Water makes up about 60% of a person's body weight and provides a fluid environment for transport throughout the body. Intracellular fluid inside cells contains mostly water and charged molecules like proteins and nucleic acids, while extracellular fluid outside cells contains mostly water and higher concentrations of sodium and lower concentrations of potassium ions. Transport across cell membranes can occur passively via diffusion down a concentration gradient without energy or actively via active transport against the gradient using metabolic energy from ATP.