36. Molecular Targets of Drug Action
??Inhalants
Serotonin receptors
Serotonin receptors
NMDA receptors
NMDA receptors
Hallucinogens
LSD
MDMA
PCP
Ketamine
Dopamine transporters
Dopamine/NE release
Stimulants
Cocaine
Amphetamines
Opioid receptorsOpioids
CannabinoidreceptorsMarijuana/THC
GABA receptors
GABA receptors
Depressants
Barbiturates
Benzodiazepines
Nicotinic Ach receptorNicotine
Adenosine ReceptorsCaffeine
Classes of Drugs Primary Target
NMDA receptors (blocked)
Kainate receptors (blocked)
GABA receptors (stimulated)
Glycine receptors (stimulated)
Nicotinic Ach receptors (stimulated)
Serotonin receptors (stimulated)
Calcium channels (blocked)
Potassium channels (blocked)
Protein Kinase C
Protein Kinase A
DARPP-32
Phosphatases
Neurosteriods
Alcohol Targets
37.
38.
39. The Aims of the Pharmacological
Treatment of Addiction
• The management of the withdrawal syndrome;
• The achiment of abstinence and its maintenance
• The reduction of harms associated with drug use
• The treatment of complications of drug use
40. Principles of Actions
of the Drugs for Addiction
• Agonists e.g. methadone, buprenorphine
• Antagonists e.g. naltrexone
• Inhibitory drugs e.g. disulfiram
42. Marie Nyswander & Vincent P. Dole
Methadone an Example of Serendipidy
43. Heroin Addiction: Functional State of a
Typical Addict
"High"
"Straight"
"Sick"
Days
AM PM AM PM AM
FunctionalState
Dole, Nyswander and Kreek, 1966
(overdose)
(arrows
indicate
times of
injection)
44. Methadone Maintenance: Functional State
of a Former Addict Treated With
Methadone Maintenance
FunctionalState
Dole, Nyswander and Kreek
"High"
"Straight"
"Sick"
AM PM AM PM AM
Days
“Functional state of a patient blockaded with methadone (a single oral dose each
morning). The effect of an intravenous injection of heroin in the blocked patient is shown
in the second day. The dotted line (---) indicates the course if methadone is omitted.”
M M
H
45. Wong et al., 2004
GHB The Anti-Alcohol Agent:
An Italian Discovery
46. New Therapeutic Strategies Against Addiction
• GABAA and GABAB enhancing agents able to contrast alcoholism and
other forms of addiction;
• Nicotine antagonists able to treat tobacco dependency;
• New formulations of opioid-modulating drugs able to favourite the
compliance and the efficacy of the heroin treatment;
• Dopamine D3 receptor antagonists and dopamine-reuptake inhibitors
able to reduce cocaine and psychostimulant
• CB1 cannabinoid antagonists able to reduce cannabis or polydrugs
intake
• Active vaccination against nicotine, cocaine, ect. able to minimize the
harmful drug effects and to alleviate the intoxication state
47.
48. New Therapeutic Agents Against Addiction
•Learning and ant-learning agents (e.g. the glutamatergic agents);
• Agents able to oppose in drug users the switch from a normal to a
dependent state (e.g. the GABA and the cannabinoids);
• Anti-stress agents (e.g. CRF antagonists);
• Molecules able to reduce the sensivity of the reward (e.g. SSRIs,
dopamine antagonists);
• Agents able to act on new pharmacological targets controlling the
drug taking behaviour and relapse (e.g. agonists of the NOP
receptors);
• Gene-silencing or tur-on (gene therapies) of endogenous
compounds (e.g. endorphins, dynorphins or endocannabinoids)