3. Structure of lipoprotein
INTEGRAL APOPROTEINS
CHOLESTEROL
ESTERS
MONOLAYER OF
PHOSPHOLIPID
AND CHOLESTERLOL
CORE
TRIGLYCERIDES
PERIPHERAL APOPROTEINS
7. CLASSIFICATION
Based on density by ultracentrifugation
i. Chylomicrons
ii. Very Low Density Lipoprotein
iii.Intermediate Density Lipoprotein
iv.Low Density Lipoprotein
v. High Density Lipoprotein
10. ďśLDL
transports cholesterol from liver to peripheral tissues.
ďśHDL
transports cholesterol from peripheral tissues to liver
âReverse Cholesterol Transportâ
13. ď HYPOLIPOPROTEINEMIAS
i. Abetalipoproteinemia
microsomal triglyceride transfer protein is defective
LDL & VLDL decreases
ii. Hypo alpha lipoproteinemia
HDL level decreases
iii. Tangier Disease
absence of ATP binding Cassette Transporter 1, involved in
transport of cellular cholesterol to HDL
17. FUNCTIONS OF
CHOLESTEROL
1. Major structural constituent of the cell membranes and lipoproteins
2. Precursor for Steroid hormones
a. Progesterons
b. Glucocorticoids
c. Mineralocorticoids
d. Androgens & Estrogens
3. Formation of Bile acids and bile salts.
4. Synthesis of Vitamin D