This document provides guidance on areas of interest (AOI) to evaluate for mergers and acquisitions from an information security perspective. It identifies 22 strategic AOIs that security must scope to understand high risk areas, including application and access management, network/DMZ security, host security, data security and privacy, security policies and training, and security operations. Each AOI includes examples of specific areas to examine to identify strengths needing no attention or areas requiring intervention. The goal is to scope projects to understand risks across a broad scope from an information security standpoint.