The document provides information about the liver, gallbladder, and spleen. It discusses the formation, location, lobes, blood supply, and clinical notes of the liver. It describes the gallbladder's formation, location, vasculature, and clinical issues like biliary colic and cholecystitis. For the spleen, it notes the location under the left ribs and impressions from other organs on its surface.
This is not a substitute for Books. Let it just help you understand some concepts in liver anatomy.
Continuation of this work will depend on your feedback. Stay Blessed.
Consists of liver, biliary tree, gall bladder
Liver is the largest gland in the body
Multiple functions
Disease of the liver and biliary tree influences drug actions
Every anesthetic drugs are metabolized by the liver
So liver is very much important for anesthetists
This is not a substitute for Books. Let it just help you understand some concepts in liver anatomy.
Continuation of this work will depend on your feedback. Stay Blessed.
Consists of liver, biliary tree, gall bladder
Liver is the largest gland in the body
Multiple functions
Disease of the liver and biliary tree influences drug actions
Every anesthetic drugs are metabolized by the liver
So liver is very much important for anesthetists
Surgical Anatomy of the Liver : Ηepatectomies - Dimitris P. KorkolisDimitris P. Korkolis
- The liver is the largest gland in the body and has a wide variety of functions
- Weight: 1/50 of body weight in adult & 1/20 of body weight in infant
- It is exocrine(bile) & endocrine organ(Albumin , prothrombin & fibrinogen)
Function of the liver :
- Secretion of bile & bile salt
- Metabolism of carbohydrate, fat and protein
- Formation of heparin & anticoagulant substances
- Detoxication
- Storage of glycogen and vitamins
- Activation of vita .D
To define the hepatobiliary system
To outline the embryological development and congenital anomalies of the hepatobiliary system.
To describe the gross anatomy and histology of the hepatobiliary system.
To outline the clinical anomalies associated with the hepatobiliary system
Composed of the liver and the bile ducts.
Mainly concerned with formation, transport, concentration and secretion of bile.
Bile is produced by the liver and transported by the bile ducts into the small intestines
Surgical Anatomy of the Liver : Ηepatectomies - Dimitris P. KorkolisDimitris P. Korkolis
- The liver is the largest gland in the body and has a wide variety of functions
- Weight: 1/50 of body weight in adult & 1/20 of body weight in infant
- It is exocrine(bile) & endocrine organ(Albumin , prothrombin & fibrinogen)
Function of the liver :
- Secretion of bile & bile salt
- Metabolism of carbohydrate, fat and protein
- Formation of heparin & anticoagulant substances
- Detoxication
- Storage of glycogen and vitamins
- Activation of vita .D
To define the hepatobiliary system
To outline the embryological development and congenital anomalies of the hepatobiliary system.
To describe the gross anatomy and histology of the hepatobiliary system.
To outline the clinical anomalies associated with the hepatobiliary system
Composed of the liver and the bile ducts.
Mainly concerned with formation, transport, concentration and secretion of bile.
Bile is produced by the liver and transported by the bile ducts into the small intestines
Liver is the largest internal organ of the body weighing about 1500g in adults. It occupies the right hypochondrium and extends into the epigastrium and left hypochondrium .
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
1. الرحيم الرحمن هللا بسم
Liver, Gall Bladder,
and Spleen
By
Ammar Mohammed Saleih
Registrar G.Surgery, MSC
Anatomy, ER.Diploma
2. objectives
By the end of this session any one can be able to:
• Identify the different relations of the liver
Gallbladder and spleen.
• Identify the lobs, blood supply and divisions
of the liver.
• Identify the Gallbladder and important
relations and clinical notes .
3. Liver
General Info
• Largest gland in the body
• Has many metabolic activities
– stores glycogen
– secretes bile
• connected to GI tract by the bile duct
• located mainly in the RUQ
5
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5. Formation
• Hepatic diverticulum arises as an endodermal
bud on the ventral surface of the distal foregut
– grows between layers of the septum transversum
– Two new buds forming the L/R lobes of liver
» these contain the blood filled sinusoids of the
liver
• Diverticular stalk between the liver buds and
primitive gut give rise to the gall bladder and
cystic duct. The remaining stalk turns into
the bile duct
5
6. • Umbilical vein in fetus is surrounded by
ventral mesentery connecting the body wall
and the fetus. This is called the falciform
ligament in the adult.
• The Ligamentum venosum is the remnant of
the ductal shunt for blood in the fetus called
the ductus venosus.
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7. Location
• RUQ beneath the diaphragm.
• R hypochondrium and epigastric region.
• Gall bladder is under the visceral surface of
the right lobe, lateral to the liver’s Quadrate
lobe.
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13. Externally
i. The superior, lateral and anterior surface contact
the inferior surface of the diaphragm: liver’s
diaphragmatic surface.
ii. The inferior base of the liver is in contact with the
digestive organs and is called the visceral
surface.
iii. 4 lobes
– R/L are separated by the falciform ligament.
– Caudate lobe is bounded laterally by the fossa for the IVC
and medially by the fissure for the ligamentum venosum.
– Quadrate lobe is inferior to the caudate lobe and lies
between the gall bladder and the fissure for the
ligamentum teres .
13
15. iv. Bare area
– lacks visceral peritoneum
– superioposterior surface adjacent to the diaphragm
– Coronary ligament: extension fo the peritoneum
between the liver and the diaphragm
– L/R Triangular ligaments: lateral extensions of
the coronary ligament
v. Subphrenic recess: cul-de-sac of
peritoneum located between the anterior
surface of the liver and the diaphragm
vi. Hepatorenal recess: cul-de-sac of
peritoneum located between the visceral
surface of the liver and the posteriorly
related right kidney
– fluids can collect in this pocket because it is the
lowest trough in the peritoneal cavity when a
person is supine
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16. vii. Visceral surface
– right lobe contacts the R kidney, hepatic flexure of
the colon and second part of the duodenum and
gall bladder
– left lobe contacts the esophagus and the stomach
viii.Porta hepatis is the area between the the
caudate and quatrate lobes
– location for passage of the portal triad : portal
vein, hepatic artery and bile duct
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19. Internally
• Functional lobes
– different than the anatomical lobes
– determined according to the independent blood
supply to each
– L functional lobe includes the left lobe, caudate
and quadrate lobes
•
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20. Green line: Surgical or functional
division of liver into Right and Left portal lobes
Purple line: Anatomical division
of liver into Right and Left anatomical lobes
Q
c
21.
22. Vasculature: ( mostly located in the
hepatogastric ligament )
• Arteries
– celiac trunk at the level of L1
» common hepatic
» proper hepatic
» right and left hepatics
» porta hepatis of the liver
• Veins
– Portal vein carries the venous return of the
abdominal organs to the liver
– Liver’s venous return in via 3 hepatic veins
emptying into the IVC
5
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23. Innervation
• Parasympathetic
– left vagal trunk: the hepatic branch and hepatic
plexus
• Sympathetic
– greater thoracic splanchnic nerve (t7-9): celiac
plexus and hepatic plexus
• Referred pain would present at level of T7-9
dermatomes
Lymphatics:
• Liver to the hepatic nodes to the celiac
nodes around the celiac trunk
• To the intestinal trunk to the lumbar trunk to
the cisterna chili and into the thoracic duct
• 23
24. Clinical Notes
i. Portal hypertension: increased venous pressure
in the portal vein due to resistance of blood flow
through the liver
causes are classified:
» pre-hepatic: partial occlusion in the portal vein
» intra-hepatic: intrinsic liver disease
» post-hepatic: occlusive pathology in the venous
drainage of the liver
3 key portal-caval anastomotic links
» esophagus: can cause life threatening
hemmorrhage
» anal canal: vein distension can cause hemorrhoids
» anterior abdominal wall in the umbilical region:
produce a snake-like radial pattern called caput
medusae
24
25. ii. Inflammation of the liver: due to infection
that can lead to erosion through the dense
liver capsule into the abdominal cavity
producing pleuritis or empyema
iii. Metastatic cancer of the liver: resulting from
deposition of spreading cancerous cells that
originated in the GI tract
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26. Gall Bladder
General Info
• Non-vital organ
• Concentrates and stores the liver’s bile
Formation :An expansion of the diverticular stalk
Location: in the gall bladder fossa of the liver
lateral to the quadrate lobe
5
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27. Externally: composed of a fundus, body, neck,
and cystic duct that joins the common hepatic
duct
Internally: spiral mucosal folds in the duct are
thought to act like a valve in response to
hormonal stimuli
27
28. D
GB
Cystic duct
(with spiral valve)
Common hepatic
duct
Bile duct
Main pancreatic duct
Ampulla of Vater
Rt. & Lt.
Hepatic ducts
Major
papilla
Hepatopancreatic Duct
System
29. Vasculature and innervation
Arteries
– celiac trunk to the common hepatic to the proper
hepatic to the cystic artery
Veins:
– cystic vein to the right branch of the portal vein
Parasympathetic
– left vagal trunk to the hepatic branch to the cystic
plexus
Sympathetic
– Greater thoracic splanchnic (T7-9) to the celiac
plexus and cystic plexus
29
30. Ant. & post.
Pancreatico-
duodenal aa.
gastroduodenal a.
Cystic a.
Rt. Hepatic a.
Cystic duct
Bile duct
Sup. Mesenteric
A. & V.
Splenic a.
Portal triad
Uncinate process (of pancreas)
S
GB
P
31. Clinical Notes
Biliary colic: with blockage of the duct will
get referred pain in the RUQ
Cholecystitis: inflammation
Gall stones: make from bilirubin metabolites,
cholesterol or calcium salts
– can obstruct the gall bladder
– can obstruct the common duct or the
hepatopancreatic duct
– when passed can stretch the sphincters making
them less useful to regulate the flow of bile and
pancreatic enzymes
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