MPD is an uncommon skin malignancy characterized by a chronic eczema-like lesion of the nipple and adjacent areolar skin. Paget cells originate in either invasive intraduct carcinoma or ductal carcinoma in-situ (DCIS) of in the deeper breast tissue.
Extramammary Paget disease (EMPD). A similar condition that involves the skin of the anogenital regions of female and male where there are an abundance of apocrine glands.
Paget's disease of the breast is an extremely challenging problem. It not only poses a diagnostic dilemma but a therapeutic as well. The paper describes the diagnostic and therapeutic challenges.
Paget's disease of the breast is an extremely challenging problem. It not only poses a diagnostic dilemma but a therapeutic as well. The paper describes the diagnostic and therapeutic challenges.
This is a presentation on most common applications of immunohistochemistry in breast lesions. Prepared by Dr Ashish Jawarkar, Assistant professor in pathology, Parul Institute of Medical sciences and research Vadodara
This is a concise presentation on the pathology of endometrial cancer based on the latest WHO female genital tumors latest edition, 5th edition
prepared on April 2022
Childhood mumps, certain bacterial infections (for example, of the tonsils or teeth), and other diseases that are typically more common among adults (such as AIDS, Sjögren syndrome, diabetes mellitus, sarcoidosis, and bulimia) often cause swelling of the major salivary glands.
This is a presentation on most common applications of immunohistochemistry in breast lesions. Prepared by Dr Ashish Jawarkar, Assistant professor in pathology, Parul Institute of Medical sciences and research Vadodara
This is a concise presentation on the pathology of endometrial cancer based on the latest WHO female genital tumors latest edition, 5th edition
prepared on April 2022
Childhood mumps, certain bacterial infections (for example, of the tonsils or teeth), and other diseases that are typically more common among adults (such as AIDS, Sjögren syndrome, diabetes mellitus, sarcoidosis, and bulimia) often cause swelling of the major salivary glands.
Subspecialty of dermatology and pathology focused on performing and interpreting tests on human tissue samples to provide scientific data and consultative opinions to referring clinicians
Vitiligo is an acquired pigmentary disorder of the skin and mucous membranes characterized by circumscribed depigmented macules and patches that result from a progressive loss of functional melanocytes that are selectively destroyed.
Androgenetic alopecia (AGA), also referred to as male-pattern hair loss or common baldness in men and as female-pattern hair loss in women is the most common hair loss disorder
Acne vulgaris is a common chronic skin disease involving blockage and/or inflammation of pilosebaceous units
Acne can present as noninflammatory lesions, inflammatory lesions, or a mixture of both,
affecting mostly the FACE but also the back and chest.
There are several dermatoses that occur during pregnancy or immediately postpartum, in particular polymorphic eruption of pregnancy, pemphigoid gestationis, and atopic eruption of pregnancy. Pruritus due to intrahepatic cholestasis of pregnancy leads to nonspecific skin lesions, including excoriations due to scratching.
Impetigo herpetiformis simply represents pustular psoriasis occurring during pregnancy, and this may be related to the relative hypocalcemia of pregnancy. Lastly, there are physiologic changes that occur during pregnancy.
ABNORMAL REDNESS of the skin resulting from dilation of blood vessels that is Blanch on pressure or Diascopy
Erythema Multiforme, Stevens Johnson Syndrome, and Toxic Epidermal Necrolysis
Figurate Erythemas
Urticaria is characterized by WEALS (hives) or ANGIOEDEMA (swellings, in 10%) or both (in 40%). There are several types of urticaria
Spontaneous urticaria
Acute spontaneous urticaria Spontaneous wheals and/or angioedema <6 />6 wk
Urticarias induced by physical agents
dermographic urticaria Eliciting factor: mechanical shearing forces (wheals arising after 1–5 min)
Cold contact urticaria Eliciting factor: cold objects/air/fluids/wind
Solar urticaria Eliciting factor: UV and/or visible light
Delayed pressure urticaria Eliciting factor: vertical pressure (wheals arising with a 3–12 h latency)
Heat contact urticaria Eliciting factor: localized heat Hot water bottle Hot drink
Vibratory urticaria/angioedema Eliciting factor: vibratory forces, e.g. pneumatic hammer/Jack hammer
Other inducible urticarias
Contact urticaria Elicitation by contact with urticariogenic substance
Aquagenic urticaria Eliciting factor: water
Cholinergic urticaria Elicitation by increase of body core temperature due to physical exercises, spicy food, stress
Exercise-induced anaphylaxis/urticaria Eliciting factor: physical exercise
The major forms of dermatitis include
Atopic,
Contact
Seborrheic,
Asteatotic (xerotic),
Stasis,
Disseminated Eczema (Autosensitization)
Nummular. (Discoid)
Pompholyx
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Atopic,
Contact
Seborrheic,
Asteatotic (xerotic),
Stasis,
Disseminated Eczema (Autosensitization)
Nummular. (Discoid)
Pompholyx
Insects Bites & Stings: can be divided into 2 groups venomous insect such as a bee or wasp, which uses this as a defense mechanism by injecting toxic and painful venom through its stinger.
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Papular Urticaria:
common disorder manifested by chronic or recurrent papules caused by a HYPERSENSITIVITY REACTION to the bites of mosquitoes, fleas, bedbugs, and other insects
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
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Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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4. MAMMARY PAGET DISEASE (MPD)/
PD OF THE NIPPLE/ PD OF THE BREAST
MPD is an uncommon skin malignancy
characterized by a chronic eczema-like
lesion of the nipple and adjacent areolar
skin.
5. MAMMARY PAGET DISEASE (MPD)/
PD OF THE NIPPLE/ PD OF THE BREAST
A progressive, well marginated (well
circumscribed), chronic eczematous change
due to invasion of the epidermis by malignant
Paget cells.
Paget cells originate in either invasive intraduct
carcinoma or ductal carcinoma in-situ (DCIS) of
in the deeper breast tissue.
6. A 55-year-old woman presented with one year history of unilateral
pruritic eczema-like rash confined to the areolar area of one breast.
7. MPD
A similar condition that involves the skin of the anogenital
regions of female and male where there are an abundance
of apocrine glands is known as extramammary Paget disease
(EMPD).
10. INCIDENCE OF MPD
Uncommon, 1-4% of female breast carcinoma cases are
associated with PD of the nipple, the areola, and the
surrounding skin.
Almost exclusively in ♀ involvement of the male breast is
rarely reported.
Is most frequent in the 5th and 6th decade mean age at
diagnosis of 55 years.
Nearly 100% of mammary PD cases are associated with an
underlying carcinoma, either invasive intraduct carcinoma
(90%) or ductal carcinoma in-situ (10%).
12. ETIOLOGY OF MPD
Intraepidermal extension of malignant ductal
epithelial cells (Paget cells) through the
lactiferous ducts and ductules into the
epidermis (EPIDERMOTROPISM) infiltrate
and proliferate in the epidermis.
14. ETIOLOGY OF MPD
PAGET CELLS MAY BE DERIVED FROM:
1. GLANDULAR STEM CELLS:
Paget cell share similar immunohistochemical characteristics with
eccrine and apocrine sweat gland epithelium.
Paget cells are periodic acid-Schiff (PAS) positive and diastase
resistant; and they are Alcian blue positive or…..
15. ETIOLOGY OF MPD
PAGET CELLS MAY BE DERIVED FROM:
2. EPIDERMAL TOKER CELLS (clear cells of the nipple epithelium):
Due to the similarity of the immunophenotypes.
Toker cells have been found in about 10% of normal nipples and
rarely in supernumerary nipples and apocrine bearing areas.
Like Paget cells of both mammary and extramammary sites, Toker
cells contain prominent clear (vacuolated) cytoplasm, and they are
considered benign counterparts of Paget cells & sometimes
proliferate, resulting in a condition known as clear cell papulosis.
20. Paget's disease. Images macroscopic woman than 50 years that had
significant areolar eczema in the left region, which had been increasing in
the last six months, accompanied by itching. See as there accompanying
nipple retraction.
21.
22. A 15yr old girl presented to the clinic with complaints of itching in the
nipple area of left breast for the past 2 years.
23. Showing an ulcerated erythematous plaque covering whole of the left
breast, the sub mammary area and adjacent part of abdominal wall,
covered with purulent to hemorrhagic crusts
26. C/P OF MPD
PHYSICAL EXAMINATION AT EARLY STAGE:
The lesion usually begins at the nipple and
gradually spread to the areola.
The early changes may be minimal, with a unilateral
small, crusted and intermittently moist area on the
nipple giving a brownish stain on clothing, or
producing itching, pricking or burning sensations.
Less often, there is a serous or blood-stained
discharge from the nipple, or a lump may be
noticed in the breast.
The surface changes persist and gradually spread
to produce an eczematous appearance.
27. C/P OF MPD
PHYSICAL EXAMINATION AT A LATER STAGE:
Skin of the breast is erythematous and moist or crusted sharply
marginated, indurated & thickened plaques and may spare a
segment of the areola.
The edge is slightly raised and irregular in outline.
If the crusts are removed, a red, glazed, moist or vegetating surface
is revealed.
Itching may be a prominent symptom and excoriations may be
found in the established lesion.
The nipple itself may be retracted, and a subjacent palpable mass
or a lump deeper in the breast may be felt. Nipple invagination is
sometimes seen.
28. C/P OF MPD
The regional LN should be examined;
they are rarely enlarged when a mass
cannot be felt, but are enlarged in more
than half the cases with a detectable
tumor.
29. C/P OF MPD
The changes may occasionally involve not only the skin of
the breast but also spread on to the chest wall.
Poor prognosis is associated with invasive disease and the
presence of a palpable mass.
30. C/P OF MPD
Pigmented mammary PD and pigmented
extramammary PD are rare clinical entities in
both males and females.
These diseases may mimic malignant
melanoma both clinically and
histopathologically. They may also mimic
melanoma on dermoscopic examination.
In pigmented lesions of PD, numbers of
benign melanocytes are present, which may
interfere with the correct diagnosis of PD.
33. DDx OF MPD
1) Eczema of the nipple
2) Bowen’s disease (very uncommon on the nipple)
3) Superficial BCC (very uncommon on the nipple)
4) Psoriasis
5) Amyloidosis
6) Erosive adenomatosis of the nipple.
7) Nipple duct adenoma
8) Drug Eruptions
9) Malignant melanoma
37. MPD: an area with microcalcifications in the lower inner left quadrant with
extension towards the nipple which shows retraction and some
calcifications within, there is also minimal extension towards the lower
outer left quadrant.
38. Paget's disease. Cranio-caudal mammograms of left breast of a patient
diagnosed with Paget. Area of 10 cm that affects the external cuadrants
which identifies multiple pleomorphic microcalcifications, very suspicious
of malignancy, which at higher magnification (right) continue the road of
the nipple lactiferous duct (arrow)
39.
40. MPD in right breast, unifocal, isolated in nipple.
41. BREAST PAGET DISEASE. 75 years old woman presenting a lesion in the
left nipple since 2 weeks ago. ULTRASOUND left retroareolar area:
where microcalcifications can be identied.
42. INVESTIGATIONS OF MPD
1. MAMMOGRAPHY:
Radiographic changes seen in MPD include the following: “4”
1. Subareolar microcalcifications (helpful in evaluating and locating
clinically occult, nonpalpable underlying breast carcinoma)
2. Architectural distortion
3. Thickening of the nipple and the areola (reflecting edema)
4. Nipple changes (in a minority of patients)
Negative preoperative mammography findings did not
reliably exclude an underlying carcinoma.
43. INVESTIGATIONS OF MPD
2. MRI of the involved breast can detect otherwise occult PD in
the setting of negative mammography findings.
44. INVESTIGATIONS OF MPD
3. ULTRASOUND to establish whether or not there is deeper
pathology in the underlying breast, as this will help determine
the extent of surgery required.
45. INVESTIGATIONS OF MPD
• Tzanck smear
• Biopsy of the tumor
• Sentinel lymph node biopsy
II. Tissue Analysis: “3”
46. INVESTIGATIONS OF MPD
TISSUE ANALYSIS: “3”
1. TZANCK SMEAR: The presence of large cells with a high nuclear-to-
cytoplasmic ratio, occasional acinar formation, and intracytoplasmic
vacuoles is diagnostic for malignant Paget cells.
2. BIOPSY OF THE TUMOR: Punch, wedge, or excisional biopsy.
3. SENTINEL LYMPH NODE BIOPSY: is performed in cases with an
invasive component.
47.
48.
49. Histopathological section showing large atypical round to oval cells
(arrow) infiltrating the lower part of epidermis having a pale cytoplasm
with prominent hyperchromatic nuclei
50. (A) The epidermis of the nipple infiltrated by large Paget’s cells with pale
abundant cytoplasm
(B) Single groups of Paget’s cells with vesicular nuclei and prominent
nucleoli
51.
52.
53. HISTOPATHOLOGY OF MPD
THE EPIDERMIS:
Hyperkeratosis or parakeratosis.
Acanthosis, with papillomatosis.
Enlargement of the rete ridges.
Characteristic Paget’s cells singly or in clusters (nests) are dispersed
between the prickle cells. They vary in number, and when profuse
the Malpighian layer may be disrupted and the surface covered by a
crust.
In the later stages, the epidermis may be atrophic or eroded.
54. HISTOPATHOLOGY OF MPD
Their ultrastructural features of Paget’s cells are those of
glandular epithelial cells it’s cytoplasm is PAS-positive &
packed with numerous rounded, membrane-bound mucin
granules.
Infiltration occurs by variable numbers of signet-ring forms
tumor cells that are present in all layers of the epidermis.
Mitotic figures are occasionally identified.
55. HISTOPATHOLOGY OF MPD
PAGET CELLS CLASSICALLY HAVE THE
FOLLOWING HISTOLOGICAL FEATURES:
1. Large rounded or ovoid atypical cells
2. Abundant pale-staining cytoplasm
3. Mucin-positive
4. Enlarged, scattered mitochondria
5. Large rounded or ovoid vesicular-to-
hyperchromatic nuclei with prominent nucleoli.
6. Scanty nuclear chromatin
7. They are devoid of intercellular bridges
56. HISTOPATHOLOGY OF MPD
In the ulcerated lesions of MPD, the epidermis is totally
replaced by Paget cells.
A large biopsy or excision may demonstrate the presence of
epidermal Paget cells and an underlying infiltrating or
intraductal carcinoma of the breast.
The Paget’s cells may also be seen in appendage ducts.
57. HISTOPATHOLOGY OF MPD
THE DERMIS chronic inflammatory reaction in the upper
dermis contains a dense infiltrate of lymphocytes, histiocytes,
plasma cells, and occasionally eosinophils.
AN UNDERLYING BREAST CARCINOMA may be seen on
large biopsy. The cells may accumulate within and distend
the ducts and spread in both directions. A number of ducts
are usually involved. At a later stage, the carcinoma becomes
invasive and behaves like classic breast carcinoma.
58. HISTOPATHOLOGY OF MPD
Several histologic variants of PD are as
follows: “5”
1. Adenocarcinomalike cell type
2. Spindle cell type
3. Anaplastic cell type
4. Acantholytic cell type
5. Pigmented cell type
59. The clear appearance of cytoplasm in Paget’s disease is due to their
abundant content of neutral and acidic mucopolysaccharides which can
be demonstrated by PAS stain
60. The malignant cells are usually immunoreactive for Carcinoembryonic
antigen (CEA)
62. SPECIAL STAINS OF PAGET’S CELLS
1. PAS STAIN:
Paget’s cells shows PAS positive diastase-resistant granules,
indicating the presence of neutral mucopolysaccharides and
supports the glandular origin of the cells.
2. Alcian blue:
Positive.
63. IMMUNOHISTOCHEMISTRY
POSITIVE MARKERS OF PAGET'S CELLS ARE “5”:
1. CEA (Carcinoembryonic Antigen)
2. EMA (Epithelial Membrane Antigen)
3. CK7 Low molecular weight cytokeratins proposed as a specific and
nearly 100% sensitive marker for MPD.
4. CAM-5.2 (Cellular adhesion molecule) Glandular epithelial cell
markers.
5. erbB-2 (>90%)
64. IMMUNOHISTOCHEMISTRY
NEGATIVE MARKERS OF PAGET'S CELLS, which serve as
differentiating features from malignant melanoma “5”:
1. Anti-s-100 protein
2. Melan A (MART-1)
3. HMB-45
4. Tyrosinase
5. DOPA
67. STAGING OF MPD
Mammary Paget disease has been classified into 4 clinical stages
Stage 0
Lesion confined to the epidermis, without underlying in situ ductal
carcinoma of the breast
Stage 1 Associated with in situ ductal carcinoma just beneath the nipple
Stage 2 Associated with extensive in situ ductal carcinoma
Stage 3 Associated with invasive ductal carcinoma
69. Rx OF MPD
I. Mastectomy (radical or modified)
and LN clearance
II. Photodynamic therapy (PDT)
III. Conservative management
70. Rx OF MPD
I. Mastectomy (radical or modified) and LN
clearance in cases with palpable mass and
underlying invasive breast carcinoma.
71. Rx OF MPD
II. Photodynamic therapy (PDT) using aminolevulinic acid (5-
ALA) for low-risk malignant cells
72. Rx OF MPD
III. Conservative management: In patients with no evidence of
an underlying breast carcinoma. Combination of “3 measures”;
1. Local excision of the nipple,
2. Wedge resection of the underlying breast tissue,
3. Radiation therapy: according to the presence or absence
of an invasive component.
75. EXTRAMAMMARY PAGET DISEASE
EMPD is an uncommon tumor characterized
by a chronic eczema-like lesion of the skin
around the anogenital regions of males and
females.
In women the most common area involved is
the vulva.
The clinical and the histopathological findings
are very similar to the more common type of
MPD.
76. Grossly inflamed erythema on the vulva extending to the perineum.
There were whitish cheesy lesions on the wall of the vagina. Superficial
erosions were noted on the left posterior area. Her regional nodes were
not enlarged.
77.
78.
79. This man presented with a pruritic, erythematous, scaly, eroded
dermatitis-like rash involved the perianal area of two months duration.
Three months before rash appearance the patient had suffered
constipation and many episodes of rectal bleeding. Sigmoidoscopy
disclosed rectal carcinoma whereas perianal skin biopsy was consistent
with extramammary Paget's disease.
82. EMPD HAS BEEN CLASSIFIED INTO
SEVERAL SUBTYPES:
primary cutaneous extramammary Paget disease arises from apocrine
glands within the epidermis (in situ) or underlying skin appendages
primary cutaneous extramammary Paget disease (15-25%) is associated
with invasive Paget disease or adenocarcinoma in situ.
extramammary Paget disease originates from underlying anal or rectal
adenocarcinoma
extramammary Paget disease originates from bladder adenocarcinoma
Type1a
Type 1b
Type 2
Type 3
83.
84.
85.
86. Rx OF EMPD
Wide local excision, vulvectomy, or Mohs micrographic
surgery is the standard treatment.
Recurrence is common (30-50%), so patients should be re-
examined every 3 months after surgery for the next 2 years,
after which annual follow-ups are recommended.
Recurrence generally leads to further surgery.
87. Rx OF EMPD
Non-surgical treatments for recurrent disease may include:
1. Radiotherapy
2. Laser ablation
3. Photodynamic therapy
4. 5-fluorouracil cream
5. Imiquimod cream