Common defects that can occur during tablet production include capping and lamination, picking and sticking, mottling, weight variation, hardness variation, and double impressions. Capping and lamination involve the separation of the tablet layers, while picking and sticking involve material adhering to the punches. Mottling is uneven color distribution. Weight and hardness variations result from issues like poor granule flow and inconsistent compression. Double impressions occur when the lower punch rotates during ejection and makes a second impression. Care must be taken to properly formulate and process the granules, operate the tablet press correctly, and maintain the equipment to minimize these defects.
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the tablets and its excipients and Ideal properties of tablet and the methods and equipment for there for manufacturing.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
The chapter deals with the preformulation studies that have to be considered while designing a dosage form and developing a formulation that is suitable for a patient. Here, physical and chemical properties of a drug substance are studied along with biopharmaceutical classification of drugs. Also a detailed study on the application of preformulation studies in different dosage forms are also studied.
Preformulation Studies: Introduction to preformulation, goals and objectives, study of
physicochemical characteristics of drug substances.
a. Physical properties: Physical form (crystal & amorphous), particle size, shape, flow
properties, solubility profile (pKa, pH, partition coefficient), polymorphism.
b. Chemical Properties: Hydrolysis, oxidation, reduction, racemisation, polymerization
BCS classification of drugs & its significant
Application of preformulation considerations in the development of solid, liquid oral and
parenteral dosage forms and its impact on stability of dosage forms.
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the tablets and its excipients and Ideal properties of tablet and the methods and equipment for there for manufacturing.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
The chapter deals with the preformulation studies that have to be considered while designing a dosage form and developing a formulation that is suitable for a patient. Here, physical and chemical properties of a drug substance are studied along with biopharmaceutical classification of drugs. Also a detailed study on the application of preformulation studies in different dosage forms are also studied.
Preformulation Studies: Introduction to preformulation, goals and objectives, study of
physicochemical characteristics of drug substances.
a. Physical properties: Physical form (crystal & amorphous), particle size, shape, flow
properties, solubility profile (pKa, pH, partition coefficient), polymorphism.
b. Chemical Properties: Hydrolysis, oxidation, reduction, racemisation, polymerization
BCS classification of drugs & its significant
Application of preformulation considerations in the development of solid, liquid oral and
parenteral dosage forms and its impact on stability of dosage forms.
Pharmaceutical film coating is considered a key part in the production of solid pharmaceutical dosage forms since it gives superior organoleptic properties products. In addition, it can improve the physical and chemical stability of dosage forms, and modify the release characteristics of the drug. Several troubleshooting problems such as twinning mottling, chipping, etc., may arise during or after or even during the shelf life of the film coated dosage forms. These troubleshooting problems may be due to tablet core faults, coating formulation faults and/or coating process faults. These problems must be overcome to avoid unnecessary product problems. Film coating as well as other parts of the pharmaceutical technology is subjecting to continuous innovation. The innovation may be at different levels including pharmaceutical excipients, processes, software, guidelines and equipment. In fact, of particular note is the growing interest in process analytical technology, quality by design, continuous coating processing and the inclusion of new ready for use coating formulations. In this review, we tried to explore and discuss the status of pharmaceutical film coating, the challenges that face this manufacturing process and the latest technological advances in this important manufacturing process.
A tablet can be imperfect in a number of ways and these defects and imperfections can either be found on the surface or in the interior layers of the product due to the formulation problems. In this tablet defect overview, we are focusing on the most common visible defects that can be discovered during the quality control, because an imperfect appearance of a single tablet in a package can raise serious doubts about integrity and quality of the product. Consequently, pharmaceutical companies continuously try to increase their efforts to assure high-quality of their products. Visual quality control can be done by various statistical schemes or by 100% visual inspection and sorting, either manual or automated. Due to the fact that statistical sampling schemes, that estimate the overall quality of a given batch of tablets at a certain confidence level, cannot assure the required quality of each tablet, they are being replaced by 100% visual inspection and sorting. Since manual visual inspection of large tablet batches is subjective, unreliable, slow, tedious and costly, automated visual tablet inspection systems are more and more commonly used.
A detailed study on every aspects of parenteral :- introduction, preformulation factors, essential requirements, vehicles and additives, isotonicity, production procedure, facilities, and controls, container and closure selection and finally the quality control evaluation of parenterals.
Excipients..different types of excipients and its applications in pharmacetical industry for manufacturing of dosage forms.
few examples of commercially available excipients in the market for the manufacturing purpose of intended dosage forms.
Pharmaceutical film coating is considered a key part in the production of solid pharmaceutical dosage forms since it gives superior organoleptic properties products. In addition, it can improve the physical and chemical stability of dosage forms, and modify the release characteristics of the drug. Several troubleshooting problems such as twinning mottling, chipping, etc., may arise during or after or even during the shelf life of the film coated dosage forms. These troubleshooting problems may be due to tablet core faults, coating formulation faults and/or coating process faults. These problems must be overcome to avoid unnecessary product problems. Film coating as well as other parts of the pharmaceutical technology is subjecting to continuous innovation. The innovation may be at different levels including pharmaceutical excipients, processes, software, guidelines and equipment. In fact, of particular note is the growing interest in process analytical technology, quality by design, continuous coating processing and the inclusion of new ready for use coating formulations. In this review, we tried to explore and discuss the status of pharmaceutical film coating, the challenges that face this manufacturing process and the latest technological advances in this important manufacturing process.
A tablet can be imperfect in a number of ways and these defects and imperfections can either be found on the surface or in the interior layers of the product due to the formulation problems. In this tablet defect overview, we are focusing on the most common visible defects that can be discovered during the quality control, because an imperfect appearance of a single tablet in a package can raise serious doubts about integrity and quality of the product. Consequently, pharmaceutical companies continuously try to increase their efforts to assure high-quality of their products. Visual quality control can be done by various statistical schemes or by 100% visual inspection and sorting, either manual or automated. Due to the fact that statistical sampling schemes, that estimate the overall quality of a given batch of tablets at a certain confidence level, cannot assure the required quality of each tablet, they are being replaced by 100% visual inspection and sorting. Since manual visual inspection of large tablet batches is subjective, unreliable, slow, tedious and costly, automated visual tablet inspection systems are more and more commonly used.
A detailed study on every aspects of parenteral :- introduction, preformulation factors, essential requirements, vehicles and additives, isotonicity, production procedure, facilities, and controls, container and closure selection and finally the quality control evaluation of parenterals.
Excipients..different types of excipients and its applications in pharmacetical industry for manufacturing of dosage forms.
few examples of commercially available excipients in the market for the manufacturing purpose of intended dosage forms.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
2. Common tableting problem
During the routine production of tablets so many
defects arise with the finished tablets may be due to
either some faults in tablet formulation or in the
tableting equipment and sometimes due to both
reasons.
The defects are as follows:
1. Capping and Lamination
2. Picking and Sticking
3. Mottling
4. Weight variation
5. Hardness Variation
6. Double impression
3. Capping and Lamination:
Capping is the partial or complete separation of
the top or bottom crowns of a tablet from the main
body of the tablet.
Lamination is the separation of a tablet into two or
more distinct layers.
Usually, these processing problems are readily
apparent immediately after compression; however,
capping and lamination may occur hours or even
days later.
Subjecting tablets to the friability test is the
quickest way of revealing such problems.
4. Reasons
1. Due to the entrapment of air among the particles
or granules during the compression
2. Too much pressure on compression.
3. Presence of either excess of fine powders of
granules or less amount of fines in granules.
4. A granulation that is too dry tends to cap or
laminate for lack of cohesion.
5. Often deep concave punches produce tablets that
cap.
6. The wear and tear of punches and dies is also
responsible for capping.
7. The wrong setting of dies or punches also causes
capping and lamination.
5. Recover
1. Slowing tableting rate.
2. By reducing the pressure adjustments.
3. By addition of hygroscopic substance e.g.
sorbitol to maintain a proper moisture level.
4. By replacing the worn out dies and
punches.
5. By correcting the level of the top of the
lower punch so as to coincide with the level
of the upper surface of the die.
6. By using proper granules and required
amount of fine powders.
6. Picking and Sticking:
In picking a small surface of the tablet
material is removed by the punches and
adheres to the surface of punches therefore
the resulting tablets show a pitted surface
instead of smooth surface.
In sticking the tablet material i.e. the
granules adhere to the die wall and thereby
the lower punch cannot move freely.
7. Reason:
1. For the presence of scratches or engraving
or embossing on the punches.
2. For using wet granulation during
compression.
3. Sticking may be happened due to the use of
damp granules or, due to worn out dies and
punches.
4. Excessive moisture may be responsible.
5. Low melting point substances, either active
ingredient or additives may soften from heat of
compression and thus can cause sticking and
picking.
8. Recover:
1. Lettering should be designed as large as possible.
2. By using chromium plated punches for producing a
smooth non-adherent face.
3. By using dry granules and by adding a lubricant to
the granules.
4. In some cases colloidal silica added to formula acts
a polishing agent and makes the punch faces smooth
sometimes additional binder or a change in binder
may make the granules more cohesive and therefore
less adherent.
5. By using higher melting point materials as diluents.
6. In case of excessive moisture further drying of the
granules.
9. Mottling:
Mottling is an unequal distribution of color on a
tablet, with light or dark areas standing out in an
otherwise uniform surface.
Causes:
1. Due to the difference of colors in the drugs
and the added excipients.
2. Due to the colored degraded products of the
drug.
3. Due to the migration of dyes during drying of
granules.
4. Due to the use of colorants in direct
compression formulation.
10. Prevention:
1. By using a dye which can mask the color
of tablet ingredients.
2. By changing the solvent system of the
granulation.
3. By drying the granules at a low
temperature.
4. By changing the binder system.
5. By grinding to a smaller particle size.
11. Weight variation:
Weight varies beyond the specifications.
Causes:
1. Poor flow of granules to the die; size separation
of granules i.e. small and large size granules.
2. Presence of too fines in the granules.
3. Separation of the mixed ingredients of granules
4. Less quantity of poor mixing of lubricants.
5. Due to automatic change in the adjustment of
punches.
6. In rotary tablet making machines this defect is
due to unequal length of lower punches.
12. Overcome:
1. Making granules of good flow properly.
2. Proper granulation
3. Removing the too fines from the
granulation etc. according to the causative
factors.
13. Hardness variation:
The tablet varies greatly in hardness.
Reasons: The reasons for this variation are the
same as discussed under weight variation. Apart
from these reasons other factors include:
1. Density of material.
2. Space between the upper and lower punches at
the time of compression.
3. Inappropriate pressure applied on the upper
punches
4.Excessive proportions of fatty lubricant such as
magnesium stearate.
5. Some times on normal storage of tablets.
14. Problem: It is important to note that the
tablets should not be harder than required.
The hard tablets may not disintegrate in the
required period of time and to soft tablets
may not withstand the hazards during
handling, transporting and dispensing.
Overcome:
This defect should be made up by addressing
the causative factors.
15. Double impression:
This defect occurs in those tablets on which
letters are printed. This involves only lower punch
which has a monogram to produce a impression
on the tablet during compression.
On some machines the punch travels uncontrolled
upward to a short distance to push the tablet out
of the die. During its free travel it rotates and
makes second impression on the tablet. This
impression is generally lighter than the original
impression.
The new tablet making machines are fitted
with devices which prevent the rotation of the
lower punch.