This document discusses a case study of a 29-year-old female patient who presented with a rapidly growing right breast lump. She had a history of multiple surgeries for left breast lumps, with the most recent being a left simple mastectomy in January 2017 that showed a borderline phyllodes tumor. Investigations of the current right breast lump showed features consistent with a phyllodes tumor. She underwent a right simple mastectomy in May 2017, and the pathology again showed a borderline phyllodes tumor. The document then discusses grading of phyllodes tumors, distinguishing between benign and borderline types, and definitions used in grading.
Seminar presentation by student under supervision of endocrinology specialist from HRPZ. References as mentioned in the slides. Mostly from Malaysia CPG.
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2. Clinical History
29 yr old female Premenopausal, multi gravida
presented on 28/04/17 with complain of Right sided
breast lump, which suddenly increased in size during 15
days.
There were no other complains with not significant
family history.
Menstrual History- normal , Age of menarche-13 years
Obstetric History- G2 P2 A0 , Breastfeed all children
3. Past History
Operated 4 times for Left Breast Lump
3 times- Left breast lumpectomy
Left simple mastectomy in January 2017 with HPE
suggestive of Borderline Phyllodes
5. Investigations
USG Right Breast
Multiple well defined heterogeneously hypo echoic lesions
in right breast with largest lesion sized 8*7*5 cm sized from
8 to 10 o'clock position.
Multiple tiny cystic areas with mild to moderate peri lesional
vascualrity
Core Biopsy
Phyllodes tumor
6. Treatment
Right Simple mastectomy with Axillary sampling was done
on 09/05/2017.
HPE
Borderline Phyllodes tumor
Mild to moderate Cytological atypia,
Mitosis = 0-1 to 4-5/hpf
Necrosis Absent
Surgical Margins -free,pushing
Stromal Hypercellularity
Lymph nodes- All 20 free of tumour
12. Gross Appearance
Phyllodes tumors are highly variable in their GROSS
APPEARANCE.
The majority are well-circumscribed, solid, grayish white, yellow,
or pink fleshy masses with cystic areas.
Foci of necrosis and hemorrhage may be seen in larger tumors
Tumors range in size from 1 to 45 cm, but on average are 4 to 5
cm in diameter.
A true histologic capsule is absent. On gross examination, these
tumors do not appear distinctly different from fibroadenomas.
13. Benign Phyllodes
It can be difficult to distinguish benign PT from cellular
fibroadenoma because increased stromal cellularity is a
prominent feature of both.
The distinction between the 2 is important, however,
because their treatment and prognosis are different.
The leaflike pattern that is typical of PT is not seen in cellular
fibroadenoma and, if present, is focal and not well
developed. One source of difficulty is the fact that
14. Biological Behavior
The perceived clinical relevance of grading phyllodes tumours is
to predict clinical behaviour
Benign tumours have the potential to locally recur.
Borderline tumours have the potential to recur locally, and have a
very low risk of metastasis.
Malignant tumours have the highest risk of metastatic behaviour,
which may eventually prove fatal. However, it
is accepted that adverse events are, in general, rare for all forms
of phyllodes tumours when they are subjected to complete local
excision.
15. Distinguishing cellular fibroadenoma from benign phyllodes
tumour
It can be difficult to distinguish benign PT from cellular
fibroadenoma because increased stromal cellularity is a
prominent feature of both.
The distinction between the 2 is important, however,
because their treatment and prognosis are different.
The leaflike pattern that is typical of PT is not seen in cellular
fibroadenoma and, if present, is focal and not well
developed.
16. One source of difficulty is the fact that fibroadenoma-like
areas can be seen in otherwise typical cases of PT.
Histologic heterogeneity in stromal cellularity and structure
in PT may further create difficulty in the distinction between
PT and cellular fibroadenoma on core biopsy.
17. (A) Low magnification showed a few elongated epithelium-
lined clefts with stromal mounds. Mild stromal
hypercellularity was observed.
(B) Higher magnification of a stromal frond pushing into the
clefted space that contained blood and haemosiderophages,
with accentuation of stromal nuclei in the periepithelial zone
18. Benign phyllodes tumor.
Leaflike projections of mildly increased stromal cellularity.
Enhanced intracanalicular pattern, characterized by projection of
cellular stroma into epithelial-lined clefts of cystic spaces
22. Definitions
Mitotic activity -Evaluated in more cellular areas and quantified
per 10 HPF
Stromal overgrowth -Stromal proliferation without accompanying
epithelial elements in at least 1 low-power field.
Infiltrative tumor margin -Projections of tumor stroma into the
peritumoral stroma or adipose tissue
23. (A) Mild nuclear atypia shows minimal variation in nuclear size with
even chromatin and smooth nuclear contours.
(B) Moderate nuclear atypia with more variation in nuclear size and
irregular nuclear membranes.
(C)Marked nuclear atypia with marked nuclear pleomorphism,
hyperchromasia, and irregular nuclear contours.
24. Stromal cellularity –Evaluated in the most cellular areas
Mild -Twice cellularity of normal perilobular stroma with
evenly spaced nuclei without overlapping
Moderate- Intermediate in degree between mildly and
markedly
Marked -Stromal cells in close contiguity with nuclei
appearing to touch and overlapping
25. Borderline Phyllodes tumour
(A)Rounded pushing contour of the tumour.
(B) Stromal hypercellularity was of moderate degree, accompanied by
focally marked nuclear atypia.
(C) Higher magnification of atypical stromal cells showed
hyperchromatic nuclei, prominent nucleoli, and occasional mitoses
(arrow).
26. Borderline phyllodes tumor.
The stroma is moderately cellular and the stromal cells show
moderate nuclear atypia
(hematoxylin-eosin,
27. Malignant phyllodes tumor.
The stroma is markedly cellular and the stromal cells show marked
nuclear pleomorphism. There are
numerous mitoses
28. Malignant phyllodes tumour with metastasis to the lung.
(A) Low magnification of the primary breast phyllodes tumour with a
cystic space into which stromal fronds projected.
Part of the tumour showed a fibroadenoma-like appearance, whereas
the remaining parts were more cellular.
29. ) Higher magnification of the cellular stromal areas showed
sheets of plump spindled cells with enlarged vesicular nuclei
with distinct nucleoli and scattered mitoses.
Several osteoclastic giant cells were dispersed among the
spindled cells.
30. (C) Metastasis to the lung 1 year later showed a similar
abnormal spindled population with scattered osteoclastic
giant cells.
No epithelial component was present in the metastasis.
31. Malignant phyllodes tumour with liposarcoma
(A)Stromal fronds contained cells with marked nuclear pleomorphism
with a few bizarre cells.
(B)Among the abnormal stromal cells were scattered lipoblasts
featuring hyperchromatic scalloped nuclei with vacuolated
cytoplasm, indicating a liposarcomatous component.
32. Malignant spindle cell proliferation.
The presence of a bland epithelial component in the upper right of
this core biopsy is typical
of malignant phyllodes tumor