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Muscles ,[object Object],[object Object]
Muscle Functions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Muscle Functions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Muscle Functions ,[object Object],[object Object],All the things muscles do fall under one of these 4 categories.
3 Types of Muscle Tissue
Characteristics of Muscle Tissue ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Characteristics of Muscle Tissue ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Skeletal Muscle – the organ ,[object Object],[object Object]
Skeletal Muscle – the organ ,[object Object],[object Object],[object Object],[object Object]
In this photomicrograph, you should notice: the epimysium on the left, the multiple fascicles, the translucent perimysium partitioning them , and the multiple muscle fibers making up the fascicles.
Skeletal Muscle – Blood & Nerve Supply ,[object Object],[object Object],[object Object]
Skeletal Muscle Attachments ,[object Object],[object Object]
Indirect attachments are typical. The muscle CT extends and forms either a cordlike structure (a  tendon ) or a sheetlike structure ( aponeurosis ) which attaches to the periosteum or perichondrium. Muscle attachments may be direct or indirect . Direct attachments are less common. The epimysium is fused to a periosteum or a perichondrium.
Skeletal Muscle Microanatomy ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Sarcoplasmic Reticulum ,[object Object],[object Object],[object Object]
Myofibrils ,[object Object],[object Object]
 
Myofilaments ,[object Object],[object Object],A single myosin protein resembles 2 golf clubs whose shafts have been twisted about one another About 300 of these myosin molecules are joined together to form a single thick filament
[object Object],[object Object],[object Object],[object Object]
Note the relationship between the thin and thick filaments
Myofibrils ,[object Object],[object Object],[object Object],[object Object],[object Object]
Sarcomere ,[object Object],[object Object],[object Object]
[object Object],[object Object],In the middle of the H zone is a structure called the  M line  which functions to hold the thick filaments to one another
Here we have several different cross sections of a myofibril. Why are they different?
Here is a longitudinal section of skeletal muscle.  See the multiple nuclei (N) pressed against the side of the muscle fibers. The light I bands and dark A bands are labeled for you. What do you think the F stands for?
T-Tubules and the SR ,[object Object],[object Object],[object Object],[object Object]
 
Muscle Contraction:  The Sliding Filament Hypothesis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Here is what happens as the filaments slide and the sarcomere and  the muscle fiber shortens. In the process of contraction, what happens to the:   1. Distance btwn Z discs   2. Length of the A band   3. Length of the H zone   4. Length of the I band
Here are 2 electron micrographs of the same sarcomere.  Do you see the Z discs, A band, H zone, M line, and I bands?  How do the 2 pictures differ?  What happened?
 
Sliding Filaments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Excitation  ,[object Object],[object Object]
Excitation ,[object Object],[object Object],[object Object]
Excitation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Excitation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Excitation ,[object Object],[object Object],The site of interaction btwn a neuron and any other cell is known as a  synapse . The synapse btwn a neuron and a muscle is known as the  neuromuscular junction .
Excitation ,[object Object],[object Object],The synaptic end bulb is filled w/ vesicles that contain the neurotransmitter,  acetylcholine . The motor end plate is chock full of  acetylcholine receptors .
Excitation ,[object Object],[object Object],[object Object]
Excitation ,[object Object],[object Object]
Excitation ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Excitation-Contraction Coupling ,[object Object],[object Object]
Excitation-Contraction Coupling ,[object Object],[object Object],[object Object]
Excitation-Contraction Coupling ,[object Object],The Ca 2+  interacts w/ the 2 regulatory proteins of the sarcomere so that the 2 contractile proteins can slide & the sarcomere can shorten.
Let’s backtrack for just a moment… ,[object Object],[object Object]
Contraction ,[object Object],[object Object]
Contraction ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object]
 
Contraction Strength ,[object Object],[object Object],[object Object],[object Object]
Relaxation ,[object Object],[object Object],[object Object],[object Object]
Relaxation ,[object Object],[object Object],[object Object],This animation shows another way to induce muscle relaxation.  Does it make sense?
QUICK THOUGHT QUESTION:  I n this sculpture, why are the lion’s back legs paralyzed even though they were not injured?
Rigor Mortis ,[object Object]
Muscle Metabolism ,[object Object],[object Object],[object Object]
Resting Muscle and the Krebs Cycle ,[object Object],[object Object],[object Object],[object Object],[object Object]
Krebs Cycle Products ,[object Object],NADH and FADH will enter another series of rxns known as the  Electron Transport Chain .  These rxns occur along the inner membrane of the mitochondrion and they basically consist of the passing of electrons from compound to compound with energy being released each time and used to drive the synthesis of ATP.  The final electron acceptor is oxygen when it combines with 2 hydrogen atoms to yield water.
Krebs Cycle Products ,[object Object],[object Object],[object Object]
ATP Use in the Resting Muscle Cell ,[object Object],[object Object],[object Object],[object Object],[object Object]
Working Muscle ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Working Muscle ,[object Object],[object Object],[object Object],[object Object]
Anaerobic Metabolism ,[object Object],[object Object],[object Object],[object Object]
Anaerobic Metabolism ,[object Object],[object Object],[object Object]
Aerobic Metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object]
Aerobic Metabolism ,[object Object],[object Object],[object Object]
Muscle Fatigue ,[object Object],[object Object],[object Object]
Oxygen Debt ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Whole Muscle Contraction ,[object Object],[object Object],[object Object],[object Object]
 
Phases of the Muscle Twitch ,[object Object],[object Object],[object Object],[object Object],[object Object],Now, let’s look at various types of muscle twitches
Here we have multiple twitches separated by ample time.  Notice that the previous twitch has no effect on a new twitch and that these twitches are similar in size.  This is why we can say that muscle contraction – at least on the level of a single fiber – is an  all-or-none event .  The black arrows signify stimulation
Here, we have an initial stimulation and resulting twitch all by itself.  Then we have 2 stimuli in somewhat rapid succession.  The 2 nd  twitch has added on to the first.  This is known as  wave or temporal summation .  It occurs because there is still calcium from the 1 st  twitch in the sarcoplasm at the time of the 2 nd  twitch.
[object Object],[object Object],[object Object],[object Object],[object Object],Btwn stimulations,  only the tiniest bit of relaxation occurs.  Since some relaxation does occur, we say the tetanus is  unfused  or incomplete. Most muscle actions occur as a result of muscle fibers undergoing asynchronous, unfused tetanus
Here, the stimuli are close enough to one another so that tetanus is complete and no relaxation occurs until fatigue sets in.
Here we have the phenomenon known as  treppe  (German for staircase).  Notice that the subsequent contractions grow stronger.  There 2 reasons for this: 1. Slight increase in sarcoplasmic [Ca2+] 2.  Heat liberated by working muscle increases the  rate and efficiency of enzyme function within the  muscle  fiber.
Motor Units ,[object Object],[object Object],[object Object],[object Object],[object Object],Notice that the muscle fibers of a single unit are not clustered together but are spread out.  What’s the advantage to this?
Graded Responses  ,[object Object],[object Object],[object Object],Thought problem:  compare the act of picking up a pencil with the act of picking up a desk
Internal vs. External Tension ,[object Object],[object Object],[object Object]
Types of Contractions ,[object Object],[object Object],[object Object],[object Object],[object Object]
Isotonic Contraction ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Resistance and Speed of Contraction ,[object Object],[object Object],[object Object]
Isometric Contractions ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Muscle Tone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Muscle Fiber Types ,[object Object],[object Object],[object Object]
Slow Fibers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Fast Fibers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Thought questions:  why do chickens have white breast meat and dark leg meat?  What does this say about the activities of the associated muscles?  Why do ducks have dark breast meat?
Myasthenia Gravis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Muscular Dystrophy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Here is a slide of skeletal muscle from someone with DMD.  Look how much connective tissue there is.  Lots of adipose tissue too.  Why do you think there’s so much?
Other Important Terms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other Important Terms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other Important Terms ,[object Object],[object Object],[object Object],[object Object],[object Object]
Smooth Muscle ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Smooth Muscle ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Smooth Muscle ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Smooth Muscle ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Smooth Muscle  Contraction  ,[object Object],[object Object]
Smooth Muscle  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Smooth Muscle Contraction ,[object Object],[object Object],[object Object],[object Object]
Smooth Muscle Contraction ,[object Object],[object Object],[object Object],[object Object]
Smooth muscle relaxation: Calcium is pumped out of the cell, which decreases the amount of active  calmodulin which decreases the  amount of active MLCK which  decreases the number of crossbridges. Relaxation can occur subsequent to contraction  or  at any time if anything causes a decrease in the calcium  permeability of the smooth muscle cell. Why are calcium channel blockers given to people with hypertension?
Types of Smooth Muscle ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Single Unit Smooth Muscle ,[object Object],[object Object],[object Object]
Single Unit Smooth Muscle ,[object Object],[object Object],[object Object]
Multi-Unit Smooth Muscle ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiac Muscle ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Notice the branching and the intercalated disc, indicated by the blue arrow.

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Muscle Ppt

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  • 5. 3 Types of Muscle Tissue
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  • 10. In this photomicrograph, you should notice: the epimysium on the left, the multiple fascicles, the translucent perimysium partitioning them , and the multiple muscle fibers making up the fascicles.
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  • 13. Indirect attachments are typical. The muscle CT extends and forms either a cordlike structure (a tendon ) or a sheetlike structure ( aponeurosis ) which attaches to the periosteum or perichondrium. Muscle attachments may be direct or indirect . Direct attachments are less common. The epimysium is fused to a periosteum or a perichondrium.
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  • 21. Note the relationship between the thin and thick filaments
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  • 25. Here we have several different cross sections of a myofibril. Why are they different?
  • 26. Here is a longitudinal section of skeletal muscle. See the multiple nuclei (N) pressed against the side of the muscle fibers. The light I bands and dark A bands are labeled for you. What do you think the F stands for?
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  • 30. Here is what happens as the filaments slide and the sarcomere and the muscle fiber shortens. In the process of contraction, what happens to the: 1. Distance btwn Z discs 2. Length of the A band 3. Length of the H zone 4. Length of the I band
  • 31. Here are 2 electron micrographs of the same sarcomere. Do you see the Z discs, A band, H zone, M line, and I bands? How do the 2 pictures differ? What happened?
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  • 57. QUICK THOUGHT QUESTION: I n this sculpture, why are the lion’s back legs paralyzed even though they were not injured?
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  • 76. Here we have multiple twitches separated by ample time. Notice that the previous twitch has no effect on a new twitch and that these twitches are similar in size. This is why we can say that muscle contraction – at least on the level of a single fiber – is an all-or-none event . The black arrows signify stimulation
  • 77. Here, we have an initial stimulation and resulting twitch all by itself. Then we have 2 stimuli in somewhat rapid succession. The 2 nd twitch has added on to the first. This is known as wave or temporal summation . It occurs because there is still calcium from the 1 st twitch in the sarcoplasm at the time of the 2 nd twitch.
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  • 79. Here, the stimuli are close enough to one another so that tetanus is complete and no relaxation occurs until fatigue sets in.
  • 80. Here we have the phenomenon known as treppe (German for staircase). Notice that the subsequent contractions grow stronger. There 2 reasons for this: 1. Slight increase in sarcoplasmic [Ca2+] 2. Heat liberated by working muscle increases the rate and efficiency of enzyme function within the muscle fiber.
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  • 95. Thought questions: why do chickens have white breast meat and dark leg meat? What does this say about the activities of the associated muscles? Why do ducks have dark breast meat?
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  • 109. Smooth muscle relaxation: Calcium is pumped out of the cell, which decreases the amount of active calmodulin which decreases the amount of active MLCK which decreases the number of crossbridges. Relaxation can occur subsequent to contraction or at any time if anything causes a decrease in the calcium permeability of the smooth muscle cell. Why are calcium channel blockers given to people with hypertension?
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