This document discusses the major histocompatibility complex (MHC) and its class I and class II molecules. It describes the structure and components of MHC class I and II molecules, including their peptide binding grooves. MHC class I molecules are expressed on nearly all nucleated cells and present peptides from intracellular pathogens to cytotoxic T cells. MHC class II molecules are only expressed on antigen-presenting cells and present peptides from extracellular pathogens to helper T cells. The MHC genes are highly polymorphic in human populations, contributing to diversity in antigen presentation.