MCB lecture 3 topics: milestones on the history of MCB as a science, people significant in the development of MCB as a science, Koch's principles and exceptions

1. Quiz # 2 1. Complete the table: (10 points) 2. Name the associated M.O. with the following conditions: gastric ulcer, diabetes, female infertility (3 points) 3. Differentiate between 1st Golden Age of MCB and 2nd Golden Age of MCB (2 points) group of M.O. uni/multicellular prokaryotic/ eukaryotic specific name of study (bonus, 0.20 points each)

2. HISTORICAL OVERVIEW OF MICROBIOLOGY MICROBIOLOGY MICROBIOLOGY

3. fossils of m.o. found in Australia date back to 3.5 BILLION years ago, whereas H. sapiens only appeared very recently

10. examined scrapings from teeth, pond water, blood, sperm, diarrheal stool

16. experiment by Francesco Redi

17. experiment by Louis Pasteur Louis Pasteur

28. exceptions to Koch’s Postulates certain pathogens do not grow on artificial medium,ex: MO for syphilis, leprosy --obligate intracellular pathogens require living host cells, therefore propagate M. leprae in armadillos, Treponema pallidum for syphilis in testes of rabbits many pathogens are species-specific some diseases are synergistic infections, caused by 2 or more M.O.. ex: acute necrotizing ulcerative gingivitis and bacterial vaginosis some pathogens become altered when grown in vitro, i.e. less or non-pathogenic some diseases are not caused by MO