Plasmodium malariae was discovered in 1889 by Feletti and Grassi, who originally named it Haemamoeba malariae. It is found primarily in sub-Saharan Africa, Southeast Asia, and Latin America. P. malariae has a low parasitemia due to producing a low number of merozoites during its asexual cycle, which occurs every 72 hours by developing inside aged red blood cells. It causes quartan malaria with fever every 72 hours and other symptoms like nausea, chills and cold sweats. Complications include nephrotic syndrome and edema. Diagnosis involves examining blood films for all parasite stages in the peripheral blood.