Molbiol 2011-03-biochem
•Download as PPT, PDF•
0 likes•463 views
The document discusses the main types of biological macromolecules - proteins, carbohydrates, lipids, and nucleic acids. It provides details on their structures, functions and examples of each type of macromolecule. The key macromolecules discussed are proteins, which are composed of amino acids, and nucleic acids like DNA and RNA, which provide genetic instructions and are made of nucleotides containing nitrogen bases. Energy production in cells is also summarized, with ATP being generated through substrate-level phosphorylation or chemiosmosis using electron transport chains.
Report
Share
Report
Share
![Биологические макромолекулы ,[object Object],[object Object],[object Object],[object Object]](https://image.slidesharecdn.com/molbiol-2011-03-biochem-120101033113-phpapp02/85/Molbiol-2011-03-biochem-1-320.jpg)
![Organic Compounds ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
Recommended
Lec 2 level 3-nu(structure of protein)
Proteins have four levels of structural organization: primary, secondary, tertiary, and quaternary. The primary structure refers to the linear sequence of amino acids in the polypeptide chain. Secondary structure involves local folding patterns like alpha helices and beta sheets. Tertiary structure describes the overall 3D shape of a single polypeptide chain. Quaternary structure is the 3D structure formed by the assembly of multiple polypeptide subunits. The structures at each level are stabilized by interactions between the R groups of amino acids in the chain.
Research paper comparing alcohol dehydrogenase
The document analyzes and compares the protein structures of AdhA and Adh1 alcohol dehydrogenases to understand their differing catalytic efficiencies in isobutanol production. AdhA is a dimer composed of 339 residue monomers with catalytic and coenzyme-binding domains, while Adh1 is a tetramer of 347 residue monomers. Their active sites contain different coordinating amino acids. AdhA has a lower Km and higher catalytic efficiency than Adh1, suggesting differences in substrate, cofactor, and amino acid interactions affect bioefficiency. Mutagenesis studies show some AdhA residues impact isobutanol production when altered.
Proteins
Some reagents or conditions that can cause protein denaturation include:
- High or low pH (acids and bases)
- Heat
- Detergents
- Organic solvents (alcohol, acetone)
- Heavy metals (salts of heavy metals like copper, mercury)
- Radiation (UV light, X-rays)
Amino acids
This document provides information on amino acids and protein structure. It begins by introducing amino acids as the building blocks of proteins. It then discusses the structures of amino acids and different classifications based on their R groups. Next, it covers properties of amino acids and how they ionize in solution. The document also discusses peptides, proteins, and different types of proteins classified by function. Finally, it describes the primary, secondary, tertiary, and quaternary levels of protein structure and provides examples to illustrate each level of structure.
AMINO ACIDS AND PROTEINS, DENATURATION OF PROTEINS
Amino acids and proteins, denaturation of proteins, primary secondary and tertiary structure of proteins
Lecture 2 3 protein chemistry
Proteins are composed of amino acids linked by peptide bonds. There are four levels of protein structure: primary, secondary, tertiary, and quaternary. The primary structure is the linear sequence of amino acids. Secondary structures form based on hydrogen bonding patterns between amino acids. The two main secondary structures are the alpha helix, where amino acids coil into a helical shape, and the beta sheet, where amino acids align into beta strands connected by hydrogen bonds.
Classif. amino acids proteins
Amino Acids are the building units of proteins. Proteins are polymers of amino acids linked together by what is called
“ Peptide bond”.
Chap 11
This document provides an overview of the general physical and chemical properties of proteins. It discusses their color, taste, shape, size, molecular weight, colloidal nature, denaturation, amphoteric properties, ion binding capacity, solubility, and optical activity. Key points include that proteins are typically colorless and tasteless, range in size and shape, have large molecular weights between 5,000-1,000,000 Daltons, exhibit colloidal properties, can be denatured by various physical and chemical agents, have isoelectric points where their net charge is zero, and are typically levorotatory.
Recommended
Lec 2 level 3-nu(structure of protein)
Proteins have four levels of structural organization: primary, secondary, tertiary, and quaternary. The primary structure refers to the linear sequence of amino acids in the polypeptide chain. Secondary structure involves local folding patterns like alpha helices and beta sheets. Tertiary structure describes the overall 3D shape of a single polypeptide chain. Quaternary structure is the 3D structure formed by the assembly of multiple polypeptide subunits. The structures at each level are stabilized by interactions between the R groups of amino acids in the chain.
Research paper comparing alcohol dehydrogenase
The document analyzes and compares the protein structures of AdhA and Adh1 alcohol dehydrogenases to understand their differing catalytic efficiencies in isobutanol production. AdhA is a dimer composed of 339 residue monomers with catalytic and coenzyme-binding domains, while Adh1 is a tetramer of 347 residue monomers. Their active sites contain different coordinating amino acids. AdhA has a lower Km and higher catalytic efficiency than Adh1, suggesting differences in substrate, cofactor, and amino acid interactions affect bioefficiency. Mutagenesis studies show some AdhA residues impact isobutanol production when altered.
Proteins
Some reagents or conditions that can cause protein denaturation include:
- High or low pH (acids and bases)
- Heat
- Detergents
- Organic solvents (alcohol, acetone)
- Heavy metals (salts of heavy metals like copper, mercury)
- Radiation (UV light, X-rays)
Amino acids
This document provides information on amino acids and protein structure. It begins by introducing amino acids as the building blocks of proteins. It then discusses the structures of amino acids and different classifications based on their R groups. Next, it covers properties of amino acids and how they ionize in solution. The document also discusses peptides, proteins, and different types of proteins classified by function. Finally, it describes the primary, secondary, tertiary, and quaternary levels of protein structure and provides examples to illustrate each level of structure.
AMINO ACIDS AND PROTEINS, DENATURATION OF PROTEINS
Amino acids and proteins, denaturation of proteins, primary secondary and tertiary structure of proteins
Lecture 2 3 protein chemistry
Proteins are composed of amino acids linked by peptide bonds. There are four levels of protein structure: primary, secondary, tertiary, and quaternary. The primary structure is the linear sequence of amino acids. Secondary structures form based on hydrogen bonding patterns between amino acids. The two main secondary structures are the alpha helix, where amino acids coil into a helical shape, and the beta sheet, where amino acids align into beta strands connected by hydrogen bonds.
Classif. amino acids proteins
Amino Acids are the building units of proteins. Proteins are polymers of amino acids linked together by what is called
“ Peptide bond”.
Chap 11
This document provides an overview of the general physical and chemical properties of proteins. It discusses their color, taste, shape, size, molecular weight, colloidal nature, denaturation, amphoteric properties, ion binding capacity, solubility, and optical activity. Key points include that proteins are typically colorless and tasteless, range in size and shape, have large molecular weights between 5,000-1,000,000 Daltons, exhibit colloidal properties, can be denatured by various physical and chemical agents, have isoelectric points where their net charge is zero, and are typically levorotatory.
33 lec aminoacid peptide biological importance
Amino acids are the building blocks of proteins and peptides. They contain non-polar, polar, and charged R groups. Peptides are formed through condensation reactions between amino acids, linking them through peptide bonds. There are four levels of protein structure - primary, secondary, tertiary, and quaternary. The secondary structure involves folding into alpha helices or beta sheets. The alpha helix is stabilized by hydrogen bonds between residues four places apart in the sequence. Tertiary structure describes the three-dimensional folding of the polypeptide chain. Quaternary structure involves the interaction of multiple polypeptide chains in a protein.
Amino acids, peptides and proteins
This document discusses several topics related to amino acids, peptides, and protein structure:
1. It describes methods for calculating the isoelectric point of amino acids and peptides.
2. It discusses the chirality and optical activity of amino acids, and notes that L-amino acids are used in natural protein synthesis.
3. It differentiates between alpha and beta amino acids and notes their relative stabilities.
4. It outlines several methods for peptide synthesis, including the use of protecting groups and automated peptide synthesis techniques.
5. It briefly summarizes protein primary, secondary, and tertiary structure.
219101 lecture 6
This document provides an overview of protein structure and function. It discusses the four levels of protein structure from primary to quaternary structure. The 20 standard amino acids that serve as building blocks of proteins are described in terms of their chemical and physical properties. Amino acids contain both polar and non-polar side chains that influence protein structure and function. Key concepts covered include protein folding, the zwitterionic nature of amino acids, and interactions like disulfide bonds and hydrophobic effects that stabilize protein tertiary structure.
Amino acids structure
General structure of amino acid
Specific learning objective (SLO): Amino acid as Ampholytes (acid and base), Zwitter ions.
Classification of amino acid on the basis of side chain, chemical composition, Nutritional Requirement and metabolic fate.
Derived amino acids.
Optical properties of amino acids.
Acid-Base properties and Buffer characteristic.
Biological Important Peptides
Proteins based on nutritional value
Campbell6e lecture ch3
- Amino acids are compounds that contain both an amino group and a carboxyl group. They exist in L- and D-stereoisomers and have common 1-letter and 3-letter codes.
- There are 20 standard amino acids that are classified by the properties of their variable side chains into nonpolar, polar, acidic, and basic groups.
- The ionization states of amino acids' functional groups depend on pH and can be calculated using pKa values and the Henderson-Hasselbalch equation.
- Amino acids join together via peptide bonds between amino and carboxyl groups, forming peptides and proteins of various lengths with restricted rotation around the peptide bond.
Biomolecules amino acids and proteins
Proteins are polymers of amino acids and are the most abundant organic molecules in living systems. They perform a variety of essential functions including structural, enzymatic, hormonal, and more. There are 20 standard amino acids that are found in protein structures. Amino acids contain both amino and carboxyl groups and most exist in ionized form in biological systems. Proteins are classified based on their structure and function, with some serving static structural roles and others having dynamic roles like enzymes and hormones. Essential amino acids cannot be synthesized by the body and must be obtained through diet.
Chemistry of Amino Acids (Protein Chemistry - I)
Chemistry of Proteins (Part I) / Chemistry of amino acids for medical, dental, nursing, Paramedical students.
Amino acids and Protein chemistry by Dr. Anurag Yadav
Amino acid chemistry
Protein chemistry
Amino acid & Protein structure, organisation, properties and classification
for MBBS, BDS, MSc, BSc, BPT, Nursing
Youtube: https://youtu.be/CP_PL21mqOc
Peptides
Peptides are formed by the condensation of amino acids through peptide bonds. They have an N-terminus and C-terminus. Peptide bonds have partial double bond character due to resonance, restricting their rotation. The primary structure of proteins can be determined through acid hydrolysis and amino acid analysis. Techniques like ion-exchange chromatography and electrophoresis are used to separate amino acids. Edman degradation and carboxypeptidase digestion help identify terminal residues. Solid phase peptide synthesis improves on solution phase methods.
Chemistry of amino acids
The document provides information about amino acids and their classification. It discusses that amino acids are the monomer units that make up protein polymers. They can be classified based on their structure, side chains, nutritional requirements, and metabolic fate. The 20 standard amino acids are discussed in detail, including their physical and chemical properties. Key reactions of amino acids involving their amino, carboxyl, and side chain groups are also summarized.
Ch02 b.chemistry.mission
This document provides an overview of biochemistry topics including organic compounds, properties of water, salts, acids and bases, carbohydrates, lipids, amino acids, proteins, and protein structure. Key points covered include that organic compounds contain carbon, water has high heat capacity and is a polar solvent, buffers resist pH changes in the body, carbohydrates include sugars and polysaccharides, lipids include fats, phospholipids, and steroids, and proteins are composed of amino acids linked by peptide bonds and have primary, secondary, tertiary, and quaternary structure.
Chapter 12 amino acids and proteins
This document summarizes key points about amino acids and proteins from Chapter 12. It discusses the structure of amino acids, including α-amino acids. It covers IUPAC naming of amino acids, classification as acidic, basic, or neutral, and physical properties like optical activity and zwitterion formation. The document also describes reactions of amino acid functional groups, formation of peptides through amide bonds, and important applications of amino acids and proteins in the human body.
Proteins and Amino Acids
Proteins are composed of amino acids and have four levels of structure - primary, secondary, tertiary, and quaternary. The primary structure is the amino acid sequence. Common secondary structures include alpha helices and beta pleated sheets formed by hydrogen bonding. Tertiary structure describes the overall 3D shape formed by interactions between amino acid side chains. Globular proteins fold such that hydrophobic residues are buried inside and hydrophilic residues face outward, while fibrous proteins form insoluble fibers.
Classification of amino acids
L-amino acids are the monomer units that make up the polypeptide chains of proteins. Short amino acid polymers called peptides also play important roles as hormones, hormone-releasing factors, neuromodulators, or neurotransmitters. There are 20 standard amino acids that are the basic building blocks of proteins in the human body. Amino acids can be classified in different ways, including by their structure, side chain properties, nutritional requirements, and metabolic fate.
PROTEIN STRUCTURE AND BIOLOGICALLY IMPORTANT PEPTIDES
1. Primary structure of proteins refers to the linear sequence of amino acids in a polypeptide chain connected by peptide bonds. Peptide bonds are covalent and rigid, adopting a planar trans configuration.
2. Glutathione is a tripeptide that contains a sulfhydryl group and plays an important role in detoxification reactions in the body by conjugating with toxins and metabolites.
3. Denaturation refers to the loss of tertiary and quaternary structure in a protein resulting in changes to its physical and chemical properties, such as decreased solubility and activity, though the primary structure remains intact. Denaturation can be caused by physical factors like heat or chemicals and is usually irreversible
Lipid & protein metabolism
1) Lipids and proteins are metabolized through multi-step processes in the body. Lipids undergo absorption, lipolysis, beta-oxidation, and ketogenesis. Proteins are broken down through transamination and oxidative deamination.
2) Beta-oxidation of fatty acids in the mitochondria generates acetyl-CoA which enters the Krebs cycle to produce energy. Ketone bodies are formed from acetyl-CoA when carbohydrate intake is low.
3) Protein metabolism involves transferring amino groups through transamination and removing them via oxidative deamination, providing substrates for other metabolic pathways. The carbon skeletons are used for energy or substrate production.
Proteins, Amino Acids and Peptides - A Review
The document discusses amino acids, which are the building blocks of proteins. It describes that amino acids contain both an amino group and a carboxyl group and exist in different ionized forms depending on pH. There are 20 standard amino acids that make up proteins in humans. Amino acids can undergo various chemical reactions due to these functional groups and are also classified based on the polarity of their side chains.
Characteristics and Properties of Amino Acids (AA)
Amino acids have several key properties:
1. They are amphoteric, taking on positive, negative, or neutral charges depending on pH. Their isoelectric point is when the net charge is neutral.
2. They have acidic and basic groups that allow them to undergo various chemical reactions like esterification, acylation, and reactions with carbonyl compounds.
3. When heated to high temperatures during cooking, amino acids can form mutagenic and potentially toxic compounds like acrylamide or heterocyclic amines. The Maillard reaction and Strecker degradation play important roles in these processes.
Chemistry of amino acids
The document discusses biochemistry for medics and provides information on amino acids. It defines that amino acids are the monomer units that make up protein polypeptides and participate in various cellular functions. It classifies amino acids based on structure, side chains, nutritional requirements, and metabolic fate. The document also discusses the structures, properties, reactions and significance of different amino acids. Testing methods to identify specific amino acids are also outlined.
MolBiol #6-7
The document discusses chromosomes, mitosis, meiosis, and apoptosis. It describes how chromosomes contain DNA and replicate during cell division. Mitosis produces genetically identical daughter cells, while meiosis results in gametes with half the number of chromosomes to allow fertilization. Apoptosis is programmed cell death that occurs through caspase activation and mitochondrial cytochrome c release, triggered by DNA damage or external death signals.
Biotech 2011-03-prokaryotic-genes
This document provides an overview of microbial genetics, including definitions of key terms like genes, genomes, genotypes, and phenotypes. It describes DNA as a double-stranded polymer made of nucleotides that carries genetic information. The flow of genetic information from DNA to RNA to protein is explained. DNA replication and transcription are summarized as semiconservative processes where DNA makes an identical copy of itself or RNA to encode proteins, respectively.
More Related Content
What's hot
33 lec aminoacid peptide biological importance
Amino acids are the building blocks of proteins and peptides. They contain non-polar, polar, and charged R groups. Peptides are formed through condensation reactions between amino acids, linking them through peptide bonds. There are four levels of protein structure - primary, secondary, tertiary, and quaternary. The secondary structure involves folding into alpha helices or beta sheets. The alpha helix is stabilized by hydrogen bonds between residues four places apart in the sequence. Tertiary structure describes the three-dimensional folding of the polypeptide chain. Quaternary structure involves the interaction of multiple polypeptide chains in a protein.
Amino acids, peptides and proteins
This document discusses several topics related to amino acids, peptides, and protein structure:
1. It describes methods for calculating the isoelectric point of amino acids and peptides.
2. It discusses the chirality and optical activity of amino acids, and notes that L-amino acids are used in natural protein synthesis.
3. It differentiates between alpha and beta amino acids and notes their relative stabilities.
4. It outlines several methods for peptide synthesis, including the use of protecting groups and automated peptide synthesis techniques.
5. It briefly summarizes protein primary, secondary, and tertiary structure.
219101 lecture 6
This document provides an overview of protein structure and function. It discusses the four levels of protein structure from primary to quaternary structure. The 20 standard amino acids that serve as building blocks of proteins are described in terms of their chemical and physical properties. Amino acids contain both polar and non-polar side chains that influence protein structure and function. Key concepts covered include protein folding, the zwitterionic nature of amino acids, and interactions like disulfide bonds and hydrophobic effects that stabilize protein tertiary structure.
Amino acids structure
General structure of amino acid
Specific learning objective (SLO): Amino acid as Ampholytes (acid and base), Zwitter ions.
Classification of amino acid on the basis of side chain, chemical composition, Nutritional Requirement and metabolic fate.
Derived amino acids.
Optical properties of amino acids.
Acid-Base properties and Buffer characteristic.
Biological Important Peptides
Proteins based on nutritional value
Campbell6e lecture ch3
- Amino acids are compounds that contain both an amino group and a carboxyl group. They exist in L- and D-stereoisomers and have common 1-letter and 3-letter codes.
- There are 20 standard amino acids that are classified by the properties of their variable side chains into nonpolar, polar, acidic, and basic groups.
- The ionization states of amino acids' functional groups depend on pH and can be calculated using pKa values and the Henderson-Hasselbalch equation.
- Amino acids join together via peptide bonds between amino and carboxyl groups, forming peptides and proteins of various lengths with restricted rotation around the peptide bond.
Biomolecules amino acids and proteins
Proteins are polymers of amino acids and are the most abundant organic molecules in living systems. They perform a variety of essential functions including structural, enzymatic, hormonal, and more. There are 20 standard amino acids that are found in protein structures. Amino acids contain both amino and carboxyl groups and most exist in ionized form in biological systems. Proteins are classified based on their structure and function, with some serving static structural roles and others having dynamic roles like enzymes and hormones. Essential amino acids cannot be synthesized by the body and must be obtained through diet.
Chemistry of Amino Acids (Protein Chemistry - I)
Chemistry of Proteins (Part I) / Chemistry of amino acids for medical, dental, nursing, Paramedical students.
Amino acids and Protein chemistry by Dr. Anurag Yadav
Amino acid chemistry
Protein chemistry
Amino acid & Protein structure, organisation, properties and classification
for MBBS, BDS, MSc, BSc, BPT, Nursing
Youtube: https://youtu.be/CP_PL21mqOc
Peptides
Peptides are formed by the condensation of amino acids through peptide bonds. They have an N-terminus and C-terminus. Peptide bonds have partial double bond character due to resonance, restricting their rotation. The primary structure of proteins can be determined through acid hydrolysis and amino acid analysis. Techniques like ion-exchange chromatography and electrophoresis are used to separate amino acids. Edman degradation and carboxypeptidase digestion help identify terminal residues. Solid phase peptide synthesis improves on solution phase methods.
Chemistry of amino acids
The document provides information about amino acids and their classification. It discusses that amino acids are the monomer units that make up protein polymers. They can be classified based on their structure, side chains, nutritional requirements, and metabolic fate. The 20 standard amino acids are discussed in detail, including their physical and chemical properties. Key reactions of amino acids involving their amino, carboxyl, and side chain groups are also summarized.
Ch02 b.chemistry.mission
This document provides an overview of biochemistry topics including organic compounds, properties of water, salts, acids and bases, carbohydrates, lipids, amino acids, proteins, and protein structure. Key points covered include that organic compounds contain carbon, water has high heat capacity and is a polar solvent, buffers resist pH changes in the body, carbohydrates include sugars and polysaccharides, lipids include fats, phospholipids, and steroids, and proteins are composed of amino acids linked by peptide bonds and have primary, secondary, tertiary, and quaternary structure.
Chapter 12 amino acids and proteins
This document summarizes key points about amino acids and proteins from Chapter 12. It discusses the structure of amino acids, including α-amino acids. It covers IUPAC naming of amino acids, classification as acidic, basic, or neutral, and physical properties like optical activity and zwitterion formation. The document also describes reactions of amino acid functional groups, formation of peptides through amide bonds, and important applications of amino acids and proteins in the human body.
Proteins and Amino Acids
Proteins are composed of amino acids and have four levels of structure - primary, secondary, tertiary, and quaternary. The primary structure is the amino acid sequence. Common secondary structures include alpha helices and beta pleated sheets formed by hydrogen bonding. Tertiary structure describes the overall 3D shape formed by interactions between amino acid side chains. Globular proteins fold such that hydrophobic residues are buried inside and hydrophilic residues face outward, while fibrous proteins form insoluble fibers.
Classification of amino acids
L-amino acids are the monomer units that make up the polypeptide chains of proteins. Short amino acid polymers called peptides also play important roles as hormones, hormone-releasing factors, neuromodulators, or neurotransmitters. There are 20 standard amino acids that are the basic building blocks of proteins in the human body. Amino acids can be classified in different ways, including by their structure, side chain properties, nutritional requirements, and metabolic fate.
PROTEIN STRUCTURE AND BIOLOGICALLY IMPORTANT PEPTIDES
1. Primary structure of proteins refers to the linear sequence of amino acids in a polypeptide chain connected by peptide bonds. Peptide bonds are covalent and rigid, adopting a planar trans configuration.
2. Glutathione is a tripeptide that contains a sulfhydryl group and plays an important role in detoxification reactions in the body by conjugating with toxins and metabolites.
3. Denaturation refers to the loss of tertiary and quaternary structure in a protein resulting in changes to its physical and chemical properties, such as decreased solubility and activity, though the primary structure remains intact. Denaturation can be caused by physical factors like heat or chemicals and is usually irreversible
Lipid & protein metabolism
1) Lipids and proteins are metabolized through multi-step processes in the body. Lipids undergo absorption, lipolysis, beta-oxidation, and ketogenesis. Proteins are broken down through transamination and oxidative deamination.
2) Beta-oxidation of fatty acids in the mitochondria generates acetyl-CoA which enters the Krebs cycle to produce energy. Ketone bodies are formed from acetyl-CoA when carbohydrate intake is low.
3) Protein metabolism involves transferring amino groups through transamination and removing them via oxidative deamination, providing substrates for other metabolic pathways. The carbon skeletons are used for energy or substrate production.
Proteins, Amino Acids and Peptides - A Review
The document discusses amino acids, which are the building blocks of proteins. It describes that amino acids contain both an amino group and a carboxyl group and exist in different ionized forms depending on pH. There are 20 standard amino acids that make up proteins in humans. Amino acids can undergo various chemical reactions due to these functional groups and are also classified based on the polarity of their side chains.
Characteristics and Properties of Amino Acids (AA)
Amino acids have several key properties:
1. They are amphoteric, taking on positive, negative, or neutral charges depending on pH. Their isoelectric point is when the net charge is neutral.
2. They have acidic and basic groups that allow them to undergo various chemical reactions like esterification, acylation, and reactions with carbonyl compounds.
3. When heated to high temperatures during cooking, amino acids can form mutagenic and potentially toxic compounds like acrylamide or heterocyclic amines. The Maillard reaction and Strecker degradation play important roles in these processes.
Chemistry of amino acids
The document discusses biochemistry for medics and provides information on amino acids. It defines that amino acids are the monomer units that make up protein polypeptides and participate in various cellular functions. It classifies amino acids based on structure, side chains, nutritional requirements, and metabolic fate. The document also discusses the structures, properties, reactions and significance of different amino acids. Testing methods to identify specific amino acids are also outlined.
What's hot (19)
Amino acids and Protein chemistry by Dr. Anurag Yadav
Amino acids and Protein chemistry by Dr. Anurag Yadav
PROTEIN STRUCTURE AND BIOLOGICALLY IMPORTANT PEPTIDES
PROTEIN STRUCTURE AND BIOLOGICALLY IMPORTANT PEPTIDES
Characteristics and Properties of Amino Acids (AA)
Characteristics and Properties of Amino Acids (AA)
Viewers also liked
MolBiol #6-7
The document discusses chromosomes, mitosis, meiosis, and apoptosis. It describes how chromosomes contain DNA and replicate during cell division. Mitosis produces genetically identical daughter cells, while meiosis results in gametes with half the number of chromosomes to allow fertilization. Apoptosis is programmed cell death that occurs through caspase activation and mitochondrial cytochrome c release, triggered by DNA damage or external death signals.
Biotech 2011-03-prokaryotic-genes
This document provides an overview of microbial genetics, including definitions of key terms like genes, genomes, genotypes, and phenotypes. It describes DNA as a double-stranded polymer made of nucleotides that carries genetic information. The flow of genetic information from DNA to RNA to protein is explained. DNA replication and transcription are summarized as semiconservative processes where DNA makes an identical copy of itself or RNA to encode proteins, respectively.
Biotech 2011-04-prokaryotic-expression
The document discusses various topics relating to microbial genetics including translation, regulation of gene expression, mutation, genetic transfer and recombination, and plasmids. It describes how translation converts mRNA into proteins using start and stop codons. Regulation of bacterial genes is discussed, including constitutive enzymes that are always expressed and inducible/repressible enzymes that are only expressed when needed. Different types of mutations like base substitutions, frameshifts, and their causes such as radiation are also outlined.
Biotech 2011-06-electrophoresis-blots
1. Electrophoresis separates nucleic acids and proteins by size and charge using agarose or acrylamide gels.
2. Southern blots allow detection of specific DNA sequences by transferring DNA from a gel to a membrane and hybridizing a labeled probe.
3. Restriction fragment length polymorphisms (RFLPs) detect variations in restriction sites between individuals' DNA that can be used for identification.
BioTech #3
This document provides an overview of microbial genetics, including definitions of key terms like genes, genomes, genotypes, and phenotypes. It describes DNA as a double-stranded polymer made of nucleotides that carries genetic information. The flow of genetic information from DNA to RNA to protein is explained. DNA replication and transcription are summarized as semiconservative processes where DNA is copied and transcribed into RNA with the help of enzymes like DNA and RNA polymerase.
Genome Rearrangements
Genome Rearrangements: from Biological Problem to Combinatorial Algorithms (and back) by Pavel Pevzner
Molbiol 2011-11-role of-proteins
Globular proteins are spherical proteins that contain heme as a prosthetic group. Globular heme proteins function as electron carriers, parts of enzyme active sites, and carriers of oxygen and carbon dioxide like hemoglobin and myoglobin. Myoglobin stores oxygen in muscle cells and facilitates oxygen transport between hemoglobin and cells. Hemoglobin transports oxygen in red blood cells through a cooperative binding mechanism between its four heme groups that allows for high oxygen affinity when oxygen levels are high. Both proteins bind oxygen reversibly to their heme groups through interactions with proximal and distal histidine residues.
Viewers also liked (9)
Biotech 2011-11-epigenetic regulation-of_human_development
Biotech 2011-11-epigenetic regulation-of_human_development
Similar to Molbiol 2011-03-biochem
Chapter2 part2
The document discusses the key biomolecules that make up living organisms: carbohydrates, lipids, proteins, and nucleic acids. It describes their monomers and polymers, how they are assembled through condensation and hydrolysis reactions, and provides examples of their structures and functions in cells.
Moléculas orgánicas proteina Qui403 USC
Carbon atoms can form four covalent bonds in straight or branched chains or rings and bond with many different elements. Polymers are long chains of monomers linked through condensation reactions, and macromolecules are large polymers including polysaccharides, proteins, and DNA that are broken down by hydrolysis reactions. Key biomolecules discussed include lipids, nucleic acids, proteins, and carbohydrates.
Macromolecules Lecture
The document summarizes the key macromolecules that make up living things: carbohydrates, lipids, proteins, and nucleic acids. It describes how each is made of monomers that polymerize through condensation reactions, and how their structures determine their functions. Carbohydrates include sugars and starches used for energy storage. Lipids include fats and phospholipids that store energy and make up cell membranes. Proteins have complex 4-level structures (primary to quaternary) that allow for their diverse functions like transport and muscle movement. Nucleic acids DNA and RNA contain nucleotides and code or aid in protein synthesis to pass on traits.
Molbiol 2011-04-metabolism
The document discusses metabolism and metabolic pathways. It summarizes that catabolism provides energy and building blocks for anabolism through metabolic pathways. Metabolic pathways involve enzymatically catalyzed reactions, with enzymes determining the pathways. Reaction rates are influenced by factors like temperature, pH, substrate concentration, and inhibitors. The document then discusses specific metabolic pathways like glycolysis, the Krebs cycle, and the electron transport chain which are involved in breaking down carbohydrates to release energy through cellular respiration.
MolBiol #3.2
The document discusses metabolism and metabolic pathways. It explains that catabolism releases energy through breakdown of molecules while anabolism uses this energy to build molecules. Metabolic pathways involve a series of enzyme-catalyzed reactions. Enzymes are proteins that catalyze specific reactions and influence reaction rates without being consumed. ATP is generated through substrate-level phosphorylation and oxidative phosphorylation during cellular respiration. Aerobic respiration using oxygen yields more ATP than anaerobic respiration with other electron acceptors.
Molbiol 2011-04-metabolism
The document discusses metabolism and metabolic pathways. It summarizes that catabolism provides energy and building blocks for anabolism through metabolic pathways. Metabolic pathways involve enzymatically catalyzed reactions, with enzymes determining the pathways. Reaction rates are influenced by factors like temperature, pH, substrate concentration, and inhibitors. The document then discusses specific metabolic pathways like glycolysis, the Krebs cycle, and the electron transport chain which are involved in breaking down carbohydrates to release energy through cellular respiration.
Untitled (8)
This document contains sample exam questions from a previous nutrition and metabolism exam. It includes multiple choice and essay questions that assess understanding of biochemical pathways and conversions, enzymes involved, and effects of deficiencies. It also contains diagrams of metabolic pathways to label and explain. Key topics covered include glycolysis, gluconeogenesis, TCA cycle, urea cycle, creatine phosphate synthesis, pentose phosphate pathway, and regulation of glycogenolysis and food intake.
Ch04
Fatty acids have four main roles in cells: as building blocks for phospholipids and glycolipids, attached to proteins to target them to membranes, as fuel molecules to generate ATP through beta-oxidation, and as hormone and messenger derivatives. Fatty acid beta-oxidation begins with activation via attachment to CoA, then undergoes cycles of reactions to generate acetyl-CoA molecules. Acetyl-CoA enters the TCA cycle to be further oxidized to CO2 and H2O to generate large amounts of ATP through oxidative phosphorylation. Fatty acid synthesis occurs in the cytosol through sequential additions of two-carbon units from malonyl-CoA to elongate the fatty acid chain.
Ch4 Ppt Lect 1
Cellular metabolism allows organisms to grow through anabolic and catabolic processes. Metabolism occurs through complex biochemical pathways using enzymes and is regulated by feedback mechanisms. Cellular respiration releases energy from glucose and occurs in three stages: glycolysis, the citric acid cycle, and the electron transport chain. Genetic information is contained in DNA and expressed through transcription of DNA to mRNA and translation of mRNA to proteins.
Cellular Respiration (2)
Cellular metabolism allows organisms to grow through anabolic and catabolic processes. Metabolism occurs through complex biochemical pathways using enzymes and is regulated by feedback mechanisms. Cellular respiration releases energy from glucose and occurs in three stages: glycolysis, the citric acid cycle, and the electron transport chain. Genetic information is contained in DNA and expressed through transcription of DNA to mRNA and translation of mRNA to proteins.
05 macromolecules
1. Carbon is the backbone of biological molecules in living organisms and can form single, double, triple, or quadruple bonds.
2. Hydrocarbons like methane, ethane and ethene are molecules made of only carbon and hydrogen. Lipids, which do not form polymers, include fats and phospholipids.
3. Carbohydrates, proteins, nucleic acids and lipids are the four major classes of macromolecules that make up living things and carry out essential functions.
forjeffpark
Cellular respiration involves three main stages - glycolysis, the citric acid cycle, and oxidative phosphorylation - to harvest chemical energy from glucose and produce ATP. Glycolysis breaks down glucose into pyruvate and generates some ATP. The citric acid cycle further oxidizes pyruvate and generates more ATP and electron carriers. During oxidative phosphorylation, electrons are passed through an electron transport chain which establishes a proton gradient used by ATP synthase to produce most of the cell's ATP.
Ch02 b.chemistry.mission
This document provides an overview of organic compounds that are important for human anatomy and physiology, including their properties and functions. It discusses carbohydrates, lipids, proteins, and nucleic acids. Carbohydrates include sugars and starches that provide energy. Lipids include fats, phospholipids, and steroids, with fats serving as energy stores and phospholipids forming cell membranes. Proteins are made of amino acids linked through peptide bonds and have four levels of structure - primary, secondary, tertiary, and quaternary. They serve structural and functional roles in the body.
22 text
This document provides an overview of protein structure and composition. It discusses the primary, secondary, tertiary, and quaternary structure of proteins. The primary structure refers to the specific sequence of amino acids in a polypeptide chain. Techniques like amino acid analysis and Edman degradation are used to determine the amino acid content and sequence. The secondary structure involves localized folding patterns like alpha helices and beta sheets. The tertiary structure describes the overall 3D shape of a protein, while quaternary structure refers to interactions between multiple polypeptide chains.
Cmc chapter 23
The document is a series of slides covering different sections of a biology textbook chapter on the chemistry of life. It begins with an outline listing the section topics: proteins, carbohydrates, lipids, nucleic acids, and metabolism. The following sections then provide more details on the structures and functions of these key biomolecules.
Amino-acids-and-protein..ppt
Amino acids are the building blocks of proteins. There are 20 standard amino acids that make up the proteins in living organisms. Amino acids contain an amino group and a carboxyl group, and can be joined together via peptide bonds to form polypeptide chains. Proteins have complex structures with four levels of organization - primary, secondary, tertiary, and quaternary structure. The primary structure is the linear sequence of amino acids in the polypeptide chain. Secondary structures include alpha helices and beta sheets formed from regular patterns of hydrogen bonds between amino acids in the chain.
Metabolism c
The document discusses various topics related to metabolism in bacteria and other microorganisms. It covers classification of bacteria based on oxygen tolerance, biochemical reactions, fermentation products, pathways of energy metabolism like glycolysis and Krebs cycle, and biosynthesis of compounds like proteins, lipids, amino acids and nucleotides. It also distinguishes between different types of microbes based on their carbon and energy sources, including photoautotrophs, chemoheterotrophs and chemoautotrophs.
Biosynthesis of fatty acids
Fatty acid synthesis and degradation occur through different pathways. Synthesis takes place in the cytosol and requires NADPH and acetyl-CoA, adding two carbon units at a time from malonyl-CoA. Degradation occurs in the mitochondria using NADH and FADH2 to split acetyl-CoA units. Fatty acid synthesis is a multi-step process beginning with activation of acetyl-CoA followed by repeated elongation cycles using acetyl-ACP and malonyl-ACP substrates until palmitate is generated, then released by thioesterase.
Amino_Acids_and_Proteins.ppt
Amino acids are organic compounds that contain an amino group and a carboxyl group. There are 20 different amino acids that serve as the building blocks of proteins. Amino acids link together through peptide bonds to form polypeptide chains that fold into complex three-dimensional protein structures. Proteins serve essential functions and 10 of the 20 amino acids must be obtained through diet as humans cannot synthesize them. Common protein tests identify the presence of proteins using reactions that detect peptide bonds, amino acid side chains, or disulfide bridges.
Problemset
This document provides problems and solutions related to biochemistry. It begins with an introductory note that the problem set was prepared for a biochemistry course and contains questions of varying difficulty. The problems are organized into chapters covering topics like acid-base equilibrium, amino acids, protein purification, and protein structure. The document lists references used in creating the problem set and indicates that full solutions are provided after the problems section.
Similar to Molbiol 2011-03-biochem (20)
More from Nikolay Vyahhi
Assembly and finishing
The document discusses genome assembly and finishing processes. It begins by outlining typical project goals of completely restoring the genome and producing a high-quality consensus sequence. It then describes the evolution of sequencing technologies from Sanger to newer platforms and their impact on draft assemblies. Key steps in the assembly and finishing process include library preparation, assembly, identifying gaps, and improving consensus quality.
Molbiol 2011-13-organelles
The cell membrane separates the intracellular components of the cell from the external environment. It is composed of a lipid bilayer with embedded proteins and acts as a selective barrier. The cytoplasm contains organelles that carry out specialized functions like the mitochondria, which generates energy, and the endoplasmic reticulum and Golgi apparatus, which modify and transport proteins. Lysosomes contain enzymes that break down materials inside and outside the cell. Together, these organelles and their membranes comprise the endomembrane system, which manufactures components and transports materials within the cell.
Molbiol 2011-12-eukaryotic gene-expression
The document discusses gene expression and regulation in eukaryotes. It covers several key points in 3 sentences:
Eukaryotic genes require complex regulatory systems involving chromatin remodeling and transcription factors to initiate expression, unlike bacterial genes which can be transcribed without regulatory proteins. Development in multicellular organisms is controlled by signaling between cells using hormones and diffusible receptors which act as transcriptional regulators. Gene expression patterns in fruit flies establish polarity, segment the body, and determine segment identities through maternal, segmentation, and homeotic genes, providing insights into human developmental gene regulation.
Molbiol 2011-10-proteins
Proteins are composed of amino acids linked together by peptide bonds to form polypeptide chains. There are 20 standard amino acids that make up proteins. Proteins have four levels of structure - primary, secondary, tertiary, and quaternary. The primary structure is the linear sequence of amino acids. Secondary structures form due to hydrogen bonding between amino acids and include alpha helices and beta sheets. Tertiary structure involves folding of secondary structures into a compact 3D structure. Hydrogen bonds, disulfide bridges, and hydrophobic interactions stabilize tertiary structure.
Molbiol 2011-09-reparation-recombination
The document discusses several DNA repair mechanisms including mismatch repair, base excision repair, nucleotide excision repair, direct repair, and recombinational repair. It also describes different types of recombination including homologous recombination, site-specific recombination, and transposition. Finally, it discusses mechanisms of meiotic recombination including gene conversion and resolution of Holliday structures.
Molbiol 2011-07-chromosomes-cell-cycle
The document discusses chromosomes, mitosis, meiosis, and apoptosis. It explains that chromosomes contain DNA and genes, and replicate during cell division. Mitosis produces genetically identical cells while meiosis creates gametes with half the number of chromosomes. Apoptosis is programmed cell death that occurs through caspase activation and DNA fragmentation, while necrosis results from external damage.
Biotech 2011-08-recombinant-dna
Cloning involves inserting foreign DNA into a vector, which is then taken up by host cells. The host cells replicate, producing multiple copies of the recombinant DNA. Libraries contain fragments of DNA from a source inserted randomly into vectors. Genomic libraries contain chromosomal DNA fragments, while cDNA libraries contain mRNA sequences converted to DNA. Expression libraries contain cDNAs in vectors allowing protein expression. Cloning allows isolation and expression of genes, enabling study and production of proteins.
Biotech 2011-09-pcr and-in_situ_methods
The document summarizes various genetic techniques including PCR, restriction mapping, the human genome project, in situ hybridization, and cloning the gene responsible for alkaptonuria. It provides an example of how PCR, genomic libraries, DNA sequencing, and other methods were used to clone the HGO gene involved in alkaptonuria. Ethical considerations are discussed around using genetic testing to predict late-onset genetic disorders in fetuses.
Biotech 2011-07-finding-orf-etc
This lecture discusses genome organization and structure. It covers topics like genome size, DNA hybridization, Cot curves, repeated sequences, introns and exons. Cot curves show that apparently large genomes are filled with repetitive sequences, resolving the C-value paradox. There are two types of repeated sequences - tandem repeats like satellites and interspersed repeats like retrotransposons and SINEs. Genome structure includes features like linear/circular chromosomes, centromeres, telomeres, GC content distributions. Genes contain exons and introns, and detecting open reading frames is a way to predict genes, though it works better in prokaryotes than eukaryotes due to intron sizes.
Biotech 2011-06-electrophoresis-blots
1. Electrophoresis separates nucleic acids and proteins by size and charge using agarose or acrylamide gels.
2. Southern blots allow detection of specific DNA sequences by transferring DNA from a gel to a membrane and hybridizing a labeled probe.
3. Restriction fragment length polymorphisms (RFLPs) detect variations in restriction sites between individuals' DNA that can be used for identification.
Biotech 2011-05-eukaryotic-genes
The document summarizes various aspects of RNA processing including splicing, capping, polyadenylation, and modifications of tRNA and rRNA. It discusses the four classes of introns and mechanisms of splicing for group I and group II introns. Alternative splicing can produce different mRNA isoforms through exon skipping or use of cryptic splice sites.
Biotech 2011-01-intro
This document provides an introduction to genomics and proteomics. It discusses key definitions and concepts related to genetics and genomics. It compares genome sizes across different species, from bacteria to humans. Key points include that the human genome is around 3 billion base pairs distributed across 23 chromosome pairs, and contains around 32,000 genes. The document outlines methods for identifying genes within genomes and discusses characteristics of prokaryotic and eukaryotic genomes.
Guests 2011-11-09-alekseyev-rearrangements
The document discusses genome rearrangements and chromosomal evolution. It begins by showing the X chromosomes of the mouse and human genomes and notes they diverged from an unknown common ancestor approximately 80 million years ago. It then poses questions about reconstructing the ancestral genome and the evolutionary scenario that transformed one genome into the other. The document goes on to discuss concepts like reversals, translocations, sorting genomes with rearrangements, and computing the rearrangement distance between genomes. It proposes modeling rearrangements as 2-break operations to more simply study rearrangements between multiple genomes.
More from Nikolay Vyahhi (20)
Recently uploaded
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
Observability Concepts EVERY Developer Should Know -- DeveloperWeek Europe.pdf
Monitoring and observability aren’t traditionally found in software curriculums and many of us cobble this knowledge together from whatever vendor or ecosystem we were first introduced to and whatever is a part of your current company’s observability stack.
While the dev and ops silo continues to crumble….many organizations still relegate monitoring & observability as the purview of ops, infra and SRE teams. This is a mistake - achieving a highly observable system requires collaboration up and down the stack.
I, a former op, would like to extend an invitation to all application developers to join the observability party will share these foundational concepts to build on:
UiPath Test Automation using UiPath Test Suite series, part 6
Welcome to UiPath Test Automation using UiPath Test Suite series part 6. In this session, we will cover Test Automation with generative AI and Open AI.
UiPath Test Automation with generative AI and Open AI webinar offers an in-depth exploration of leveraging cutting-edge technologies for test automation within the UiPath platform. Attendees will delve into the integration of generative AI, a test automation solution, with Open AI advanced natural language processing capabilities.
Throughout the session, participants will discover how this synergy empowers testers to automate repetitive tasks, enhance testing accuracy, and expedite the software testing life cycle. Topics covered include the seamless integration process, practical use cases, and the benefits of harnessing AI-driven automation for UiPath testing initiatives. By attending this webinar, testers, and automation professionals can gain valuable insights into harnessing the power of AI to optimize their test automation workflows within the UiPath ecosystem, ultimately driving efficiency and quality in software development processes.
What will you get from this session?
1. Insights into integrating generative AI.
2. Understanding how this integration enhances test automation within the UiPath platform
3. Practical demonstrations
4. Exploration of real-world use cases illustrating the benefits of AI-driven test automation for UiPath
Topics covered:
What is generative AI
Test Automation with generative AI and Open AI.
UiPath integration with generative AI
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
GraphSummit Singapore | Enhancing Changi Airport Group's Passenger Experience...
Dr. Sean Tan, Head of Data Science, Changi Airport Group
Discover how Changi Airport Group (CAG) leverages graph technologies and generative AI to revolutionize their search capabilities. This session delves into the unique search needs of CAG’s diverse passengers and customers, showcasing how graph data structures enhance the accuracy and relevance of AI-generated search results, mitigating the risk of “hallucinations” and improving the overall customer journey.
A tale of scale & speed: How the US Navy is enabling software delivery from l...
Rapid and secure feature delivery is a goal across every application team and every branch of the DoD. The Navy’s DevSecOps platform, Party Barge, has achieved:
- Reduction in onboarding time from 5 weeks to 1 day
- Improved developer experience and productivity through actionable findings and reduction of false positives
- Maintenance of superior security standards and inherent policy enforcement with Authorization to Operate (ATO)
Development teams can ship efficiently and ensure applications are cyber ready for Navy Authorizing Officials (AOs). In this webinar, Sigma Defense and Anchore will give attendees a look behind the scenes and demo secure pipeline automation and security artifacts that speed up application ATO and time to production.
We will cover:
- How to remove silos in DevSecOps
- How to build efficient development pipeline roles and component templates
- How to deliver security artifacts that matter for ATO’s (SBOMs, vulnerability reports, and policy evidence)
- How to streamline operations with automated policy checks on container images
Cosa hanno in comune un mattoncino Lego e la backdoor XZ?
ABSTRACT: A prima vista, un mattoncino Lego e la backdoor XZ potrebbero avere in comune il fatto di essere entrambi blocchi di costruzione, o dipendenze di progetti creativi e software. La realtà è che un mattoncino Lego e il caso della backdoor XZ hanno molto di più di tutto ciò in comune.
Partecipate alla presentazione per immergervi in una storia di interoperabilità, standard e formati aperti, per poi discutere del ruolo importante che i contributori hanno in una comunità open source sostenibile.
BIO: Sostenitrice del software libero e dei formati standard e aperti. È stata un membro attivo dei progetti Fedora e openSUSE e ha co-fondato l'Associazione LibreItalia dove è stata coinvolta in diversi eventi, migrazioni e formazione relativi a LibreOffice. In precedenza ha lavorato a migrazioni e corsi di formazione su LibreOffice per diverse amministrazioni pubbliche e privati. Da gennaio 2020 lavora in SUSE come Software Release Engineer per Uyuni e SUSE Manager e quando non segue la sua passione per i computer e per Geeko coltiva la sua curiosità per l'astronomia (da cui deriva il suo nickname deneb_alpha).
“Building and Scaling AI Applications with the Nx AI Manager,” a Presentation...
“Building and Scaling AI Applications with the Nx AI Manager,” a Presentation...Edge AI and Vision Alliance
For the full video of this presentation, please visit: https://www.edge-ai-vision.com/2024/06/building-and-scaling-ai-applications-with-the-nx-ai-manager-a-presentation-from-network-optix/
Robin van Emden, Senior Director of Data Science at Network Optix, presents the “Building and Scaling AI Applications with the Nx AI Manager,” tutorial at the May 2024 Embedded Vision Summit.
In this presentation, van Emden covers the basics of scaling edge AI solutions using the Nx tool kit. He emphasizes the process of developing AI models and deploying them globally. He also showcases the conversion of AI models and the creation of effective edge AI pipelines, with a focus on pre-processing, model conversion, selecting the appropriate inference engine for the target hardware and post-processing.
van Emden shows how Nx can simplify the developer’s life and facilitate a rapid transition from concept to production-ready applications.He provides valuable insights into developing scalable and efficient edge AI solutions, with a strong focus on practical implementation.Alt. GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using ...
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
20 Comprehensive Checklist of Designing and Developing a Website
Dive into the world of Website Designing and Developing with Pixlogix! Looking to create a stunning online presence? Look no further! Our comprehensive checklist covers everything you need to know to craft a website that stands out. From user-friendly design to seamless functionality, we've got you covered. Don't miss out on this invaluable resource! Check out our checklist now at Pixlogix and start your journey towards a captivating online presence today.
Communications Mining Series - Zero to Hero - Session 1
This session provides introduction to UiPath Communication Mining, importance and platform overview. You will acquire a good understand of the phases in Communication Mining as we go over the platform with you. Topics covered:
• Communication Mining Overview
• Why is it important?
• How can it help today’s business and the benefits
• Phases in Communication Mining
• Demo on Platform overview
• Q/A
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...
The choice of an operating system plays a pivotal role in shaping our computing experience. For decades, Microsoft's Windows has dominated the market, offering a familiar and widely adopted platform for personal and professional use. However, as technological advancements continue to push the boundaries of innovation, alternative operating systems have emerged, challenging the status quo and offering users a fresh perspective on computing.
One such alternative that has garnered significant attention and acclaim is Nitrux Linux 3.5.0, a sleek, powerful, and user-friendly Linux distribution that promises to redefine the way we interact with our devices. With its focus on performance, security, and customization, Nitrux Linux presents a compelling case for those seeking to break free from the constraints of proprietary software and embrace the freedom and flexibility of open-source computing.
GraphSummit Singapore | Neo4j Product Vision & Roadmap - Q2 2024
Maruthi Prithivirajan, Head of ASEAN & IN Solution Architecture, Neo4j
Get an inside look at the latest Neo4j innovations that enable relationship-driven intelligence at scale. Learn more about the newest cloud integrations and product enhancements that make Neo4j an essential choice for developers building apps with interconnected data and generative AI.
GraphSummit Singapore | The Art of the Possible with Graph - Q2 2024
Neha Bajwa, Vice President of Product Marketing, Neo4j
Join us as we explore breakthrough innovations enabled by interconnected data and AI. Discover firsthand how organizations use relationships in data to uncover contextual insights and solve our most pressing challenges – from optimizing supply chains, detecting fraud, and improving customer experiences to accelerating drug discoveries.
Generative AI Deep Dive: Advancing from Proof of Concept to Production
Join Maher Hanafi, VP of Engineering at Betterworks, in this new session where he'll share a practical framework to transform Gen AI prototypes into impactful products! He'll delve into the complexities of data collection and management, model selection and optimization, and ensuring security, scalability, and responsible use.
Climate Impact of Software Testing at Nordic Testing Days
My slides at Nordic Testing Days 6.6.2024
Climate impact / sustainability of software testing discussed on the talk. ICT and testing must carry their part of global responsibility to help with the climat warming. We can minimize the carbon footprint but we can also have a carbon handprint, a positive impact on the climate. Quality characteristics can be added with sustainability, and then measured continuously. Test environments can be used less, and in smaller scale and on demand. Test techniques can be used in optimizing or minimizing number of tests. Test automation can be used to speed up testing.
How to Get CNIC Information System with Paksim Ga.pptx
Pakdata Cf is a groundbreaking system designed to streamline and facilitate access to CNIC information. This innovative platform leverages advanced technology to provide users with efficient and secure access to their CNIC details.
みなさんこんにちはこれ何文字まで入るの？40文字以下不可とか本当に意味わからないけどこれ限界文字数書いてないからマジでやばい文字数いけるんじゃないの？えこ...
ここ3000字までしか入らないけどタイトルの方がたくさん文字入ると思います。
Full-RAG: A modern architecture for hyper-personalization
Mike Del Balso, CEO & Co-Founder at Tecton, presents "Full RAG," a novel approach to AI recommendation systems, aiming to push beyond the limitations of traditional models through a deep integration of contextual insights and real-time data, leveraging the Retrieval-Augmented Generation architecture. This talk will outline Full RAG's potential to significantly enhance personalization, address engineering challenges such as data management and model training, and introduce data enrichment with reranking as a key solution. Attendees will gain crucial insights into the importance of hyperpersonalization in AI, the capabilities of Full RAG for advanced personalization, and strategies for managing complex data integrations for deploying cutting-edge AI solutions.
Unlock the Future of Search with MongoDB Atlas_ Vector Search Unleashed.pdf
Discover how MongoDB Atlas and vector search technology can revolutionize your application's search capabilities. This comprehensive presentation covers:
* What is Vector Search?
* Importance and benefits of vector search
* Practical use cases across various industries
* Step-by-step implementation guide
* Live demos with code snippets
* Enhancing LLM capabilities with vector search
* Best practices and optimization strategies
Perfect for developers, AI enthusiasts, and tech leaders. Learn how to leverage MongoDB Atlas to deliver highly relevant, context-aware search results, transforming your data retrieval process. Stay ahead in tech innovation and maximize the potential of your applications.
#MongoDB #VectorSearch #AI #SemanticSearch #TechInnovation #DataScience #LLM #MachineLearning #SearchTechnology
Recently uploaded (20)
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024
Observability Concepts EVERY Developer Should Know -- DeveloperWeek Europe.pdf
Observability Concepts EVERY Developer Should Know -- DeveloperWeek Europe.pdf
UiPath Test Automation using UiPath Test Suite series, part 6
UiPath Test Automation using UiPath Test Suite series, part 6
GraphSummit Singapore | Enhancing Changi Airport Group's Passenger Experience...
GraphSummit Singapore | Enhancing Changi Airport Group's Passenger Experience...
A tale of scale & speed: How the US Navy is enabling software delivery from l...
A tale of scale & speed: How the US Navy is enabling software delivery from l...
Cosa hanno in comune un mattoncino Lego e la backdoor XZ?
Cosa hanno in comune un mattoncino Lego e la backdoor XZ?
“Building and Scaling AI Applications with the Nx AI Manager,” a Presentation...
“Building and Scaling AI Applications with the Nx AI Manager,” a Presentation...
Monitoring Java Application Security with JDK Tools and JFR Events
Monitoring Java Application Security with JDK Tools and JFR Events
Alt. GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using ...
Alt. GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using ...
20 Comprehensive Checklist of Designing and Developing a Website
20 Comprehensive Checklist of Designing and Developing a Website
Communications Mining Series - Zero to Hero - Session 1
Communications Mining Series - Zero to Hero - Session 1
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...
GraphSummit Singapore | Neo4j Product Vision & Roadmap - Q2 2024
GraphSummit Singapore | Neo4j Product Vision & Roadmap - Q2 2024
GraphSummit Singapore | The Art of the Possible with Graph - Q2 2024
GraphSummit Singapore | The Art of the Possible with Graph - Q2 2024
Generative AI Deep Dive: Advancing from Proof of Concept to Production
Generative AI Deep Dive: Advancing from Proof of Concept to Production
Climate Impact of Software Testing at Nordic Testing Days
Climate Impact of Software Testing at Nordic Testing Days
How to Get CNIC Information System with Paksim Ga.pptx
How to Get CNIC Information System with Paksim Ga.pptx
みなさんこんにちはこれ何文字まで入るの？40文字以下不可とか本当に意味わからないけどこれ限界文字数書いてないからマジでやばい文字数いけるんじゃないの？えこ...
みなさんこんにちはこれ何文字まで入るの？40文字以下不可とか本当に意味わからないけどこれ限界文字数書いてないからマジでやばい文字数いけるんじゃないの？えこ...
Full-RAG: A modern architecture for hyper-personalization
Full-RAG: A modern architecture for hyper-personalization
Unlock the Future of Search with MongoDB Atlas_ Vector Search Unleashed.pdf
Unlock the Future of Search with MongoDB Atlas_ Vector Search Unleashed.pdf
Molbiol 2011-03-biochem
- 13. Amino Acids Figure 2.16a–c
- 14. Amino Acids Figure 2.16d, e
- 26. Structural Levels of Proteins Figure 2.18a–c
- 27. Structural Levels of Proteins Figure 2.18b,d,e
- 35. Characteristics of Enzymes Figure 2.20
- 37. Figure 2.21 Active site Amino acids Enzyme (E) Enzyme-substrate complex (E-S) Internal rearrangements leading to catalysis Dipeptide product (P) Free enzyme (E) Substrates (S) Peptide bond H 2 O +
- 38. Figure 2.21 Active site Amino acids Enzyme (E) Enzyme-substrate complex (E-S) Substrates (S) H 2 O +
- 39. Figure 2.21 Active site Amino acids Enzyme (E) Enzyme-substrate complex (E-S) Internal rearrangements leading to catalysis Substrates (S) H 2 O +
- 40. Figure 2.21 Active site Amino acids Enzyme (E) Enzyme-substrate complex (E-S) Internal rearrangements leading to catalysis Dipeptide product (P) Free enzyme (E) Substrates (S) Peptide bond H 2 O +
- 44. Structure of DNA Figure 2.22a
- 45. Structure of DNA Figure 2.22b
- 48. Adenosine Triphosphate (ATP) Figure 2.23
- 49. Figure 2.24 Solute Solute transported Contracted smooth muscle cell Product made Relaxed smooth muscle cell Reactants Membrane protein P P i ATP P X X Y Y + (a) Transport work (b) Mechanical work (c) Chemical work P i P i + ADP
- 50. Figure 2.24 Solute Membrane protein P ATP (a) Transport work
- 51. Figure 2.24 Solute Solute transported Membrane protein P P i ATP (a) Transport work P i + ADP
- 52. Figure 2.24 Relaxed smooth muscle cell ATP (b) Mechanical work
- 53. Figure 2.24 Contracted smooth muscle cell Relaxed smooth muscle cell ATP (b) Mechanical work P i + ADP
- 54. Figure 2.24 Reactants ATP P X Y + (c) Chemical work
- 55. Figure 2.24 Product made Reactants ATP P X X Y Y + (c) Chemical work P i P i + ADP
- 56. Figure 2.24 Solute Solute transported Contracted smooth muscle cell Product made Relaxed smooth muscle cell Reactants Membrane protein P P i ATP P X X Y Y + (a) Transport work (b) Mechanical work (c) Chemical work P i P i + ADP