The liver is divided into eight segments based on its vascular supply. Each segment has its own branch of the portal vein, hepatic artery, and bile duct supplying it. The hepatic veins drain the periphery of each segment. The middle hepatic vein divides the liver into right and left lobes, while the left and right hepatic veins further divide the lobes into segments. Because each segment has its own vascular inflow and outflow, segments can be surgically resected individually without damaging other segments.