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Viruses
What is a virus?
‘Infectious particle’
Genetic material
Protein coat
Properties of a virus
• A virus is a very small, infectious, obligate
intracellular parasite
• Virus particles are not living
• Viruses are chemicals, and by themselves cannot
reproduce
• A susceptible and permissive cellular host is
needed for viruses to reproduce
• All viruses must make mRNA that can be
translated by host ribosomes
Basic virus structure
DNA
RNA
OR
Basic virus structure
DNA
RNA
OR
DNA
RNA
OR +
Basic virus structure
DNA
RNA
OR +
DNA
RNA
OR + Capsid
Protein
Basic virus structure
DNA
RNA
OR + Capsid
Protein
DNA
RNA
OR + Capsid
Protein
Basic virus structure
DNA
RNA
OR + Capsid
Protein
Basic virus structure
DNA
RNA
OR + Capsid
Protein
Nucleocapsid
DNA
RNA
OR + Capsid
Protein
Basic virus structure
DNA
RNA
+
Capsid
Protein
Nucleocapsid
DNA
RNA
OR
+
Capsid
Protein
Basic virus structure
DNA
RNA
OR
+
Capsid
Protein
Nucleocapsid
DNA
RNA
+
Capsid
Protein =
Basic virus structure
DNA
RNA
OR
+
Capsid
Protein
Nucleocapsid
DNA
RNA
+
Capsid
Protein =
+
Basic virus structure
DNA
RNA
OR
+
Capsid
Protein
Nucleocapsid
DNA
RNA
+
Capsid
Protein =
+
Lipid membrane
Glycoproteins
Basic virus structure
DNA
RNA
OR
+
Capsid
Protein
Nucleocapsid
DNA
RNA
+
Capsid
Protein =
+
Lipid membrane
Glycoproteins
Enveloped
virus
Capsid symmetry
Icosahedral Helical
Attachment
Attachment: tropism
Lock and key
Penetration
Disassembly
Viral genome
Disassembly
mRNA
Viral genome
Viral
enzymes
Transcription
mRNA
Viral
proteins
Viral
enzymes
Viral genome
Translation
mRNA
Viral
proteins
Viral
genome
Genome replication
mRNA
Viral
proteins
Assembly
mRNA
Viral
proteins
Viral genome
Assembly
Release
Retroviruses
Outcome of cellular infection
Immune response
• Cell mediated immunity
– Important in the recovery from viral illness
• Antibodies
– Important in the protection from repeat exposure
M2 basic virus_hg

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M2 basic virus_hg