MCL. LCL.ALL injuries
To understand the relevant anatomy of the side ligaments of the knee
To study the mechanism of injury of each ligament and how to diagnose such injury
To highlight the different treatment options in acute or chronic situations
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In early stage, tendon becomes red and swollen, as tendonitis develops the tendon sheath can thicken.
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In early stage, tendon becomes red and swollen, as tendonitis develops the tendon sheath can thicken.
In late stage, often become dark red in color due to inflammation.
posterior curciate liagment injury, machanisum of injury, type of injury, special test, associated injuries ti PCL injury, physiotherapy treatment
posteior sag test, posterior drawer test, abduction stress test, adduction stress test, day wie trsetment
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Historically, open fractures were associated with infection, delayed union, nonunion, amputation, or death.
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Anti ulcer drugs and their Advance pharmacology ||
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
1. MCL,LCL & ALL injuries
Mohamed Abulsoud (M.D)
Lecturer of orthopedic surgery
Al-Azhar university
Cairo- Egypt
AOTRAUMA international faculty
2. Learning outcomes
•To understand the relevant anatomy of the side
ligaments of the knee
•To study the mechanism of injury of each ligament
and how to diagnose such injury
•To highlight the different treatment options in acute
or chronic situations
6. Function
• The sMCL is the main valgus stabilizer of the knee in all flexion angles
• The dMCL ia a secondary valgus stabilizer and has a minor role in the
prevention of anterior tibial translation.
• The POL acts as a stabilizer of valgus, internal and external rotation of
the knee in extension.
10. Radiological Evaluation
• The medial collateral ligament (MCL).
is evaluated primarily on the coronal
fat–saturated T2 or (STIR) sequences.
11. Radiological Evaluation
• Grade 1 intact ligament, normal in signal,
with surrounding edema and/or
hemorrhage .
• Grade 2 partial rupture, abnormal signal
within the ligament itself and/or fluid
surrounding the ligament in the MCL bursa
• Grade 3 complete rupture, frank
disruption and discontinuity of the
ligament
14. Treatment
Non operative treatment
• Isolated injury to the MCL results in a robust healing response
• Rich blood supply,
• Relatively wide surface area,
• Association with other secondary stabilizers,
• Extra-articular location.
• 80 % return to sports within 9 weeks , 20 % hidden meniscal or ACL injuries
Holden DL, Eggert AW, Butler JE: The nonoperative treatment of grade
1 and 2 medial collateral ligament injuries to the knee. Am J Sports Med 1983.
• 91 % return to sports after grade 3 injury
Jones RE, Henley MB, Francis P: Non-operative management of
isolated grade III collateral ligament injury in high school football players. Clin Orthop 213:137, 1986.
15. Indications of operative treatment
• open injury
• MCL entrapment causing incongruent reduction of the
tibiofemoral joint
• fracture avulsion of the MCL origin
• distal MCL avulsion and pes anserinus interposition (a ‘Stener’
lesion)
• multi-ligament knee injury (the timing of this is controversial)
• other injuries requiring surgery (e.g. meniscal tear ,ACL)
• chronic instability after non-operative management
16. Anatomic double bundle MCL
reconstruction
Anatomic single bundle MCL
reconstruction
Non Anatomic double bundle MCL
reconstruction
25. • The LCL is the primary stabilizer to varus stress of the knee.
• The PFL provides an important restraint to external rotation.
• Popliteus is dynamic stabilizer +/- static
LCL & PLC
26. Mechanism of injury
• Varus, Rotation, extension
• 75% combined injury (PCL, ACL or both )
• CPN injury 15 %
29. Clinical Evaluation
• The prone external rotation test (dial test )
• Performed at both 30 and 90 degrees of knee flexion
30. X ray
• Stress views
• Arcuate sign
• Avulsion fractures
31. Radiological Evaluation
• Most commonly, LCL injury manifests as complete
midsubstance disruption with surrounding soft tissue
edema.
• Injury to the LCL complex can be graded on MRI,
Grade 1 :- Edema surrounding an intact ligament .
grade 2 :-Intrasubstance ligamentous signal, possibly
with ligamentous thickening or thinning and
surrounding edema.
grade 3 :-Frank disruption and discontinuous fibers
32. Radiological Evaluation
• the popliteus muscle and tendon are best
evaluated with both sagittal and coronal MRI
sequences.
• They are most commonly injured at the
musculotendinous junction
• in the setting of a traumatic knee injury and
subsequent MRI, the popliteus can be
considered the “window to the
posterolateral corner.”
33. Fanelli A Fanelli B Fanelli C
Increase External rotation Increase external rotation and
mild varus instability
Significant rotational and varus
instability
Isolated injury to PFL Injury to PFL and partial FCL Complete injury to PFL, FCL,
and cruciate ligaments
PFL reconstruction Arciero Laprade Vs Arciero
41. History
• As early as 1879, Paul Segond described a ‘‘pearly,
resistant, fibrous band’’ at the anterolateral
aspect of the knee.
• This eponymous Segond fracture was reported to
occur in the tibial region above and behind the
Gerdy’s tubercle