This document discusses decision support systems (DSS) and their medical applications. It defines DSS as systems that serve middle managers and support non-routine decision making. The document then discusses how computers can aid medical decision making by simplifying access to data, providing reminders and prompts, assisting with diagnosis and order entry, and giving patient-specific recommendations. It provides examples of successful DSS like one for antimicrobial use in ICU that reduced costs and improved outcomes. Finally, it outlines requirements for implementing DSS, including infrastructure, guidelines incorporation, and resources.