The document discusses microbial control through various physical and chemical methods. It begins with a brief history of bubonic plague in Europe during the Middle Ages caused by the Yersinia pestis bacterium. It then defines key terms like sterilization, disinfection, bactericidal and bacteriostatic. The document outlines several conditions that influence the effectiveness of antimicrobial agents and describes various physical methods of microbial control including heat, filtration and radiation. It provides details on how these methods kill microbes and examples of their applications.