Meiosis is a type of cell division that produces gametes, such as sperm and egg cells, with half the number of chromosomes as the original parent cell. It involves two rounds of division called Meiosis I and Meiosis II. In Meiosis I, homologous chromosomes pair up and may exchange genetic material through crossing over. The homologous chromosomes then separate, resulting in two haploid cells. Meiosis II then separates the sister chromatids, resulting in a total of four haploid cells each with a unique combination of the parent cell's chromosomes.
It is the presentation on the MEIOSIS phase of the Cell division.
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The slides contain all about meiosis. in this slides i collected all information about meiosis. which is useful for everyone.
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It is the presentation on the MEIOSIS phase of the Cell division.
It includes all the details and definitions that are related to the topic of meiosis with the labelled diagrams.
If you have any query or a question, you may ask in the comment box.
thanks.
The slides contain all about meiosis. in this slides i collected all information about meiosis. which is useful for everyone.
so watch these slides and comment for any problems.
thanks
– Male and female gametes fuse together during fertilization to form a zygote. The chromosome number is halved during the formation of gametes by the process of meiosis. This maintains the chromosome number generations after generations. Meiosis leads to genetic diversity which is very essential for evolution.
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Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
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Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Body fluids_tonicity_dehydration_hypovolemia_hypervolemia.pptx
Meiosis
1.
2. Meiosis preceded by duplication of
chromosomes which is followed by meiosis I
and meiosis II. These two divisions result in
four daughter cells each with half the
number of chromosomes that of the parents.
In this division single pair of homologous
chromosomes in diploid cell, that both
members of the pair are duplicated and the
copies sorted into four haploid daughter
cells.
3. In 1876 meiosis was first discovered and described in sea
urchin eggs by the German biologist Oscar Hertwig.
In 1883 it was described at the level of chromosomes, by
the Belgian zoologist Edouard Van Beneden.
In 1890 the significance of meiosis for reproduction and
inheritance, was described by German biologist August
Weismann, who noted that two cell divisions were
necessary to transform one diploid cell into four haploid
cells if the number of chromosomes had to be maintained.
In 1911 the American geneticist Thomas Hunt
Morgan observed crossover in Drosophila
melanogaster meiosis and provided the first genetic
evidence that genes are transmitted on chromosomes.
In 1905 the term meiosis was introduced by J.B. Farmer
and J.E.S. Moore.
Meiosis is derived from the Greek word meaning 'lessening'
4. Meiosis is a special type of cell division necessary
for sexual reproduction in eukaryotes such as
animals, plants and fungi. The number of sets
of chromosomes reduced to half the original
number, typically from two sets (diploid) to one set
(haploid). The cells produced by meiosis are
either gametes. In many organisms gametes are
called sperm and egg cells.
Meiotic division occurs in two stages, meiosis I and
meiosis II.
Meiosis I: The first stage begins with a diploid cell
that has two copies of each type of chromosome,
one from each the mother and father,
called homologous chromosomes. All homologous
chromosomes pair up and may exchange genetic
material with each other in a process called crossing
over. Each pair then separates as two haploid cells
are formed, each with one chromosome from every
homologous pair.
5. Meiosis II: In the second stage, each
chromosome splits into two, with each half,
called a sister chromatid, being separated
into two new cells, which are still haploid.
Therefore from each original cell, four
genetically distinct haploid cells are
produced. These cells can mature into
gametes
6.
7. Meiosis I separates homologous chromosomes,
producing two haploid cells and thus meiosis I is
referred to as a reductional division.
A regular diploid human cell contains 46 (2n)
chromosomes because it contains 23 pairs of
homologous chromosomes. However, after
meiosis I 46 chromatids, it is only considered as
being N, with 23 chromosomes. This is because
later, in Anaphase I, the sister chromatids will
remain together as the spindle fibers pull the
pair toward the pole of the new cell.
In meiosis II, an equational division like mitosis
will occur whereby the sister chromatids are
finally split, creating a total of 4 haploid cells
(23 chromosomes, N) - two from each daughter
cell from the first division.
8. Prophase I
It is the longest phase of meiosis.
Chromosomes begin to condense
Homologous chromosomes pair along their length
aligned gene by gene by zipper like protein called
synaptonemal complex and state is called synapsis.
Crossing over between non sister chromatids leading
to exchange of segments of DNA. Chiasmata forms at
the site of crossover.
At mid prophase synapsis ends and chromosomes in
each pair moved apart.
Centrosomes move, spindle forms and nuclear
envelope breakdown.
Microtubules of each pole attach to the kinetochores
(protein) at centromeres of two homologs
Homologous pairs move towards the metaphase
plate.
These events occur in various stages of prophase I.
9.
10. 1. Leptotene
It is the first stage of prophase I.
Also known as leptonema, from Greek origin
meaning "thin threads”.
In this stage individual chromosomes each
consisting of two sister chromatids become
condense into visible strands within the
nucleus.
However the two sister chromatids are
tightly bound that they are indistinguishable
from one another.
The synaptonemal complex assemble.
Leptotene is of very short duration and
progressive condensation and coiling of
chromosome fibers takes place
11. 2. Zygotene
The zygotene or zygonema, from Greek
origin meaning "paired threads”.
Homologous chromosomes line up with each
other into pairs.
At this stage, the synapsis (pairing/coming
together) of homologous chromosomes takes
place from the centromere the chromosome
ends or portion.
Individuals of a pair are equal in length and
in position of the centromere. Thus pairing is
highly specific and exact.
The paired chromosomes are called bivalent
or tetrad chromosomes.
12. 3. Pachytene
The pachytene or pachynema, from Greek words
meaning "thick threads“.
It is the stage when chromosomal
crossover(crossing over) occurs.
Nonsister chromatids of homologous
chromosomes may exchange segments over
regions of homology.
Sex chromosomes, however, are not wholly
identical, and only exchange information over a
small region of homology.
At the site of exchange chiasmata form.
Recombination of information occurs.
The actual act of crossing over is not perceivable
through the microscope, and chiasmata are not
visible until the next stage.
13. 4. Diplotene
Diplotene or diplonema, from Greek words
meaning "two threads",
The synaptonemal complex degrades and
homologous chromosomes separate from one
another a little.
However, the homologous chromosomes of
each bivalent remain tightly bound at
chiasmata, the regions where crossing-over
occurred. The chiasmata remain on the
chromosomes until they are severed in
anaphase.
14. 5. Diakinesis
Chromosomes condense further during
the diakinesis stage, from Greek words
meaning "moving through".
This is the first point in meiosis where the
four parts of the tetrads are actually visible.
Chiasmata clearly visible.
The nucleoli disappear.
The nuclear membrane disintegrates into
vesicles
The meiotic spindle begins to form.
15. Synchronous processes
Two centrosomes, containing a pair of centrioles in
animal cells, migrate to the two poles of the cell.
These centrosomes, function as microtubule
organizing centers.
The microtubules attaches at the kinetochore. The
kinetochore functions as a motor, pulling the
chromosome along the attached microtubule toward
the originating centriole.
Microtubules that attach to the kinetochores are
known as kinetochore microtubules.
Microtubules that interact with microtubules from
the opposite centriole are called nonkinetochore
microtubules or polar microtubules.
A third type of microtubules, the aster microtubules,
radiates from the centrosome into the cytoplasm.
16. Metaphase I
Homologous pairs move together along the
metaphase plate
Homologous chromosomes align along an equatorial
plane that bisects the spindle.
Anaphase I
Kinetochore (bipolar spindles) microtubules shorten,
severing the recombination nodules and pulling
homologous chromosomes apart.
Whole chromosomes are pulled toward opposing
poles, forming two haploid sets.
Each chromosome still contains a pair of sister
chromatids.
During this time disjunction occurs, which is one of
the processes leading to genetic diversity.
Nonkinetochore microtubules lengthen, pushing the
centrioles farther apart.
17. Telophase I
The first meiotic division ends with the arrival of
chromosomes at the poles.
Each daughter cell now has half the number of
chromosomes but each chromosome consists of a pair
of chromatids.
Microtubules spindle network disappear
New nuclear membrane synthesize
The chromosomes uncoil back into chromatin.
Cytokinesis
Pinching of the cell membrane in animal cells or the
formation of the cell wall in plant cells, occurs
Creation of two daughter cells
Sister chromatids remain attached during telophase
Cells may enter in interphase II.
No DNA replication occurs during this stage.
18.
19.
20.
21. Meiosis II
Meiosis II is the second part of the meiotic
process, also known as equational division.
Mechanically, the process is similar to
mitosis, though its genetic results are
fundamentally different.
The end result is production of four haploid
cells (23 chromosomes, N in humans).
The four main steps of Meiosis II are:
Prophase II, Metaphase II, Anaphase II, and
Telophase II.
22. Prophase II :
Nucleoli and nuclear envelope disappears.
Shortening and thickening of the chromatids.
Centrioles move to the polar regions and
arrange spindle fibers for the second meiotic
division.
Metaphase II:
The centromeres contain two kinetochores
that attach to spindle fibers from the
centrosomes (centrioles) at each pole.
The new equatorial metaphase plate is
rotated by 90 degrees when compared to
meiosis I, perpendicular to the previous
plate.
23. Aanaphase II
The centromeres are cleaved
Microtubules attached to the kinetochores to
pull the sister chromatids apart.
The sister chromatids by convention are now
called sister chromosomes as they move toward
opposing poles
Telophase II
Marked by uncoiling and lengthening of the
chromosomes.
Disappearance of the spindle.
Nuclear envelopes reform
Cleavage or cell wall formation eventually
produces a total of four daughter cells, each
with a haploid set of chromosomes